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公开(公告)号：US20220168667A1
公开(公告)日：2022-06-02
申请号：US17437132
申请日：2020-03-31
Applicant: Puridify Ltd.
Inventor： Ian Scanlon , Anna Gronberg , Matthew Townsend
IPC: B01D15/18 , B01D15/14 , B01D15/38 , B01D15/36 , B01J20/286 , B01J20/28 , B01J41/20 , B01J47/127
Abstract: A chromatography system comprising at least two chromatography units (3) connected in parallel, wherein said at least two chromatography units (3) each comprises a convection-based chromatography material, wherein an initial difference in back pressure provided from the different chromatography units (3) is compensated dynamically during run of the system due to a change of chromatography unit properties provided during the chromatography process.
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公开(公告)号：US20230173407A1
公开(公告)日：2023-06-08
申请号：US17996777
申请日：2021-04-27
Applicant: Puridify Ltd
Inventor： Matthew Townsend , Ian Scanlon , Ola Lind , Gunnar Malmquist
CPC classification number: B01D15/1885 , B01D15/203 , B01D15/424 , B01D15/247
Abstract: The present invention relates to a preparative chromatography system (200, 500, 800) and a chromatography process (400, 700) adapted to repetitive cycling of chromatography volumes. The system (200, 500, 800) comprises at least two upstream pumps (203a, 803a, 203b, 803b) and separate flow paths (220) from process liquid sources to the chromatography device (200, 500, 800). The system (200, 500, 800) is arranged to prime one flow path (220) with one process liquid while providing another process liquid to the chromatography device and thereby minimizing the hold-up volume of the system (200, 500, 800).
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Patent Agency Ranking
公开(公告)号：US20220268745A1
公开(公告)日：2022-08-25
申请号：US17737163
申请日：2022-05-05
Applicant: Puridify Ltd.
Inventor： Michael Williams , Iwan Roberts , Oliver Hardick , Matthew Townsend , Christopher Morris , Shameer Subratty
Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.
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公开(公告)号：US20240210365A1
公开(公告)日：2024-06-27
申请号：US18408693
申请日：2024-01-10
Applicant: Puridify Ltd.
Inventor： Michael Williams , Iwan Roberts , Oliver Hardick , Matthew Townsend , Christopher Morris , Shameer Subratty
CPC classification number: G01N30/38 , G01N30/6017 , G01N2030/386
Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.
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公开(公告)号：US11913918B2
公开(公告)日：2024-02-27
申请号：US17737163
申请日：2022-05-05
Applicant: Puridify Ltd.
Inventor： Michael Williams , Iwan Roberts , Oliver Hardick , Matthew Townsend , Christopher Morris , Shameer Subratty
CPC classification number: G01N30/38 , G01N30/6017 , G01N2030/386 , G01N30/6017 , G01N2030/386
Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.
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公开(公告)号：US11353433B2
公开(公告)日：2022-06-07
申请号：US16327985
申请日：2017-08-25
Applicant: Puridify Ltd.
Inventor： Michael Williams , Iwan Roberts , Oliver Hardick , Matthew Townsend , Christopher Morris , Shameer Subratty
Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.
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公开(公告)号：US20190234914A1
公开(公告)日：2019-08-01
申请号：US16327985
申请日：2017-08-25
Applicant: Puridify Ltd.
Inventor： Michael Williams , Iwan Roberts , Oliver Hardick , Matthew Townsend , Christopher Morris , Shameer Subratty
CPC classification number: G01N30/38 , G01N30/6017 , G01N30/84 , G01N2030/386
Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.
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