公开(公告)号：US20150312968A1

公开(公告)日：2015-10-29

申请号：US14791964

申请日：2015-07-06

Applicant: Abbott Laboratories

Inventor： Brad Weston ,  Jeffrey Mitchell

IPC: H05B6/10 ,  H05B6/08 ,  A61L2/04

CPC classification number: A61L2/04 ,  A61L2202/17 ,  A61L2202/24 ,  B01L3/021 ,  B01L99/00 ,  B01L2200/141 ,  B08B3/04 ,  B08B7/00 ,  B08B7/0071 ,  B08B7/04 ,  H05B6/08 ,  H05B6/101 ,  H05B6/108

Abstract: Methods, systems, apparatus and machine readable media are disclosed to reduce biological carryover. An example method includes generating an alternating electromagnetic field and introducing an aspiration and dispense device into the electromagnetic field. The example method also includes inductively heating the aspiration and dispense device with the electromagnetic field to at least one of denature or deactivate at least one of a protein or a biological entity on a surface of the aspiration and dispense device.

Abstract translation: 公开了减少生物携带的方法，系统，装置和机器可读介质。 示例性方法包括产生交变电磁场并将抽吸和分配装置引入到电磁场中。 该示例性方法还包括将具有电磁场的抽吸和分配装置感应加热至在抽吸和分配装置的表面上变性或去活化蛋白质或生物实体中的至少一种。

公开(公告)号：US20150292990A1

公开(公告)日：2015-10-15

申请号：US14692508

申请日：2015-04-21

Applicant: Abbott Laboratories

Inventor： Abe S. Mamaghani ,  Koshy T. Chacko ,  Rupa Rao ,  Rene Nieves Alicea

IPC: G01N1/30

CPC classification number: G01N1/312 ,  G01N1/30 ,  G01N2001/302 ,  G01N2001/307 ,  Y10T436/2575

Abstract: The present disclosure provides methods for carrying out Romanowsky-type stains, specifically Wright-Giemsa and May-Grünwald stains, quickly and efficiently. The methods greatly reduce the overall amount of time required to complete a Wright-Giemsa stain or a May-Grünwald stain of sufficient quality on a biological sample. The subject methods can be applied to both manual and automated staining procedures.

Abstract translation: 本公开提供了用于快速有效地进行罗曼诺斯基型污渍的方法，特别是Wright-Giemsa和May-Grünwald污渍。 该方法大大减少了完成Wright-Giemsa染色或生物样品中足够质量的May-Grünwald染色所需的总体时间。 主题方法可以应用于手动和自动染色程序。

公开(公告)号：US09155535B2

公开(公告)日：2015-10-13

申请号：US13752095

申请日：2013-01-28

Applicant: Abbott Laboratories

Inventor： Scott A. McIntosh

IPC: A61B17/04 ,  A61B17/122 ,  A61B19/00 ,  A61B17/00

CPC classification number: A61B17/0469 ,  A61B17/0491 ,  A61B17/122 ,  A61B90/39 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00615 ,  A61B2017/0472 ,  A61B2017/0475 ,  A61B2017/0477

Abstract: In accordance with the present invention there is provided a suturing device. The suturing device includes a length of suture that will be delivered to the site of the PFO and placed through the tissue adjacent the opening to close the PFO. As described in greater detail below, the suture is advanced through the tissue surrounding the opening by a pair of needles that penetrate the tissue adjacent to the opening. A knot is then loosely tied with the length of suture and advanced to the site of the PFO. The tails of the suture extending from the knot are then cut and removed. It is also contemplated that a pre-formed or pre-tied knot may be disposed on the device, wherein after deployment of the suture through the tissue adjacent to the PFO and removal of the device a loop of suture having a pre-tied knot will remain, wherein the pre-tied knot may then be tightened to close the PFO. Further still it is contemplated that other means may be utilized to retain the sutures. For example, it is contemplated that a suture clip or other clip like device may be utilized to retain the suture in a position such that the PFO is closed.

