公开(公告)号：US08137620B2

公开(公告)日：2012-03-20

申请号：US11869300

申请日：2007-10-09

Applicant: Kelly G. Ammann ,  Robert E. Schneider ,  Robert J. Smith

Inventor： Kelly G. Ammann ,  Robert E. Schneider ,  Robert J. Smith

IPC: C12M1/36

CPC classification number: C12Q1/6834 ,  B01F9/0001 ,  B01F9/0014 ,  B01F9/0021 ,  B01F2009/0074 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B03C1/282 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/26 ,  C12Q1/6813 ,  C12Q1/6832 ,  C12Q2537/10 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T29/53657 ,  Y10T29/53683 ,  Y10T29/53843 ,  Y10T156/1105 ,  Y10T156/1906 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

Abstract translation: 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备标本样品的台站，在规定温度下培养样品规定的时间，进行分析物分离程序，并确定目标分析物的存在。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。 在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。

公开(公告)号：US20110290119A1

公开(公告)日：2011-12-01

申请号：US13143576

申请日：2010-02-05

Applicant: Caroline M. Ylitalo ,  Narina Y. Stepanova ,  John M. Sebastian ,  Sonja K. Belgrade ,  David R. Holm ,  Fuming B. Li

Inventor： Caroline M. Ylitalo ,  Narina Y. Stepanova ,  John M. Sebastian ,  Sonja K. Belgrade ,  David R. Holm ,  Fuming B. Li

IPC: B01D46/00 ,  B05D3/10 ,  B05D5/00 ,  B05D3/14

CPC classification number: A61K33/38 ,  A61K31/28 ,  A61K31/352 ,  A61K45/06 ,  B01D2239/0414 ,  B01D2239/0435 ,  B01D2239/0442 ,  B03C3/30 ,  B03C2201/26 ,  D06M11/42 ,  D06M11/83 ,  D06M13/358 ,  D06M13/432 ,  D06M15/13 ,  D06M16/00 ,  A61K2300/00

Abstract: Antimicrobial electret material are described. In some embodiments, the materials comprise a unitary web comprising an antimicrobial surface treatment and having certain properties. In other embodiments, an antimicrobial electret material is described comprising an electret web comprising an antimicrobial surface treatment wherein the surface treatment comprises a sparingly soluble silver-containing compound, a photosensitive antimicrobial agent that forms reactive oxygen species, a biguanide compound, or a combination thereof.

Abstract translation: 描述了抗微生物驻极体材料。 在一些实施方案中，材料包括包含抗微生物表面处理并具有某些性质的整体网。 在其它实施方案中，描述了一种抗微生物驻极体材料，其包括包含抗微生物表面处理的驻极体纤维网，其中所述表面处理包括微溶银的化合物，形成活性氧的光敏抗微生物剂，双胍化合物或其组合 。

公开(公告)号：US20110203997A1

公开(公告)日：2011-08-25

申请号：US12709085

申请日：2010-02-19

Applicant: Thomas Meyer

Inventor： Thomas Meyer

IPC: B03C1/02 ,  G01N33/00

CPC classification number: B03C1/00 ,  B03C1/288 ,  B03C2201/26 ,  G01N35/0098 ,  G01N35/028 ,  Y10T436/25375

Abstract: A magnetic separation plate for use in methods employing magnetic particles, said magnetic separation plate comprising a support plate and magnetic pins in a predetermined geometrical arrangement, said magnetic pins having a fastening portion, an intermediate portion and a separation portion and being fastened to said support plate at their fastening portion, wherein said magnetic pins are individually displaceable at their separation portion. The invention further provides a method for the separation of magnetic particles using the separation plate.

