NONINVASIVE MEASUREMENT OF CAROTENOIDS IN BIOLOGICAL TISSUE
    162.
    发明申请
    NONINVASIVE MEASUREMENT OF CAROTENOIDS IN BIOLOGICAL TISSUE 有权
    生物组织中非生物活性测定

    公开(公告)号:US20090306521A1

    公开(公告)日:2009-12-10

    申请号:US12134667

    申请日:2008-06-06

    Abstract: A method and apparatus are provided for the determination of carotenoid antioxidants and similar chemical compounds in biological tissue such as living skin. The method and apparatus provide a noninvasive, rapid, accurate, and safe determination of carotenoid levels which in turn can provide diagnostic information of the antioxidant status of tissue. Reflection spectroscopy is used to measure the concentrations of carotenoids and similar substances in tissue. White light is directed upon the area of tissue that is of interest. A small fraction of diffusively scattered light is collected and measured. The tissue is pressured to temporarily squeeze blood out of the measured tissue volume while the reflection spectrum is continuously monitored, displayed, and analyzed in near real time. After an optimal time period of typically 15 seconds, the influence of the dominating hemoglobin and oxyhemoglobin tissue absorptions on the reflection spectra are minimized.

    Abstract translation: 提供了一种方法和装置,用于测定生物组织如活皮中的类胡萝卜素抗氧化剂和类似化合物。 该方法和装置提供无创,快速,准确和安全的类胡萝卜素水平的测定,这又可以提供组织的抗氧化状态的诊断信息。 反射光谱法用于测量组织中类胡萝卜素和类似物质的浓度。 白光指向感兴趣的组织区域。 收集并测量一小部分漫射散射光。 对组织进行加压以暂时将血液挤出测量的组织体积,同时连续监测,显示和近实时分析反射光谱。 在最佳时间段通常为15秒后,主要血红蛋白和氧合血红蛋白组织吸收对反射光谱的影响最小化。

    PORTABLE ANALYTICAL DEVICE
    163.
    发明申请
    PORTABLE ANALYTICAL DEVICE 有权
    便携式分析装置

    公开(公告)号:US20090304547A1

    公开(公告)日:2009-12-10

    申请号:US12158558

    申请日:2006-12-20

    Abstract: A portable analytical device is provided for analysis of a component of a body fluid. A measuring facility within the device may carry out the analysis on a test element inserted therein. The test element may contain a reagent that reacts with a liquid sample of the body fluid when the test element is contacted thereby to produce a change that is characteristic of the analysis. A processor may process measuring values determined by the measuring facility to yield analytical measuring data taking into account calibration values. A standardized, wire-based computer interface may be provided on the analytical device via which the analytical device can be operated by a computer, the analytical measuring data can be transmitted from the analytical device to the computer, the analytical device can be supplied with electrical power by the computer, and the analytical device can provide software to be read-out by the computer.

    Abstract translation: 提供便携式分析装置用于分析体液的组分。 设备内的测量设备可以对插入其中的测试元件进行分析。 当测试元件接触时,测试元件可以含有与体液的液体样品反应的试剂,从而产生作为分析特征的变化。 处理器可以处理由测量设备确定的测量值,以产生考虑校准值的分析测量数据。 可以在分析装置上提供标准化的基于线的计算机接口,通过该分析装置,分析装置可以由计算机操作,分析测量数据可以从分析装置传输到计算机,分析装置可以提供电 计算机的电源,分析设备可以提供由计算机读取的软件。

    FIBRE OPTIC SWEAT SENSOR
    164.
    发明申请
    FIBRE OPTIC SWEAT SENSOR 审中-公开
    光纤光纤传感器

    公开(公告)号:US20090269003A1

    公开(公告)日:2009-10-29

    申请号:US12310082

    申请日:2007-07-30

    Abstract: A sensor for sweat or other aqueous discharge onto skin comprises a plastic optical fibre comprising a core and cladding, said core being in intimate contact at a first end with a light emitter and at a second end with a light detector, and said fibre having a sensing zone in which the cladding is replaced by a water-permeable translucent biocompatible polymer containing dispersed therein a biocompatible indicator that varies the intensity of an optical signal at a selected wavelength depending on whether the indicator is wet or dry. Such a sensor permits real time monitoring of sweating or other discharge, and can also enable electronic recording and/or remote monitoring.

