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    Methods, Systems, and Products for Conducting Droplet Operations
    91.
    发明申请
    Methods, Systems, and Products for Conducting Droplet Operations 审中-公开
    用于进行液滴操作的方法，系统和产品

    公开(公告)号：US20130178968A1

    公开(公告)日：2013-07-11

    申请号：US13737514

    申请日：2013-01-09

    Applicant: ADVANCED LIQUID LOGIC, INC.

    Inventor： Ryan A. Sturmer ,  Gregory F. Smith ,  Keith R. Brafford ,  Michael Fogleman ,  Sai Ram Rongali

    IPC: G06F19/00

    CPC classification number: G06F19/00 ,  B01F13/0076 ,  B01L3/502715 ,  B01L3/502792 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/089 ,  F04B17/00 ,  F04B19/006 ,  F04B49/065

    Abstract: The present invention provides modified droplet actuator systems, software, and software-executed methods for use in droplet actuator operation and droplet actuator systems that are configured and programmed to execute such software. The invention provides a computer readable medium storing processor executable code for performing a method, the method comprising receiving a selection of a function to be performed by a droplet actuator, associating the function to a predefined electrode element, associating the predefined electrode element to a grouping of one or more electrodes that perform the function, and adding the grouping of one or more electrodes to an electronic layout of the droplet actuator.

    Abstract translation: 本发明提供了用于在液滴致动器操作中使用的修改的液滴致动器系统，软件和软件执行方法以及配置和编程为执行这样的软件的液滴致动器系统。 本发明提供了一种存储用于执行方法的处理器可执行代码的计算机可读介质，该方法包括接收由液滴致动器执行的功能的选择，将功能与预定电极元件相关联，将预定电极元件与分组 执行功能的一个或多个电极，以及将一个或多个电极的分组添加到液滴致动器的电子布局。

    Mitigation of biomolecular adsorption with hydrophilic polymer additives
    92.
    发明授权
    Mitigation of biomolecular adsorption with hydrophilic polymer additives 有权
    用亲水性聚合物添加剂缓解生物分子吸附

    公开(公告)号：US08481125B2

    公开(公告)日：2013-07-09

    申请号：US11915308

    申请日：2006-05-18

    Applicant: Uichong B. Yi ,  Peter-Patrick De Guzman ,  Wayne Po-Wen Liu

    Inventor： Uichong B. Yi ,  Peter-Patrick De Guzman ,  Wayne Po-Wen Liu

    IPC: B05D3/10

    CPC classification number: B01L3/502792 ,  B01J2219/00837 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/089 ,  B01L2300/165 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0424 ,  B01L2400/0427 ,  Y10T428/139

    Abstract: Molecular adsorption to the microfluidic device surfaces can be passively and actively mitigated by mixing certain hydrophilic polymers (organic polymers with repeating hydrophilic groups—the preferred polymers being amphipathic surfactants—with the sample liquid during or prior to relevant microfluidic operations. Nonionic surfactants such as polyoxyethylene sorbitan monooleate and polyoxyethylene octyl phenyl ether are especially effective. High molecular weight polyethylene polymers are also effective. The hydrophilic polymers appear to prevent binding of the fouling molecules to the microfluidic by occupying the surface sites in place of the fouling molecules or by interacting with the fouling molecules to prevent binding of the fouling molecules the surface. When surface adsorption is thus mitigated, microfluidic devices can readily handle samples containing biomolecules to enable active sample concentration, filtering, washing, transport, mixing and other sample handling operations.

    Abstract translation: 通过将某些亲水性聚合物（具有重复亲水基团的有机聚合物 - 优选的两亲性表面活性剂聚合物 - 与相关微流控操作期间或之前的样品液体）混合，可以对微流体装置表面进行分子吸附，非离子表面活性剂如聚氧乙烯 脱水山梨糖醇单油酸酯和聚氧乙烯辛基苯基醚是特别有效的，高分子量聚乙烯聚合物也是有效的。亲水性聚合物似乎通过占据表面位置代替结垢分子或通过与污染分子相互作用而阻止污染分子与微流体结合 污染分子以防止污垢分子与表面的结合，当表面吸附因此减轻时，微流体装置可以容易地处理含有生物分子的样品，以使活性样品浓度，过滤，洗涤，运输，混合和其他样品处理操作 ns。

    Modular Droplet Actuator Drive
    99.
    发明申请
    Modular Droplet Actuator Drive 有权
    模块化滴液致动器驱动

    公开(公告)号：US20100143963A1

    公开(公告)日：2010-06-10

    申请号：US12707081

    申请日：2010-02-17

    Applicant: Michael G. Pollack ,  Philip Paik

    Inventor： Michael G. Pollack ,  Philip Paik

    IPC: C12Q1/02 ,  B05C11/00

    CPC classification number: B01L3/502792 ,  B01L2200/025 ,  B01L2200/04 ,  B01L2300/089 ,  B01L2400/0427 ,  G01N21/59 ,  G01N2021/035 ,  G01N2035/1046

    Abstract: The invention provides a droplet actuator drive. In certain embodiments, the droplet actuator drive may include a detection apparatus for sensing a property of a droplet on a droplet actuator; circuitry for controlling the detection apparatus electronically coupled to the detection apparatus; a droplet actuator cartridge connector; circuitry for controlling a droplet actuator coupled to the droplet actuator connector; and/or a means for coupling the droplet actuator circuitry to a processor. Systems, kits and methods of conducting assays are also provided.

    Abstract translation: 本发明提供一种液滴致动器驱动装置。 在某些实施例中，液滴致动器驱动器可以包括用于感测液滴致动器上的液滴的特性的检测装置; 用于控制检测装置的电路，电子耦合到检测装置; 液滴致动器盒连接器; 用于控制耦合到液滴致动器连接器的液滴致动器的电路; 和/或用于将液滴致动器电路耦合到处理器的装置。 还提供了进行测定的系统，试剂盒和方法。

    Sample Collector and Processor
    100.
    发明申请
    Sample Collector and Processor 审中-公开
    样品收集器和处理器

    公开(公告)号：US20100087012A1

    公开(公告)日：2010-04-08

    申请号：US12596902

    申请日：2008-04-23

    Applicant: Alexander Shenderov

    Inventor： Alexander Shenderov

    IPC: G01N33/543 ,  B01L3/00 ,  G01N1/28

    CPC classification number: G01N1/2202 ,  G01N2001/2217 ,  Y10T436/25375

    Abstract: An aerosol sample collector with an air flow path comprising: (i) at a first segment thereof, a particle charging device, and (i) at a second segment thereof, deflection plates configured to focus particles of a desired charge into a preselected cross-section of the air flow path. The air flow path also includes charged substrates arranged at an outflow portion of the air flow path to collect charged particles on a collection surface of the charged substrates; and an exit path for flowing particles not in the preselected cross-section of the air flow path away from the charged substrates. Related methods are also provided.

    Abstract translation: 一种具有空气流动路径的气溶胶样品收集器，包括：（i）在其第一部分处具有颗粒充电装置，和（i）在其第二部分处，配置成将所需电荷的颗粒聚焦成预选交联的偏转板， 空气流路的截面。 空气流路还包括布置在空气流动路径的流出部分处的带电基板，以将带电粒子收集在带电基板的收集表面上; 以及用于使不在所述空气流路的预选横截面中的颗粒流过所述带电基板的出口路径。 还提供了相关方法。

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