公开(公告)号：US20230384222A1

公开(公告)日：2023-11-30

申请号：US18323727

申请日：2023-05-25

Applicant: University of Florida Research Foundation, Incorporated

Inventor： Harry S. Nick ,  Clive H. Wasserfall ,  Seith W. Currlin ,  Jerelyn A. Nick ,  Andrew J. Nick

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N2021/6432 ,  G01N2201/0636 ,  G01N2201/062

Abstract: Autofluorescence is the inherent emission of light from cells or tissues that occurs when biological samples are exposed to different wavelengths of excitation light. Tissue autofluorescence is usually ascribed to biological components such as flavins, porphyrins, chlorophyll (in plants), collagen, elastin, red blood cells (RBCs), and lipofuscin. Tissue autofluorescence often presents a significant problem in microscopy, pathology, and surgical applications. Autofluorescence interferes and complicates signal detection in a variety of fluorescence microscopy methods. Tissue autofluorescence reduces the signal detection sensitivity, and in some cases may cause failure in the detection of fluorescent dye signals. Accordingly, there is a need for further improved methods to decrease the autofluorescence intensity from microscopy samples both in research and clinical venues. Described herein is a photobleaching device utilizing a light source tuned to the full spectrum of light to quench autofluorescence of a biological sample.

公开(公告)号：US11828703B2

公开(公告)日：2023-11-28

申请号：US17382317

申请日：2021-07-21

Applicant: Gemological Institute of America, Inc. (GIA)

Inventor： Hiroshi Takahashi ,  Pradeep N. Perera

IPC: G01N21/33 ,  G01N21/64 ,  G01N21/87 ,  G01J3/44

CPC classification number: G01N21/33 ,  G01N21/645 ,  G01N21/87 ,  G01J3/4406 ,  G01N2021/6471 ,  G01N2201/061 ,  G01N2201/0636

Abstract: Systems and methods here may be used for capturing and analyzing spectrometer data of multiple sample gemstones on a stage, including mapping digital camera image data of samples, for both reflective and transmission modes.

公开(公告)号：US11828697B2

公开(公告)日：2023-11-28

申请号：US15612647

申请日：2017-06-02

Applicant: Verily Life Sciences LLC

Inventor： Supriyo Sinha ,  Brian Rabkin

IPC: G01N15/14 ,  B01L3/00 ,  G02B21/16 ,  G01N21/64 ,  G01N15/10 ,  G01N35/00 ,  G01N15/00

CPC classification number: G01N15/1484 ,  B01L3/502715 ,  B01L3/502761 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1436 ,  G01N21/6428 ,  G02B21/16 ,  B01L2200/0652 ,  B01L2300/0654 ,  B01L2300/0816 ,  G01N15/1459 ,  G01N21/6458 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1075 ,  G01N2015/144 ,  G01N2015/149 ,  G01N2015/1438 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2035/00158 ,  G01N2201/068 ,  G01N2201/0636 ,  G01N2201/06113

Abstract: A system for fluorescence activated cell sorting includes at least two excitation lasers having different orientations relative to an objective such that light from the at least two lasers passes through the objective and intersects a fluidic channel at different positions within an interrogation region. The fluidic channel directs a flow of a plurality of fluorescently labeled particles through the interrogation region. The system further includes at least one detector and at least one optical element that directs light emitted from the plurality of fluorescently labeled particles and transmitted through the objective to the at least one detector. The system may further include optics for generating and detecting side and forward scattered light. Methods for operating example systems to collect fluorescent, side scattered and forward scattered light from a plurality of particles are also described herein.

公开(公告)号：US11821836B2

公开(公告)日：2023-11-21

申请号：US17327172

申请日：2021-05-21

Applicant: Analog Devices, Inc.

