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91.发明申请公开(公告)号：US20180136295A1
公开(公告)日：2018-05-17
申请号：US15850931
申请日：2017-12-21
Applicant: University Health Network
Inventor： Tony Tadic , Teodor Marius Stanescu
IPC: G01R33/387 , G01R33/58 , G01R33/565 , G01R33/48
CPC classification number: G01R33/387 , G01R33/4808 , G01R33/56572 , G01R33/58
Abstract: Various embodiments are described herein for an apparatus and a method for measuring and characterizing geometric distortions for a region of interest in images obtained using magnetic resonance. The method comprises deriving a computed set of 3D distortion vectors for a set of points within a region of interest covered by a phantom by using harmonic analysis to solve an associated boundary value problem based on boundary conditions derived from a measured set of 3D distortion vectors. The characterized image distortions may be used for various purposes such as for image correction or for shimming, for example.
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公开(公告)号：US09949667B2
公开(公告)日：2018-04-24
申请号：US13710160
申请日：2012-12-10
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Hisham Alshaer , Geoffrey Roy Fernie , T. Douglas Bradley , Oleksandr Igorovich Levchenko , Steven M. Pong
CPC classification number: A61B5/087 , A61B5/097 , A61B5/4818 , A61B5/7257 , A61B7/003
Abstract: Disclosed is a mask for use in respiratory monitoring and/or diagnostics. The mask comprises at least one transducer responsive to sound and/or airflow for generating a signal, and a support structure to rest on the subject's face. In one embodiment, the support structure comprises two or more limbs that provide a transducer support for supporting the transducer at a distance from a nose and mouth area, allowing monitoring via the transducer of sound and/or airflow produced by the subject. Also described is a mask comprising a transducer responsive to airflow for generating a signal and a support structure to rest on the subject's face and extend outwardly over a nose and mouth area to provide a transducer support supporting the transducer at a distance from a nose and mouth area of the subject's face and at a preset orientation, for monitoring via the transducer of airflow produced by the subject.
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公开(公告)号：US09925220B2
公开(公告)日：2018-03-27
申请号：US14674548
申请日：2015-03-31
Applicant: University Health Network
Inventor： Li Zhang , Mei Han , Pouneh Dokouhaki
IPC: C12N5/0783 , A61K35/17
CPC classification number: A61K35/17 , C12N5/0636 , C12N2501/23 , C12N2501/2302 , C12N2501/2304 , C12N2501/515
Abstract: A method of expanding double negative T cells in culture is described. The method comprises (a) providing a starting sample comprising DN T cells or precursors thereof; (b) substantially depleting CD8+ and CD4+ T cells from the starting sample; (c) culturing the sample from step (b) with an immobilized T cell mitogen in a culture medium comprising an agent that can stimulate DN T cell growth (d) washing the cells obtained in step (c) and resuspending in a culture medium comprising the agent without the T cell mitogen; and (e) washing the cells obtained in step (d) and resuspending in a culture medium comprising the agent and a soluble T cell mitogen. The DN T cells obtained by the method are useful in a variety of applications including the treatment of cancer, infectious diseases, graft versus host disease and autoimmune disease.
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公开(公告)号：US09833446B2
公开(公告)日：2017-12-05
申请号：US14386326
申请日：2013-03-14
Applicant: Rhode Island Hospital , University Health Network
Inventor： Wentian Yang , Benjamin G. Neel
IPC: A61K31/454 , A61K31/438 , A61K31/4402 , A61K31/4184 , A61K31/4436 , A61K31/496 , A61K31/4545 , A61K31/517 , A61K31/5377 , A61K31/4355 , A61K31/4418
CPC classification number: A61K31/454 , A61K31/4184 , A61K31/4355 , A61K31/438 , A61K31/4402 , A61K31/4418 , A61K31/4436 , A61K31/4545 , A61K31/496 , A61K31/517 , A61K31/5377
Abstract: A method for preventing, slowing, or blocking the formation of an exostosis or an enchondromas comprising administering to an animal in need thereof a hedgehog pathway inhibitor such as a Smoothened inhibitor.
