公开(公告)号：US20170367583A1

公开(公告)日：2017-12-28

申请号：US15683277

申请日：2017-08-22

Applicant: Cedars-Sinai Medical Center

Inventor： Keith L. Black ,  Michael Baker ,  Howland Jones ,  Pramod Butte

IPC: A61B5/00 ,  G06K9/62 ,  A61B10/02 ,  G06T7/00 ,  G01N21/64 ,  A61B5/08

CPC classification number: A61B5/0071 ,  A61B5/00 ,  A61B5/0075 ,  A61B5/0091 ,  A61B5/08 ,  A61B5/4064 ,  A61B5/4255 ,  A61B5/441 ,  A61B5/7267 ,  A61B10/02 ,  A61B2576/026 ,  G01N21/6402 ,  G01N21/6408 ,  G01N2201/06113 ,  G01N2201/129 ,  G06K9/6267 ,  G06T7/0012 ,  G06T2207/10064 ,  G06T2207/30016 ,  G06T2207/30028 ,  G06T2207/30061 ,  G06T2207/30068 ,  G06T2207/30088

Abstract: Described herein are methods and systems for analyzing a sample by applying time resolved laser induced fluorescence spectroscopy to the sample to measure lifetime time decay profile data relating to the sample, and applying multivariate analysis to process the data so as to classify a sample as, for example, normal or abnormal. The sample may be cells, fluid or tissue from any organ. The sample may be in vitro or in vivo. The data may be obtained in situ or in vitro.

公开(公告)号：US20170363696A1

公开(公告)日：2017-12-21

申请号：US15672953

申请日：2017-08-09

Applicant: LOCKHEED MARTIN CORPORATION

Inventor： Joseph W. Hahn ,  Arul Manickam ,  Peter G. Kaup ,  Gregory Scott Bruce ,  Wilbur Lew ,  Nicholas M. Luzod ,  Duc Huynh

IPC: G01R33/032 ,  G01N21/64 ,  G01R33/26 ,  G01R33/12 ,  G01N21/87

CPC classification number: G01R33/032 ,  G01N21/64 ,  G01N21/6489 ,  G01N21/87 ,  G01N2021/1727 ,  G01N2021/646 ,  G01N2201/06113 ,  G01R33/0023 ,  G01R33/0047 ,  G01R33/1284 ,  G01R33/26

Abstract: A magneto-optical defect center magnetometer, such as a diamond nitrogen vacancy (DNV) magnetometer, can include an excitation source, a magneto-optical defect center element, a collection device, a top plate, a bottom plate, and a printed circuit board. The excitation source, the magneto-optical defect center element, and the collection device are each mounted to the printed circuit board

公开(公告)号：US09846122B2

公开(公告)日：2017-12-19

申请号：US15178484

申请日：2016-06-09

Applicant: Nanometrics Incorporated

Inventor： Andrzej Buczkowski ,  Mikhail Sluch

IPC: G01N21/00 ,  G01N21/64 ,  G01J3/28 ,  G01N21/47 ,  G01N21/55 ,  G01N21/88 ,  G01N21/95 ,  G01B11/06 ,  H04N3/14

CPC classification number: G01N21/6489 ,  G01B11/0625 ,  G01J3/2823 ,  G01N21/47 ,  G01N21/55 ,  G01N21/6456 ,  G01N21/88 ,  G01N21/9501 ,  G01N2021/4735 ,  G01N2021/646 ,  G01N2021/8822 ,  G01N2021/8825 ,  G01N2201/06113 ,  G01N2201/0638 ,  G01N2201/1053 ,  H04N3/155

Abstract: An optical metrology device is capable of detection of any combination of photoluminescence light, specular reflection of broadband light, and scattered light from a line across the width of a sample. The metrology device includes a first light source that produces a first illumination line on the sample. A scanning system may be used to scan an illumination spot across the sample to form the illumination line. A detector collects the photoluminescence light emitted along the illumination line. Additionally, a broadband illumination source may be used to produce a second illumination line on the sample, where the detector collects the broadband illumination reflected along the second illumination line. A signal collecting optic may collect the photoluminescence light and broadband light and focus it into a line, which is received by an optical conduit. The output end of the optical conduit has a shape that matches the entrance of the detector.

