公开(公告)号：WO2023274880A1

公开(公告)日：2023-01-05

申请号：PCT/EP2022/067374

申请日：2022-06-24

Applicant: BOEHRINGER INGELHEIM VETMEDICA GMBH

Inventor： NIEMEYER, Axel ,  GRIESSNER, Matthias ,  OSÓRIO, Ricardo

IPC: G01N21/25 ,  G01N21/31 ,  G01N21/33 ,  G01N21/35 ,  G01N21/359 ,  G01J3/0218 ,  G01J3/28 ,  G01J3/44 ,  G01J3/4406 ,  G01N2021/3155 ,  G01N21/255 ,  G01N2201/0624 ,  G01N2201/0627 ,  G01N2201/08 ,  G01N33/487

Abstract: The present invention relates to an optical system having a chamber (26) for receiving an element (E) of body fluid or tissue or environmental sample to be characterized by the optical system, a light source (5) for illuminating the chamber (26) with light, and a spectrometer (6) for recording a spectrum of light originating from the chamber (26), wherein the light source (5) comprising two separate LEDs (5A, 5B) to emit light having at least two spectral maxima of different wavelength ranges, and the light source (5) is coupled to the chamber (26) such that the light is directed from the light source (5) to the chamber (26) when the light source (5) is activated. Further, the present invention relates to a method for determining a parameter with an optical system, wherein the optical system comprises a chamber (26) for receiving an element of body fluid or tissue or environmental sample to be characterized by the optical system, a light source (5) for illuminating the chamber with light, and a spectrometer (6) for measuring a spectrum of light originating from the chamber (26), wherein, in order to determine a parameter representing a property of the element, light having at least two spectral maxima of different wavelength ranges are generated by separate LEDs (5A, 5B) and is directed onto the element, a spectrum comprising reflected components of the light, scattered components of the light, and/or light caused by raman scattering or fluorescence of the element is measured with the spectrometer (6), and the parameter is determined by evaluating the spectrum.

公开(公告)号：WO2021254889A1

公开(公告)日：2021-12-23

申请号：PCT/EP2021/065714

申请日：2021-06-10

Applicant: CYTIVA SWEDEN AB

Inventor： EHRING, Hanno ,  GEBAUER, Klaus

IPC: G01N21/03 ,  G01N21/05 ,  G01N2021/0307 ,  G01N21/0303 ,  G01N2201/08

Abstract: Disclosed is an optical flow cell (100, 300) and a method (400) for bioprocessing applications. The optical flow cell (100, 300) comprises a fluid inlet (102, 302), a fluid outlet (104, 304), and a fluid flow channel (106, 306) provided between said fluid inlet (102, 302) and said fluid outlet (104, 304). The optical flow cell (100, 300) also comprises an output optical waveguide (108, 308) configured to emit light into said fluid flow channel (106, 306), and a collector optical waveguide (110, 310) configured to collect light from said fluid flow channel (106, 306). An optical pathlength adjuster (120, 320) for varying the optical pathlength (130, 330) between said output optical waveguide (108, 308) and said collector optical waveguide (110, 310) is also provided.

公开(公告)号：WO2021154991A1

公开(公告)日：2021-08-05

申请号：PCT/US2021/015485

申请日：2021-01-28

Applicant: KING'S COLLEGE LONDON ,  TRUSTEES OF BOSTON UNIVERSITY ,  BERGHOLT, Mads S. ,  ALBRO, Michael B.

Inventor： SNYDER, Brian D. ,  JENSEN, Magnus

IPC: A61B5/00 ,  G01J3/44 ,  A61B5/0075 ,  A61B5/4528 ,  G01J3/0224 ,  G01N21/21 ,  G01N21/65 ,  G01N2201/08 ,  G01N2201/129

Abstract: Methods and systems for obtaining biochemical and/or structural information relating to tissues using Raman spectroscopy. Polarised light is directed to tissue using a probe. The light is reflected from the tissue, producing Raman scattering. The Raman scattering is collected by the system and split into two polarised components. The two polarised components are simultaneously imaged using a spectrometer to produce two Raman spectra. The Raman spectra are then processed and analysed using a computer program to obtain biochemical and/or structural information relating to the tissue.

公开(公告)号：WO2022214536A2

公开(公告)日：2022-10-13

申请号：PCT/EP2022/059092

申请日：2022-04-06

Applicant: FOX BIOSYSTEMS NV

Inventor： DELPORT, Filip ,  JESPERS, Jens

IPC: A61B5/00 ,  G01N21/00 ,  G02B6/38 ,  G02B6/42 ,  G02B6/36 ,  G01N21/553 ,  G01N2201/08 ,  G02B6/3624 ,  G02B6/3652 ,  G02B6/3801 ,  G02B6/3802 ,  G02B6/3825 ,  G02B6/3897 ,  G02B6/423

Abstract: The present invention relates to an optical fiber connector to position and align an optical fiber into an analytical device, in particular into a bioanalytical device. Also a method for positioning and aligning an optical fiber in such a device is disclosed.

公开(公告)号：WO2022056003A1

公开(公告)日：2022-03-17

申请号：PCT/US2021/049472

申请日：2021-09-08

Applicant: BREWMETRIX LLC

Inventor： SUKUTA, Sydney

IPC: C12Q1/04 ,  G01N21/01 ,  G01J3/28 ,  G01N2033/4975 ,  G01N21/31 ,  G01N2201/064 ,  G01N2201/08 ,  G01N2201/129 ,  G01N33/487 ,  G01N33/497

Abstract: The presence of a virus, such as a coronavirus, or other pathogen can be determined through spectroscopic methods. In one example, the method includes obtaining a biological sample from a subject and obtaining spectrographic data from the sample in an onsite portable spectroscopic unit. The spectroscopic data may be transmitted to a remote lab to determine the presence of the virus or other pathogen within the sample, providing a simple to understand result that does not require significant interpretation by a medical practitioner Contrary to existing test methods such as PCR, this method has no supply chain requirements other than distilled water and results are out in real-time at a highly subdued cost.