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公开(公告)号：US20170320881A1
公开(公告)日：2017-11-09
申请号：US15598402
申请日：2017-05-18
Applicant: University Health Network
Inventor： Radoslaw Laufer , Grace Ng , Sze-Wan Li , Heinz W. Pauls , Yong Liu , Narendra Kumar B. Patel
IPC: C07D487/04 , C07D519/00
CPC classification number: C07D487/04 , C07D519/00
Abstract: The present teachings provide a compound represented by the following structural formula: (Formula (I)); or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.
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Patent Agency Ranking
公开(公告)号：US20170267977A1
公开(公告)日：2017-09-21
申请号：US15500240
申请日：2015-07-30
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Ling HUANG , Senthil MUTHUSWAMY
CPC classification number: C12N5/0678 , C12N5/0062 , C12N5/0676 , C12N5/0693 , C12N2500/38 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/15 , C12N2501/16 , C12N2501/33 , C12N2501/385 , C12N2501/999 , C12N2506/02 , C12N2533/90 , G01N33/5011 , G01N33/507 , G01N33/5088
Abstract: There is provided herein cell culture mediums for generating organoids, including tumour organoids.
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公开(公告)号：US09763744B2
公开(公告)日：2017-09-19
申请号：US14367829
申请日：2012-12-21
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Brian C. Wilson , Anthony Taywon Kim , Pablo A. Valdes , Keith D. Paulsen , David W. Roberts
IPC: A61B6/00 , A61B19/00 , A61B10/02 , A61B17/34 , A61B5/00 , A61B5/1459 , A61B5/145 , A61B5/1455 , A61B10/04 , A61K49/00 , A61B34/20 , A61B90/00 , A61B90/11
CPC classification number: A61B34/20 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/14546 , A61B5/14556 , A61B5/1459 , A61B5/489 , A61B5/6848 , A61B10/0275 , A61B10/04 , A61B17/3403 , A61B90/11 , A61B2010/0208 , A61B2010/045 , A61B2034/2055 , A61B2090/3945 , A61K49/0017 , F04C2270/041
Abstract: An optical spectroscopy probe for providing optical spectroscopy guidance of a mechanical biopsy procedure, and a tissue biopsy device including an optical spectroscopy probe. The optical spectroscopy probe is positionable in a lumen of a mechanical biopsy device. The probe may enable optical spectroscopy guidance in biopsy procedures, include brain biopsy procedures.
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公开(公告)号：US20170252440A1
公开(公告)日：2017-09-07
申请号：US15301682
申请日：2015-04-07
Inventor： Xiaoyu WU , Claudia Regina GORDIJO , Azhar Z. ABBASI , Preethy PRASAD , Ralph DACOSTA , Azusa MAEDA , Mohammad Ali AMINI
Abstract: Disclosed herein are multifunctional nanoparticle compositions. The compositions can be useful for the treatment of cancer by enhancing the anti-tumor effectiveness of radiation directed to a tissue, cell or a tumor and the methods of use thereof. The multifunctional nanoparticle composition comprises a metal oxide nanoparticle core; a functional coating on the surface of the metal oxide nanoparticle core; and a matrix carrier in which the coated nanoparticle is embedded.
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公开(公告)号：US09657025B2
公开(公告)日：2017-05-23
申请号：US14926977
申请日：2015-10-29
Applicant: University Health Network
Inventor： Radoslaw Laufer , Grace Ng , Sze-Wan Li , Heinz W. Pauls , Yong Liu , Narendra Kumar B. Patel
IPC: A61K31/519 , C07D487/04 , C07D519/00
CPC classification number: C07D487/04 , C07D519/00
Abstract: The present teachings provide a compound represented by the following structural formula: (Formula (I)); or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.
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公开(公告)号：US09636327B2
公开(公告)日：2017-05-02
申请号：US14889767
申请日：2014-05-05
Inventor： Kumaraswamy Nanthakumar
IPC: A61K31/41 , A61K31/415 , A61K31/4178 , A61K45/06 , A61K31/422
CPC classification number: A61K31/4178 , A61K31/422 , A61K45/06 , A61K2300/00
Abstract: The present description relates to methods of administering effective amounts of an anti-arrhythmic agent, e.g., dantrolene, azumolene or a pharmaceutically acceptable salt thereof, for the acute treatment of cardiac arrhythmias, e.g., atrial fibrillation, premature ventricular contraction, ventricular tachycardia or ventricular fibrillation, and prevention of subsequent cardiac arrhythmias, wherein the methods effectuate a reduction in morbidity and mortality.
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