公开(公告)号：US20230173407A1

公开(公告)日：2023-06-08

申请号：US17996777

申请日：2021-04-27

Applicant: Puridify Ltd

Inventor： Matthew Townsend ,  Ian Scanlon ,  Ola Lind ,  Gunnar Malmquist

IPC: B01D15/18 ,  B01D15/20 ,  B01D15/42 ,  B01D15/24

CPC classification number: B01D15/1885 ,  B01D15/203 ,  B01D15/424 ,  B01D15/247

Abstract: The present invention relates to a preparative chromatography system (200, 500, 800) and a chromatography process (400, 700) adapted to repetitive cycling of chromatography volumes. The system (200, 500, 800) comprises at least two upstream pumps (203a, 803a, 203b, 803b) and separate flow paths (220) from process liquid sources to the chromatography device (200, 500, 800). The system (200, 500, 800) is arranged to prime one flow path (220) with one process liquid while providing another process liquid to the chromatography device and thereby minimizing the hold-up volume of the system (200, 500, 800).

公开(公告)号：US20220168667A1

公开(公告)日：2022-06-02

申请号：US17437132

申请日：2020-03-31

Applicant: Puridify Ltd.

Inventor： Ian Scanlon ,  Anna Gronberg ,  Matthew Townsend

IPC: B01D15/18 ,  B01D15/14 ,  B01D15/38 ,  B01D15/36 ,  B01J20/286 ,  B01J20/28 ,  B01J41/20 ,  B01J47/127

Abstract: A chromatography system comprising at least two chromatography units (3) connected in parallel, wherein said at least two chromatography units (3) each comprises a convection-based chromatography material, wherein an initial difference in back pressure provided from the different chromatography units (3) is compensated dynamically during run of the system due to a change of chromatography unit properties provided during the chromatography process.

公开(公告)号：US20190255513A1

公开(公告)日：2019-08-22

申请号：US16314943

申请日：2017-07-14

Applicant: Puridify Ltd.

Inventor： Ian Scanlon

IPC: B01J20/285 ,  C12N7/00 ,  A61K48/00 ,  A61P35/00 ,  B01J20/28

Abstract: The present invention provides a process for recovering a viral product from a composition comprising said product and product-related impurities, which process comprises contacting the composition with a functionalised chromatography medium comprising one or more polymer nanofibres, wherein the viral product comprises a plurality of viruses, virus particles/virions, viral cores, membrane-stripped viruses, viral cores with outer membrane(s) removed and/or capsids removed, or proviruses, each of which contains one or more polynucleotides, and wherein the product-related impurities comprise a plurality of viruses, virus particles/virions, virus-like particles, viral cores, membrane-stripped viruses, viral cores with outer membrane(s) removed and/or capsids removed or proviruses, each of which is substantially devoid of polynucleotides.

公开(公告)号：US11103853B2

公开(公告)日：2021-08-31

申请号：US16314943

申请日：2017-07-14

Applicant: Puridify Ltd.

Inventor： Ian Scanlon

IPC: B01J20/285 ,  A61P35/00 ,  A61K48/00 ,  B01J20/28 ,  C12N7/00 ,  C12N7/02

Abstract: The present invention provides a process for recovering a viral product from a composition comprising said product and product-related impurities, which process comprises contacting the composition with a functionalised chromatography medium comprising one or more polymer nanofibres, wherein the viral product comprises a plurality of viruses, virus particles/virions, viral cores, membrane-stripped viruses, viral cores with outer membrane(s) removed and/or capsids removed, or proviruses, each of which contains one or more polynucleotides, and wherein the product-related impurities comprise a plurality of viruses, virus particles/virions, virus-like particles, viral cores, membrane-stripped viruses, viral cores with outer membrane(s) removed and/or capsids removed or proviruses, each of which is substantially devoid of polynucleotides.