Abstract translation: 一种用于使用磁性颗粒的方法的磁分离板，所述磁分离板包括支撑板和预定几何布置的磁性销，所述磁性销具有紧固部分，中间部分和分离部分，并且紧固到所述支撑件 在其紧固部分处的板，其中所述磁性销在其分离部分处可单独移位。 本发明还提供了使用分离板分离磁性颗粒的方法。

公开(公告)号：US20110203593A1

公开(公告)日：2011-08-25

申请号：US12991917

申请日：2009-05-14

Applicant: Makoto Ishigami ,  Naohito Takeuchi

Inventor： Makoto Ishigami ,  Naohito Takeuchi

IPC: A62B7/10

CPC classification number: A62B23/025 ,  A41D13/113 ,  A41D13/1138 ,  B03C3/30 ,  B03C3/32 ,  B03C2201/26

Abstract: An effective technique for balancing mask breathability and mask trapping capability at higher levels is provided in a mask to be worn on a wearer's face. A mask 1 has a mask body 10 that covers at least wearer's mouth and nose and a pair of ear straps 20 that extend from both sides of the mask body 10 and are designed to be hooked around wearer's ears. The mask body 10 includes a first fiber sheet and a second fiber sheet which are electret nonwoven fabric sheets formed of polyolefin fiber. The first fiber sheet is a nonwoven fabric sheet having an average fiber diameter of 0.5 to 3 μm and a basis weight of 1.5 to 5 g/m2, and the second fiber sheet is a nonwoven fabric sheet having a larger average fiber diameter and a heavier basis weight than the first fiber sheet.

Abstract translation: 在面罩上设置有用于平衡面罩透气性和较高水平的面膜捕获能力的有效技术，以佩戴在佩戴者的脸部上。 面具1具有覆盖至少佩戴者的嘴和鼻的面罩主体10和从面罩主体10的两侧延伸并被设计成钩在佩戴者的耳朵周围的一对耳带20。 面罩主体10包括由聚烯烃纤维形成的驻极体无纺布片的第一纤维片和第二纤维片。 第一纤维片是平均纤维直径为0.5〜3μm，单位面积重量为1.5〜5g / m 2的无纺布片，第二纤维片为平均纤维直径较大的无纺布片 基重比第一纤维片材。

公开(公告)号：US20110180701A1

公开(公告)日：2011-07-28

申请号：US13011413

申请日：2011-01-21

Applicant: Jorg C. Woehl ,  Christine A. Carlson

Inventor： Jorg C. Woehl ,  Christine A. Carlson

IPC: B01D59/44 ,  B05D5/12

CPC classification number: B82B3/0076 ,  B03C5/00 ,  B03C2201/26

Abstract: A method of trapping a charged particle. The method includes providing a planar substrate having a conductive surface thereon, the conductive surface having at least one non-conductive region. The method also includes applying a solution to the conductive surface, the solution comprising at least one charged particle. The method further includes applying a voltage of a threshold level to the conductive surface. The method also includes, in response to the voltage, generating an electrostatic field in the solution adjacent to a boundary between the conductive surface and the non-conductive region. The method also includes setting the threshold level of voltage to result in a strength of the electrostatic field sufficient to prevent the particle from crossing the electrostatic field.

Abstract translation: 捕获带电粒子的方法。 该方法包括提供其上具有导电表面的平面基板，该导电表面具有至少一个非导电区域。 该方法还包括将溶液施加到导电表面，该溶液包含至少一个带电粒子。 该方法还包括向导电表面施加阈值电平的电压。 该方法还包括响应于电压，在与导电表面和非导电区域之间的边界相邻的溶液中产生静电场。 该方法还包括设置电压的阈值电平以产生足以防止颗粒穿过静电场的静电场的强度。

公开(公告)号：US20110177592A1

公开(公告)日：2011-07-21

申请号：US13003435

申请日：2009-07-13

Applicant: Denise L. Faustman ,  Douglas E. Burger

Inventor： Denise L. Faustman ,  Douglas E. Burger

IPC: C12N5/02 ,  C12M1/00

CPC classification number: B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N33/491 ,  G01N33/5094 ,  G01N33/54326 ,  G01N35/0098 ,  G01N2446/00

Abstract: An apparatus for magnetically separating constituents of blood includes: a first portion having a solid support haying fixedly attached thereon a plurality of ring magnets, each ring magnet defining an interior perimeter enclosing an aperture; and a second portion removably attached to the first portion, wherein the second portion includes a solid substrate having surfaces defining a plurality of second apertures, each second aperture configured to removably hold a vial.

