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    Systems and methods for deriving and collecting platelet products
    93.
    发明授权
    Systems and methods for deriving and collecting platelet products 有权

    公开(公告)号：US10772916B2

    公开(公告)日：2020-09-15

    申请号：US15705445

    申请日：2017-09-15

    Applicant: Fenwal, Inc.

    Inventor： Kyungyoon Min ,  Benjamin E. Kusters ,  Richard I. Brown

    IPC: A61K35/19 ,  A61M1/02 ,  A61M1/36 ,  C12N5/078

    Abstract: Systems and methods are provided for deriving a platelet product from a plurality of buffy coats. A plurality of buffy coats are separately collected, for example, using a conventional floor centrifuge. Plasma and/or a platelet additive solution may be added to the buffy coats. The buffy coats are pooled into a container and conveyed into a centrifuge or are sequentially conveyed into the centrifuge without being pooled, where they are continuously processed to separate platelets from the other cellular blood components. The separated platelets are conveyed out of the centrifuge as a platelet product, which may be passed through a leukocyte removal filter to reduce the white blood cell content of the platelet product. By continuously separating the buffy coats, fewer buffy coats are required to produce a single-dose platelet product, while also allowing for the derivation and collection of a plurality of single-dose platelet products.

    Collection, Genome Editing, And Washing Of T-Cell Lymphocytes
    94.
    发明申请
    Collection, Genome Editing, And Washing Of T-Cell Lymphocytes 审中-公开

    公开(公告)号：US20200282116A1

    公开(公告)日：2020-09-10

    申请号：US16807254

    申请日：2020-03-03

    Applicant: Fenwal, Inc.

    Inventor： Kyungyoon Min ,  Benjamin E. Kusters

    IPC: A61M1/02 ,  A61M1/36 ,  B01D21/26

    Abstract: Blood from a blood source is drawn into a fluid flow circuit. A mononuclear cell product is separated from the blood, followed by at least a portion of the mononuclear cell product being conveyed into an electroporation device without disconnecting the blood source from the fluid flow circuit. The electroporation device opens pores in a membrane of at least one of the cells of the mononuclear cell product to allow DNA material (which is added to the mononuclear cell product prior to electroporation) to enter and modify the genome of the cell. At least a portion of the modified mononuclear cell product is returned to the blood source. The mononuclear cell product may be washed prior to being conveyed into the electroporation device. The modified mononuclear cell product may be washed after exiting the electroporation device.

    System and Method for Controlling Outlet Flow of a Device for Separating Cellular Suspensions
    95.
    发明申请
    System and Method for Controlling Outlet Flow of a Device for Separating Cellular Suspensions 审中-公开

    公开(公告)号：US20200261851A1

    公开(公告)日：2020-08-20

    申请号：US16869968

    申请日：2020-05-08

    Applicant: Fenwal, Inc.

    Inventor： Richard I. Brown ,  Benjamin E. Kusters ,  Kyungyoon Min

    IPC: B01D61/38 ,  B01D15/18 ,  B01D15/12 ,  B01D63/16 ,  B01D61/22 ,  A61M1/34 ,  A61M1/26 ,  B01D63/06

    Abstract: A system for separating a suspension of biological cells is disclosed comprising a single-use fluid circuit and a durable hardware component. The fluid circuit comprises a separator having a housing that includes an inlet for introducing the suspension of biological cells into the gap, a first outlet in communication with the gap for flowing a first type of cells from the separator, and a second outlet in communication with the second side of the filter membrane for flowing a second type of cells from the separator. The hardware component comprises a pump for flowing the suspension of biological cells to the inlet of the separator and at least one flow control device associated with the first outlet and the second outlet of the separator for selectively opening and closing the outlets so as to permit one of the first type of cells and the second type of cells to flow out of the separator in accordance with a predetermined duty cycle equal to the ratio of a target flow rate of first type of cells through the first outlet to the predetermined inlet flow rate.

    Systems And Methods For Deriving And Collecting Platelet Products
    96.
    发明申请
    Systems And Methods For Deriving And Collecting Platelet Products 审中-公开

    公开(公告)号：US20180078582A1

    公开(公告)日：2018-03-22

    申请号：US15705445

    申请日：2017-09-15

    Applicant: Fenwal, Inc.

    Inventor： Kyungyoon Min ,  Benjamin E. Kusters ,  Richard I. Brown

    IPC: A61K35/19 ,  C12N5/078

    CPC classification number: A61K35/19 ,  A61M1/0209 ,  A61M1/0272 ,  A61M1/0286 ,  A61M1/3696 ,  C12N5/0644

    Abstract: Systems and methods are provided for deriving a platelet product from a plurality of buffy coats. A plurality of buffy coats are separately collected, for example, using a conventional floor centrifuge. Plasma and/or a platelet additive solution may be added to the buffy coats. The buffy coats are pooled into a container and conveyed into a centrifuge or are sequentially conveyed into the centrifuge without being pooled, where they are continuously processed to separate platelets from the other cellular blood components. The separated platelets are conveyed out of the centrifuge as a platelet product, which may be passed through a leukocyte removal filter to reduce the white blood cell content of the platelet product. By continuously separating the buffy coats, fewer buffy coats are required to produce a single-dose platelet product, while also allowing for the derivation and collection of a plurality of single-dose platelet products.

    Systems and methods for single needle continuous plasma processing
    100.
    发明授权
    Systems and methods for single needle continuous plasma processing 有权
    单针连续等离子体处理的系统和方法

    公开(公告)号：US09011359B2

    公开(公告)日：2015-04-21

    申请号：US13912337

    申请日：2013-06-07

    Applicant: Fenwal, Inc.

    Inventor： Christopher J. Wegener ,  Daniel R. Boggs ,  Kyungyoon Min ,  Prakash Mathew ,  Marc N. Weasler ,  Benjamin E. Kusters

    IPC: A61M37/00 ,  A61M1/34 ,  A61M1/38 ,  A61M1/26 ,  A61M1/36 ,  B01D35/00 ,  B01D35/14 ,  B01D33/00 ,  C02F3/30

    CPC classification number: A61M1/3496 ,  A61M1/262 ,  A61M1/3603 ,  A61M1/38 ,  A61M2202/0415

    Abstract: Certain examples describe systems and methods for increasing plasma extracted from donor blood. An example method includes receiving blood extracted from a donor connected to a blood collection machine. The example method includes filtering the blood using a filtration device to remove at least a portion of plasma included in the blood to separate the plasma removed from remaining blood. The example method includes routing the plasma removed for collection. The example method includes re-filtering the remaining blood using a or the filtration device to remove additional plasma from the remaining blood. The example method includes routing the additional plasma removed for collection.

    Abstract translation: 某些实例描述了用于增加从供体血液中提取的血浆的系统和方法。 示例性方法包括接收从连接到采血机的供体供体的血液。 该示例性方法包括使用过滤装置过滤血液以去除包含在血液中的血浆中的至少一部分血浆以分离从血液中除去的血浆。 示例性方法包括将已去除的等离子体进行路由以进行采集。 示例性方法包括使用或过滤装置对剩余血液进行再过滤以从剩余血液中除去附加血浆。 示例性方法包括路由附加的等离子体以进行收集。

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