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    Method of fabricating micro-needle array
    152.
    发明授权
    Method of fabricating micro-needle array 失效
    微针阵列制作方法

    公开(公告)号：US07456112B2

    公开(公告)日：2008-11-25

    申请号：US11327463

    申请日：2006-01-09

    Applicant: Chang-seung Lee

    Inventor： Chang-seung Lee

    IPC: H01L21/302

    CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C2201/0115

    Abstract: A method of fabricating a micro-needle array is provided. The method of fabricating a micro-needle array having a substrate having a first surface and a second surface spaced in a predetermined interval apart from the first surface, includes patterning on the first surface, thereby forming a shape of micro-needle bodies. Further, micro-passageways are formed that penetrate the first surface of the substrate from the second surface by a porous silicon process, and integrates the micro-passageways, thereby forming the bodies and channels of micro-needles.

    Abstract translation: 提供一种制造微针阵列的方法。 制造具有第一表面和与第一表面隔开预定间隔的第二表面的基底的微针阵列的方法包括在第一表面上的图案化，从而形成微针体的形状。 此外，通过多孔硅工艺形成从第二表面穿透基板的第一表面的微通道，并且将微通道整合，从而形成微针的主体和通道。

    Methods of fabricating microneedle arrays using sacrificial molds, and microneedle arrays fabricated thereby
    155.
    发明授权
    Methods of fabricating microneedle arrays using sacrificial molds, and microneedle arrays fabricated thereby 有权
    使用牺牲模具制造微针阵列的方法和由此制造的微针阵列

    公开(公告)号：US07332197B2

    公开(公告)日：2008-02-19

    申请号：US10304277

    申请日：2002-11-26

    Applicant: Robert L. Wood ,  Henry A. Wynands ,  Karen W. Markus

    Inventor： Robert L. Wood ,  Henry A. Wynands ,  Karen W. Markus

    IPC: B05D7/22 ,  B05D1/36

    CPC classification number: B81C99/0085 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055 ,  Y10T29/302 ,  Y10T29/49222

    Abstract: Microneedle arrays are fabricated by providing a sacrificial mold including a substrate and an array of posts, preferably solid posts, projecting therefrom. A first material is coated on the sacrificial mold including on the substrate and on the array of posts. The sacrificial mold is removed to provide an array of hollow tubes projecting from a base. The inner and outer surfaces of the array of hollow tubes are coated with a second material to create the array of microneedles projecting from the base. The sacrificial mold may be fabricated by fabricating a master mold, including an array of channels that extend into the master mold from a face thereof. A third material is molded into the channels and on the face of the master mold, to create the sacrificial mold. The sacrificial mold then is separated from the master mold. Alternatively, wire bonding may be used to wire bond an array of wires to a substrate to create the sacrificial mold. The first material preferably is coated on the sacrificial mold by plating. Prior to plating, a plating base preferably is formed on the sacrificial mold including on the substrate and on the array of posts. The inner and outer surfaces of the array of hollow tubes preferably are coated with the second material by overplating the second material on the inner and outer surfaces of the array of hollow tubes.

    Abstract translation: 微针阵列通过提供包括基底和从其突出的柱的阵列（优选固体柱）的牺牲模具来制造。 第一材料涂覆在牺牲模具上，包括在基板上和柱阵列上。 去除牺牲模具以提供从基部突出的中空管阵列。 中空管阵列的内表面和外表面涂覆有第二材料以产生从基底突出的微针阵列。 牺牲模具可以通过制造主模具来制造，该模具包括从其表面延伸到主模具中的通道阵列。 将第三种材料模制到通道中并在母模的表面上，以形成牺牲模具。 然后将牺牲模具与主模具分离。 或者，引线接合可用于将线阵列引线接合到基底以产生牺牲模。 第一种材料优选通过电镀涂覆在牺牲模具上。 在电镀之前，优选在包括在基板和柱阵列上的牺牲模具上形成镀覆基底。 优选地，中空管阵列的内表面和外表面通过在中空管阵列的内表面和外表面上的第二材料的上镀敷而涂覆有第二材料。

    METHOD AND APPARATUS FOR MANUFACTURING A DEVICE
    156.
    发明申请
    METHOD AND APPARATUS FOR MANUFACTURING A DEVICE 审中-公开
    用于制造装置的方法和装置

    公开(公告)号：US20060197004A1

    公开(公告)日：2006-09-07

    申请号：US11419298

    申请日：2006-05-19

    Applicant: Kenneth Powell ,  Larry Monahan ,  Burton Sage

    Inventor： Kenneth Powell ,  Larry Monahan ,  Burton Sage

    IPC: B29C33/42

    CPC classification number: B29C33/405 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C33/424 ,  B29C45/372 ,  B29C2045/0094 ,  B29K2883/00 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00111 ,  B81C2201/034

    Abstract: A device, preferably a micro-device, is molded from a plastic material by injection molding, compression molding or embossing. A microabrader can be molded having microneedles for abrading the stratum corneum of the skin to form an abraded site in the tissue for enhancing drug delivery. The micro-device is molded using a mold assembly having a silicon molding surface. The silicon molding surface can include a recess corresponding to the desired shape and length of the microneedles. The silicon molding surface enables micron and submicron size features to be molded from polymeric materials without the polymeric material adhering to the mold surface. Micro-devices having molded features having micron and submicron dimensions can be rapidly produced without the use of a release agent.