Abstract translation: 根据本发明，提供了一种缝合装置。 缝合装置包括一段缝合线，其将被输送到PFO的位置并且通过靠近开口的组织放置以封闭PFO。 如下面更详细地描述的，缝合线通过穿过组织的开口相邻的一对针穿过开口周围的组织。 然后将结结与缝合长度松散地捆扎并且前进到PFO的部位。 然后将从结中延伸的缝合线的尾部切割并移除。 还可以设想，预先形成或预先束缚的结可以设置在该装置上，其中在将缝合线展开穿过与PFO相邻的组织并且移除该装置之后，具有预先束缚结的缝合线将会 保留，其中可以紧固预先束缚的结以关闭PFO。 此外，预期可以使用其它手段来保持缝合线。 例如，可以想到可以使用缝合夹或其他夹子类装置将缝合线保持在使得PFO闭合的位置。

公开(公告)号：US20150238447A1

公开(公告)日：2015-08-27

申请号：US14428535

申请日：2013-09-17

Applicant: ABBOTT LABORATORIES

Inventor： Shreeram Sathyavageeswaran ,  Rema Vazhappilly ,  Tapas Das ,  Richard Gelling

IPC: A61K31/19 ,  A23L2/52 ,  A61K47/36 ,  A23L1/305 ,  A61K47/42 ,  A61K47/44

CPC classification number: A61K31/19 ,  A23L2/52 ,  A23L33/10 ,  A23L33/115 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A23L33/40 ,  A61K47/36 ,  A61K47/42 ,  A61K47/44

Abstract: Disclosed are compositions, such as liquid and solid nutritional compositions, that contain beta-hydroxy-beta-methylbutyric acid and optionally at least one protein, carbohydrate, fat, or a combination of protein, carbohydrate, and fat. Also disclosed are methods of using the compositions for improving physical endurance, locomotion, mobility and cognition in an individual, including a pediatric individual.

Abstract translation: 公开了含有β-羟基-β-甲基丁酸和任选的至少一种蛋白质，碳水化合物，脂肪或蛋白质，碳水化合物和脂肪的组合的组合物，例如液体和固体营养组合物。 还公开了使用组合物来改善包括儿科个体在内的个体的身体耐力，运动，移动性和认知的方法。

公开(公告)号：US09101740B2

公开(公告)日：2015-08-11

申请号：US14200498

申请日：2014-03-07

Applicant: Abbott Laboratories

Inventor： Benjamyn Serna ,  Binh Nguyen

IPC: A61M31/00 ,  A61M25/10 ,  A61L29/08 ,  A61L29/16

CPC classification number: A61M25/1027 ,  A61L29/08 ,  A61L29/16 ,  A61M25/1029 ,  A61M2025/1031

Abstract: Device, system, method of coating an expandable member is provided. The method comprises providing an expandable member with a plurality of folds defined therein, the expandable member having a folded configuration and a fully expanded configuration at a rated nominal pressure. The expandable member is inflated to an initial pressure of from 10% to about 300% of nominal pressure. A therapeutic agent is disposed on at least a portion of the expandable member. The expandable member is partially deflated to an intermediate pressure by withdrawing an amount of inflation medium from the expandable member, and by applying an external force to the expandable member.

Abstract translation: 提供了一种涂覆可扩张部件的装置，系统，方法。 该方法包括提供具有限定在其中的多个折叠的可扩张构件，该可扩张构件具有折叠构型和在额定公称压力下的完全膨胀构型。 可膨胀构件膨胀至初始压力为标称压力的10％至约300％。 治疗剂设置在可扩张构件的至少一部分上。 可膨胀构件通过从可膨胀构件中抽出一定量的充气介质，并且通过向可膨胀构件施加外力而部分地放气到中间压力。

公开(公告)号：US20150208706A1

公开(公告)日：2015-07-30

申请号：US14421100

申请日：2013-08-13

Applicant: ABBOTT LABORATORIES

Inventor： Gaurav Patel ,  Isabela Balassiano Hahn ,  Ai-Mey Chuah ,  Chea Yun Se

IPC: A23L1/29 ,  A23L1/30

CPC classification number: A23L29/212 ,  A23L29/271 ,  A23L33/105 ,  A23L33/21 ,  A23L33/30 ,  A23V2002/00 ,  A23V2250/5034 ,  A23V2250/5118

Abstract: Disclosed are nutritional compositions comprising a dryblended mixture of a neat cereal beta-glucan and a resistant starch. The dryblending of the neat cereal beta-glucan and the resistant starch improves the cold water solubility of the nutritional compositions. The dryblended nutritional compositions may further include a Salacia extract.

