公开(公告)号：US20250148577A1

公开(公告)日：2025-05-08

申请号：US18933696

申请日：2024-10-31

Applicant: Optos plc

Inventor： Enrico Pellegrini ,  Peter Wakeford ,  Gavin Robertson

IPC: G06T5/70 ,  G06T5/50 ,  G06T7/00

Abstract: A computer-implemented method of processing at least one image of a retina of an eye acquired by an ophthalmic imaging device, wherein the at least one image shows a texture of the retina. The method comprises processing a first image of the at least one image using a noise reduction algorithm based on machine learning to generate a de-noised image of the retina, wherein the texture of the retina shown in the first image is at least partially removed by the noise reduction algorithm to generate the de-noised image. The method further comprises combining a second image of the at least one image with the de-noised image to generate at least one hybrid image of the retina which shows more of the texture of the retina than the de-noised image.

公开(公告)号：US20250143568A1

公开(公告)日：2025-05-08

申请号：US19014662

申请日：2025-01-09

Applicant: Optos plc

Inventor： Praveen Ashok ,  Alan Anderson

IPC: A61B3/10 ,  A61B5/00 ,  G16H30/40

Abstract: A method of processing B-scans acquired by an OCT imaging system to generate correction data for compensating for axial displacements between B-scans caused by a variation in distance between the OCT imaging system and an imaging target, and to generate a reliability indicator indicative of a reliability of the correction data. The correction data is generated (S10) by determining, for each pair of adjacent B-scans, a respective indicator of an axial shift between respective representations of a common ocular feature in the adjacent B-scans. The reliability indicator is generated by: calculating (S20) values indicative of speeds or accelerations of the imaging target relative to the OCT imaging system when pairs of B-scans were acquired; where at least a predetermined number of calculated values exceed a threshold, setting (S40A) the reliability indictor to indicate that the correction data is unreliable, and otherwise (S40B) to indicate that the correction data is reliable.

公开(公告)号：US20250082195A1

公开(公告)日：2025-03-13

申请号：US18884903

申请日：2024-09-13

Applicant: Optos plc

Inventor： Miguel Preciado ,  Paul McCool ,  Margaret Normand ,  Ewan Rycroft

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/14

Abstract: A Fourier-domain OCT apparatus for optoretinography is provided. An example Fourier-domain OCT apparatus comprises: a fixation target which fixes a gaze direction of an eye; an optical system which applies an optical stimulus which is confined to a portion of a retina of the eye whose location is controllable; an OCT imaging system which acquires OCT data from the retina; and a controller which: acquires a target location on the retina; uses the target location to control the optical system, while a position of the fixation target relative to the eye remains fixed, to apply the optical stimulus to a first portion of the retina at the target location; controls the OCT imaging system to acquire OCT data of a second portion of the retina which is stimulated by the applied optical stimulus during acquisition of the OCT data; and generates the ORG data based on the acquired OCT data.

公开(公告)号：US20240344820A1

公开(公告)日：2024-10-17

申请号：US18621321

申请日：2024-03-29

Applicant: Optos plc

Inventor： Bavishna Balagopal ,  Gonzalo Muyo

IPC: G01B9/02091 ,  A61B3/00 ,  A61B3/10 ,  A61B3/15 ,  G01B9/02015

CPC classification number: G01B9/02091 ,  A61B3/0025 ,  A61B3/102 ,  A61B3/152 ,  G01B9/02015

Abstract: An optical coherence tomography, OCT, imaging system for imaging an object, comprising an interferometer having a sample arm, and a reference arm which comprises: a first optical fibre; an optical switch controllable to guide reference light from the first optical fibre to a selected optical path of N optical paths, where N is an integer greater than or equal to 2, each of the N optical paths having a respective optical path length and/or chromatic dispersion that differs from the respective optical path length and/or chromatic dispersion of each of the other optical paths; and an optical coupler to guide the reference light propagating along the selected optical path to a second optical fibre. The OCT imaging system detects an interference between the reference light propagating via the second optical fibre and the sample light propagating via the sample arm after having been scattered by the object.

公开(公告)号：US20240324873A1

公开(公告)日：2024-10-03

申请号：US18621342

申请日：2024-03-29

Applicant: Optos plc

Inventor： Margaret Catherine Normand ,  Miguel Angel Preciado

IPC: A61B3/10 ,  A61B3/12 ,  G06T5/80

CPC classification number: A61B3/102 ,  A61B3/1225 ,  G06T5/80 ,  G06T2207/10101 ,  G06T2207/30041

Abstract: A line-field Fourier-domain optical coherence tomography, OCT, imaging system, comprising: a curved mirror, and a scanning element at a first focus of the mirror which scans, via the mirror, a line of light across an object at a second focus of the mirror, and receives, via the mirror, light scattered by the object and aberrated by the mirror to form an aberrated line of light; a photodetector array; an interferometer which projects an interference line of light resulting from an interference between a reference light and the aberrated line of light onto the photodetector array. The OCT imaging system generates OCT data based on the interference line of light detected by the photodetector array, and corrects the OCT data using phase information in the OCT data such that the corrected OCT data has less optical aberration than the OCT data.

