公开(公告)号：US08992443B2

公开(公告)日：2015-03-31

申请号：US13946967

申请日：2013-07-19

Applicant: OptiScan Biomedical Corporation

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/00 ,  B65D81/00 ,  A61M37/00 ,  A61B5/15 ,  A61B5/155 ,  A61B5/145 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/157 ,  A61B10/00 ,  A61M5/142 ,  A61M5/168 ,  A61M5/36 ,  A61M5/38 ,  G01N21/03

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  G06F19/00 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.

Abstract translation: 提供了可移除地与体液分析器接合的流体处理模块。 模块可以包括流体处理元件和流体部件分离器，其可经由流体处理元件接近并且被配置为分离输送到流体组分分离器的体液的至少一个组分。 流体处理元件可以具有至少一个控制元件接口。

公开(公告)号：US08936755B2

公开(公告)日：2015-01-20

申请号：US13423077

申请日：2012-03-16

Applicant: Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/00 ,  A61B5/15 ,  A61B5/155 ,  A61B5/145 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/157 ,  A61B10/00 ,  A61M5/142 ,  A61M5/168 ,  A61M5/36 ,  A61M5/38 ,  G01N21/03

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14525 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1486 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/251 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

Abstract translation: 公开了一种用于分析体液组成的装置。 该装置可以包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端和与流体处理网络可操作地接合的泵单元。 泵单元可以具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中，泵单元可操作以从体外抽取体液样本 患者通过病人结束。 该装置可以包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。

公开(公告)号：US08917392B2

公开(公告)日：2014-12-23

申请号：US13791971

申请日：2013-03-09

Applicant: Singulex, Inc.

Inventor： Richard Livingston

IPC: G01N21/00

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1463 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N33/53 ,  G01N2015/0038 ,  G01N2015/1402 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/0697

Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.

公开(公告)号：US20140038166A1

公开(公告)日：2014-02-06

申请号：US14044247

申请日：2013-10-02

Applicant: OPKO Diagnostics, LLC

Inventor： Vincent Linder ,  David Steinmiller

IPC: B01L3/00 ,  G01N21/59

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.

Abstract translation: 通常描述用于控制微流体系统中的流体的系统和方法。 在一些实施例中，流体的控制涉及使用来自在微流体系统中发生的一个或多个过程或事件的反馈。 例如，检测器可以在微流体系统的测量区域处检测一种或多种流体，并且可以对应于流体产生一个或多个信号或信号模式。 在某些情况下，信号的信号或图案可以对应于强度，持续时间，在时间上或相对于另一进程相对于第二位置的时间位置和/或事件之间的平均时间段。 使用该数据，控制系统可以确定是否调制微流体系统中随后的流体流动。 在一些实施方案中，这些和其它方法可用于进行质量控制以确定微流体系统的操作异常。

公开(公告)号：US08634075B2

公开(公告)日：2014-01-21

申请号：US13791972

申请日：2013-03-09

Applicant: Singulex, Inc.

Inventor： Richard Livingston

IPC: G01N21/00

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1463 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N33/53 ,  G01N2015/0038 ,  G01N2015/1402 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/0697

Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.

Abstract translation: 本发明包括分析仪和分析仪系统，其包括单分子分析仪，使用分析仪和分析仪系统分析样品的单分子或分子复合物的方法。 单分子使用通过样品翻译的电磁辐射来检测单个分子的存在或不存在。 本文提供的单分子分析仪可用于诊断，因为分析仪检测样品之间具有零携带的单分子。

公开(公告)号：US08491501B2

公开(公告)日：2013-07-23

申请号：US13046611

申请日：2011-03-11

Applicant: Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/00 ,  B65D81/00 ,  A61M37/00 ,  G01N35/00 ,  G01N9/30

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  G06F19/00 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.

公开(公告)号：US20120232362A1

公开(公告)日：2012-09-13

申请号：US13423077

申请日：2012-03-16

Applicant: Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/00

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14525 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1486 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/251 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

Abstract translation: 公开了一种用于分析体液组成的装置。 该装置可以包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端和与流体处理网络可操作地接合的泵单元。 泵单元可以具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中，泵单元可操作以从体外抽取体液样本 患者通过病人结束。 该装置可以包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。

公开(公告)号：US20110206241A1

公开(公告)日：2011-08-25

申请号：US13099964

申请日：2011-05-03

Applicant: Adda Sayers ,  Dean M. Tranel ,  Travis A. Hanselman ,  Stephen D. Strachan

Inventor： Adda Sayers ,  Dean M. Tranel ,  Travis A. Hanselman ,  Stephen D. Strachan

IPC: G06K9/00

CPC classification number: G01N21/17 ,  A01G7/00 ,  G01N1/4077 ,  G01N15/06 ,  G01N15/10 ,  G01N15/1463 ,  G01N33/0098 ,  G01N2021/1765 ,  G01N2201/02 ,  G01N2201/125 ,  G06K9/00134 ,  G06Q99/00

Abstract: An apparatus and method of quantitatively obtaining a measurement of pollen of a plant. One method of counting comprises imaging the sample with the pollen well-distributed in the focal plane of the imager. Image evaluation software can identify and count objects in the image that are consistent with pollen. Total pollen count for the plant can be derived from the count of pollen of the sample, proportionality of the sample volume to the starting volume, and proportionality of area of sample imaged to total area of sample. Pollen quantification can be used for research or commercial production decisions relative to the plant or its seed.

Abstract translation: 一种定量获得植物花粉测量的装置和方法。 一种计数方法包括用分布在成像器的焦平面中的花粉成像样品。 图像评估软件可以识别和计数与花粉一致的图像中的对象。 植物的总花粉计数可以从样品的花粉计数，样品体积与起始体积的比例以及样品的面积与样品总面积的比例来得出。 花粉量化可用于相对于植物或其种子的研究或商业生产决策。

公开(公告)号：US07914734B2

公开(公告)日：2011-03-29

申请号：US12338955

申请日：2008-12-18

Applicant: Richard A. Livingston

Inventor： Richard A. Livingston

IPC: G01N21/00 ,  G01N23/00 ,  G01N21/63

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1463 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N33/53 ,  G01N2015/0038 ,  G01N2015/1402 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/0697

Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.

Abstract translation: 本发明包括分析仪和分析仪系统，其包括单分子分析仪，使用分析仪和分析仪系统分析样品的单分子或分子复合物的方法。 单分子使用通过样品翻译的电磁辐射来检测单个分子的存在或不存在。 本文提供的单分子分析仪可用于诊断，因为分析仪检测样品之间具有零携带的单分子。

公开(公告)号：US20100249547A1

公开(公告)日：2010-09-30

申请号：US12815372

申请日：2010-06-14

Applicant: James R. Braig ,  Peter Rule ,  Phillip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Phillip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: A61B5/15

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。