Abstract translation: 公开了包含纯谷物β-葡聚糖和抗性淀粉的干混混合物的营养组合物。 纯谷物β-葡聚糖和抗性淀粉的干混改善了营养组合物的冷水溶解度。 干混合营养组合物还可包含Salacia提取物。

公开(公告)号：US20150196407A1

公开(公告)日：2015-07-16

申请号：US14665764

申请日：2015-03-23

Applicant: ABBOTT LABORATORIES VASCULAR ENTERPRISES LIMITED

Inventor： Ivonne HEUMANN ,  Anna Marie HAARMANN genannt THIEMANN ,  Simon HILDEBRAND

IPC: A61F2/966

CPC classification number: A61F2/966 ,  A61M25/005

Abstract: The invention relates to a catheter for delivery of a self-expanding stent into a body lumen, comprising a shaft having a distal end and a proximal end, the shaft defining a lumen and a stent accommodating portion at its outside for carrying a self-expanding stent, a catheter tip arranged at the distal end of the shaft, a sheath arranged concentrically to the shaft, a pusher coil arranged concentrically in between the shaft and the sheath, and proximal to the stent accommodating portion, wherein the sheath comprises an inside layer, an outside layer, and a wire layer of interwoven wires, the wire layer being arranged in between the inside layer and the outside layer.

Abstract translation: 本发明涉及一种用于将自扩张支架输送到体腔中的导管，包括具有远端和近端的轴，所述轴在其外部限定内腔和支架容纳部分，用于承载自扩张 支架，布置在轴的远端的导管尖端，与轴同心地布置的护套，同心地布置在轴和护套之间并且靠近支架容纳部分的推动器线圈，其中护套包括内层 ，外层和交织丝的线层，所述线层布置在所述内层和外层之间。

公开(公告)号：US20150164824A1

公开(公告)日：2015-06-18

申请号：US14421564

申请日：2013-08-14

Applicant: ABBOTT LABORATORIES

Inventor： Tapas Das ,  Bindya Jacob

IPC: A61K31/122 ,  A61K33/06 ,  A61K31/593 ,  A23L1/29 ,  A61K31/12

CPC classification number: A61K31/122 ,  A23L33/15 ,  A23L33/155 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/12 ,  A61K31/593 ,  A61K33/06 ,  A61K36/00 ,  A61K2300/00 ,  A23V2200/306 ,  A23V2250/2112 ,  A23V2250/7144

Abstract: Compositions for improving bone health, joint health, or both in an individual in need thereof are provided, along with methods of using the compositions. Generally, the compositions include a combination of Curcumin and Vitamin K2. The compositions may also include a protein, a carbohydrate, and a fat. The compositions and methods may be particularly useful in the treatment or prevention of osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, osteopenia, and osteoporosis.

Abstract translation: 提供了用于在有需要的个体中改善骨骼健康，关节健康或两者的组合物，以及使用组合物的方法。 通常，组合物包括姜黄素和维生素K2的组合。 组合物还可以包括蛋白质，碳水化合物和脂肪。 组合物和方法可以特别用于治疗或预防骨关节炎，类风湿性关节炎，系统性红斑狼疮，骨质减少症和骨质疏松症。

公开(公告)号：US20150132466A1

公开(公告)日：2015-05-14

申请号：US14600344

申请日：2015-01-20

Applicant: ABBOTT LABORATORIES

Inventor： CHRON-SI LAI ,  JOHN B. LASEKAN ,  GARY E. KATZ ,  CHRISTOPHER T. CORDLE

IPC: A23L1/29

CPC classification number: A61K31/05 ,  A23K20/158 ,  A23K50/30 ,  A23L33/12 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/00 ,  A61K31/20

Abstract: Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.

Abstract translation: 公开了营养配方，其包括可以对早产儿，婴儿，幼儿和儿童施用的预消化脂肪，用于改善营养物质的耐受性，消化和吸收以及降低坏死性小肠结肠炎，绞痛和短肠综合征的发生率。 预先消化的脂肪包括含脂肪酸的单甘油酯和/或脂肪酸组分。

公开(公告)号：US20150119319A1

公开(公告)日：2015-04-30

申请号：US14588805

申请日：2015-01-02

Applicant: Abbott Laboratories

Inventor： Keith F. McDaniel ,  Hui-Ju Chen ,  Ming Yeung ,  Timothy Middleton ,  Liangjun Lu ,  Kevin Kurtz

IPC: C07K5/02

CPC classification number: C07K5/02 ,  A61K38/00 ,  C07K5/0804 ,  C07K5/0827

Abstract: The present invention relates to novel fluorinated macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

Abstract translation: 本发明涉及新的氟化大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。