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101.发明授权Methods for fabricating self-aligning semiconductor hetereostructures using nanowires 有权使用纳米线制造自对准半导体hetereostructures的方法公开(公告)号：US09406823B2
公开(公告)日：2016-08-02
申请号：US14329748
申请日：2014-07-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Andrew P. Homyk , Michael D. Henry , Axel Scherer , Sameer Walavalkar
IPC: H01L29/06 , H01L31/0352 , B82Y10/00 , H01L29/66 , H01L29/775 , H01L33/06 , B82Y40/00 , H01L29/12 , H01L29/41 , H01L21/02 , H01L29/267
CPC classification number: H01L31/035227 , B82Y10/00 , B82Y40/00 , H01L21/02381 , H01L21/0243 , H01L21/02521 , H01L21/0259 , H01L21/02639 , H01L29/0665 , H01L29/0676 , H01L29/127 , H01L29/267 , H01L29/413 , H01L29/66439 , H01L29/775 , H01L33/06 , Y10S977/762
Abstract: Methods for fabricating self-aligned heterostructures and semiconductor arrangements using silicon nanowires are described.
Abstract translation: 描述了使用硅纳米线制造自对准异质结构和半导体布置的方法。
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公开(公告)号：US09243277B2
公开(公告)日：2016-01-26
申请号：US14753741
申请日：2015-06-29
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya Rajagopal , Axel Scherer , Michael D. Henry , Sameer Walavalkar , Thomas A. Tombrello , Andrew P. Homyk
IPC: G01R1/067 , G01R31/00 , C12Q1/02 , H01L29/78 , H01L29/66 , G01N27/327 , G01N27/414 , A61B5/04 , H01L29/41 , H01L29/423 , H01L29/49 , G01R1/073
CPC classification number: C12Q1/02 , A61B5/04001 , G01N27/3275 , G01N27/4146 , G01R1/06711 , G01R1/07342 , H01L29/413 , H01L29/42376 , H01L29/4966 , H01L29/66477 , H01L29/78 , H01L29/7831
Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.
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103.发明授权公开(公告)号：US09238833B2
公开(公告)日：2016-01-19
申请号：US14028431
申请日：2013-09-16
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson Chen , Aditya Rajagopal , Axel Scherer
CPC classification number: C12Q1/686 , B01L7/52 , B01L2200/12 , B01L2300/0877 , B01L2300/1827 , H05K1/0212 , H05K1/0272 , H05K1/16 , H05K3/4644 , H05K3/4697 , Y10T29/49155
Abstract: Novel methods and systems for polymerase chain reaction (PCR) are disclosed. A PCR device has a bottom heater layer, a central reacting layer, and a top heater layer. The central reacting layer has a PCR reacting chamber connected with fluidics channels. Photoluminescence of a DNA solution in the PCR reactive chamber is carried out through the transparent top layers.
Abstract translation: 公开了用于聚合酶链反应（PCR）的新方法和系统。 PCR装置具有底部加热器层，中央反应层和顶部加热器层。 中央反应层具有与流体通道连接的PCR反应室。 PCR反应室中DNA溶液的光致发光通过透明顶层进行。
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公开(公告)号：US09173605B2
公开(公告)日：2015-11-03
申请号：US14340498
申请日：2014-07-24
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Muhammad Mujeeb-U-Rahman , Meisam Honarvar Nazari , Mehmet Sencan , Axel Scherer
IPC: H01L27/14 , A61B5/1473 , A61B5/145 , B82Y15/00 , G01N27/48 , H01L21/77 , H01L25/16 , H01L27/04 , H01L49/02 , B82Y10/00 , H01L29/06 , H01L29/41
CPC classification number: A61B5/1473 , A61B5/14532 , B82Y10/00 , B82Y15/00 , G01N27/48 , H01L21/77 , H01L25/16 , H01L27/04 , H01L28/10 , H01L29/0676 , H01L29/413 , H01L2924/0002 , Y10T29/49018 , H01L2924/00
Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.
Abstract translation: 描述了完全集成的小尺寸植入式感测装置，其可以包括传感器和电子电路以与传感器接口并与外部设备通信。 描述了用于感测装置的各种制造方法，包括提供使用与电子电路相同的制造技术产生的孔，以容纳传感器的电极和相应的功能化学品。 这种植入式感测装置可以用于生物体内的各种电化学测量应用，以及通过将电流注入生物体来启动。
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公开(公告)号：US09099436B2
公开(公告)日：2015-08-04
申请号：US13852476
申请日：2013-03-28
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya Rajagopal , Axel Scherer , Michael D. Henry , Sameer Walavalkar , Thomas A. Tombrello , Andrew P. Homyk
IPC: G01R1/067 , H01L29/423 , H01L29/78 , H01L29/66 , G01N27/327 , G01N27/414 , A61B5/04 , H01L29/41 , H01L29/49 , G01R1/073
CPC classification number: C12Q1/02 , A61B5/04001 , G01N27/3275 , G01N27/4146 , G01R1/06711 , G01R1/07342 , H01L29/413 , H01L29/42376 , H01L29/4966 , H01L29/66477 , H01L29/78 , H01L29/7831
Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.
Abstract translation: 本文公开的探针的基本结构和功能允许灵活地并入到探针中，用于各种感测应用的各种感测元件。 这些各种感测应用中的两个示例应用包括生物感测和化学感测应用。 对于生物感测应用，制造在硅衬底上的探针包括诸如纳米柱晶体管的生物感测元件，并且对于化学感测应用，探针包括具有功能化接触区域的感测元件， 当暴露于感兴趣的一种或多种化学品时，感测元件产生电压。
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Patent Agency Ranking
公开(公告)号：US09090890B2
公开(公告)日：2015-07-28
申请号：US14070460
申请日：2013-11-01
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R Malik , Erika F Garcia , Xiomara Linnette Madero , Axel Scherer
CPC classification number: C12N15/1017 , F17D3/00 , G01N21/75
Abstract: Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers.