Abstract translation: 用于磁性分离血液成分的装置包括：第一部分，其具有固定地附着在其上的多个环形磁体的固体支撑件，每个环形磁体限定包围孔的内部周边; 以及第二部分，其可拆卸地附接到所述第一部分，其中所述第二部分包括具有限定多个第二孔的表面的固体基底，每个第二孔被配置为可移除地保持小瓶。

公开(公告)号：US07981696B2

公开(公告)日：2011-07-19

申请号：US11061461

申请日：2005-02-18

Applicant: John Moreland ,  Elizabeth Mirowski ,  Stephen E. Russek

Inventor： John Moreland ,  Elizabeth Mirowski ,  Stephen E. Russek

IPC: G01N33/00 ,  G01N33/553

CPC classification number: B01L3/502761 ,  B01J2219/00655 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00743 ,  B01L3/502738 ,  B01L2200/0663 ,  B01L2200/0668 ,  B01L2300/0819 ,  B01L2400/043 ,  B03C2201/18 ,  B03C2201/26 ,  B82Y5/00 ,  B82Y10/00 ,  C40B40/06 ,  C40B40/14 ,  G01N15/1056 ,  G01N2015/1081 ,  G01N2035/00247

Abstract: Arrays of spin-valve elements that can be selectively activated to trap, hold, manipulate and release magnetically tagged biological and chemical particles, including molecules and polymers. The spin-valve elements that can be selectively activated and deactivated by applying a momentary applied magnetic field thereto. The spin valve element array can be used for selectively sorting and transporting magnetic particles one particle at a time within the array. As the magnetically tagged particles are held by the spin-valve elements, application of an auxiliary magnetic field can be used to apply tension or torsion to the held particles or to move, e.g. rotate, the trapped particles. The arrays of spin-valve elements can be used in a variety of applications including drug screening, nucleic acid sequencing, structural control and analysis of RNA/DNA and protiens, medical diagnosis, and magnetic particle susceptibility and size homogenization for other medical applications.

Abstract translation: 可以选择性地激活以捕获，保持，操纵和释放磁性标记的生物和化学颗粒（包括分子和聚合物）的自旋阀元件阵列。 可以通过向其施加瞬时施加的磁场来选择性地激活和去激活自旋阀元件。 自旋阀元件阵列可以用于在阵列内一次选择性地分选和输送一个粒子的磁性颗粒。 由于磁性标记的颗粒由自旋阀元件保持，所以可以使用辅助磁场来施加张力或扭转到所保持的颗粒或移动，例如， 旋转，被捕获的颗粒。 自旋阀元件的阵列可以用于各种应用，包括药物筛选，核酸测序，RNA / DNA和蛋白质的质子结构控制和分析，医学诊断和其他医疗应用的磁性粒子易感性和大小均质化。

公开(公告)号：US20110147278A1

公开(公告)日：2011-06-23

申请号：US12761339

申请日：2010-04-15

Applicant: Mean-Jue Tung ,  Li-Kou Chen ,  Yu-Ting Huang ,  Hsin-Hsin Shen ,  Wei-Lin Yu ,  Yi-Shan Lin ,  Shinn-Zong Lin ,  Woei-Cherng Shyu ,  Hsiao-Jung Wang

Inventor： Mean-Jue Tung ,  Li-Kou Chen ,  Yu-Ting Huang ,  Hsin-Hsin Shen ,  Wei-Lin Yu ,  Yi-Shan Lin ,  Shinn-Zong Lin ,  Woei-Cherng Shyu ,  Hsiao-Jung Wang

IPC: B03C1/32

CPC classification number: B03C1/288 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26

Abstract: A magnetic separation device is provided, including a first magnetic field unit and a first separation unit disposed at a side of the first magnetic field unit. The first magnetic field unit includes a first magnetic yoke having opposite first and second surfaces, and a plurality of first magnets respectively disposed over the first and second surfaces, wherein the same magnetic poles of the plurality of first magnets face the first magnetic yoke. The first separation unit includes a body made of non-magnetic materials and a continuous piping disposed in the body, including at least one first section and at least one second section, wherein at least one second section is perpendicular to at least one first section, and at least one second section is adjacent to, and in parallel to a side of the first magnetic yoke not in contact with the plurality of first magnets.

