公开(公告)号：US5123731A

公开(公告)日：1992-06-23

申请号：US701376

申请日：1991-05-13

Applicant: Kazuo Yoshinaga ,  Moritoshi Miyamoto

Inventor： Kazuo Yoshinaga ,  Moritoshi Miyamoto

IPC: G01N15/14 ,  G01N21/25

CPC classification number: G01N15/0205 ,  G01N15/1434 ,  G01N21/255 ,  G01N15/1459 ,  G01N2015/0092 ,  G01N2201/067

Abstract: A particle measuring device having a light source for irradiating particles to be examined, light wavelength convertor provided in the optical path of the a light source and at least emitting a light converted into the short wavelength side relative to the wavelength of the incident light from the light source, and photometer for photometering the light from the particles to be examined.

Abstract translation: 一种粒子测量装置，其具有用于照射被检查的粒子的光源，设置在光源的光路中的光波长转换器，并且至少发射相对于来自所述入射光的入射光的波长而转换成短波长侧的光 光源和光度计，用于对要检查的颗粒的光进行光度测量。

公开(公告)号：US4772127A

公开(公告)日：1988-09-20

申请号：US682794

申请日：1984-12-18

Applicant: Eric T. Chase ,  Sergey V. Broude ,  George S. Quackenbos

Inventor： Eric T. Chase ,  Sergey V. Broude ,  George S. Quackenbos

IPC: G01N21/94 ,  G01N21/956 ,  G01N21/00

CPC classification number: G01N21/95623 ,  G01N2021/4711 ,  G01N21/94 ,  G01N2201/067 ,  G01N2201/0833

Abstract: In the surface inspection apparatus disclosed herein, an elongate array of electro-optical shutters is interposed between a laser beam which scans across the surface to be inspected and a photodetector system which collects light scattered from the surface along the scan line. The shutters are operated in a shifting pattern in synchronism with the scanning means thereby to block unwanted regular signal components.

Abstract translation: 在本文所公开的表面检查装置中，电子快门的细长阵列插入在要被检查的表面上扫描的激光束和从扫描线收集从表面散射的光的光电检测器系统。 快门以与扫描装置同步的移动模式操作，从而阻止不想要的常规信号分量。

公开(公告)号：US11815447B2

公开(公告)日：2023-11-14

申请号：US17114647

申请日：2020-12-08

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Hoon Sohn ,  Peipei Liu

IPC: G01N21/17 ,  B33Y30/00 ,  G01N21/88 ,  B33Y50/02 ,  B22F12/90 ,  B22F10/25

CPC classification number: G01N21/1702 ,  B22F12/90 ,  B33Y30/00 ,  B33Y50/02 ,  G01N21/8806 ,  B22F10/25 ,  G01N2201/067 ,  G01N2201/06113

Abstract: Disclosed are a femtosecond laser-based ultrasonic measuring apparatus for a 3D printing process, and a 3D printing system including the apparatus. The apparatus includes a femtosecond laser source for generating a femtosecond laser beam irradiated to inspect a state of a printing object formed by melting a base material by a printing laser beam irradiated from the laser source for 3D printing, a beam splitter for separating the femtosecond laser beam generated by the femtosecond laser source into a pump laser beam and a probe laser beam, an electric/acoustic optical modulator for modulating the pump laser beam, a time delay unit for delaying the probe laser beam, a photo detector for detecting the probe laser beam reflected by the printing object, and a lock-in amplifier for detect an amplitude and a phase of the output signal from the photo detector. The femtosecond laser source is disposed coaxially with a laser source for 3D printing.

公开(公告)号：US20230288331A1

公开(公告)日：2023-09-14

申请号：US18180228

申请日：2023-03-08

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Shaopeng WANG ,  Yunlei ZHAO ,  Guangzhong MA

IPC: G01N21/51 ,  B82Y15/00

CPC classification number: G01N21/51 ,  B82Y15/00 ,  G01N2201/0461 ,  G01N2201/0484 ,  G01N2201/067

Abstract: Provided herein are methods of determining molecular binding kinetics on particles, such as magnetic nanoparticles. In some embodiments, the methods include introducing an incident light from a light source toward a sample container that comprises a particle-bound biomolecule-ligand composition comprising a plurality of particle-bound biomolecules and a plurality of ligands that binds, or is capable of binding, to biomolecules of the plurality of particle-bound biomolecules, detecting light scattered from particle-bound biomolecule-ligand complexes in the particle-bound biomolecule-ligand composition over a duration to produce a set of imaging data using the detector, and determining size or volume changes of one or more of the particle-bound biomolecule-ligand complexes during at least a portion of the duration from the set of imaging data to thereby determine the molecular binding kinetics on the particles. Related systems and computer readable media are also provided.

公开(公告)号：US20230175060A1

公开(公告)日：2023-06-08

申请号：US17939760

申请日：2022-09-07

Applicant: Pacific Biosciences of California, Inc.

