公开(公告)号：US11305271B2

公开(公告)日：2022-04-19

申请号：US15677526

申请日：2017-08-15

Applicant: EMD Millipore Corporation

Inventor： David Yavorsky ,  John Amara ,  Joaquin Umana ,  William Cataldo ,  Mikhail Kozlov ,  Matthew Stone

IPC: B01D15/36 ,  B01J20/28 ,  B01J47/12 ,  B01J39/26 ,  C12N7/02 ,  B01J47/014 ,  B01J47/127 ,  B01D15/38 ,  C07K1/18 ,  B01J41/20 ,  B01D15/32 ,  B01J20/285 ,  B01J20/287 ,  B01J20/32 ,  C07K16/00 ,  C12N7/00 ,  G01N30/52

Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).

公开(公告)号：US20220098060A1

公开(公告)日：2022-03-31

申请号：US17494463

申请日：2021-10-05

Applicant: Electric Power Research Institute, Inc.

Inventor： Paul L. Frattini ,  Keith Paul Fruzzetti

IPC: C02F1/42 ,  B01J47/127 ,  B01J43/00 ,  B01J20/22 ,  B01J20/30 ,  B01J20/32

Abstract: The present invention is directed to a ligated metal-organic framework (MOF) for use in removing both anionic and cationic species from a liquid or liquid stream. The present invention also provides methods for placing the MOF on a substrate to form a MOF-containing product that can be used in the removal of certain species from a given fluid. The MOF may be a Zr-based MOF, such as NU-1000, for removal of certain anions, such as oxy-anions, or having an attached thiosulfonyl-thiol (—SO2—S—R2—SH, where R2 is an alkyl group) ligand for complexation with certain cationic species in addition to the anions. The substrate may be any substrate to which a given MOF may be attached, including inert polypropylene polymer resin beads, a macroscopic fabric such as a mesh material or mesh filter, and a molecular fabric.

公开(公告)号：US11168006B2

公开(公告)日：2021-11-09

申请号：US16550237

申请日：2019-08-25

Applicant: Electric Power Research Institute, Inc.

Inventor： Paul L. Frattini ,  Keith Paul Fruzzetti

IPC: C02F1/42 ,  C02F1/28 ,  B01J20/02 ,  B01J20/22 ,  B01J20/30 ,  B01J20/32 ,  B01J47/12 ,  B01J43/00 ,  B01J47/127 ,  C02F101/10 ,  C02F101/20 ,  C02F103/34

Abstract: The present invention is directed to a ligated metal-organic framework (MOF) for use in removing both anionic and cationic species from a liquid or liquid stream. The present invention also provides methods for placing the MOF on a substrate to form a MOF-containing product that can be used in the removal of certain species from a given fluid. The MOF may be a Zr-based MOF, such as NU-1000, for removal of certain anions, such as oxy-anions, or having an attached thiosulfonyl-thiol (—SO2—S—R2—SH, where R2 is an alkyl group) ligand for complexation with certain cationic species in addition to the anions. The substrate may be any substrate to which a given MOF may be attached, including inert polypropylene polymer resin beads, a macroscopic fabric such as a mesh material or mesh filter, and a molecular fabric.

公开(公告)号：US20180273401A1

公开(公告)日：2018-09-27

申请号：US15934548

申请日：2018-03-23

Applicant: Lehigh University

Inventor： Arup K. SenGupta ,  Hang Dong ,  Michael German ,  Chelsey Shepsko

IPC: C02F1/42 ,  B01J41/12 ,  B01J39/07 ,  B01J47/127

CPC classification number: C02F1/42 ,  B01J39/07 ,  B01J41/12 ,  B01J47/127 ,  C02F2001/422 ,  C02F2001/425 ,  C02F2101/101 ,  C02F2101/103 ,  C02F2101/105 ,  C02F2101/12 ,  C02F2101/14 ,  C02F2101/163 ,  C02F2101/203 ,  C02F2101/206 ,  C02F2103/06 ,  C02F2301/08 ,  C02F2303/16 ,  C02F2305/08