公开(公告)号：US20170350690A1

公开(公告)日：2017-12-07

申请号：US15611254

申请日：2017-06-01

Applicant: SHIMADZU CORPORATION

Inventor： Takahide HATAHORI ,  Kenji TAKUBO

IPC: G01B9/02 ,  G01N21/17 ,  G01N21/88

CPC classification number: G01B9/02095 ,  G01B9/02096 ,  G01B9/02098 ,  G01B17/00 ,  G01M5/0033 ,  G01M5/0066 ,  G01M5/0091 ,  G01M7/00 ,  G01N21/1702 ,  G01N21/8806 ,  G01N29/043 ,  G01N29/045 ,  G01N29/2418 ,  G01N2021/1706 ,  G01N2021/8838 ,  G01N2201/06113 ,  G01N2201/0697 ,  G01N2291/0232 ,  G01N2291/0234

Abstract: A defect detection apparatus is provided that can inspect a measurement region of a target object at one time and without inconsistencies arising within the measurement region. A defect detection apparatus 10 includes: a generation unit (signal generator 11 and vibrator 12) for generating an elastic wave in a target object S; an illumination unit (pulsed laser light source 13 and illumination light lens 14) for performing stroboscopic illumination onto a measurement region of a surface of the target object S; and a displacement measurement unit (speckle shearing interferometer 15) for collectively measuring displacements in a normal direction at each point of the measurement region with respect to at least three mutually-different phases of the elastic wave by controlling a phase of the elastic wave and a timing of the stroboscopic illumination. Defects in the measurement region are detected based on the displacements in the normal direction at each point of the measurement region with respect to at least three phases that are obtained by the displacement measurement unit.

公开(公告)号：US09827144B2

公开(公告)日：2017-11-28

申请号：US15248977

申请日：2016-08-26

Applicant: Novartis AG

Inventor： Mario Abraham ,  Peter Riedel

IPC: G01B9/00 ,  A61F9/008 ,  G01N21/84

CPC classification number: A61F9/00802 ,  A61F9/00825 ,  A61F2009/00846 ,  A61F2009/00855 ,  A61F2009/00859 ,  A61F2009/00872 ,  G01N21/84 ,  G01N2201/06113

Abstract: A method for testing a laser device configured to emit pulsed, focused laser radiation includes providing an artificial eye body with a pattern that simulates a pupil and/or an iris structure. An irradiation test object is arranged above the pattern. The irradiation test object is separate from the eye body and is made of a material that is modifiable by the laser radiation. The laser radiation is applied to the irradiation test object according to a predefined application profile, so that a material modification that corresponds to the application profile is generated in the irradiation test object.

公开(公告)号：US20170336610A1

公开(公告)日：2017-11-23

申请号：US15511580

申请日：2015-09-24

Applicant: The USA, as Represented by the Secretary, Dept. of Health and Human Services

Inventor： Hari Shroff ,  Yicong Wu ,  Sara Abrahamsson

IPC: G02B21/00 ,  G01N21/64 ,  G02B21/18

CPC classification number: G02B21/0072 ,  G01N21/6458 ,  G01N2021/6463 ,  G01N2201/06113 ,  G02B21/0044 ,  G02B21/0076 ,  G02B21/10 ,  G02B21/16 ,  G02B21/18 ,  G02B27/0075 ,  G02B27/42

Abstract: Embodiments of a resolution enhancement technique for a light sheet microscopy system having a three objective lens arrangement in which one objective lens illuminates a sample and the second and third objective lenses collect the fluorescence emissions emitted by the sample are disclosed. The second objective lens focuses a first portion of the fluorescence emissions for detection by a second detection component, while the third objective lens focuses a second portion of the fluorescence emissions through a diffractive or refractive optic component for detection by a first detector component. A processor combines the images resulting from the first and second portions of the fluorescence emissions for generating composite images with increased axial and lateral resolution.

公开(公告)号：US20170336316A1

公开(公告)日：2017-11-23

申请号：US15670297

申请日：2017-08-07

Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

Inventor： Matthias Hartrumpf

IPC: G01N21/21 ,  G01N15/14

CPC classification number: G01N21/21 ,  G01N15/1434 ,  G01N15/1463 ,  G01N15/1475 ,  G01N21/84 ,  G01N2015/144 ,  G01N2021/845 ,  G01N2201/0438 ,  G01N2201/06113

Abstract: The present invention relates to a device for optical characterisation of a sample and/or of the material(s) of the same having an illumination unit that can be orientated to illuminate with incident light a sample spatial portion into which the sample can be introduced, a detection unit which is orientated or can be orientated to image the sample introduced into the sample spatial portion by receiving light reflected by the sample, and which is configured to detect at least two different, preferably orthogonal, polarization components in the reflected light, and an evaluation unit with which, in the imaging data recorded by the detection unit, those imaged surface elements (reflection elements) of the sample can be identified, and with which the detected different polarization components for these reflection elements can be evaluated for optical characterisation.

