公开(公告)号：US09011773B2

公开(公告)日：2015-04-21

申请号：US13725763

申请日：2012-12-21

Applicant: Abbott Laboratories

Inventor： John Scott Shoffner ,  Koshy T. Chacko ,  Roei Solomon

IPC: G01N21/00 ,  B05C13/02 ,  G01N1/28 ,  G01N1/31 ,  G01N35/00

CPC classification number: G01N1/2813 ,  B05C13/02 ,  B05D3/007 ,  B60T15/00 ,  G01N1/312 ,  G01N35/00029 ,  G01N2035/00039 ,  G01N2035/00138 ,  Y10T436/2575

Abstract: An automated smear making apparatus used to prepare and smear samples on glass slides. In one embodiment, there is provided a smearing subsystem that generally includes a smear cartridge having: an input reel; at least one roll bar; a take-up reel; and a smearing tape. The smearing tape is initially wound within the input reel and coupled to the take-up reel such that the smearing tape can be drawn from the input reel and into the take-up reel. The smearing tape may include a plurality of perforations formed therein. The smearing tape may then be wrapped around the roll bar such that each of the plurality of perforations forms a blade that extends from the smearing tape to expose a smear surface as the smearing tape is drawn into the take-up reel. Alternatively, the smearing tape may be bent such that an edge of the smearing tape forms a smear surface between two roll bars. A slide transport surface is also provided to move a slide across the smear surface.

Abstract translation: 一种用于在玻片上制备和涂抹样品的自动涂片装置。 在一个实施例中，提供了一个拖放子系统，其通常包括拖尾盒，该拖尾盒具有：输入卷轴; 至少一个滚筒; 卷取卷轴 和一个涂胶带。 涂抹带最初卷绕在输入卷轴内并且联接到卷带盘上，使得涂抹带可以从输入卷轴拉出并进入收纸卷轴。 涂抹带可以包括形成在其中的多个穿孔。 然后，涂抹带可以缠绕在辊条周围，使得多个穿孔中的每一个形成从拖线带延伸的刀片，以在涂抹带被拉入卷取卷轴时暴露涂抹表面。 或者，涂抹带可以弯曲，使得涂抹带的边缘在两个辊条之间形成污迹表面。 还提供滑动输送表面以使滑块在涂片表面上移动。

公开(公告)号：US20150072378A1

公开(公告)日：2015-03-12

申请号：US14480466

申请日：2014-09-08

Applicant: Abbott Laboratories

Inventor： Hidesuke Kokawa

IPC: G01N1/16 ,  G01N33/49 ,  G01N1/38

CPC classification number: G01N33/492 ,  G01N1/38 ,  G01N35/00 ,  G01N2035/00356

Abstract: Provided are incubation systems for incubating samples for an assay. In certain aspects, the systems include a rotary platform, a sample container positioned at a peripheral edge of the platform, a plurality of activity sites including at least a first and a second activity site, a processor, and a memory that includes instructions. When executed by the processor, the instructions cause the system to rotate the rotary platform to move the sample container from the first activity site to the second activity site, extract a first portion of the sample from the sample container at the first activity site for a measurement based on a first incubation time period, and extract a second portion of the sample from the sample container at the second activity site for a measurement based on a second incubation time period, the second incubation time period being longer than the first incubation time period. Methods for incubating samples, e.g., methods which employ the systems of the present disclosure, are also provided.

Abstract translation: 提供用于孵育用于测定的样品的孵育系统。 在某些方面，系统包括旋转平台，位于平台周边边缘的样本容器，包括至少第一和第二活动场所的多个活动场所，处理器和包括指令的存储器。 当由处理器执行时，指令使系统旋转旋转平台以将样品容器从第一活动位置移动到第二活动位点，在第一活动位置从样品容器中提取样品的第一部分，用于 基于第一孵育时间进行测量，并且在第二活动部位从样品容器提取第二部分样品，以进行基于第二孵育时间段的测量，第二孵育时间段长于第一孵育时间段 。 还提供了用于孵育样品的方法，例如采用本公开的系统的方法。

公开(公告)号：US08951805B2

公开(公告)日：2015-02-10

申请号：US14247887

申请日：2014-04-08

Applicant: Abbott Laboratories

Inventor： Patrick P. Fritchie ,  Gregory E. Gardner ,  Richard W. Mahoney

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N1/28 ,  G01N35/10

CPC classification number: G01N35/1002 ,  G01N1/28 ,  G01N35/1009 ,  G01N35/1016 ,  G01N35/1065 ,  G01N35/1074 ,  G01N2035/1025 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: A system for managing bulk liquids for an automated clinical analyzer. The system comprises (a) at least one local reservoir for storing a bulk liquid for impending use, (b) at least one container for holding a bulk liquid before the liquid is transferred to a local reservoir, and (c) a controller for monitoring the level of a bulk liquid in a local reservoir. The local reservoir for storing a bulk liquid for impending use can be a trough. The use of troughs for storing a reagent, a diluent, or some other treating agent for impending use enables an aspirating/dispensing device having a plurality of pipettes to aspirate and dispense the reagent, diluent, or other treating agent at a high rate of throughput. The controller can monitor the level of a liquid in (a) a local reservoir for storing a bulk liquid for imminent use and the level of liquid in a (b) container for holding a bulk liquid before the liquid is transferred to a local reservoir. In the laboratory automation system described herein, the container for holding a bulk liquid before the liquid is transferred to a local reservoir can be a bottle. Other desirable features in the system include, but are not limited to, pump(s), valves, liquid level sensors.

