公开(公告)号：US07532326B2

公开(公告)日：2009-05-12

申请号：US11175955

申请日：2005-07-06

Applicant: Timothy C. Corcoran

Inventor： Timothy C. Corcoran

IPC: G01J3/12

CPC classification number: G01N21/6456 ,  G01J3/02 ,  G01J3/021 ,  G01J3/14 ,  G01J3/4406 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6486 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2201/10 ,  G01N2201/1042

Abstract: Methods and devices are disclosed which apply an excitation-emission matrix (EEM) to a heterogeneous, two-dimensional sample, allowing a considerably larger number of emitting, e.g. fluorescent, labels to be used simultaneously. This may be accomplished by employing a spectroscopic method of excitation-emission matrices which allows discrimination of species with similar emission spectra, and also allows positive identification of energy transfer between emitting species. The methods and devices may employ a novel excitation-light scanning technique which allows imaging of the emission from the heterogeneous sample both in two spatial dimensions (length and width) and in two spectral dimensions (excitation and emission wavelength). This light scanning technique maximizes the throughput of excitation light, increasing the sensitivity and hence the reading speed of the instrument.

Abstract translation: 公开了将激发发射矩阵（EEM）施加到异质二维样品的方法和装置，允许相当大量的发射，例如， 荧光，标签同时使用。 这可以通过采用激发发射矩阵的光谱方法来实现，其允许区分具有相似发射光谱的物质，并且还允许阳性鉴定发射物质之间的能量转移。 所述方法和装置可以采用新的激发光扫描技术，其允许在两个空间维度（长度和宽度）和两个光谱尺寸（激发和发射波长）中成像来自异质样品的发射。 这种光扫描技术使激发光的吞吐量最大化，从而提高了仪器的灵敏度和读取速度。

公开(公告)号：US07498577B2

公开(公告)日：2009-03-03

申请号：US11717714

申请日：2007-03-14

Applicant: Ryoji Kurosaka ,  Takeaki Itsuji

Inventor： Ryoji Kurosaka ,  Takeaki Itsuji

IPC: G01S13/00 ,  G01J1/00

CPC classification number: G01J3/42 ,  G01N21/3581 ,  G01N2201/10

Abstract: A sensing device includes a transmission path, an electromagnetic-wave input unit through which an electromagnetic wave enters the transmission path, an electromagnetic-wave detector configured to detect the electromagnetic wave propagating through the transmission path, and a bent portion provided in the transmission path. The electromagnetic wave propagates through the transmission path while radiating to the periphery of the transmission path. The bent portion is provided in the transmission path for allowing an interaction to occur between a test subject and the electromagnetic wave in the transmission path. When the test subject is positioned relative to the bent portion, the electromagnetic-wave detector detects a change in the state of the electromagnetic wave caused by the interaction occurring between the test subject and the electromagnetic wave in the bent portion. The detected information provides a basis for obtaining information on the test subject.

Abstract translation: 感测装置包括传输路径，电磁波进入传输路径的电磁波输入单元，被配置为检测通过传输路径传播的电磁波的电磁波检测器和设置在传输路径中的弯曲部分 。 电磁波通过传输路径传播，同时辐射到传输路径的周围。 弯曲部设置在传输路径中，用于允许测试对象与传输路径中的电磁波之间发生相互作用。 当测试对象相对于弯曲部分定位时，电磁波检测器检测由弯曲部分中的测试对象和电磁波之间发生的相互作用引起的电磁波状态的变化。 检测到的信息为获得测试对象的信息提供依据。

公开(公告)号：US07468507B2

公开(公告)日：2008-12-23

申请号：US11339044

申请日：2006-01-25

Applicant: Steven R. Rogers ,  Nissim Elmaliach ,  Emanuel Elyasef ,  Alon Litman ,  Ron Naftali ,  Doron Meshulach

Inventor： Steven R. Rogers ,  Nissim Elmaliach ,  Emanuel Elyasef ,  Alon Litman ,  Ron Naftali ,  Doron Meshulach