    Abstract translation: 一种装置，优选一种微型装置，通过注塑，压塑或压花由塑料材料模制。 微型造型机可以模制成具有用于研磨皮肤角质层的微针，以在组织中形成用于增强药物递送的磨损部位。 使用具有硅模制表面的模具组件来模制微型装置。 硅成型表面可以包括对应于所需形状和长度的微针的凹部。 硅成型表面使得微米和亚微米尺寸的特征能够由聚合物材料模制而不会使聚合材料粘附到模具表面。 具有微米和亚微米尺寸的模制特征的微型装置可以在不使用脱模剂的情况下快速生产。

    Surface micromachined microneedles
    158.
    发明授权
    Surface micromachined microneedles 有权
    表面微加工微针

    公开(公告)号：US07048723B1

    公开(公告)日：2006-05-23

    申请号：US09787498

    申请日：1999-09-17

    Applicant: A. Bruno Frazier ,  John D. Brazzle

    Inventor： A. Bruno Frazier ,  John D. Brazzle

    IPC: A61M5/32

    CPC classification number: B81C99/008 ,  A61M37/0015 ,  A61M2037/0053 ,  A61M2205/0244 ,  B81B2201/055

    Abstract: Surface micro-machined micro-needles (32) are formed as single needles (32) or in two-dimensional or three-dimensional micro-needle arrays (30). The micro-needles (32) are fabricated on a substrate (12) which can remain attached to the micro-needles (32) or can be subsequently removed. The two-dimensional or three-dimensional micro-needle arrays (30) can have cross-coupling flow channels (36) which allow for pressure equalization, and balance of fluid flow within the micro-needle arrays (30). Each of the micro-needles (32) has a micro-channel (36) therethrough that provides communication between at least one input port (37) at a proximal end of the micro-needles (32), and at least on output port (39) at an opposite distal end.

    Abstract translation: 表面微加工微针（32）形成为单针（32）或二维或三维微针阵列（30）。 微针（32）制造在可以保持附着到微针（32）上或可以随后去除的基底（12）上。 二维或三维微针阵列（30）可以具有允许压力平衡和微针阵列（30）内的流体平衡的交叉耦合流动通道（36）。 每个微针（32）具有穿过其中的微通道（36），其提供在微针（32）的近端处的至少一个输入端口（37）与至少一个输出端口 39）在相对的远端。

    Intracutaneous microneedle array apparatus
    160.
    发明申请
    Intracutaneous microneedle array apparatus 有权

    公开(公告)号：US20050209565A1

    公开(公告)日：2005-09-22

    申请号：US11121291

    申请日：2005-05-03

    Applicant: Vadim Yuzhakov ,  Faiz Sherman ,  Grover Owens ,  Vladimir Gartstein

    Inventor： Vadim Yuzhakov ,  Faiz Sherman ,  Grover Owens ,  Vladimir Gartstein

    IPC: A61M5/00 ,  A61M5/172 ,  A61M37/00 ,  A61N1/30

    CPC classification number: B81C99/0085 ,  A61M5/1723 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053 ,  A61M2037/0061 ,  A61N1/30 ,  B81B2201/055

    Abstract: Improved microneedle arrays are provided having a sufficiently large separation distance between each of the individual microneedles to ensure penetration of the skin while having a sufficiently small separation distance to provide high transdermal transport rates. A very useful range of separation distances between microneedles is in the range of 100-300 microns, and more preferably in the range of 100-200 microns. The outer diameter and microneedle length is also very important, and in combination with the separation distance will be crucial as to whether or not the microneedles will actually penetrate the stratum corneum of skin. For circular microneedles, a useful outer diameter range is from 20-100 microns, and more preferably in the range of 20-50 microns. For circular microneedles that do not have sharp edges, a useful length for use with interstitial fluids is in the range of 50-200 microns, and more preferably in the range of 100-150 microns; for use with other biological fluids, a useful length is in the range of 200 microns—3 mm, and more preferably in the range of 200-400 microns. For circular microneedles having sharp side edges, a useful length for use with interstitial fluids is in the range of 50-200 microns, and more preferably in the range of 80-150 microns; for use with other biological fluids, a useful length is again in the range of 200 microns—3 mm, and more preferably in the range of 200-400 microns. For solid microneedles having a star-shaped profile with sharp edges for its star-shaped blades, a useful length for use with interstitial fluids is in the range of 50-200 microns, and more preferably in the range of 80-150 microns; for use with other biological fluids, a useful length is again in the range of 200 microns—3 mm, and more preferably in the range of 200-400 microns, while the radius of each of its blades is in the range of 10-50 microns, and more preferably in the range of 10-15 microns.

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