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公开(公告)号:US20230003813A1
公开(公告)日:2023-01-05
申请号:US17781246
申请日:2020-11-26
Applicant: National Institute of Advanced Industrial Science and Technology , NATIONAL INSTITUTE FOR MATERIALS SCIENCE , Tokyo University of Science Foundation
Inventor: Yasumoto TANAKA , Hirotake YAMAMORI , Takashi YANAGISAWA , Shunichi ARISAWA , Taichiro NISHIO
IPC: G01R33/035 , H01L39/22 , G06N10/00
Abstract: Proposed is a phase shift introduction method, a structure, and a circuit device for eliminating or minimizing a risk associated with dissimilar materials, solving in principle a problem of mixing of a signal current and a control current that occurs due to DC connection of a phase shifter to a signal line, and stably and reliably providing a phase shift that is desired to be introduced without being adversely effected by noise generated by an ambient magnetic field, which is generated due to use of an external power supply. A structure according to the present invention includes a phase shifter 101 and a closed-loop circuit 103 that is directly used for computation or storage, and a quantum phase shift is generated in the closed-loop circuit 103 by using a fractional flux quantum captured by the phase shifter 101 that is DC-separated from the closed-loop circuit 103.
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公开(公告)号:US11542292B2
公开(公告)日:2023-01-03
申请号:US16349438
申请日:2017-11-09
Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION
Inventor: Takeshi Wada , Tatsuya Saito , Yuka Ishii , Yohei Nukaga
IPC: C07H19/073 , C07H19/173 , C07H21/00 , C07F5/02 , C07F9/6584 , C07F9/6558 , C12N15/113
Abstract: Provided a polymerizable compound represented by the following Formula A-1 or Formula A-2: In Formula A-1 or Formula A-2, R1 represents an electron-donating group; n represents an integer from 1 to 5; R2 represents a hydrogen atom, a halogen atom, or —ORO, wherein RO represents a hydrogen atom, an alkyl group, or a protecting group of a hydroxy group; R3 represents a hydrogen atom or a protecting group of a hydroxy group; and X represents a structure represented by any one of Formula B-1 to Formula B-5.
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公开(公告)号:US20220380763A1
公开(公告)日:2022-12-01
申请号:US17755165
申请日:2020-10-26
Applicant: NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY , TOKYO UNIVERSITY OF SCIENCE FOUNDATION
Inventor: Keisuke TANIUCHI , Takeshi WADA , Rintaro HARA , Kazuki SATO , Kazunori TAKAGI
IPC: C12N15/113 , A61K47/42 , A61K47/22 , A61P35/00
Abstract: A novel anti-tumor agent capable of delivering siRNA or shRNA specifically to pancreatic cancer cells and suppressing tumor growth, invasion, and metastasis of pancreatic cancer is provided. The present invention provides a nucleic acid delivery enhancer for delivering siRNA or shRNA into cells, which consists of a folic acid-cationic oligopeptide complex. The present invention also provides an anti-tumor agent having siRNA or shRNA capable of binding to mRNA or snoRNA expressed in pancreatic cancer cells to inhibit its expression and a folic acid-cationic oligopeptide complex. The siRNA is capable of binding to RNA selected from the group consisting of, for example, SNORA18 snoRNA, NUP85 mRNA, WASF2 mRNA, and SNORA22 snoRNA.
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公开(公告)号:US20220281746A1
公开(公告)日:2022-09-08
申请号:US17624939
申请日:2020-07-06
Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION
Inventor: Kazuo WATANABE
IPC: C01B23/00
Abstract: An embodiment of the present invention provides a noble gas hydride having the following formula 1: NgnHm. In formula 1, Ng represents a noble gas atom, n represents an integer from 1-8, and m represents an integer from 1-46.
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公开(公告)号:US20220204459A1
公开(公告)日:2022-06-30
申请号:US17557751
申请日:2021-12-21
Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION , JEOL Ltd.
Inventor: Tatsuya Higashi , Shoujiro Ogawa , Masaki Takiwaki , Seketsu Fukuzawa
IPC: C07D249/12
Abstract: A compound represented by Chemical formula 1: wherein n is an integer of 2 or more, is provided. Also provided is a derivatization reagent for derivatizing a diene-containing compound, including a compound represented by Chemical formula 1. Further provided is a synthesis method for a compound, including a nucleophilic substitution reaction between an aryl halide and a heterocyclic amine compound being saturated, the compound being represented by Chemical formula 1.