    Abstract translation: 用于汗水或其它水性排放到皮肤上的传感器包括包括芯和包层的塑料光纤,所述芯在第一端处与光发射器紧密接触,在第二端处与光检测器紧密接触,并且所述光纤具有 感测区域,其中包层由透水的半透明生物相容性聚合物代替,所述透水性半透明生物相容性聚合物包含分散在其中的生物相容性指示剂,其根据所述指示剂是湿的还是干的而改变选定波长的光信号的强度。 这种传感器可以实时监测出汗或其他放电,并且还可以实现电子记录和/或远程监控。

    STABLE PHOTO ACOUSTIC TRACE GAS DETECTOR WITH OPTICAL POWER ENHANCEMENT CAVITY
    165.
    发明申请
    STABLE PHOTO ACOUSTIC TRACE GAS DETECTOR WITH OPTICAL POWER ENHANCEMENT CAVITY 审中-公开
    具有光功率增强空间的稳定照片声学跟踪气体探测器

    公开(公告)号:US20090249861A1

    公开(公告)日:2009-10-08

    申请号:US12438571

    申请日:2007-08-31

    Abstract: A photo acoustic trace gas detector (100) is provided for detecting a concentration of a trace gas in a gas mixture. The photo acoustic trace gas detector (100) comprises a light source (101), an optical cavity (104a, 104b), ratio modulating means (105, 111) and a transducer (109). The optical cavity (104a, 104b) contains the gas mixture and amplifies light intensity. Maximum amplification is provided when a ratio of a wavelength of the light beam and a length of the optical cavity (104a, 104b) has a resonance value. Ratio modulating means (105, 111) modulate the ratio for transformation of the light beam into a series of light pulses for generating the sound waves, an amplitude of the sound waves being a measure of the concentration of the trace gas. A transducer (109) converts the sound waves into electrical signals.

    Abstract translation: 提供了一种用于检测气体混合物中痕量气体的浓度的光声气体检测器(100)。 光声气体检测器(100)包括光源(101),光腔(104a,104b),比率调制装置(105,111)和换能器(109)。 光腔(104a,104b)包含气体混合物并放大光强度。 当光束的波长与光腔(104a,104b)的长度的比率具有谐振值时,提供最大的放大。 比率调制装置(105,111)将用于将光束变换成用于产生声波的一系列光脉冲的比率进行调制,声波的幅度是痕量气体的浓度的量度。 换能器(109)将声波转换成电信号。

    Compact Raman or fluorescence excitation system
    166.
    发明授权
    Compact Raman or fluorescence excitation system 有权
    紧凑型拉曼或荧光激发系统

    公开(公告)号:US07573570B2

    公开(公告)日:2009-08-11

    申请号:US11894402

    申请日:2007-08-21

    Applicant: Jingyun Zhang

    Inventor: Jingyun Zhang

    Abstract: A compact Raman and fluorescence spectroscopy system that uses a microprism or micromirror based optical structure to accomplish the introduction of excitation radiation with compactness and simplified system configuration for portable or mobile spectroscopy applications. A microprism may be glued to a surface location of a focusing lens in the system to directly receive the illumination signal without intervening optical components. Alternatively, the microprism may be simply placed in close physical proximity of the focusing lens without being glued thereto. On the other hand, a micromirror may be used instead of the microprism. The illuminating photons received by the microprism or micromirror may be directly transferred to the sample under investigation via the focusing lens. The compact system may be made portable and may further include an on-board spectrometer with or without a display unit. For chemical detecting applications, a detector (e.g., a CCD array) may also be provided along with the spectrometer.

    Abstract translation: 一种紧凑的拉曼和荧光光谱系统,其使用基于微棱镜或微镜的光学结构来实现便携式或移动光谱应用的致密性和简化的系统配置的激发辐射的引入。 微棱镜可以胶合到系统中的聚焦透镜的表面位置,以直接接收照明信号而无需中间的光学部件。 或者,微棱镜可以简单地放置在聚焦透镜的紧密物理附近而不粘合到聚焦透镜上。 另一方面,可以使用微镜而不是微棱镜。 由微棱镜或微反射镜接收的照明光子可以通过聚焦透镜被直接转移到被研究的样品。 紧凑型系统可以是便携式的,并且还可以包括具有或不具有显示单元的车载光谱仪。 对于化学检测应用,也可以与光谱仪一起提供检测器(例如,CCD阵列)。

    Optical integrated nanospectrometer and method of manufacturing thereof
    167.
    发明申请
    Optical integrated nanospectrometer and method of manufacturing thereof 有权
    光学综合纳米光度计及其制造方法

    公开(公告)号:US20090195778A1

    公开(公告)日:2009-08-06

    申请号:US12012045

    申请日:2008-02-01

    Inventor: Vladimir Yankov

    Abstract: A planar nanospectrometer formed as a single chip that uses diffraction structures, which are combinations of numerous nano-features placed in a predetermined configuration and providing multiple functionalities such as guiding light, resonantly reflecting light at multiple wavelengths, directing light to detectors, and focusing light on the detectors. The diffraction structure can be described as a digital planar hologram that comprises an optimized combination of overlaid virtual sub-gratings, each of which is resonant to a single wavelength of light. Each device includes at least one sensor, at least one light source, and at least one digital planar hologram in an optical waveguide. The device of the present invention allows detection of small amounts of analytes in gases and liquids or on solid surfaces and can be particularly advantageous for field analysis of environmental safety in multiple locations because of its miniature size and low cost.