Abstract translation: 公开了用于生物样品制备和分析的方法和装置。 装置可以具有容器的线性或圆形布置，其具有连接结构，例如杆或盘。 容器之间的流体通道允许执行不同的样品制备技术，如裂解，洗涤和洗脱。 可以将不同的功能元件，例如研磨机或混合器附接到容器。
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公开(公告)号：US20150183633A1
公开(公告)日：2015-07-02
申请号：US14503252
申请日：2014-09-30
Applicant: California Institute of Technology
Inventor： Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake
IPC: B81B3/00
CPC classification number: B32B3/00 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/046 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B32B2037/1081 , B81B3/0032 , B81B3/0051 , B81B2201/036 , B81B2201/054 , B81C1/00119 , B81C2201/019 , C12Q1/6874 , F04B43/043 , F15C5/00 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , Y10T137/0491 , Y10T137/2224 , Y10T137/87716 , Y10T137/87804 , Y10T137/87812 , Y10T137/87893 , Y10T156/10 , Y10T156/1002 , Y10T156/1064 , Y10T428/24479 , Y10T428/2457 , Y10T428/24612 , Y10T428/24744 , C12Q2535/125
Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.
Abstract translation: 一种制造弹性体结构的方法，包括：在第一微加工模具的顶部上形成第一弹性体层，所述第一微加工模具具有形成沿所述第一弹性体层的底表面延伸的第一凹槽的第一凸起突起; 在第二微加工模具的顶部上形成第二弹性体层，所述第二微加工模具具有第二凸起突起，所述第二凸起突起形成沿所述第二弹性体层的底表面延伸的第二凹槽; 将第二弹性体层的底表面粘合到第一弹性体层的顶表面上，使得控制通道在第一和第二弹性体层之间的第二凹部中形成; 以及将第一弹性体层定位在平面基底的顶部上，使得流动通道在第一弹性体层和平面基底之间的第一凹部中形成。
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108.发明授权Nanopillar field-effect and junction transistors with functionalized gate and base electrodes 有权具有功能化栅极和基极的纳米柱场效应和结型晶体管公开(公告)号：US09070733B2
公开(公告)日：2015-06-30
申请号：US13941295
申请日：2013-07-12
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , SANOFI
Inventor： Aditya Rajagopal , Chieh-feng Chang , Oliver Plettenburg , Stefan Petry , Axel Scherer , Charles L. Tschirhart
IPC: H01L29/73 , H01L29/78 , B82Y15/00 , H01L29/732 , H01L29/06 , H01L29/41 , G01N27/414
CPC classification number: H01L29/413 , B82Y15/00 , G01N27/4145 , G01N27/4146 , H01L29/0676 , H01L29/45 , H01L29/49 , H01L29/73 , H01L29/732 , H01L29/735 , H01L29/78
Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.
Abstract translation: 描述了用于分子感测的系统和方法。 描述了基于场效应或双极结型晶体管的分子传感器。 这些晶体管具有纳米柱，其具有与基极或栅电极接触的官能化层。 功能层可以结合分子，导致传感器中的电信号。
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公开(公告)号：US09042418B2
公开(公告)日：2015-05-26
申请号：US14139799
申请日：2013-12-23
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Seheon Kim , William Dos Santos Fegadolli , Axel Scherer
CPC classification number: H01S5/2275 , B82Y20/00 , H01S5/021 , H01S5/026 , H01S5/0425 , H01S5/1028 , H01S5/1042 , H01S5/105 , H01S5/2045 , H01S5/2228 , H01S5/3013 , H01S5/3213 , H01S5/34306 , H01S2304/00 , H01S2304/02
Abstract: Novel methods and systems for miniaturized lasers are described. A photonic crystal is bonded to a silicon-on-insulator wafer. The photonic crystal includes air-holes and can include a waveguide which couples the laser output to a silicon waveguide.
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110.发明授权Methods of modulating microlasers at ultralow power levels, and systems thereof 有权在超低功率水平下调节微量激光器的方法及其系统公开(公告)号：US09031102B2
公开(公告)日：2015-05-12
申请号：US13764620
申请日：2013-02-11
Applicant: California Institute of Technology
Inventor： Seheon Kim , Axel Scherer , Aditya Rajagopal , Chieh-Feng Chang
CPC classification number: H01S3/0627 , A61B5/1459 , H01S3/025 , H01S3/091 , H01S3/102 , H01S3/1028 , H01S3/105 , H01S3/115 , H01S5/0607 , H01S5/0612 , H01S5/1042 , H01S5/3013
Abstract: A microlaser system includes an optical source, a microlaser, an actuator switch, and a photovoltaic power source. The microlaser, which includes a control element, is optically pumped by at least a portion of light emitted by the optical source. The actuator switch is configured to be activated by a triggering event. Furthermore, the photovoltaic power source is coupled in a series connection with the actuator switch and the control element, the series connection configured to connect the photovoltaic power source to the control element of the microlaser when the actuator switch is activated by the triggering event.
Abstract translation: 微型激光系统包括光源，微激光器，致动器开关和光伏电源。 包括控制元件的微激光器被由光源发射的光的至少一部分光泵浦。 执行器开关被配置为由触发事件激活。 此外，光伏电源与致动器开关和控制元件串联连接，串联连接被配置为当致动器开关被触发事件激活时将光伏电源连接到微型激光器的控制元件。
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