公开(公告)号：US08809093B2

公开(公告)日：2014-08-19

申请号：US12949758

申请日：2010-11-18

Applicant: Andrew P. Homyk ,  Michael D. Henry ,  Axel Scherer ,  Sameer Walavalkar

Inventor： Andrew P. Homyk ,  Michael D. Henry ,  Axel Scherer ,  Sameer Walavalkar

IPC: H01L21/20 ,  B82Y10/00 ,  H01L29/06 ,  H01L29/775 ,  H01L29/66

CPC classification number: H01L31/035227 ,  B82Y10/00 ,  B82Y40/00 ,  H01L21/02381 ,  H01L21/0243 ,  H01L21/02521 ,  H01L21/0259 ,  H01L21/02639 ,  H01L29/0665 ,  H01L29/0676 ,  H01L29/127 ,  H01L29/267 ,  H01L29/413 ,  H01L29/66439 ,  H01L29/775 ,  H01L33/06 ,  Y10S977/762

Abstract: Methods for fabricating self-aligned heterostructures and semiconductor arrangements using silicon nanowires are described.

Abstract translation: 描述了使用硅纳米线制造自对准异质结构和半导体布置的方法。

公开(公告)号：US08574513B2

公开(公告)日：2013-11-05

申请号：US13448810

申请日：2012-04-17

Applicant: Samson Chen ,  Aditya Rajagopal ,  Axel Scherer

Inventor： Samson Chen ,  Aditya Rajagopal ,  Axel Scherer

IPC: G01N15/06

CPC classification number: H05K3/10 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  H01L23/473 ,  H01L2924/0002 ,  H05K1/0272 ,  H05K3/284 ,  H05K2201/10189 ,  H05K2203/1327 ,  Y10T29/49 ,  Y10T29/49002 ,  Y10T29/49155 ,  Y10T29/49165 ,  Y10T137/85938 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575 ,  H01L2924/00

Abstract: A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.

Abstract translation: 印刷电路板结构涂覆有已经形成微流体通道的密封剂。 在封装之前，通过将流体连接焊接到印刷电路板结构的表面上的金属迹线来形成微流体通道。 在封装后通过蚀刻去除金属迹线，以在密封剂内形成微通道。

公开(公告)号：US08550119B2

公开(公告)日：2013-10-08

申请号：US11932552

申请日：2007-10-31

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake ,  Markus Enzelberger ,  Mark L. Adams ,  Carl L. Hansen

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake ,  Markus Enzelberger ,  Mark L. Adams ,  Carl L. Hansen

IPC: F15C3/00 ,  F16K31/126

CPC classification number: F15C3/00 ,  B01J2219/00355 ,  B01J2219/00378 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00439 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/54 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/18 ,  B01L2400/0481 ,  B01L2400/0655 ,  B01L2400/0688 ,  B32B2037/1081 ,  F04B19/006 ,  F04B43/043 ,  F16K99/0001 ,  F16K99/0026 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084 ,  Y10T137/2202 ,  Y10T137/2224 ,  Y10T137/87885

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US08424560B2

公开(公告)日：2013-04-23

申请号：US12636086

申请日：2009-12-11

Applicant: Emil P. Kartalov ,  John Liu ,  Axel Scherer ,  Clive Taylor

Inventor： Emil P. Kartalov ,  John Liu ,  Axel Scherer ,  Clive Taylor

IPC: F16K31/365 ,  F16K31/36 ,  F15C3/04 ,  F15C1/06

CPC classification number: G05D7/0694 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0057 ,  F16K2099/008 ,  Y10T137/0318 ,  Y10T137/218 ,  Y10T137/2202 ,  Y10T137/2224 ,  Y10T137/7795 ,  Y10T137/7796

Abstract: Multi-valve autoregulatory microfluidic devices and methods are described. The described devices and methods offer improved performance and new means of tuning autoregulatory effects in microfluidic devices.

Abstract translation: 描述了多瓣膜自动调节微流体装置和方法。 所描述的装置和方法提供改进的性能和调整微流体装置中的自动调节效应的新手段。

公开(公告)号：US08361738B2

公开(公告)日：2013-01-29

申请号：US12717402

申请日：2010-03-04

Applicant: Emil P. Kartalov ,  Axel Scherer ,  Clive Taylor

Inventor： Emil P. Kartalov ,  Axel Scherer ,  Clive Taylor

IPC: G01N33/00

CPC classification number: G01N33/5306 ,  B01L3/502738 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/088 ,  B01L2300/0883 ,  B01L2400/0475

Abstract: Described herein is a method for detection of a target in a sample and related devices and systems.

Abstract translation: 这里描述了用于检测样品中的目标物和相关装置和系统的方法。

公开(公告)号：US08356763B2

公开(公告)日：2013-01-22

申请号：US13427672

申请日：2012-03-22

Applicant: Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

Inventor： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

IPC: B02C17/10

CPC classification number: C12N13/00 ,  C12M47/06 ,  C12N1/066

Abstract: Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is generated by the electromagnets.