    Abstract translation: 形成为使用衍射结构的单个芯片的平面纳米光谱仪,其是以预定配置放置的许多纳米特征的组合,并且提供多个功能,例如引导光,共振地反射多个波长的光,将光引导到检测器,以及聚焦光 在探测器上。 衍射结构可以描述为数字平面全息图,其包括叠加的虚拟子光栅的优化组合,每个虚拟子光栅与单个波长的光共振。 每个装置在光波导中包括至少一个传感器,至少一个光源和至少一个数字平面全息图。 本发明的装置允许在气体和液体或固体表面上检测少量的分析物,并且由于其微型尺寸和低成本,可以特别有利于在多个位置的环境安全的现场分析。

    Detection of nitrates from tobacco for correlation with the amount of tobacco-specific nitrosamines within the tobacco
    168.
    发明授权
    Detection of nitrates from tobacco for correlation with the amount of tobacco-specific nitrosamines within the tobacco 有权
    检测烟草中的硝酸盐与烟草中烟草特异性亚硝胺的量的相关性

    公开(公告)号:US07538324B2

    公开(公告)日:2009-05-26

    申请号:US11902347

    申请日:2007-09-20

    Abstract: A system for detecting nitrates in a tobacco sample having a light source, and a detection device. The light source provides a beam of light incident to a tobacco sample, which is reflected from the tobacco sample to the detection device. A computing device computes the amount of nitrates within the tobacco sample based on data received from the detection device to correlate the amount of tobacco-specific nitrosamines within the tobacco sample.

    Abstract translation: 一种用于检测具有光源的烟草样品中的硝酸盐的系统和检测装置。 光源提供入射到烟草样品的光束,其从烟草样品反射到检测装置。 计算设备基于从检测装置接收的数据来计算烟草样品中的硝酸盐的量,以使烟草样品中烟草特异性亚硝胺的量相关。

    Portable acousto-optical spectrometers
    169.
    发明授权
    Portable acousto-optical spectrometers 有权
    便携式声光谱仪

    公开(公告)号:US07535617B2

    公开(公告)日:2009-05-19

    申请号:US11208123

    申请日:2005-08-18

    Abstract: A portable acousto-optical (AO) spectrometer system comprised of at least one AO crystal cell device specially designed for cancellation of side-lobe noise at a desired tuned wavelength of operation. Each AO crystal cell device has a transducer attached and forms an AO tunable filter (AOTF) and forms part of a photo-head assembly. The system can include an optical fiber link between the AO spectrometer photo-head assembly and additional features such as an optical alignment coupling attachment that couple an excitation source such as a laser that operates in either pulse or continuous mode, a probing fiber that provides a hand-held member that can emit a source radiation and in turn observe radiation reflected from an observed sample. There are two embodiment of the AO crystal cell device. Either embodiment of the AO crystal cell design can be used in the system, providing a vibration-insensitive AO spectrometer instrument having high sensitivity, accuracy and resolution capabilities. The types of spectroscopic measurements that can be performed using the invention include fluorescence, Raman, absorption and emission.

    Abstract translation: 一种便携式声光(AO)光谱仪系统,包括至少一个专门设计用于消除所需调谐波长工作波长的旁瓣噪声的AO晶体元件。 每个AO晶体元件都安装有传感器,并形成一个AO可调谐滤波器(AOTF),并形成光头组件的一部分。 该系统可以包括在AO光谱仪光头组件和附加特征之间的光纤链路,例如耦合诸如以脉冲或连续模式操作的激光器的激发源的光学对准耦合附件,提供 可以发射源辐射的手持构件,然后观察从观察到的样品反射的辐射。 AO晶体元件的两个实施例。 可以在系统中使用AO晶体设计的任一实施例,提供具有高灵敏度,精确度和分辨率能力的不振动的AO光谱仪器。 可以使用本发明进行的光谱测量的类型包括荧光,拉曼,吸收和发射。

    Pulsed terahertz spectrometer
    170.
    发明授权
    Pulsed terahertz spectrometer 有权
    脉冲太赫兹光谱仪

    公开(公告)号:US07535005B2

    公开(公告)日:2009-05-19

    申请号:US11669685

    申请日:2007-01-31

    Inventor: Joseph R. Demers

    CPC classification number: G01N21/3581 G01J3/42 G01N2201/0221

    Abstract: An apparatus for analyzing, identifying or imaging an object including a source of pulsed signals in the range of frequencies from 100 GHz to over 2 THz focused on the object; and a detector for acquiring spectral information from signals reflected from the object and using a heterodyning process to generate an electrical signal representative of some characteristics of the object. The source of pulse signals and the detector is a photoconductive switch activated by a pulsed laser beam.

    Abstract translation: 一种用于分析,识别或成像对象的装置,所述对象包括聚焦在所述对象上的从100GHz到超过2Hz的频率范围内的脉冲信号源; 以及检测器,用于从对象反射的信号中获取光谱信息,并使用外差处理来产生表示对象的某些特性的电信号。 脉冲信号源和检测器是由脉冲激光束激活的光导开关。

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