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    Device for Filtration of Fluids Therethrough and Accompanying Method
    2.
    发明申请
    Device for Filtration of Fluids Therethrough and Accompanying Method 有权
    流体过滤装置及其附带方法

    公开(公告)号：US20120149021A1

    公开(公告)日：2012-06-14

    申请号：US13144572

    申请日：2010-01-15

    Applicant: Chong Wing Yung ,  Donald E. Ingber ,  Jason O. Fiering ,  Mathew Varghese

    Inventor： Chong Wing Yung ,  Donald E. Ingber ,  Jason O. Fiering ,  Mathew Varghese

    IPC: B03C1/02 ,  C12Q1/68 ,  H01J49/26 ,  C12Q1/18 ,  C12M1/42 ,  G01N33/53 ,  C12Q1/02

    CPC classification number: B03C1/01 ,  B03C1/288 ,  B03C2201/18 ,  G01N1/40 ,  G01N33/54326 ,  G01N33/54366

    Abstract: A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.

    Abstract translation: 用于从源流体分离目标部件的微流体装置包括通过一个或多个传输通道连接到一个或多个收集通道的一个或多个源通道。 源流体的目标组分可以使用已知的结合剂磁性或与磁性颗粒结合。 含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。 磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。 收集通道可以包括滞留的收集流体，直到预定量的源流体被处理或者预定量的目标组分积聚在收集通道中，此时收集流体可被泵入收集通道以冲洗目标组分 离开收集渠道。 随后分析目标成分进行检测和诊断。

    Microfluidic device and uses thereof
    4.
    发明授权
    Microfluidic device and uses thereof 有权
    微流体装置及其用途

    公开(公告)号：US09156037B2

    公开(公告)日：2015-10-13

    申请号：US13144572

    申请日：2010-01-15

    Applicant: Chong Wing Yung ,  Donald E. Ingber ,  Jason O. Fiering ,  Mathew Varghese

    Inventor： Chong Wing Yung ,  Donald E. Ingber ,  Jason O. Fiering ,  Mathew Varghese

    IPC: C12Q1/68 ,  B03C1/01 ,  B03C1/28 ,  G01N33/543 ,  G01N1/40

    CPC classification number: B03C1/01 ,  B03C1/288 ,  B03C2201/18 ,  G01N1/40 ,  G01N33/54326 ,  G01N33/54366

    Abstract: A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.

    Abstract translation: 用于从源流体分离目标部件的微流体装置包括通过一个或多个传送通道连接到一个或多个收集通道的一个或多个源通道。 源流体的目标组分可以使用已知的结合剂磁性或与磁性颗粒结合。 含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。 磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。 收集通道可以包括滞留的收集流体，直到预处理的体积的源流体被处理或预定量的目标组分积聚在收集通道中，此时收集流体可被泵入收集通道以冲洗目标组分 离开收集渠道。 随后分析目标成分进行检测和诊断。

    HIGHLY SENSITIVE CAPACITIVE SENSOR AND METHODS OF MANUFACTURING THE SAME
    7.
    发明申请
    HIGHLY SENSITIVE CAPACITIVE SENSOR AND METHODS OF MANUFACTURING THE SAME 审中-公开
    高敏感电容传感器及其制造方法

    公开(公告)号：US20120048019A1

    公开(公告)日：2012-03-01

    申请号：US12869222

    申请日：2010-08-26

    Applicant: Hanqin Zhou ,  Leyue Jiang ,  Mathew Varghese ,  Haidong Liu

    Inventor： Hanqin Zhou ,  Leyue Jiang ,  Mathew Varghese ,  Haidong Liu

    IPC: G01P15/125 ,  C23F1/00

    CPC classification number: G01P15/125 ,  G01P2015/0814

    Abstract: Micro-machined capacitive sensors implemented in micro-electro-mechanical system (MEMS) processes that have higher sensitivity, while providing an increased linear capacitive sensing range. Capacitive sensing is achieved via variable-area sensing, which employs a transduction mechanism in which the relationship between changes in the capacitance of variable, parallel-plate capacitors and displacements of a proof mass is generally linear. Each respective variable, parallel-plate capacitor is formed by a finger/electrode pair, in which both the finger and the electrode have rectangular tooth profiles that include a plurality of rectangular teeth. Because changes in the overlapping area of the finger and the electrode are multiplied by the number of rectangular teeth, while the standing capacity of the micro-machined capacitive sensor remains relatively high, the sensitivity of the micro-machined capacitive sensor employing variable-area sensing is significantly increased per unit area of the finger and the electrode.

    Abstract translation: 在微机电系统（MEMS）工艺中实现的微加工电容传感器具有更高的灵敏度，同时提供增加的线性电容感测范围。 通过可变区域感测实现电容感测，其采用转换机制，其中可变平行板电容器的电容变化与校准质量的位移之间的关系通常是线性的。 每个可变平行板电容器由手指/电极对形成，其中手指和电极均具有包括多个矩形齿的矩形齿廓。 由于手指和电极的重叠区域的变化乘以矩形齿的数量，而微加工的电容式传感器的静态容量保持相对较高，所以采用可变面积感测的微加工电容传感器的灵敏度 手指和电极的每单位面积显着增加。

    METHOD AND APPARATUS FOR BUILDING THREE-DIMENSIONAL MEMS ELEMENTS
    9.
    发明申请
    METHOD AND APPARATUS FOR BUILDING THREE-DIMENSIONAL MEMS ELEMENTS 有权
    用于建立三维MEMS元件的方法和装置

    公开(公告)号：US20130207511A1

    公开(公告)日：2013-08-15

    申请号：US13397174

    申请日：2012-02-15

    Applicant: Brian Lee Wardle ,  Fabio Ferruccio Fachin ,  Stefan Nikles ,  Mathew Varghese

    Inventor： Brian Lee Wardle ,  Fabio Ferruccio Fachin ,  Stefan Nikles ,  Mathew Varghese

    IPC: H02N11/00 ,  H05K13/00

    CPC classification number: B81C1/00007 ,  B81B2203/0109 ,  B81C1/0019 ,  Y10T29/49002

    Abstract: The disclosure generally relates to method and apparatus for forming three-dimensional MEMS. More specifically, the disclosure relates to a method of controlling out-of-plane buckling in microstructural devices so as to create micro-structures with out-of-plane dimensions which are 1×, 5×, 10×, 100× or 500× the film's thickness or above the surface of the wafer. An exemplary device formed according to the disclosed principles, includes a three dimensional accelerometer having microbridges extending both above and below the wafer surface.

    Abstract translation: 本发明一般涉及用于形成三维MEMS的方法和装置。 更具体地说，本公开涉及一种控制微结构装置中的平面外屈曲的方法，以便产生具有1×，5×，10×，100×或500× 膜的厚度或晶片表面之上。 根据所公开的原理形成的示例性装置包括具有在晶片表面上方和下方延伸的微桥的三维加速度计。

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