IPC: H01J3/14 ,  H01J5/16 ,  H01J40/14

CPC classification number: G01N21/8806 ,  G01N21/9501 ,  G01N21/956 ,  G01N2201/10 ,  G01N2201/1042 ,  G01N2201/106

Abstract: A method for scanning a surface, consisting of focusing an array of optical beams using optics having an axis, so as to illuminate a region of the surface intercepted by the axis, such that each optical beam illuminates a portion of a respective sub-region within the region. The method further includes moving at least one of the array and the surface so as to cause a translation of the surface relative to the axis in a first direction. During the translation in the first direction, each of the optical beams is scanned over the respective sub-region in a second direction, which is different from the first direction.

Abstract translation: 一种用于扫描表面的方法，其包括使用具有轴的光学器件聚焦光束阵列，以便照亮由所述轴线截取的表面的区域，使得每个光束照亮所述光束中的相应子区域的一部分 该区域。 所述方法还包括移动所述阵列和所述表面中的至少一个，以使所述表面相对于所述轴线在第一方向上平移。 在第一方向的平移期间，每个光束在与第一方向不同的第二方向上在相应的子区域上被扫描。

公开(公告)号：US20070257182A1

公开(公告)日：2007-11-08

申请号：US11666629

申请日：2005-11-01

Applicant: Ryuji Sawada ,  Yoshio Nakashima

Inventor： Ryuji Sawada ,  Yoshio Nakashima

IPC: G02B27/40

CPC classification number: G01N21/6458 ,  G01N2201/10 ,  G02B21/0076 ,  G02B21/16

Abstract: A light fluctuation measuring apparatus, comprising a parameter setting unit 2 which sets parameters of a microscopic image obtaining unit and/or parameters of a light emission measuring unit used for observing light emission in a desired area of a sample in time series, a parameter storage 4 which stores parameters, a mode selector 3 which selects one of a microscopic image obtaining mode for obtaining a microscopic image by a microscopic image obtaining unit, and a light emission measuring mode for observing light emission in a desired area by a light emission measuring unit, and a control unit 1 which reads parameters stored in the storage 4 based on a selected mode, inputs the parameter to a microscopic image obtaining unit or a light emission measuring unit, and controls these units.

Abstract translation: 一种光波动测量装置，包括参数设置单元2，其设置用于以时间序列观察样品的期望区域中的发光的微观图像获得单元的参数和/或用于观察发光的发光测量单元的参数;参数存储 存储参数的模式选择器3，选择由微观图像获得单元获得显微图像的显微图像获得模式之一的模式选择器3以及用于通过发光测量单元观察所需区域中的发光的发光测量模式 以及基于所选择的模式读取存储在存储器4中的参数的控制单元1，将参数输入到显微图像获取单元或发光测量单元，并且控制这些单元。

公开(公告)号：US20070133077A1

公开(公告)日：2007-06-14

申请号：US11339044

申请日：2006-01-25

Applicant: Steven Rogers ,  Nissim Elmaliach ,  Emanuel Elyasef ,  Alon Litman ,  Ron Naftali ,  Doron Meshulach

Inventor： Steven Rogers ,  Nissim Elmaliach ,  Emanuel Elyasef ,  Alon Litman ,  Ron Naftali ,  Doron Meshulach

IPC: G02B26/08

CPC classification number: G01N21/8806 ,  G01N21/9501 ,  G01N21/956 ,  G01N2201/10 ,  G01N2201/1042 ,  G01N2201/106

Abstract: A method for scanning a surface, consisting of focusing an array of optical beams using optics having an axis, so as to illuminate a region of the surface intercepted by the axis, such that each optical beam illuminates a portion of a respective sub-region within the region. The method further includes moving at least one of the array and the surface so as to cause a translation of the surface relative to the axis in a first direction. During the translation in the first direction, each of the optical beams is scanned over the respective sub-region in a second direction, which is different from the first direction.

