公开(公告)号：US09302903B2

公开(公告)日：2016-04-05

申请号：US10023259

申请日：2001-12-14

Applicant: Jung-Hwan Park ,  Mark R. Prausnitz

Inventor： Jung-Hwan Park ,  Mark R. Prausnitz

IPC: A61N1/30 ,  B81C1/00 ,  A61B5/15 ,  A61M37/00 ,  A61B5/145

CPC classification number: B81C1/00111 ,  A61B5/1411 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  A61N1/30 ,  B81B2201/055

Abstract: Microneedle devices and methods of manufacture are provided for transport of molecules or energy across or into biological barriers, such as skin. The device can comprise one or more microneedles formed of a first material and a second material, wherein the second material is dispersed throughout the first material or forms a portion of the microneedle. The first material preferably is a polymer. The second material can be pore forming agents, structural components, biosensor, or molecules for release, such as drug. The device also can comprise a substrate and a plurality of microneedles extending from the substrate, wherein the microneedles have a beveled or tapered tip portion, a longitudinally extending exterior channel, or both. Methods of making these devices include providing a mold having a plurality of microdepressions which define the surface of a microneedle; filling the microdepressions with a first molding material; and molding the material, thereby forming microneedles.

公开(公告)号：US09238384B2

公开(公告)日：2016-01-19

申请号：US13752959

申请日：2013-01-29

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Kazuhiko Shiomitsu ,  Hiroshi Sugimura ,  Toshiaki Kurosu ,  Gaku Suzuki ,  Takao Tomono

IPC: B44C1/20 ,  B44C1/22 ,  A61M37/00 ,  B29C33/42 ,  B81C1/00

CPC classification number: B44C1/227 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C33/42 ,  B81B2201/055 ,  B81C1/00111 ,  B81C2201/0198

Abstract: The invention discloses a method of manufacturing a microneedle including the steps of forming an island etching mask having thickness distribution on a substrate, and processing the substrate into a needle by taking advantage of a difference in etching rates between the etching mask and the substrate. The invention enables to readily control a point angle and height of the manufactured needle.

公开(公告)号：US20150191688A1

公开(公告)日：2015-07-09

申请号：US14422565

申请日：2013-03-15

Applicant: Presodemt and Fellows of Harvard College

Inventor： Hongkun Park ,  Alexander K. Shalek ,  Ruihua Ding ,  Joseph Park

IPC: C12M1/32 ,  C12M1/12 ,  C12N5/00 ,  C12N1/20

CPC classification number: B81C1/00111 ,  B01L3/5085 ,  B01L99/00 ,  B01L2300/0851 ,  B01L2300/0896 ,  B01L2300/163 ,  B01L2400/086 ,  B81B7/04 ,  B81B2201/055 ,  B81B2203/0361 ,  B81B2207/056 ,  B82Y15/00 ,  B82Y30/00 ,  C12M23/12 ,  C12M25/00 ,  C12N1/20 ,  C12N5/0068 ,  Y10T156/10

Abstract: The present invention generally relates to nanowires and, in particular, to multiwell plates comprising nanowires, including systems and methods of making the same. Such multiwell plates can, in some cases, be used in automated equipment or high-throughput applications. For example, a plurality of cells may be placed in at least some of the wells of the multiwell plate, and one or more nanowires may be inserted into at least some of the cells within the wells of the multiwell plate. In some cases, one or more of the nanowires may have coated thereon a biological effector. The cells in each of the wells may be identical or different, and/or the biological effector may the same or different. Such multiwell plates may be used, for example, to test a biological effector against a variety of cell types, or to test a variety of biological effectors against a one or more cell types, or the like.

Abstract translation: 本发明一般涉及纳米线，特别涉及包含纳米线的多孔板，包括其制备方法和系统。 在某些情况下，这种多孔板可用于自动化设备或高通量应用中。 例如，可以将多个细胞放置在多孔板的至少一些孔中，并且一个或多个纳米线可以插入到多孔板的孔内的至少一些细胞中。 在一些情况下，一个或多个纳米线可以在其上涂覆有生物效应物。 每个孔中的细胞可以相同或不同，和/或生物效应物可以相同或不同。 这样的多孔板可以用于例如针对各种细胞类型测试生物效应物，或者针对一种或多种细胞类型等测试各种生物效应物。

公开(公告)号：US08986256B2

公开(公告)日：2015-03-24

申请号：US12925804

申请日：2010-10-29

Applicant: Dick Scholten ,  Michael Stumber ,  Franz Laermer ,  Ando Feyh

Inventor： Dick Scholten ,  Michael Stumber ,  Franz Laermer ,  Ando Feyh

IPC: A61M5/00 ,  A61M37/00 ,  B81C1/00

CPC classification number: A61M37/0015 ,  A61M2037/0053 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C1/00111 ,  B81C2201/0114 ,  B81C2201/0115 ,  B81C2203/0118 ,  B81C2203/054 ,  Y10T225/10 ,  Y10T225/12

Abstract: A manufacturing method for a porous microneedle array includes: forming a plurality of porous microneedle arrays, each having at least one microneedle and a porous carrier zone lying beneath it on the face of a semiconductor substrate; forming an interlayer between a non-porous residual layer of the semiconductor substrate located on the back side of the semiconductor substrate and the carrier zone, which has greater porosity than the carrier zone; detaching the residual layer from the carrier zone by breaking up the interlayer; and separating the microneedle arrays into corresponding chips.