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公开(公告)号:US20220144757A1
公开(公告)日:2022-05-12
申请号:US17434579
申请日:2020-02-28
Applicant: Tokyo University of Science Foundation
Inventor: Tatsushi Imahori , Ryo Motoyama
IPC: C07C245/08 , B01D53/62
Abstract: A compound represented by Formula (1): each of L1 and L2 independently represents an alkyl group having from 1 to 20 carbon atoms, an alkoxy group having from 1 to 20 carbon atoms, NH2, NHR3, NR3R4, an ester group, a carboxy group, an amide group, a cyano group, a nitro group, a halogen atom, an acyl group, CF3, O(CH2)1OCH3, a carbamate group, or an aryl group. 1 represents 1 or 2. Each of R1 and R2 independently represents a divalent hydrocarbon group having from 1 to 10 carbon atoms, at least one hydrogen atom of the divalent hydrocarbon group is optionally substituted with an alkyl group, an aryl group, an ester group, a carboxy group, an amide group, a cyano group, a nitro group, a halogen atom, an acyl group, CF3, O(CH2)1OCH3, a carbamate group, or an alkoxy group, each of R3 and R4 independently represents an alkyl group, an aryl group, an acyl group, an ester group, an alkylsulfonyl group, or an arylsulfonyl group, each of R5 and R6 independently represents a hydrogen atom, an alkyl group having from 1 to 20 carbon atoms, or an aryl group, and n+m≥1.
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公开(公告)号:US11273405B2
公开(公告)日:2022-03-15
申请号:US16325275
申请日:2016-08-23
Inventor: Kiyoshi Dowaki , Noboru Katayama , Naoki Dowaki , Mitsuo Kameyama
IPC: B01D53/047 , C01B3/56 , B01D53/053 , H01M8/0606 , B09B3/00 , H01M8/10 , H01M8/00 , C01B3/00 , C10K1/32 , C10K1/00 , C01B3/38 , C10B53/02 , H01M8/04082 , H01M8/0612 , H01M8/0668
Abstract: A method for recovering hydrogen which is capable of efficiently recovering high concentration hydrogen gas by adsorbing and removing hydrocarbon gas such as carbon dioxide from biomass pyrolysis gas under a relatively low pressure, and also capable of storing the recovered high concentration hydrogen gas, preferably, in a cartridge type container that can be used as is as a hydrogen storing container for an apparatus equipped with a fuel cell. The method includes a first purifying stare of purifying biomass pyrolysis gas and a second purifying stage of purifying the obtained purified gas under a pressure equal to or less than the pressure in the first purifying stage to recover gas that contains hydrogen, and further includes a hydrogen storing stage of feeding the gas containing hydrogen recovered in the second purifying stage into the container filled with a hydrogen storage alloy and storing high purity hydrogen.
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公开(公告)号:US11227726B2
公开(公告)日:2022-01-18
申请号:US16479783
申请日:2018-01-19
Applicant: Tokyo University of Science Foundation
Inventor: Shinichi Komaba , Kei Kubota , Tomooki Hosaka
IPC: H01G11/06 , H01M10/054 , H01M10/0569 , H01G11/60 , H01G11/32
Abstract: An electrolyte solution for a potassium ion battery or a potassium ion capacitor, the electrolyte solution comprising at least one potassium salt compound selected from the group consisting of potassium bis(trifluoromethanesulfonyl)amide and potassium bis(fluorosulfonyl)amide and at least one solvent selected from the group consisting of ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, triethylene glycol dimethyl ether, tetraethylene glycol dimethyl ether, pentaethylene glycol dimethyl ether, ethylene carbonate, and propylene carbonate, in which a concentration of the potassium salt compound in the electrolyte solution is from 1.5 mol/kg to 12.0 mol/kg.
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公开(公告)号:US11106132B2
公开(公告)日:2021-08-31
申请号:US16390429
申请日:2019-04-22
Inventor: Kunihiro Noda , Dai Shiota , Koji Arimitsu
IPC: G03F7/004 , C08G77/12 , C07C257/10 , C07F9/22
Abstract: An energy-sensitive composition including at least one of a silane compound monomer capable of forming a polysilane compound, a silane compound oligomer and the polysilane compound, and a base generator (B) represented by the following formula (1): in which R1 to R11 each independently represents a hydrogen atom, a halogen atom, a nitro group, an alkyl group, an aryl group, an arylalkyl group or an alkoxy group, R5 and R6 may be connected to each other via a single bond or a divalent linking group, Zq+ represents a q-valent counter cation composed of a base having a pKa of 24 or more, and q represents an integer of 1 or more.
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公开(公告)号:US11052154B2
公开(公告)日:2021-07-06
申请号:US16349689
申请日:2017-11-13
Applicant: Tokyo University of Science Foundation
Inventor: Etsuko Miyamoto , Masaaki Ozawa
Abstract: A Ras protein degradation inducing molecule that can induce degradation of Ras proteins, and a pharmaceutical composition that contains this Ras protein degradation inducing molecule are provided. The Ras protein degradation inducing molecule is a conjugate of a Ras protein affinity molecule which has affinity to Ras proteins, and a proteolysis-inducing tag which has affinity to protease and does not inhibit proteolysis of proteins by the protease.
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