Inventor： Adrian FEHR ,  Nathaniel Joseph MCCAFFREY ,  Stephen TURNER

IPC: C12Q1/6874 ,  B01L3/00 ,  G01N21/64 ,  B82Y20/00 ,  G01N33/543 ,  G02B6/122 ,  G01N21/03 ,  G01N21/05 ,  G01N21/75 ,  G01N21/77 ,  C12Q1/6825 ,  C12Q1/6869

CPC classification number: C12Q1/6874 ,  B01L3/502707 ,  G01N21/6452 ,  G01N21/648 ,  B82Y20/00 ,  G01N21/6456 ,  G01N21/6454 ,  G01N33/54373 ,  G02B6/1226 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/75 ,  G01N21/64 ,  G01N21/77 ,  B01L3/502715 ,  C12Q1/6825 ,  G01N21/6428 ,  G01N21/03 ,  C12Q1/6869 ,  G01N21/645 ,  Y10T436/143333 ,  B01L2300/0654 ,  B01L2300/168 ,  G01N2021/0346 ,  G01N2021/757 ,  B01L2300/0663 ,  B01L2300/0816 ,  G01N2021/6434 ,  G01N2021/6441 ,  G01N2201/067 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2201/08 ,  G01N2021/7786 ,  G01N2201/068

Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.

公开(公告)号：US20190145882A1

公开(公告)日：2019-05-16

申请号：US16247426

申请日：2019-01-14

Applicant: The Regents of the University of California

Inventor： Bahram Jalali ,  Eric Diebold ,  Brandon Buckley

IPC: G01N15/14 ,  G01N21/64 ,  G01N33/537

CPC classification number: G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/537 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2021/6421 ,  G01N2201/067

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.

公开(公告)号：US09995761B2

公开(公告)日：2018-06-12

申请号：US15485261

申请日：2017-04-12

Applicant: The United States of America, as represented by the Secretary of the Army

Inventor： Bradley W. Libbey ,  James D. Perea

IPC: G01B9/02 ,  G01P3/36

CPC classification number: G01P3/36 ,  G01H9/00 ,  G01H9/002 ,  G01N21/1702 ,  G01N2201/06113 ,  G01N2201/067 ,  G01N2201/0683 ,  G01N2201/12

Abstract: A laboratory system has demonstrated the measurement of three degrees of vibrational freedom simultaneously using a single beam through heterodyne speckle imaging. The random interference pattern generated by the illumination of a rough surface with coherent light can be exploited to extract information about the surface motion. The optical speckle pattern is heterodyne mixed with a coherent reference. The recorded optical data is then processed to extract three dimensions of surface motion. Axial velocity is measured by demodulating the received time-varying intensity of high amplitude pixels. Tilt, a gradient of surface velocity, is calculated by measuring speckle translation following reconstruction of the speckle pattern from the mixed signal.

公开(公告)号：US09989527B2

公开(公告)日：2018-06-05

申请号：US15005776

申请日：2016-01-25

Applicant: Alverix, Inc.

Inventor： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman

IPC: G01N33/543 ,  G01N21/84 ,  G01N33/558 ,  G01N21/17 ,  G01N21/64 ,  G01N21/27

CPC classification number: G01N33/54386 ,  G01N21/17 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/067 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

Abstract: In one aspect, a diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port for receiving a test strip. The reader obtains separable light intensity measurements from localized regions of an area of the detection zone exposed for optical inspection, wherein each of the localized regions is characterized by at least one surface dimension smaller than the first dimension. The data analyzer identifies ones of the light intensity measurements obtained from the at least one test region and computes at least one parameter from the identified ones of the light intensity measurements. In another aspect, the reader obtains a respective set of light intensity measurements from each of multiple corresponding regions of the exposed surface area of the detection zone, and the data analyzer computes at least one parameter from at least one of the sets of light intensity measurements.

公开(公告)号：US09829428B2

公开(公告)日：2017-11-28

申请号：US15400554

申请日：2017-01-06

Applicant: Honeywell International Inc.

Inventor： Wei Yang ,  Teresa M. Marta ,  Martin Willett ,  Rodney R. Watts

IPC: G01N21/3504 ,  G01N21/17 ,  G01N21/61 ,  G01N33/00

CPC classification number: G01N21/1702 ,  G01J5/02 ,  G01J5/42 ,  G01N21/61 ,  G01N33/0027 ,  G01N2021/1704 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/12

Abstract: Gas detector devices, systems, and methods using a Golay cell are described herein. One device includes a microphone having a front surface with a sound collecting aperture for receiving sound, a substrate, a gas cavity formed in the substrate such that the gas cavity is in gas communication with the sound collecting aperture and the front surface forms a side surface of the gas cavity, and a window abutting the substrate to form a side surface of the gas cavity.

公开(公告)号：US20170309360A1

公开(公告)日：2017-10-26

申请号：US15645324

申请日：2017-07-10

Applicant: Honeywell International Inc.

Inventor： Matthew E. L. Jungwirth ,  James Edward Goeders

IPC: G21K1/00 ,  G01N21/64

CPC classification number: G21K1/003 ,  G01N21/64 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/7786 ,  G01N2201/067

Abstract: A single cell apparatus and method for single ion addressing are described herein. One apparatus includes a single cell configured to set a frequency, intensity, and a polarization of a laser, shutter the laser, align the shuttered laser to an ion in an ion trap such that the ion fluoresces light and/or performs a quantum operation, and detect the light fluoresced from the ion.