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    Cells for biochemical analysis, kit for biochemical analysis, and biochemical analyzer
    151.
    发明授权
    Cells for biochemical analysis, kit for biochemical analysis, and biochemical analyzer 有权
    用于生化分析的细胞，生化分析试剂盒和生化分析仪

    公开(公告)号：US08325335B2

    公开(公告)日：2012-12-04

    申请号：US13303830

    申请日：2011-11-23

    Applicant: Toru Fujimura ,  Kosuke Kuwabara ,  Tatsuro Ide

    Inventor： Toru Fujimura ,  Kosuke Kuwabara ,  Tatsuro Ide

    IPC: G01N21/00 ,  G01N30/74 ,  C12M1/34

    CPC classification number: G01N21/05 ,  G01N21/31 ,  G01N21/55 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2201/061 ,  G01N2201/08

    Abstract: The invention makes it possible to measure binding of a biochemical substance with a high throughput and with high sensitivity using a small cell capable of being filled with a small amount of chemical solution. A space between a first substrate and a second substrate such that probes are immobilized on their mutually facing planes is used as a cell that houses a specimen solution. Light is irradiated from a first substrate side, and reflected light is subjected to spectroscopy. Binding of the target with the probe is detected by a wavelength shift in the refection spectrum.

    Abstract translation: 本发明能够使用能够填充少量化学溶液的小细胞来测量生物化学物质与高产量和高灵敏度的结合。 使用第一基板和第二基板之间的空间，使得将探针固定在其相互面对的平面上，作为容纳样本溶液的单元。 从第一基板侧照射光，反射光进行光谱分析。 通过反射光谱中的波长偏移来检测靶与探针的结合。

    GRADIENT INDEX (GRIN)-BASED ABSORPTION SPECTROSCOPY APPARATUS, METHOD, AND APPLICATIONS
    152.
    发明申请
    GRADIENT INDEX (GRIN)-BASED ABSORPTION SPECTROSCOPY APPARATUS, METHOD, AND APPLICATIONS 有权
    梯度指数（GRIN） - 吸收光谱仪器，方法和应用

    公开(公告)号：US20120242992A1

    公开(公告)日：2012-09-27

    申请号：US13425670

    申请日：2012-03-21

    Applicant: Alfons Schulte ,  Silki Arora

    Inventor： Alfons Schulte ,  Silki Arora

    IPC: G01N21/59

    CPC classification number: G01N21/31 ,  G01N2201/08 ,  G01N2201/0866

    Abstract: Apparatus and method to measure optical absorption spectra with spatial resolution on the micron scale. An exemplary setup combines a continuous white light excitation beam in transmission geometry with a GRIN-based detection path in place of a typical confocal microscope. The apparatus and method enables the investigation of spatial variations in the optical density of small samples on the micron scale and the study of biological assemblies at the single cell level, leading to applications in optical diagnostics, microfluidics, cytology, and other areas.

    Abstract translation: 用微米尺度测量空间分辨率的光吸收光谱的装置和方法。 示例性设置将透射几何中的连续白光激发光束与基于GRIN的检测路径代替典型的共焦显微镜组合。 该装置和方法能够研究微量级小样品的光密度的空间变化以及单细胞水平的生物装配的研究，从而在光学诊断，微流体学，细胞学和其他领域的应用。

    Monitoring method and device by shadowscopy
    155.
    发明授权
    Monitoring method and device by shadowscopy 失效
    监控方法和设备通过阴影检查

    公开(公告)号：US08138446B2

    公开(公告)日：2012-03-20

    申请号：US10589797

    申请日：2005-02-21

    Applicant: Christophe Chagnot

    Inventor： Christophe Chagnot

    IPC: B23K37/04 ,  G01B5/00

    CPC classification number: G01N21/952 ,  G01N2021/8411 ,  G01N2201/021 ,  G01N2201/06113 ,  G01N2201/08

    Abstract: A monitoring device by laser shadowscopy, which comprises a light emitter (5) and receiver (6), mounted on an arm (8) oscillating at will around two joints (13, 14), in order to restore the image of the monitored profile more accurately.An important application relates to welding methods and especially in hollow beveled edges.

    Abstract translation: 一种通过激光影像检查的监测装置，其包括光发射器（5）和接收器（6），安装在围绕两个关节（13,14）摆动的臂（8）上，以便恢复所监视的轮廓的图像 更精确地。 一个重要的应用涉及焊接方法，尤其涉及中空斜边。

    Multi-capillary electrophoresis cartridge interface mechanism
    156.
    发明授权
    Multi-capillary electrophoresis cartridge interface mechanism 有权
    多毛细管电泳盒接口机理

    公开(公告)号：US08092762B2

    公开(公告)日：2012-01-10

    申请号：US12624363

    申请日：2009-11-23

    Applicant: Varouj Amirkhanian ,  Bob G. Heitel ,  Ming-Sun Liu ,  Paul Mooney

    Inventor： Varouj Amirkhanian ,  Bob G. Heitel ,  Ming-Sun Liu ,  Paul Mooney

    IPC: A61J1/06

    CPC classification number: G01N21/645 ,  G01N27/44721 ,  G01N2021/6463 ,  G01N2021/6484 ,  G01N2201/08

    Abstract: The present invention provides for an interface mechanism in a bio-separation instrument that makes interface connections to a multi-channel cartridge. The interface mechanism precisely positions the cartridge in relation to the support elements in the instrument (e.g., high-voltage, gas pressure, incident radiation and detector), and makes automated, reliable and secured alignments and connections between various components in the cartridge and the support elements in the supporting instrument. The interface mechanism comprises pneumatically or electromechanically driven actuators for engaging support elements in the instrument to components on the cartridge. After the cartridge has been securely received by the interface mechanism, the connection sequence is initiated. The interface provides separate high voltage and optical connections for each separation channel in the cartridge, thus providing channel-to-channel isolation from cross talk both electrically and optically.