Abstract translation: 一种用于扫描表面的方法，其包括使用具有轴的光学器件聚焦光束阵列，以便照亮由所述轴线截取的表面的区域，使得每个光束照亮所述光束中的相应子区域的一部分 该区域。 所述方法还包括移动所述阵列和所述表面中的至少一个，以使所述表面相对于所述轴线在第一方向上平移。 在第一方向的平移期间，每个光束在与第一方向不同的第二方向上在相应的子区域上被扫描。

公开(公告)号：US20070114418A1

公开(公告)日：2007-05-24

申请号：US11512693

申请日：2006-08-30

Applicant: Eric Mueller ,  Raymond Michaud

Inventor： Eric Mueller ,  Raymond Michaud

IPC: G01J5/02

CPC classification number: G01J3/42 ,  G01N21/3563 ,  G01N21/3581 ,  G01N2201/10 ,  G01S13/887

Abstract: A portal for security screening of transport passengers includes a THz trans-receiver. In one example of the portal, the trans-receiver includes a small-spot, reflective scanning arrangement including a single detector in a heterodyne receiver configuration. In another example, the trans-receiver includes a large-beam reflective scanning arrangement with the trans-receiver in a synthetic aperture radar (SAR) configuration.

Abstract translation: 运输乘客的安全检查门户包括一个THz转接头。 在门户的一个示例中，转接收器包括小外点反射扫描装置，其包括外差接收器配置中的单个检测器。 在另一示例中，转接收器包括具有合成孔径雷达（SAR）配置中的反式接收器的大束反射扫描装置。

公开(公告)号：US20060033918A1

公开(公告)日：2006-02-16

申请号：US11200170

申请日：2005-08-10

Applicant: Yoshinori Kuroiwa ,  Shinichi Tanaka

Inventor： Yoshinori Kuroiwa ,  Shinichi Tanaka

IPC: G01N21/25

CPC classification number: G01N21/6458 ,  G01N2201/10 ,  G02B21/008

Abstract: A scanning microscope includes: a light source; an optical system that irradiates light from the light source onto a sample while two-dimensionally scanning the light, and collects light from the sample; a photo-detector that receives the light from the sample which has been collected by the optical system, and converts the light thus received into a brightness signal; an integrating circuit that integrates the brightness signal from the photo-detector for each pixel; and an image forming circuit that forms an image of the sample based upon the brightness signal of each pixel integrated by the integrating circuit. And the integrating circuit includes a plurality of integrators for integrating the brightness signal from the photo-detector and an adder for adding output signals from the plurality of integrators, and integrates the brightness signal while sequentially switching the plurality of integrators for each of a plurality of periods obtained by dividing a period corresponding to a pixel.

Abstract translation: 扫描显微镜包括：光源; 将来自光源的光照射到样品上的光学系统，同时二维地扫描光，并从样品中收集光; 光检测器，其接收由所述光学系统收集的来自所述样品的光，并将由此接收的光转换为亮度信号; 积分电路，对来自每个像素的光检测器的亮度信号进行积分; 以及图像形成电路，其基于由积分电路积分的每个像素的亮度信号，形成样本的图像。 并且积分电路包括用于积分来自光电检测器的亮度信号的多个积分器和用于相加来自多个积分器的输出信号的加法器，并且对亮度信号进行积分，同时对多个积分器中的每一个依次切换多个积分器 通过对与像素对应的周期进行划分而获得的周期。

公开(公告)号：US20060031029A1

公开(公告)日：2006-02-09

申请号：US10912427

申请日：2004-08-04

Applicant: Kenneth Staton

Inventor： Kenneth Staton

IPC: G01N31/00

CPC classification number: G01N21/6452 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2201/10 ,  G01N2201/12

Abstract: Methods for evaluating a pixel signal produced during scanning of a chemical array are provided. In general, the methods involve producing at least two analog signals for a pixel using a multi-gain signal detection system, integrating at least one of these signals, and outputting data representing the pixel. Also provided are systems and computer program products for performing the subject methods, and an array scanner containing these systems and program products.