Abstract translation: 多孔微针阵列的制造方法包括：形成多个多孔微针阵列，每个多孔微针阵列在半导体衬底的表面上具有至少一个微针和位于其下方的多孔载体区; 在位于半导体衬底背面的半导体衬底的非多孔残留层与载体区之间形成中间层，所述载流区具有比载体区更大的孔隙率; 通过破坏夹层从载体区分离残留层; 并将微针阵列分离成相应的芯片。

公开(公告)号：US08671544B2

公开(公告)日：2014-03-18

申请号：US10592559

申请日：2004-03-12

Applicant: Meí Ma Chen ,  Zhongli Li ,  Chee Yen Lim ,  Pei Ying Joyce Tan ,  Minghua Wang

Inventor： Yuan Xu ,  Meí Ma Chen ,  Zhongli Li ,  Chee Yen Lim ,  Pei Ying Joyce Tan

IPC: B23P25/00 ,  B28B1/48 ,  B29C33/00 ,  B23P17/00

CPC classification number: B29C33/0061 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B29C33/301 ,  B29C33/3857 ,  B29C33/40 ,  B29C33/424 ,  B29C33/56 ,  B29C59/026 ,  B29C2791/001 ,  B29C2793/0009 ,  B29L2031/756 ,  B29L2031/759 ,  B81B2201/055 ,  B81C99/009 ,  C25D1/02 ,  Y10T29/49885 ,  Y10T29/4998 ,  Y10T29/49982 ,  Y10T29/49984 ,  Y10T29/49986 ,  Y10T29/49988

Abstract: A microneedle mold and a method of manufacturing a microneedle mold are provided for use in fabricating microneedles. The method includes providing a microneedle mold base with recesses therein, the recesses corresponding to the microneedles to be fabricated and extending from a first surface of the microneedle mold base; and forming side-port forming holes in the microneedle mold base, the side-port forming holes extend in side surfaces of the recesses within the microneedle mold base at side-port forming positions of the recesses.

Abstract translation: 提供微针模具和制造微针模具的方法用于制造微针。 该方法包括：在其中设置微针模具基座，其中凹部对应于待制造的微针并从微针模具底座的第一表面延伸; 并且在微针模具基座中形成侧口形成孔，所述侧端口形成孔在所述凹部的侧端口形成位置处在所述微针基座内的凹部的侧面上延伸。

公开(公告)号：US20140027404A1

公开(公告)日：2014-01-30

申请号：US14040582

申请日：2013-09-27

Applicant: HON HAI PRECISION INDUSTRY CO., LTD. ,  Tsinghua University

Inventor： YANG WEI ,  LIANG LIU ,  SHOU-SHAN FAN

IPC: C01B31/02

CPC classification number: C01B32/168 ,  B81B2201/055 ,  B81C1/00111 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/162 ,  C01B2202/02 ,  C01B2202/04 ,  C01B2202/06 ,  C01B2202/08 ,  C01B2202/34 ,  C01B2202/36 ,  Y10T428/2982

Abstract: A method for manufacturing a carbon nanotube needle is provided. A carbon nanotube film comprising of a plurality of commonly aligned carbon nanotubes, a first electrode, and a second electrode are provided. The carbon nanotube film is fixed to the first electrode and the second electrode. An organic solvent is applied to treat the carbon nanotube film to form at least one carbon nanotube string. A voltage is applied to the carbon nanotube string until the carbon nanotube string snaps

Abstract translation: 提供了一种制造碳纳米管针的方法。 提供由多个共同排列的碳纳米管构成的碳纳米管膜，第一电极和第二电极。 碳纳米管膜固定在第一电极和第二电极上。 施加有机溶剂来处理碳纳米管膜以形成至少一个碳纳米管串。 向碳纳米管串施加电压，直到碳纳米管串咬合为止

公开(公告)号：US08585910B2

公开(公告)日：2013-11-19

申请号：US12397197

申请日：2009-03-03

Applicant: Douglas Ray Sparks ,  Nader Najafi

Inventor： Douglas Ray Sparks ,  Nader Najafi

IPC: G01F1/84 ,  G01F1/76 ,  B81C1/00 ,  B01L3/00

CPC classification number: B81B1/002 ,  B01L3/5027 ,  B81B2201/0242 ,  B81B2201/055 ,  B81B2203/0323 ,  B81B2203/0338 ,  B81C1/00 ,  B81C1/00119 ,  B81C1/0019 ,  B81C1/00357 ,  B81C1/00468 ,  G01F1/84 ,  G01F1/8404 ,  G01F1/8409 ,  G01F1/844 ,  G01F1/8445 ,  Y10T428/13 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A process for producing a micromachined tube (microtube) suitable for microfluidic devices. The process entails isotropically etching a surface of a first substrate to define therein a channel having an arcuate cross-sectional profile, and forming a substrate structure by bonding the first substrate to a second substrate so that the second substrate overlies and encloses the channel to define a passage having a cross-sectional profile of which at least half is arcuate. The substrate structure can optionally then be thinned to define a microtube and walls thereof that surround the passage.

