公开(公告)号：US20190232078A1

公开(公告)日：2019-08-01

申请号：US16262565

申请日：2019-01-30

Applicant: California Institute of Technology

Inventor： Yu-Chong Tai ,  Colin A. Cook

IPC: A61N5/06 ,  A61B5/0496 ,  A61B3/12

CPC classification number: A61N5/0613 ,  A61B3/12 ,  A61B5/0496 ,  A61N2005/0627 ,  A61N2005/0648 ,  A61N2005/0651 ,  A61N2005/0662

Abstract: Embodiments of the present disclosure are directed to a wearable phototherapy eye device. In an example, phototherapy can be controlled by varying an emission property of light emitted from the wearable phototherapy eye device to a user eye. In particular, the wearable phototherapy eye device includes a light source oriented to emit the light towards the user eye. The wearable phototherapy eye device also includes controls, such as electrical, mechanical, and/or electro-mechanical controls, to vary the emission property of the light based on an emission target associated with a sleep phase.

公开(公告)号：US10261088B2

公开(公告)日：2019-04-16

申请号：US14877711

申请日：2015-10-07

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Amir Goldkorn ,  Yu-Chong Tai ,  Tong Xu ,  Bo Lu

IPC: G01N33/574 ,  C12N5/09 ,  C12Q1/6806 ,  C12Q1/6886 ,  G01N33/50 ,  G01N1/30 ,  G01N1/40

Abstract: The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.

公开(公告)号：US10251780B2

公开(公告)日：2019-04-09

申请号：US14749487

申请日：2015-06-24

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Yu-Chong Tai ,  Yu Zhao ,  Mark S. Humayun ,  James D. Weiland

IPC: A61N1/378 ,  C23F1/00 ,  H01F27/28 ,  A61N1/36 ,  A61F9/007 ,  A61N1/05

Abstract: A three-coil electromagnetic induction power transfer system is disclosed for epiretinal prostheses and other implants. A third, buffer coil is disposed between an external transmitting coil and a receiver coil buried within the body to improve efficiency and robustness to misalignments. One or more of the coils can be manufactured using micromechanical machining techniques to lay out conductors in a ribbon of biocompatible insulator, folding lengths of the insulated conductor traces longitudinally over one another, and then spiraling them into a ring. The traces change axial position in the ring by shifting across fold lines. One or more U-shaped sections on the traces can be folded so that adjacent traces can project opposite one another, lengthening the resulting ribbon that can be wound into a coil.

公开(公告)号：US20190025610A1

公开(公告)日：2019-01-24

申请号：US16017667

申请日：2018-06-25

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Yu-Chong Tai ,  Nicholas E. Scianmarello ,  Charles M. T. DeBoer ,  Mark S. Humayun

IPC: G02C7/04 ,  G02C7/08 ,  A61K9/00

CPC classification number: G02C7/049 ,  A61K9/0051 ,  G02C7/04 ,  G02C7/041 ,  G02C7/085

Abstract: A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.

公开(公告)号：US20180325373A1

公开(公告)日：2018-11-15

申请号：US15948187

申请日：2018-04-09

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Damien C. Rodger ,  Yu-Chong Tai ,  Mark S. Humayun ,  Aubrey M. Shapero ,  Abhinav Agarwal ,  Azita Emami

IPC: A61B3/16 ,  A61M1/00

CPC classification number: A61B3/16 ,  A61B2562/0247 ,  A61B2562/166 ,  A61B2562/168 ,  A61M1/008 ,  A61M2205/04 ,  A61M2210/0612

Abstract: A miniature, low power electronic pressure sensor with a first, oil-filled chamber to protect its microelectromechanical systems (MEMS) pressure sensitive membrane and a second chamber filled with saline or body fluids connected by tube into an organ in the body, such as an eyeball, that needs pressure sensing, is described. The tube carries pressure from a sensitive area within the organ to the electronic pressure sensor. The pressure sensor may communicate wirelessly with external readers and pass data to a server or other computer. Running alongside the tube is another tube for draining and pressure relief. The tubes, or cannulas, can share an opening into the organ in order to minimize the number of holes needed. The tubes may be molded into a single oval cross section, combined coaxially, or share a lumen for a portion that enters the wall of an organ so as to promote healing.

公开(公告)号：US10092387B2

公开(公告)日：2018-10-09

申请号：US15274229

申请日：2016-09-23

Applicant: California Institute of Technology ,  City of Hope

Inventor： Yu-Chong Tai ,  Dongyang Kang ,  Hirotake Komatsu ,  Henry K. Lin ,  Yoko Mullen

IPC: A61F2/02 ,  C12M1/00

Abstract: An implantable medical device, a method of manufacturing, and a method of use are described. The implantable medical device includes an absorption bag connected by a cannula to a discharge bag. The implantable medical device also includes a reservoir external to the discharge bag and attached to a surface of the discharge bag. At least a portion of the absorption bag and at least a portion of a bottom surface of the reservoir are permeable to a predefined class of small molecules, such as molecular oxygen. The reservoir can retain live cells that rely on the small molecules for survival and growth. Based on concentration of the small molecules, the small molecules permeate into the absorption bag and are transported to the discharge bag for permeation into the reservoir, thereby providing a supply of the small molecules to the live cells.