Abstract translation: 提供一种磁分离装置，包括设置在第一磁场单元一侧的第一磁场单元和第一分离单元。 第一磁场单元包括具有相对的第一和第二表面的第一磁轭和分别设置在第一和第二表面上的多个第一磁体，其中多个第一磁体中的相同磁极面对第一磁轭。 第一分离单元包括由非磁性材料制成的主体和布置在主体中的连续管道，其包括至少一个第一部分和至少一个第二部分，其中至少一个第二部分垂直于至少一个第一部分， 并且至少一个第二部分与第一磁轭的不与多个第一磁体接触的一侧相邻并平行。

公开(公告)号：US20110124098A1

公开(公告)日：2011-05-26

申请号：US12943677

申请日：2010-11-10

Applicant: Klint A. Rose ,  Raymond P. Mariella, JR. ,  Christopher G. Bailey ,  Kevin Dean Ness

Inventor： Klint A. Rose ,  Raymond P. Mariella, JR. ,  Christopher G. Bailey ,  Kevin Dean Ness

IPC: C12M1/12

CPC classification number: B01L3/502761 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/0681 ,  B01L2400/0436 ,  B01L2400/0439 ,  B03C5/026 ,  B03C2201/26 ,  G01N2035/00326

Abstract: A reconfigurable modular microfluidic system for preparation of a biological sample including a series of reconfigurable modules for automated sample preparation adapted to selectively include a) a microfluidic acoustic focusing filter module, b) a dielectrophoresis bacteria filter module, c) a dielectrophoresis virus filter module, d) an isotachophoresis nucleic acid filter module, e) a lyses module, and f) an isotachophoresis-based nucleic acid filter.

Abstract translation: 一种用于制备生物样品的可重构模块化微流体系统，包括用于自动化样品制备的一系列可重新配置模块，其适于选择性地包括a）微流体声学聚焦滤光器模块，b）介电电泳细菌滤膜模块，c）介电泳病毒过滤器模块， d）等速电泳核酸过滤器模块，e）裂解模块和f）基于等电泳的核酸过滤器。

公开(公告)号：US20110072887A1

公开(公告)日：2011-03-31

申请号：US12957890

申请日：2010-12-01

Applicant: Akio OKI

Inventor： Akio OKI

IPC: G01N37/00

CPC classification number: B03C3/017 ,  B03C3/014 ,  B03C3/383 ,  B03C3/68 ,  B03C2201/24 ,  B03C2201/26 ,  B03C2201/32 ,  G01N1/4022 ,  G01N2001/4033

Abstract: The present invention provides a method for detecting easily and efficiently a chemical substance contained in a gas sample at an ultralow amount.The present invention is directed to detecting method of a chemical substance contained in a gas sample, using an analyzing device with electrostatic atomizer. The analyzing device comprises a vessel, a inlet, a cooling part, an atomizing electrode, a counter electrode, an intermediate electrode, a liquid detecting part, and a detecting electrode. According to a detecting method of the present invention, the gas sample is condensed as a first condensate liquid at the surface of the atomizing electrode. The first condensate liquid is configured to be electric-charged fine particles to obtain a second condensate liquid at the surface of the counter electrode. The resulted second condensate liquid is brought in contact with the detecting electrode and a current voltage is applied between the counter electrode and the detecting electrode. The chemical substance is detected on the basis of the generated current value.

Abstract translation: 本发明提供一种容易且高效地检测气体样品中含有的化学物质的方法。 本发明涉及使用具有静电雾化器的分析装置来检测包含在气体样品中的化学物质的方法。 分析装置包括容器，入口，冷却部分，雾化电极，对电极，中间电极，液体检测部分和检测电极。 根据本发明的检测方法，气体样品在雾化电极的表面作为第一冷凝液冷凝。 第一冷凝液被配置为带电的微粒，以在对电极的表面获得第二冷凝液。 所得到的第二冷凝液与检测电极接触，并且在对电极和检测电极之间施加电流电压。 根据产生的电流值检测化学物质。