Abstract translation: 一种适用于微流体装置的微加工管（微管）的制造方法。 该方法需要各向同性蚀刻第一衬底的表面以在其中限定具有弓形横截面轮廓的通道，并且通过将第一衬底粘合到第二衬底来形成衬底结构，使得第二衬底覆盖并封闭沟道以限定 具有至少一半弧形的截面轮廓的通道。 衬底结构可任选地被减薄以限定围绕通道的微管及其壁。

公开(公告)号：US20130136924A1

公开(公告)日：2013-05-30

申请号：US13806558

申请日：2011-06-07

Applicant: Koji Ikuta ,  Masashi Ikeuchi

Inventor： Koji Ikuta ,  Masashi Ikeuchi

IPC: B29C67/00

CPC classification number: B29C64/135 ,  A61M2037/0023 ,  A61M2037/0053 ,  B29L2031/7544 ,  B33Y10/00 ,  B33Y70/00 ,  B81B2201/055 ,  B81C1/00373 ,  B81C2201/0188 ,  Y10T428/2933 ,  Y10T428/31678

Abstract: Disclosed is a method for producing a three-dimensional polymer-metal complex microstructure including forming a polymer structure by stereolithography using a photocurable resin having a reactive group X and dipping it in a liquid of a metal-containing nanoparticle having a reactive group X′ which is bound to the reactive group X, thereby forming a metal-containing layer on the polymer structure through binding the reactive group X and the reactive group X′.According to this method, it is possible to produce a polymer-metal complex structure having a steric structure and to produce a three-dimensional polymer-metal complex microstructure which does not denature biomolecules in a metal complexation process.

Abstract translation: 公开了一种三维聚合物 - 金属络合物显微组织的制造方法，包括通过使用具有反应性基团X的光固化树脂通过立体光刻法形成聚合物结构并将其浸渍在具有反应性基团X'的含金属纳米颗粒的液体中， 与反应性基团X结合，从而通过结合反应性基团X和反应性基团X'在聚合物结构上形成含金属层。 根据该方法，可以制造具有立体结构的聚合物 - 金属络合物结构体，并且能够生成在金属络合过程中不使生物分子变性的三维聚合物 - 金属络合物微结构。

公开(公告)号：US08377364B2

公开(公告)日：2013-02-19

申请号：US12749001

申请日：2010-03-29

Applicant: Kazuhiko Shiomitsu ,  Hiroshi Sugimura ,  Toshiaki Kurosu ,  Gaku Suzuki ,  Takao Tomono

Inventor： Kazuhiko Shiomitsu ,  Hiroshi Sugimura ,  Toshiaki Kurosu ,  Gaku Suzuki ,  Takao Tomono

IPC: B28B1/14 ,  B29C33/40 ,  B29C45/00 ,  A61M5/32 ,  C25F3/00

CPC classification number: B44C1/227 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C33/42 ,  B81B2201/055 ,  B81C1/00111 ,  B81C2201/0198

Abstract: The invention discloses a method of manufacturing a microneedle including the steps of forming an island etching mask having thickness distribution on a substrate, and processing the substrate into a needle by taking advantage of a difference in etching rates between the etching mask and the substrate. The invention enables to readily control a point angle and height of the manufactured needle.

公开(公告)号：US20120328835A1

公开(公告)日：2012-12-27

申请号：US13507368

申请日：2012-06-22

Applicant: Astrid CACHEMAILLE ,  Francois CANNEHAN

Inventor： Astrid CACHEMAILLE ,  Francois CANNEHAN

IPC: B32B3/30 ,  B44C1/22

CPC classification number: A61M37/0015 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C1/00111 ,  Y10T29/49826 ,  Y10T428/24479

Abstract: An out-of-plane microneedle manufacturing process comprises the simultaneous creation of a network of microneedles and the creation of a polygonal shaped hat above each microneedle under formation. The process comprises the following steps: providing bridges between the hats, maintaining the bridges during the remaining microneedle manufacturing steps, removing the bridges, together with the hats, when the microneedles are formed.

Abstract translation: 平面外的微针制造方法包括同时创建微针网络并在形成之前在每个微针上方形成多边形帽。 该方法包括以下步骤：在所述帽子之间提供桥梁，在剩余的微针制造步骤期间保持桥梁，当形成微针时，与帽子一起去除桥梁。