公开(公告)号：US11893663B2

公开(公告)日：2024-02-06

申请号：US17218480

申请日：2021-03-31

Applicant: OPTOS PLC

Inventor： Enrico Pellegrini

IPC: G06T11/00 ,  A61B3/10 ,  A61B3/12 ,  G06F18/2431 ,  G06T7/143 ,  G06T7/11

CPC classification number: G06T11/008 ,  A61B3/102 ,  A61B3/12 ,  G06F18/2431 ,  G06T7/11 ,  G06T7/143 ,  G06T2207/10101 ,  G06T2207/20076 ,  G06T2207/30041

Abstract: A method of generating a segmentation confidence map by processing classification values each indicating a respective classification of a respective voxel of a retinal C-scan into a respective retinal layer class of a predefined set of retinal layer classes, the method comprising: generating, for each voxel, a respective confidence value which indicates a level of confidence in the classification of the voxel; for a retinal layer class of the predefined set, identifying a subset of the voxels such that the classification value generated for each voxel indicates a classification of the voxel into the retinal layer class; calculating, for each A-scan having voxels in the identified subset, a respective average of the confidence indicator values generated for the voxels; and using the calculated averages to generate the map, which indicates a spatial distribution of a level of confidence in the classification of the voxels.

公开(公告)号：US11857257B2

公开(公告)日：2024-01-02

申请号：US18071677

申请日：2022-11-30

Applicant: OPTOS PLC

Inventor： Jano van Hemert ,  Michael Verhoek

IPC: G06T7/11 ,  A61B3/00 ,  A61B3/10 ,  G06T7/00

CPC classification number: A61B3/102 ,  A61B3/0008 ,  A61B3/0025 ,  G06T7/0012 ,  G06T7/11 ,  G06T2207/30041

Abstract: A method of processing functional OCT image data, acquired by an OCT scanner scanning a retina that is being repeatedly stimulated by a light stimulus, to obtain a response of the retina to the light stimulus, comprising: receiving OCT image data generated by the OCT scanner repeatedly scanning the retina over a time period, and a sequence of stimulus indicators each indicative of a stimulation of the retina by the light stimulus in a respective time interval of a sequence of time intervals spanning the time period; calculating, for each stimulus indicator, a product of the stimulus indicator and a respective windowed portion of the sequence of B-scans comprising a B-scan based on a portion of the OCT image data generated while the retina was being stimulated in accordance with the stimulus indicator; and combining the calculated products to generate the indication of the response.

公开(公告)号：US11747584B2

公开(公告)日：2023-09-05

申请号：US17196796

申请日：2021-03-09

Applicant: OPTOS PLC

Inventor： Rainer Heidemann

IPC: G02B7/00 ,  G02B7/02 ,  G01J3/02

CPC classification number: G02B7/008 ,  G01J3/0237 ,  G02B7/028

Abstract: An apparatus for providing temperature-dependent movement of an optical element, the apparatus comprising: a moveable mount for the optical element; a mount moving component attached to the moveable mount; and a guide attached to the mount moving component and configured to guide a movement of the moveable mount. The apparatus is configured such that a difference in thermal contraction or thermal expansion between the mount moving component and the guide in response to a change in temperature of the apparatus causes the mount moving component to move the moveable mount relative to the guide.

公开(公告)号：US11717159B2

公开(公告)日：2023-08-08

申请号：US16990742

申请日：2020-08-11

Applicant: Optos Plc

Inventor： Clark Pentico ,  Brendan Hamel-Bissell ,  Andre E. Adams

IPC: A61B3/14 ,  H04N5/232 ,  G02B13/06 ,  H04N23/698

CPC classification number: A61B3/14 ,  G02B13/06 ,  H04N23/698

Abstract: An imaging system may include a panoramic gonioscopic imaging apparatus that includes a disposable component configured to rest against a cornea of a patient, and an objective optical device configured to direct a continuous panoramic image of an entire circumference of an iridocorneal angle of the patient on an intermediate imaging plane, and a relay lens configured to direct the continuous panoramic image from the intermediate imaging plane to a sensor such that the sensor captures the entire circumference of the iridocorneal angle at once. The imaging system may also include a computing device in communication with the panoramic gonioscopic imaging apparatus, where the computing device configured to display an image of the entire circumference of the iridocorneal angle.

公开(公告)号：US11669968B2

公开(公告)日：2023-06-06

申请号：US16637023

申请日：2017-08-14

Applicant: Optos PLC

Inventor： Praveen Ashok ,  Alan Anderson ,  Gonzalo Muyo ,  Alistair Gorman ,  Jano Van Hemert

IPC: G06K9/00 ,  G06T7/00 ,  A61B3/00 ,  A61B3/10 ,  A61B3/12

CPC classification number: G06T7/0014 ,  A61B3/0008 ,  A61B3/0025 ,  A61B3/102 ,  A61B3/1025 ,  A61B3/12 ,  G06T2207/30041 ,  G06T2207/30204

Abstract: A method of controlling an ophthalmic device operable to image an imaging region of a retina and concurrently illuminate an illumination region of the retina, the method including acquiring a reference retinal image by imaging a reference imaging area of the retina; designating a target in the reference retinal image; acquiring a current retinal image of an initial imaging region within the reference imaging area; moving the imaging region from the initial imaging region to a destination imaging region using the target and the reference retinal image, and acquiring a retinal image of the destination imaging region; illuminating the illumination region while the imaging region is the destination imaging region; acquiring one or more retinal images while the illumination module is being illuminated; and comparing a marker retinal image based on the one or more retinal image(s) with a comparison image based on the reference retinal image.