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    Methods and Compositions for Assessing Lung Grafts
    111.
    发明申请
    Methods and Compositions for Assessing Lung Grafts 有权
    评估肺移植物的方法和组成

    公开(公告)号：US20150377904A1

    公开(公告)日：2015-12-31

    申请号：US14768948

    申请日：2014-02-20

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： Shaf Keshavjee ,  Marcelo Cypel ,  Mingyao Liu

    IPC: G01N33/68 ,  C40B30/02

    CPC classification number: G01N33/6884 ,  C40B30/02 ,  G01N33/68 ,  G01N2333/5754 ,  G01N2800/245

    Abstract: A method of classifying a lung graft subjected to normothermic ex vivo lung perfusion (EVLP), during perfusion and/or after perfusion, the method comprising: a) collecting a test sample from the lung graft; b) measuring a polypeptide level of a negative transplant predictor gene product selected from CCG predictor gene products M-CSF, IL-8 SCGF-beta, GRO-alpha, G-CSF, MIP-1 alpha, and/or MIP-1beta, endothelin predictor gene products endothelin 1 (ET-1) and/or big ET-1, and/or apoptosis predictor gene products cytokeratin 18 (CK-18), caspase 3 and/or HMGB-1 in the sample and/or determining a metabolite profile of the sample for lung grafts that are from donors where the death was due to cardiac death (DCD); c) identifying the graft as a good candidate for transplant or a poor candidate for transplant wherein an increased polypeptide level of one or more negative transplant outcome predictor gene products compared to an outcome control or a reference metabolic profile is indicative the graft is a poor candidate for transplant.

    Abstract translation: 一种在灌注和/或灌注后进行正常体温离体肺灌注（EVLP）分类的肺移植物的方法，所述方法包括：a）从肺移植物中收集测试样品; b）测量选自CCG预测基因产物M-CSF，IL-8 SCGF-β，GRO-α，G-CSF，MIP-1α和/或MIP-1beta的阴性移植预测基因产物的多肽水平， 内皮素预测基因产物内皮素1（ET-1）和/或大ET-1和/或凋亡预测基因产物细胞角蛋白18（CK-18），半胱天冬酶3和/或HMGB-1在样品中和/或确定 来自供体的肺移植物的样品的代谢物谱，其中死亡是由于心脏死亡（DCD）; c）将移植物鉴定为移植的良好候选者或用于移植的不良候选者，其中与结果对照或参照代谢特征相比，一种或多种阴性移植结果预测基因产物的多肽水平增加指示移植物是不良候选物 用于移植。

    METHODS AND COMPOSITIONS FOR MODIFYING THE IMMUNE RESPONSE
    114.
    发明申请
    METHODS AND COMPOSITIONS FOR MODIFYING THE IMMUNE RESPONSE 审中-公开
    用于修改免疫应答的方法和组合物

    公开(公告)号：US20150250853A1

    公开(公告)日：2015-09-10

    申请号：US14640318

    申请日：2015-03-06

    Applicant: University Health Network

    Inventor： Tak W. Mak

    IPC: A61K38/17 ,  C12N15/113 ,  A61K39/395

    Abstract: The present invention is directed to methods and compositions for modulating proteins involved in the immune response. The present invention further provides methods and compositions for treatment of autoimmune disease and cancer by modulating the expression and activity of such proteins.

    Abstract translation: 本发明涉及用于调节参与免疫应答的蛋白质的方法和组合物。 本发明还提供了通过调节这些蛋白质的表达和活性来治疗自身免疫疾病和癌症的方法和组合物。

    Functional Electrical Stimulation Device and System, and Use Thereof
    116.
    发明申请
    Functional Electrical Stimulation Device and System, and Use Thereof 有权
    功能电刺激装置和系统及其应用

    公开(公告)号：US20150039051A1

    公开(公告)日：2015-02-05

    申请号：US14500749

    申请日：2014-09-29

    Applicant: University Health Network

    Inventor： Milos R. Popovic ,  Massimo Tarulli ,  Aleksandar Prodic ,  Peter Lehn

    IPC: A61N1/36

    CPC classification number: A61N1/36125 ,  A61N1/0476 ,  A61N1/36003 ,  A61N1/36014 ,  A61N1/36067 ,  A61N1/36103 ,  A61N1/3615 ,  A61N1/36167 ,  A61N1/36171 ,  H03K3/78