Inventor： Shrenik Deliwala

IPC: G01N21/3504 ,  G01N21/01

CPC classification number: G01N21/3504 ,  G01N21/01 ,  G01N2021/3513 ,  G01N2201/0636 ,  G01N2201/1211

Abstract: System and apparatus for robust, portable gas detection. Specifically, this disclosure describes apparatuses and systems for optical gas detection in a compact package using two optical pathways. There is a need for a very compact, low-power, gas detection system for gases such as CO2, NOx, water vapor, methane, etc. This disclosure provides an ultra-compact and highly stable and efficient optical measurement system based on principals of optical absorption spectroscopy using substantially collinear pathways.

公开(公告)号：US11808707B2

公开(公告)日：2023-11-07

申请号：US16854213

申请日：2020-04-21

Applicant: THERMO ELECTRON SCIENTIFIC INSTRUMENTS LLC

Inventor： George L. Skupniewicz ,  Francis J. Deck

IPC: G01N21/65 ,  G02B27/10 ,  G02B26/08 ,  G02B21/00 ,  G02B21/18 ,  G02B27/14 ,  G02B21/36 ,  G01N21/64 ,  G02B21/16

CPC classification number: G01N21/65 ,  G01N21/64 ,  G02B21/0004 ,  G02B21/16 ,  G02B21/18 ,  G02B21/362 ,  G02B26/0816 ,  G02B27/1006 ,  G02B27/141 ,  G01N2201/0636 ,  G01N2201/06113 ,  G01N2201/084

Abstract: An embodiment of a module system configured to interface with a microscope is described that comprises an input optical fiber configured to provide an excitation light beam from an external light source; dynamic alignment mirrors configured to adjust the position of the beams paths of the excitation light beam on a first plane; a coupling comprising a first end configured to engage with a complementary end, wherein the excitation light reflects off a turning mirror and travels along a beam path on a second plane through an orifice in the coupling; and an output optical fiber for delivering light from a sample to an external detector, wherein the light from the sample travels along the beam path on the second plane through the orifice in the coupling, reflects off the turning mirror and travels along one of the beam paths on the first plane to the output optical fiber.

公开(公告)号：US20230296504A1

公开(公告)日：2023-09-21

申请号：US18168838

申请日：2023-02-14

Applicant: Kabushiki Kaisha Toshiba

Inventor： Masatoshi HIRONO ,  Shinji SAITO ,  Tsutomu KAKUNO ,  Rei HASHIMOTO ,  Kei KANEKO

IPC: G01N21/3504

CPC classification number: G01N21/3504 ,  G01N2201/06113 ,  G01N2201/0636

Abstract: A gas detection device according to an embodiment includes a first light source irradiating infrared, a second light source irradiating visible light, a low-pass filter that transmits the infrared irradiated from the first light source, reflects the visible light irradiated from the second light source, and aligns an optical axis of the visible light with an optical axis of the infrared, a first retroreflector on which the infrared and the visible light having the aligned optical axes are incident, a first detecting part detecting the infrared reflected by the first retroreflector, and a scattering body located at a center of the first retroreflector.

公开(公告)号：US20230296503A1

公开(公告)日：2023-09-21

申请号：US18168764

申请日：2023-02-14

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Yasutomo SHIOMI ,  Shinji SAITO ,  Rei HASHIMOTO ,  Kei KANEKO ,  Tsutomu KAKUNO

IPC: G01N21/3504

CPC classification number: G01N21/3504 ,  G01N2201/06113 ,  G01N2201/0636

Abstract: A gas detection device according to an embodiment includes a first irradiation part configured to irradiate a first light having a first wavelength on a gas released into a space, a second irradiation part configured to irradiate, on the gas, a second light having a second wavelength that is less than the first wavelength, an irradiation position adjustment part configured to control an irradiation position of the first light on the gas, a gas analysis part configured to analyze a component of the gas based on the first light having passed through the gas, and a gas visualization part configured to visualize a concentration distribution of the gas based on the second light having passed through the gas. The irradiation position adjustment part controls the irradiation position of the first light on the gas based on the visualized concentration distribution of the gas.