公开(公告)号：US20170328826A1

公开(公告)日：2017-11-16

申请号：US15593959

申请日：2017-05-12

Applicant: BD Biosciences

Inventor： Eric Diebold ,  Keegan Owsley ,  Jonathan Lin ,  Matthew Bahr

IPC: G01N15/14 ,  G06T7/00 ,  G06T7/246 ,  G01N21/64 ,  G01N15/00 ,  G01N15/10

CPC classification number: G01N15/1475 ,  G01N15/1429 ,  G01N15/147 ,  G01N21/6456 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/144 ,  G01N2201/06113 ,  G01N2201/10 ,  G01N2201/12 ,  G01N2201/129 ,  G06T7/0012 ,  G06T7/246 ,  G06T7/521 ,  G06T2207/30024

Abstract: In one aspect, a system for performing flow cytometry is disclosed, which comprises a laser for generating laser radiation for illuminating a sample, at least one detector for detecting at least a portion of a radiation emanating from the sample in response to said illumination so as to generate a temporal signal corresponding to said detected radiation, and an analysis module for receiving said temporal signal and performing a statistical analysis of said signal based on a forward model to reconstruct an image of said sample.

公开(公告)号：US09816932B2

公开(公告)日：2017-11-14

申请号：US15313420

申请日：2015-08-13

Applicant: CANON KABUSHIKI KAISHA

Inventor： Naoki Kohara

IPC: G01N21/25 ,  G01N21/65 ,  G02B21/00 ,  H01S3/13 ,  H01S3/23 ,  G02F1/35

CPC classification number: G01N21/65 ,  G01J3/10 ,  G01N2021/655 ,  G01N2201/06113 ,  G01N2201/0697 ,  G01N2201/105 ,  G02B21/0032 ,  G02B21/0076 ,  G02F1/3534 ,  H01S3/13 ,  H01S3/2391

Abstract: A pulsed light synchronizer synchronizes a first pulsed light having a first period and a second pulsed light and having a second period equal to the first period with each other. A third pulsed light is acquired by providing a first delay time between two pulsed lights acquired by dividing the first pulsed light, and by multiplexing the pulsed lights acquired from the first pulsed light. A fourth pulsed light is acquired by providing a second delay time between two pulsed lights acquired by dividing the second pulsed light, and by multiplexing the pulsed lights acquired from the second pulsed light. The pulsed light synchronizer detects, through a detector, a pulsed light acquired by multiplexing the third and fourth pulsed lights, and adjusts at least one of the first and second periods based on a timing difference between the third and fourth pulsed lights acquired from the detector.

公开(公告)号：US09816931B2

公开(公告)日：2017-11-14

申请号：US14008990

申请日：2012-03-28

Applicant: Adam Abate ,  John Lawrence Emhoff ,  Tony Hung ,  Adnan Moez Esmail ,  Sepehr Kiani ,  Pascaline Mary

Inventor： Adam Abate ,  John Lawrence Emhoff ,  Tony Hung ,  Adnan Moez Esmail ,  Sepehr Kiani ,  Pascaline Mary

IPC: G01J3/30 ,  G01N21/64 ,  C12Q1/68 ,  G01N21/25 ,  G01N21/76

CPC classification number: G01N21/6486 ,  C12Q1/6806 ,  G01N21/255 ,  G01N21/76 ,  G01N2201/06113 ,  G01N2201/062 ,  C12Q2545/101 ,  C12Q2563/107 ,  C12Q2563/159 ,  C12Q2563/161 ,  C12Q2565/629

Abstract: The present invention generally pertains to methods and kits for managing the variation in spectroscopic intensity measurements through the use of a reference component. The reference component may comprise a reference spectroscopic substance and may be contained together with a sample of interest in a sample to be tested, wherein the sample of interest may comprise a sample spectroscopic substance. Each sample to be tested may be uniquely identified and, hence, “barcoded” by combinations of different colors and concentrations of spectroscopic substances, contained therein.