    Abstract: A functional electrical stimulation (FES) device and system. In one embodiment, sequential bipolar pulse stimulation may be provided to an area of a living body via one or more electrode leads applied to the area via a FES device comprising a current pulse generating circuit comprising output nodes for operative coupling to the one or more electrode leads, and configured for operative coupling to a voltage supply. The current pulse generating circuit generally comprises positive and negative stimulation paths drawing from the voltage supply to respectively apply positive and negative currents through the area via the one or more electrode leads. In one example, the stimulation paths comprise respective capacitive elements, a capacitance ratio of which dictating, at least in part, an amplitude ratio of the positive and negative currents, wherein periodic alternative activation of the stimulation paths provides the sequential bipolar pulse stimulation.

    Abstract translation: 功能性电刺激（FES）装置和系统。 在一个实施例中，顺序双极脉冲刺激可以经由经由FES装置施加到该区域的一个或多个电极引线提供给生物体的一个区域，该FES装置包括电流脉冲发生电路，该电流脉冲发生电路包括用于与一个或多个电极 引线，并被配置为与电压源的操作耦合。 电流脉冲发生电路通常包括从电压源抽取的正和负刺激路径，以分别通过一个或多个电极引线通过该区域施加正电流和负电流。 在一个示例中，刺激路径包括相应的电容元件，其电容比至少部分地表示正和负电流的振幅比，其中刺激路径的周期性替代激活提供顺序的双极脉冲刺激。

    SYSTEMS AND METHODS FOR BALANCE STABILIZATION
    117.
    发明申请
    SYSTEMS AND METHODS FOR BALANCE STABILIZATION 有权
    用于平衡稳定的系统和方法

    公开(公告)号：US20150032186A1

    公开(公告)日：2015-01-29

    申请号：US14384610

    申请日：2013-03-12

    Applicant: THE HOSPITAL FOR SICK CHILDREN ,  UNIVERSITY HEALTH NETWORK

    Inventor： Sharon Cushing ,  Blake Papsin ,  David Pothier ,  Cian Hughes

    IPC: A61N1/36

    CPC classification number: A61N1/36032 ,  A61N1/36036

    Abstract: A system for rehabilitating patients affected by balance disorders with or without vestibular hypofunction and/or malfunction with or without an associated hearing loss, which includes sensors of sound and head movement, processing circuitry, a power source coupled to head phones, an air conduction hearing aid, bone conduction hearing aid, middle ear implant or an electrical stimulator implanted into the cochlea capable of stimulating areas within the cochlea with the potential for current spread to surrounding non-auditory areas including the vestibular system.

    Abstract translation: 影响平衡障碍患者的系统，包括或不伴有或不伴有相关听力损失的前庭功能障碍和/或故障，包括声音和头部运动的传感器，处理电路，耦合到头戴式电话的电源，空气传导听觉 辅助，骨传导助听器，中耳植入物或植入耳蜗中的电刺激器，其能够刺激耳蜗内的区域，具有潜在的电流扩散到包括前庭系统的周围非听觉区域。

    FUNCTIONAL ELECTRICAL STIMULATION METHOD, USE AND APPARATUS FOR MOOD ALTERATION
    120.
    发明申请
    FUNCTIONAL ELECTRICAL STIMULATION METHOD, USE AND APPARATUS FOR MOOD ALTERATION 有权
    功能电刺激方法，用于改变肌肉的使用和装置

    公开(公告)号：US20140277309A1

    公开(公告)日：2014-09-18

    申请号：US14204829

    申请日：2014-03-11

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： Milos R. POPOVIC ,  Jose ZARIFFA ,  Sander L. HITZIG

    IPC: A61N1/36

    CPC classification number: A61N1/36096 ,  A61N1/0452 ,  A61N1/0504

    Abstract: A method and apparatus for providing functional electrical stimulation to an individual for altering a mood or emotional parameter associated with a mood or emotional state is provided. The method involves providing functional electrical stimulation to facial muscles of the individual so as to elicit a detectable contraction in said muscles associated with a facial expression associated with a desired mood or emotional parameter.

    Abstract translation: 提供了一种用于向个人提供功能性电刺激以改变与情绪或情绪状态相关联的情绪或情绪参数的方法和装置。 该方法涉及对个体的面部肌肉提供功能性电刺激，从而在与期望的情绪或情绪参数相关联的面部表情相关联的所述肌肉中引发可检测的收缩。

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