    Abstract translation: 本发明提供了生物分离仪器中的接口机构，其使接口连接到多通道盒。 接口机构将盒相对于仪器中的支撑元件（例如，高压，气体压力，入射辐射和检测器）精确定位，并且使得盒中的各种部件之间的自动化，可靠和可靠的对准和连接 配套仪器中的支撑元件。 接口机构包括气动或机电驱动的致动器，用于将仪器中的支撑元件接合到盒上的部件。 在通过接口机构安全接收到盒式磁带后，启动连接顺序。 该接口为盒中的每个分离通道提供单独的高电压和光学连接，从而提供电气和光学上的串扰通道间通道隔离。

    Optical subassembly for in-and/or out-coupling of electromagnetic radiation into, and/or out of, a pressure-tight housing
    157.
    发明授权
    Optical subassembly for in-and/or out-coupling of electromagnetic radiation into, and/or out of, a pressure-tight housing 有权
    用于将电磁辐射进入和/或外耦合到和/或离开耐压外壳的光学子组件

    公开(公告)号：US08086081B2

    公开(公告)日：2011-12-27

    申请号：US12379391

    申请日：2009-02-20

    Applicant: Hakon Mikkelsen ,  Andreas Muller ,  Martin Hertel

    Inventor： Hakon Mikkelsen ,  Andreas Muller ,  Martin Hertel

    IPC: G02B6/26 ,  G02B6/42 ,  G02B6/00

    CPC classification number: G01N21/0317 ,  G01N21/552 ,  G01N2201/08 ,  G02B6/4428

    Abstract: An optical subassembly for in- and/or out-coupling of electromagnetic radiation of a predetermined wavelength, especially IR-radiation, into, and/or out of, a pressure-tight housing. The subassembly includes at least one housing wall section of the pressure-tight housing having at least one opening, wherein, in the opening, mechanical setting means are provided, with which a plug transparent for the electromagnetic radiation is set, wherein the transparent plug has two mutually oppositely lying, base surfaces and a cylindrical lateral surface, and wherein the setting means include as least one setting ring, characterized in the a volume region between at least a first section of the setting ring and at least a section of the cylindrical lateral surface is filled with a pressure-tight, potting compound.

    Abstract translation: 一种用于将预定波长的电磁辐射（特别是IR辐射）输入和/或耦合到和/或外耦合到压力密封外壳中的光学子组件。 所述子组件包括至少一个所述压力密封壳体的壳体壁部分，所述至少一个壳体壁部分具有至少一个开口，其中在所述开口中设置有机械设置装置，通过所述机械设置装置设置用于电磁辐射的透明塞，其中所述透明塞具有 两个相互相对放置的基部表面和圆柱形侧表面，并且其中所述设置装置包括至少一个固定环，其特征在于，所述设定环的至少第一部分和所述圆柱形侧面的至少一部分之间的体积区域 表面填充有压力密封的灌封料。

    SYSTEMS AND METHODS FOR ENDOSCOPIC ANGLE-RESOLVED LOW COHERENCE INTERFEROMETRY
    159.
    发明申请
    SYSTEMS AND METHODS FOR ENDOSCOPIC ANGLE-RESOLVED LOW COHERENCE INTERFEROMETRY 有权
    内镜角解决低相干干涉的系统与方法

    公开(公告)号：US20110157596A1

    公开(公告)日：2011-06-30

    申请号：US13042672

    申请日：2011-03-08

    Applicant: Adam Wax ,  John W. Pyhtila

    Inventor： Adam Wax ,  John W. Pyhtila

    IPC: G01J3/45 ,  G01B9/02

    CPC classification number: A61B5/0084 ,  A61B1/00165 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/0075 ,  G01B9/02043 ,  G01B9/02044 ,  G01B9/02084 ,  G01B9/02087 ,  G01B9/0209 ,  G01B9/02091 ,  G01J3/45 ,  G01N21/31 ,  G01N21/4795 ,  G01N2021/4704 ,  G01N2021/4709 ,  G01N2021/4735 ,  G01N2201/08

    Abstract: Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth-resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

    Abstract translation: 傅里叶域a / LCI（faLCI）系统和方法，使用单次扫描能够以快速的速率进行体内数据采集。 通过一次扫描获得角度分辨和深度分辨的光谱信息。 由于仅需要一次扫描，参考臂可以相对于样品保持固定。 参考信号和反射的采样信号以相对于样本的多个反射角度相互相关并分散，从而同时并行地表示来自样品上的多个点的反射。 可以通过大约40毫秒量级的一次扫描获得关于样本上多个不同点的每个样本的所有深度的信息。 从空间相互关联的参考信号，也可以使用允许从角度分辨数据获得散射体的尺寸信息的技术来获得结构（尺寸）信息。

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