公开(公告)号：US11740179B2

公开(公告)日：2023-08-29

申请号：US17090118

申请日：2020-11-05

Applicant: Lumileds LLC

Inventor： Hisashi Masui ,  Oleg Borisovich Shchekin ,  Franklin Chiang

IPC: G01N21/15 ,  G01N21/61 ,  G01N33/00 ,  G01N21/47

CPC classification number: G01N21/61 ,  G01N21/47 ,  G01N33/0004 ,  G01N33/004 ,  G01N33/0047 ,  G01N2201/0631 ,  G01N2201/0636

Abstract: In a gas sensing system, a light emitter can emit light through a gas sample toward a concave reflective surface. The reflective surface can redirect the emitted light to propagate through the gas sample toward a light sensor. Using, optionally, the Beer-Lambert Law, the system can determine a concentration of the gas material in the gas sample. By selecting a specified shape for the reflective surface, such as a complete or partial ellipsoid, and locating the light emitter and the light sensor in specified locations, such as at one or both foci of the ellipsoid, the gas sensing system can reduce variation in optical path length, from optical path to optical path, in the light that propagates from the light emitter, to the reflective surface, and to the light sensor. Reducing the variation in optical path length can improve an accuracy in determining the concentration of the gas material.

公开(公告)号：US11719629B2

公开(公告)日：2023-08-08

申请号：US17781003

申请日：2021-01-27

Applicant: JIANGSU UNIVERSITY

Inventor： Zhiqiang Zhou ,  Jiawei Cong ,  Yanqun Tong ,  Mingyang Chen ,  Liu Lv ,  Yonghong Fu ,  Naifei Ren

IPC: G01N21/359 ,  G02B5/00 ,  G02B17/02 ,  G02B17/06 ,  G02B19/00 ,  G02B27/14 ,  G02B5/20

CPC classification number: G01N21/359 ,  G02B5/005 ,  G02B17/023 ,  G02B17/0668 ,  G02B19/0014 ,  G02B27/144 ,  G02B27/145 ,  G01N2201/0636 ,  G01N2201/06113 ,  G02B5/205

Abstract: A non-linear optical pumping detection apparatus and a non-linear optical absorption cross-section measurement method, which can simultaneously measure degenerate and non-degenerate two-photon absorption cross-section spectra. The measurement process is automatic, efficient and fast. The working wavelength band is from 380 nm to near infrared 1064 nm, and the non-linear performance measurement of the super-continuous wide spectra can be realized. A zoom optical system with a larger entrance pupil diameter is adopted as a weak signal acquisition lens. So the weak signal can be effectively extracted from background noise. Meanwhile, the mean square root diameter of an on-axis image point of the zoom optical system is 100 to 150 microns, the divergence angle 2α of the on-axis image point is 30.6 degrees, which well match the optical fiber coupling condition, thereby improving the coupling efficiency of the space light coupling into the optical fiber, and greatly improving the measurement sensitivity.

公开(公告)号：US20230236127A1

公开(公告)日：2023-07-27

申请号：US18012140

申请日：2021-06-30

Applicant: ams International AG

Inventor： Remco VERDOOLD ,  Erik Jan LOUS

IPC: G01N21/552

CPC classification number: G01N21/554 ,  G01N2201/062 ,  G01N2201/0636 ,  G01N2201/0634

Abstract: An apparatus for determining the presence or concentration of target molecules comprises: a radiation source; a surface; a waveguide; a detector; and a spectral filter. The radiation source is operable to produce electromagnetic radiation. The surface defines a two dimensional array of receptor sites. The waveguide is arranged to receive the electromagnetic radiation produced by the radiation source, divide the electromagnetic radiation and direct a portion of the electromagnetic radiation to each one of a two dimensional array of receptor sites. The detector comprises a two dimensional array of sensing elements, each sensing element arranged to receive electromagnetic radiation from a different one of the two dimensional array of receptor sites. The spectral filter is provided between the surface and the detector.