Abstract translation: 描述了裂解生物样品的方法和布置。 该装置包括含有样品的裂解管，产生磁场的一个或多个电磁体和裂解管内的一个或多个永磁体。 当电磁铁产生磁场时，永久磁铁移动并裂开样品。

公开(公告)号：US20120328834A1

公开(公告)日：2012-12-27

申请号：US13360261

申请日：2012-01-27

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

IPC: B32B3/00

CPC classification number: B29C51/00 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0655 ,  B33Y80/00 ,  B81B5/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2201/034 ,  C12Q1/6874 ,  F04B43/043 ,  F15C1/06 ,  F15C5/00 ,  F16K11/20 ,  F16K13/00 ,  F16K31/126 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/0491 ,  Y10T137/0497 ,  Y10T137/2224 ,  Y10T137/87249 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24744 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US08187541B2

公开(公告)日：2012-05-29

申请号：US11856722

申请日：2007-09-18

Applicant: George Maltezos ,  Jeremy Witzens ,  Axel Scherer

Inventor： George Maltezos ,  Jeremy Witzens ,  Axel Scherer

IPC: G01N21/00 ,  G01N21/01 ,  G01N21/76 ,  G21K5/00 ,  C25B13/00 ,  G01N33/48 ,  F17D1/16 ,  F17D3/00 ,  G01J3/30 ,  G01B9/02

CPC classification number: G01N21/6428 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/141 ,  B01L2200/142 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/148 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/14 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0638 ,  B01L2400/0655 ,  B01L2400/0683 ,  B81C1/00119 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/6456 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2021/0364 ,  G01N2201/024 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T137/1714 ,  Y10T137/2202 ,  Y10T137/8811

Abstract: An apparatus for analysis of a sample and in particular of a biological sample. The apparatus contains a microfluidic chip with dies, adapted to be selectively activated or deactivated by presence of target molecules in the biological sample. The apparatus further contains a light source to emit light for illumination of the microfluidic chip and an optical filter to allow passage of the light from the dies once activated or deactivated by the presence of the target molecules. A method for pressurizing a microfluidic chip is also disclosed, where a chamber is provided, the chamber is connected with the microfluidic chip and pressure is applied to the chamber.

Abstract translation: 用于分析样品，特别是生物样品的装置。 该装置包含具有管芯的微流体芯片，适于通过生物样品中目标分子的存在而被选择性地活化或失活。 该装置还包含用于发射微流芯片照明的光源和滤光器，以允许通过靶分子的存在激活或去激活来自模具的光的通过。 还公开了一种用于对微流体芯片加压的方法，其中设置有腔室，腔室与微流体芯片连接，并且将压力施加到腔室。

公开(公告)号：US08137626B2

公开(公告)日：2012-03-20

申请号：US11804112

申请日：2007-05-17

Applicant: George Maltezos ,  John Kim Lee ,  Axel Scherer ,  Emil Kartalov

Inventor： George Maltezos ,  John Kim Lee ,  Axel Scherer ,  Emil Kartalov

IPC: G01N21/64

CPC classification number: G01N21/6456 ,  G01N21/6452 ,  Y10T137/2224

Abstract: Microfluidic assay detectors and microfluidic assay detection methods are disclosed. A microfluidic chip is coupled to a light emitting device, emission filters and excitation filters. Excited fluorescent light is detected by a camera and a lens. The correspondent reading allows parallel detection of features such as antigens and biomarkers. A microfluidic filter and related methods are also disclosed. The filter can be used with on-chip fluid filtration such as whole blood filtration for microfluidic blood analysis. The filter is able to filter the necessary volume of fluid and in particular blood in an acceptable time frame.

Abstract translation: 公开了微流控测定检测器和微流控测定检测方法。 微流控芯片耦合到发光器件，发射滤光器和激发滤光器。 激发的荧光灯由相机和透镜检测。 通讯阅读允许并行检测抗原和生物标志物等特征。 还公开了微流体过滤器和相关方法。 过滤器可用于片上流体过滤，如全血过滤用于微流体血液分析。 过滤器能够在可接受的时间范围内过滤所需体积的流体，特别是血液。

公开(公告)号：US20120026509A1

公开(公告)日：2012-02-02

申请号：US13157245

申请日：2011-06-09

Applicant: Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer ,  Demetri Psaltis

Inventor： Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer ,  Demetri Psaltis

IPC: G01B9/02 ,  G02B21/10 ,  G02B5/18

CPC classification number: G02B21/0056 ,  G01N21/553 ,  G02B21/18 ,  G02B21/361

Abstract: A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination source, and a photodetector to receive Young's interference from the illumination passing through the pair of two apertures. In addition, a surface wave assisted optofluidic microscope and method utilize an illumination source, a fluid channel having a layer with at least one aperture as a surface, and a photodetector that receives a signal based on the illumination passing through the aperture. The layer is corrugated (e.g., via fabrication) and parameters of the corrugation optimize the signal received on the photodetector.

Abstract translation: 差分干涉对比度（DIC）确定装置和方法利用照明源，具有一对两个孔的层，其接收来自照明源的照明，以及光电检测器，用于接收来自穿过该对两个孔的照明的杨氏干扰。 此外，表面波辅助光流体显微镜和方法利用照明源，具有至少一个孔的层作为表面的流体通道，以及基于穿过孔的照明而接收信号的光电检测器。 该层是波纹状的（例如通过制造），并且波纹的参数优化了在光电检测器上接收的信号。