Abstract translation: 提供了用于评估在扫描化学阵列期间产生的像素信号的方法。 通常，所述方法涉及使用多增益信号检测系统为像素产生至少两个模拟信号，集成这些信号中的至少一个，并输出表示像素的数据。 还提供了用于执行主题方法的系统和计算机程序产品，以及包含这些系统和程序产品的阵列扫描器。

公开(公告)号：US20060007439A1

公开(公告)日：2006-01-12

申请号：US11175955

申请日：2005-07-06

Applicant: Timothy Corcoran

Inventor： Timothy Corcoran

IPC: G01J3/30

CPC classification number: G01N21/6456 ,  G01J3/02 ,  G01J3/021 ,  G01J3/14 ,  G01J3/4406 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6486 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2201/10 ,  G01N2201/1042

Abstract: Methods and devices are disclosed which apply an excitation-emission matrix (EEM) to a heterogeneous, two-dimensional sample, allowing a considerably larger number of emitting, e.g. fluorescent, labels to be used simultaneously. This may be accomplished by employing a spectroscopic method of excitation-emission matrices which allows discrimination of species with similar emission spectra, and also allows positive identification of energy transfer between emitting species. The methods and devices may employ a novel excitation-light scanning technique which allows imaging of the emission from the heterogeneous sample both in two spatial dimensions (length and width) and in two spectral dimensions (excitation and emission wavelength). This light scanning technique maximizes the throughput of excitation light, increasing the sensitivity and hence the reading speed of the instrument.

Abstract translation: 公开了将激发发射矩阵（EEM）施加到异质二维样品的方法和装置，允许相当大量的发射，例如， 荧光，标签同时使用。 这可以通过采用激发发射矩阵的光谱方法来实现，其允许区分具有相似发射光谱的物质，并且还允许阳性鉴定发射物质之间的能量转移。 所述方法和装置可以采用新的激发光扫描技术，其允许在两个空间维度（长度和宽度）和两个光谱尺寸（激发和发射波长）中成像来自异质样品的发射。 这种光扫描技术使激发光的吞吐量最大化，从而提高了仪器的灵敏度和读取速度。

公开(公告)号：US20030210885A1

公开(公告)日：2003-11-13

申请号：US10163153

申请日：2002-06-04

Inventor： Dennis Chi Zhou ,  Kai Zhang ,  Shou-Jong Sheih

IPC: G02B006/00

CPC classification number: G01J1/4257 ,  G01J1/04 ,  G01J1/0418 ,  G01N2021/95676 ,  G01N2201/10 ,  G01N2201/104 ,  G02B6/266 ,  G02B6/4215 ,  G02B6/4286 ,  H04B10/077 ,  H04B10/07955

Abstract: The present invention is directed towards a channel power monitor for monitoring channel power levels for each of N signal channels. The value of each channel power level is designated as p(nulli), where nulll is a channel parameter that characterizes each channel. An embodiment of the invention includes a variable channel attenuator having M attenuation profiles where MnullN, and where a k-th attenuation profile is characterized as a function of the channel parameter nulll by Ak(nulll). This embodiment also includes a detector for measuring a k-th integrated attenuated power level, the value of which is represented by Pk. An analysis unit receives all of the values Pk of the integrated attenuated power levels and thereupon derives the values p(nulll) of the channel power levels by solving a set of linear equations.

Abstract translation: 本发明涉及用于监视N个信号信道中的每一个的信道功率电平的信道功率监视器。 每个通道功率电平的值被指定为p（lambdai），其中lambdal是表示每个通道的通道参数。 本发明的实施例包括具有M衰减分布的可变信道衰减器，其中M> = N，其中第k衰减分布被Ak（lambdal）的信道参数lambdal的函数表征。 该实施例还包括用于测量第k个积分衰减功率电平的检测器，其值由Pk表示。 分析单元接收积分衰减功率电平的所有值Pk，并且通过求解一组线性方程式导出信道功率电平的值p（lambdal）。