Abstract: A method for purifying waste water, and a dual chamber purification system, in which feed water may be passed first through a hybrid anion exchange unit, and subsequently through a weak acid cationic exchange unit. The hybrid anion exchanger may comprise a hybrid sorbent (HAIX-NanoZr) with dual functional sorption sites. The weak acid cationic exchanger may be a fiber having a shell-core physical configuration with relatively short intra-particle diffusion path length so that the ion exchange sites reside predominantly on the periphery. The system may be used to achieve partial desalination or TDS reduction and concurrent removal of target contaminants (e.g., phosphate, hardness). Further, the system may be regenerated using CO2 as the sole regenerant for both the hybrid anion exchanger and the weak acid cationic exchanger, thus producing spent regenerant with no externally added chemicals.

公开(公告)号：US20240325989A1

公开(公告)日：2024-10-03

申请号：US18621873

申请日：2024-03-29

Applicant: Donaldson Company, Inc.

Inventor： Matthew P. Goertz ,  Stephen K. Sontag ,  Bradly G. Hauser

IPC: B01D69/14 ,  B01D69/12 ,  B01D71/60 ,  B01J47/127

CPC classification number: B01D69/147 ,  B01D69/1214 ,  B01D69/1216 ,  B01D69/125 ,  B01D71/601 ,  B01J47/127 ,  B01D2323/12 ,  B01D2323/30

Abstract: A layered separation media includes a fibrous layer including a non-woven media; and a first coating disposed on the non-woven media, the first coating comprising a crosslinked hydrogel; and a membrane layer including a membrane; and a second coating disposed on the membrane. The second coating may also include a crosslinked hydrogel. The layered separation media may be used in a system for membrane chromatography. A method of separating a protein from a liquid stream may include flowing the liquid stream through the layered separation media. The protein may bind with functional groups in the hydrogel. The layered separation media may have a DBC10 of 50 mg/mL or greater.

公开(公告)号：US20230256393A1

公开(公告)日：2023-08-17

申请号：US17940172

申请日：2022-09-08

Applicant: POSTECH Research and Business Development Foundation

Inventor： Geunbae LIM ,  Hyukjin J. KWON ,  Minsoo LEE

IPC: B01D61/48 ,  B01J47/127 ,  B01D61/50

CPC classification number: B01D61/48 ,  B01J47/127 ,  B01D61/50

Abstract: A sample concentrator includes a lower frame and an upper frame coupled to overlap each other, wherein the lower frame includes a first electrode buffer channel and a second electrode buffer channel spaced apart from each other, a main channel formed in the lower frame and connecting the first electrode buffer channel to the second buffer channel, a first ion exchange membrane located between the first electrode buffer channel and the main channel, a second ion exchange membrane located between the second electrode buffer channel and the main channel, a first electrode electrically connected to the main channel with the first electrode buffer channel interposed therebetween, and a second electrode electrically connected to the main channel with the second electrode buffer channel interposed therebetween.

公开(公告)号：US20230088379A1

公开(公告)日：2023-03-23

申请号：US18053637

申请日：2022-11-08

Applicant: Carbon Sink Inc.

Inventor： Shawn Mortimore ,  Karin Yaccato ,  John Bergin ,  Raffaella Sordella ,  Frank T. O'Keefe

IPC: B01J41/05 ,  B01J41/12 ,  B01J47/127 ,  B01J47/014 ,  B01D53/02

Abstract: Disclosed herein are compositions and methods for manufacturing composite paper-based sorbents configured for durability, and high surface area exposure to air. Composite paper-based sorbents can comprise fibers (e.g. natural and/or synthetic fibers), anion exchange resins, and additives. Composite paper-based sorbents can be configured for durability when used in various forming processes, e.g., corrugation, and when used under a variety of conditions, for example, in high and low humidity environments.