公开(公告)号：US20180092738A1

公开(公告)日：2018-04-05

申请号：US15722751

申请日：2017-10-02

Applicant: California Institute of Technology

Inventor： Yu-Chong Tai ,  Colin A Cook

IPC: A61F2/16 ,  A61K9/00 ,  A61K51/12 ,  A61N5/04 ,  A61N5/06

CPC classification number: A61F2/1613 ,  A61F2/16 ,  A61F2002/1699 ,  A61K9/0051 ,  A61K49/0015 ,  A61K51/1282 ,  A61L27/54 ,  A61L2300/44 ,  A61L2430/16 ,  A61N5/045 ,  A61N5/0601 ,  A61N5/0622 ,  A61N5/1001 ,  A61N2005/0648 ,  A61N2005/0656 ,  A61N2005/0662

Abstract: Embodiments of the present disclosure are directed to a phototherapy eye device. In an example, the phototherapy eye device includes a number of radioluminescent light sources and an anchor. Each radioluminescent light source includes an interior chamber coated with phosphor material, such as zinc sulfide, and containing a radioisotope material, such as gaseous tritium. The volume, shape, phosphor material, and radioisotope material are selected for emission of light at a particular wavelength and delivering a particular irradiance on the retina (when implanted in an eyeball). The wavelength is in the range of 400 to 600 nm and the irradiance is substantially 109 to 1011 photons per second per cm2.

公开(公告)号：US20170009097A1

公开(公告)日：2017-01-12

申请号：US15276328

申请日：2016-09-26

Applicant: California Institute of Technology

Inventor： Yu-Chong Tai ,  Dongyang Kang

IPC: C09D165/04 ,  B05D1/00 ,  C03C17/32

CPC classification number: C09D165/04 ,  B05D1/60 ,  C03C17/328 ,  C03C2217/20 ,  C03C2217/76 ,  C03C2218/152 ,  C08G2261/3424 ,  C08G2261/65 ,  Y10T428/249958

Abstract: A composition of matter is described in which a porous material, such as polydimethylsiloxane (PDMS), is coated with parylene N, C, D, or AF-4 by vapor deposition polymerization while a temperature of the porous material's surface being coated is heated to between 60° C. and 120° C., or 80° C. and 85° C., during deposition. The parylene forms nano roots within the porous material that connect with a conformal surface coating of parylene. In some embodiments, a watertight separation chamber in an integrated microfluidic liquid chromatography device is fabricated by heating tunnels in micro-fabricated PDMS and depositing parylene within the heated tunnels.

Abstract translation: 描述了一种物质组合物，其中诸如聚二甲基硅氧烷（PDMS）的多孔材料通过气相沉积聚合被聚对二甲苯N，C，D或AF-4涂覆，同时将多孔材料被涂覆的表面的温度加热到 在60℃至120℃，或80℃和85℃之间。 聚对二甲苯形成多孔材料内的纳米根，其与聚对二甲苯的共形表面涂层连接。 在一些实施方案中，集成的微流体液相色谱装置中的水密分离室通过在微制造的PDMS中加热隧道并在加热的隧道内沉积聚对二甲苯来制造。

公开(公告)号：US20160361463A1

公开(公告)日：2016-12-15

申请号：US15184934

申请日：2016-06-16

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Yu-Chong Tai ,  Bo Lu ,  Mark Humayun

IPC: A61L27/16 ,  A61L27/56 ,  C12N5/00 ,  A61L27/50

CPC classification number: A61L27/16 ,  A61L27/50 ,  A61L27/56 ,  A61L2430/16 ,  B01D71/44 ,  B01D2325/06 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2535/10 ,  C12N2539/00

Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there.

公开(公告)号：US20160310739A1

公开(公告)日：2016-10-27

申请号：US15199580

申请日：2016-06-30

Applicant: California Institute of Technology ,  University of Louisville Research Foundation, Inc. ,  The Regents of the University of California

Inventor： Joel W. Burdick ,  Yu-Chong Tai ,  John F. Naber ,  Robert S. Keynton ,  Victor Reggie Edgerton ,  Roland R. Roy ,  Yury Gerasimenko ,  Susan J. Harkema ,  Jonathan Hodes ,  Claudia A. Angeli ,  Mandheerej S. Nandra ,  Thomas Anthony Desautels ,  Steven L. Upchurch ,  Douglas J. Jackson ,  Nicholas A. Terrafranca ,  Yangsheng Chen

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/36103 ,  A61B5/0492 ,  A61B5/1106 ,  A61B5/407 ,  A61B5/4076 ,  A61B5/4836 ,  A61B2505/09 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36003 ,  A61N1/36007 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36107 ,  A61N1/3611 ,  A61N1/36114 ,  A61N1/36125 ,  A61N1/36139

Abstract: Neurostimulator devices and methods of using these devices are described. The neurostimulator devices can include a stimulation assembly connectable to a plurality of electrodes; one or more sensors; and at least one processor configured to modify at least one complex stimulation pattern.

Abstract translation: 描述神经刺激装置和使用这些装置的方法。 神经刺激器装置可以包括可连接到多个电极的刺激组件; 一个或多个传感器; 以及配置成修改至少一个复杂刺激模式的至少一个处理器。