公开(公告)号：US20200062616A1

公开(公告)日：2020-02-27

申请号：US16489278

申请日：2018-02-28

Applicant: TORAY INDUSTRIES, INC.

Inventor： Ryoma MIYAMOTO ,  Keisuke YONEDA ,  Kumiko OGAWA ,  Satoko KANAMORI ,  Ryuichiro HIRANABE ,  Yoichiro KOZAKI

IPC: C02F1/42 ,  B01D15/36 ,  B32B5/02 ,  B32B5/26 ,  B01J47/127 ,  B01J39/07 ,  B01J39/20

Abstract: The present invention provides a filter which, even when raw water is subjected to high-speed treatment, enables achieving a high solute rejection ratio and a long solute filtration life and which exhibits a low water flow resistance. The present invention pertains to a filter obtained by laminating woven fabrics or knitted fabrics, the filter being characterized in that: said woven fabrics or knitted fabrics comprise a fiber capable of adsorbing components dissolved in liquid: said fiber has a diameter of 100-600 μm; the woven fabrics or knitted fabrics have a porosity of 15-70%; and variation in area porosity in the thickness direction of the laminate is 15% or less.

公开(公告)号：US20190022634A1

公开(公告)日：2019-01-24

申请号：US15760440

申请日：2016-09-19

Applicant: AMOGREENTECH CO., LTD.

Inventor： Ui Young JEONG

IPC: B01J47/127 ,  B01D69/10 ,  B01D67/00

Abstract: A method for manufacturing an ion exchange membrane is provided. The method for manufacturing an ion exchange membrane, according to one embodiment of the present invention, comprises the step of electrospinning a support fiber producing solution and an ion exchange fiber producing solution respectively to prepare a laminate in which a support fiber mat consisting of a support fiber and an ion exchange fiber mat consisting of an ion exchange fiber are alternatively laminated. According to the present invention, it is possible to simply control factors, such as the thickness, electroconductivity and mechanical strength of the membrane, and the diameter/ratio of a pore, etc. to be suitable for the use of ion exchange membrane during the manufacturing process, to simplify the manufacturing process. As such, the ion exchange membrane manufactured by the method can be utilized as a universal ion exchange membrane which has a large ion exchange capacity, a small electrical resistance, and a small diffusion coefficient as well as excellent mechanical strength and durability.

公开(公告)号：US09816901B2

公开(公告)日：2017-11-14

申请号：US14438961

申请日：2013-12-13

Applicant: EMD Millipore Corporation

Inventor： Benjamin Cacace

IPC: G01N30/00 ,  B01L3/00 ,  G01N1/34 ,  G01N1/40 ,  C07K1/14 ,  C07K1/36 ,  B01J39/26 ,  B01J41/20 ,  B01J47/022 ,  B01J47/014 ,  B01J47/127

CPC classification number: G01N1/34 ,  B01J39/26 ,  B01J41/20 ,  B01J47/014 ,  B01J47/022 ,  B01J47/127 ,  B01L3/505 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/123 ,  C07K1/14 ,  C07K1/36 ,  G01N1/405

Abstract: The invention relates to a liquid sample preparation device such as a disposable, collapsible, flexible polymeric bag containing an adsorptive curtain of a functionalized shaped polymeric fiber bed for the direct capture of biomolecules from liquid samples. The functionalized shaped polymeric fiber bed includes fibrillated, ridged or winged-shaped fiber structures that significantly increases the surface area of the fiber resulting in enhanced separation, retention and/or purification of liquid samples containing biomolecules of interest as the liquid samples contact the adsorptive curtain of functionalized shaped fibers. Liquid samples include unclarified liquid feeds or other liquids containing one or more biomolecules of interest, including, but not limited to vaccines, recombinant proteins, cells, stem cells, monoclonal antibodies (mAbs), proteins, antibody, peptides, oligopeptides, nucleic acids, oligonucleotides, RNA, DNA, oligosaccharides and polysaccharides.