Abstract translation: 用于管理自动化临床分析仪的散装液体的系统。 该系统包括（a）至少一个用于储存即将使用的散装液体的局部储存器，（b）至少一个用于在液体被转移到局部储存器之前保持散装液体的容器，以及（c）用于监测的控制器 局部水库中大量液体的水平。 用于储存即将使用的散装液体的局部储存罐可以是槽。 用于储存用于即将使用的试剂，稀释剂或一些其它处理剂的槽使得具有多个移液管的抽吸/分配装置可以以高生产率将吸入和分配试剂，稀释剂或其它处理剂 。 控制器可以监测（a）用于储存即将使用的散装液体的局部储存器中的液体的液面，以及（b）容器中用于保存大量液体的液体的液面，然后液体被转移到局部储存器。 在本文所述的实验室自动化系统中，在将液体转移到局部储存器之前用于保持散装液体的容器可以是瓶子。 该系统中的其它期望特征包括但不限于泵，阀，液位传感器。

公开(公告)号：US20150031645A1

公开(公告)日：2015-01-29

申请号：US14456221

申请日：2014-08-11

Applicant: ABBOTT LABORATORIES

Inventor： RACHAEL BUCK ,  GERALYN O. DUSKA-MCEWEN ,  STEVEN R. DAVIS

IPC: A61K31/702 ,  A61K31/05 ,  A23C9/20

CPC classification number: A61K31/702 ,  A23C9/206 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/05 ,  A61K31/716 ,  A61K2300/00 ,  A23V2200/324 ,  A23V2250/282

Abstract: Disclosed are nutritional compositions including human milk oligosaccharides that can be administered to preterm infants, term infants, toddlers, and children for improving airway defense mechanisms.

Abstract translation: 公开了营养组合物，其包括可以对早产儿，婴儿，幼儿和儿童施用的人乳寡糖，以改善气道防御机制。

公开(公告)号：US20140352409A1

公开(公告)日：2014-12-04

申请号：US14363999

申请日：2013-01-03

Applicant: ABBOTT LABORATORIES

Inventor： Kenneth William Botterbrodt ,  David Carl Ulstad

IPC: G01M3/40 ,  G01M3/16 ,  G01M3/02

CPC classification number: G01M3/40 ,  G01M3/02 ,  G01M3/16 ,  G01M3/187

Abstract: A device for detecting leaks or weaknesses in a flexible package. The device includes a first member having a non-conductive surface, a second member secured in a position adjacent the first member, and a control system. The second member has an electrically conductive first portion and an electrically conductive second portion. The electrically conductive first portion of the second member is normally electrically insulated from the electrically conductive second portion of the second member. The control system is arranged to detect an electrical current between the electrically conductive first portion and the electrically conductive second portion. The second member may be positioned relative the first member to compress a flexible package between the first member and the second member.

Abstract translation: 用于检测柔性包装中的泄漏或弱点的装置。 该装置包括具有非导电表面的第一构件，固定在与第一构件相邻的位置的第二构件和控制系统。 第二构件具有导电的第一部分和导电的第二部分。 第二构件的导电的第一部分通常与第二构件的导电的第二部分电绝缘。 控制系统被布置成检测导电的第一部分和导电的第二部分之间的电流。 第二构件可以相对于第一构件定位，以在第一构件和第二构件之间压缩柔性包装。

公开(公告)号：US20140335258A1

公开(公告)日：2014-11-13

申请号：US14362532

申请日：2012-12-03

Applicant: ABBOTT LABORATORIES

Inventor： Mustafa Vurma ,  Gul Konuklar

IPC: A23L1/29 ,  A23L1/035

CPC classification number: A23L29/212 ,  A23L2/52 ,  A23L5/00 ,  A23L21/00 ,  A23L29/10 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23L33/40 ,  A23V2002/00

Abstract: Disclosed are stabilized nutritional compositions having a stabilizer system including starch, or a combination of starch and maltotriose, and methods for manufacturing the compositions. The retrogradation effect commonly seen with starch stabilizers is substantially reduced or even eliminated in the disclosed nutritional compositions.

Abstract translation: 公开了具有包括淀粉或淀粉和麦芽三糖的组合的稳定剂体系的稳定的营养组合物以及制备组合物的方法。 在所公开的营养组合物中，淀粉稳定剂常见的退化效应显着降低甚至消除。

公开(公告)号：US20140324157A1

公开(公告)日：2014-10-30

申请号：US14323658

申请日：2014-07-03

Applicant: Abbott Laboratories Vascular Enterprises Limited

Inventor： Joost J. Fierens ,  Silvio R. Schaffner ,  Marc Gianotti ,  Gerd Seibold ,  Randolf von Oepen

IPC: A61F2/856 ,  A61F2/82

CPC classification number: A61F2/07 ,  A61F2/82 ,  A61F2/856 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/0086 ,  A61F2002/91508 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005

Abstract: Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.

Abstract translation: 提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。 提供优选的支架设计，以及优选的制造技术。 还提供了用于血管分支的装置和方法。 此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。 预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。

公开(公告)号：US20140308393A1

公开(公告)日：2014-10-16

申请号：US14364115

申请日：2012-12-14

Applicant: ABBOTT LABORATORIES

Inventor： Barbara J. Marriage ,  Christine L. Gallardo

IPC: A23L1/29 ,  A23L1/305

CPC classification number: A23L33/19 ,  A23L33/40 ,  A61K35/20 ,  A61K38/018

Abstract: The present disclosure is directed to nutrition systems including at least a first and a second reduced calorie infant formula having varying whey to casein protein weight ratios for reducing inflammation-related diseases later in life. Particularly, the nutrition systems may be administered to a newborn infant to reduce the risk of obesity later in life.

Abstract translation: 本公开涉及营养系统，其包括至少第一和第二低卡路里婴儿配方，其具有改变的酪蛋白乳清与酪蛋白重量比，以减少生命后期的炎症相关疾病。 特别地，营养系统可以施用于新生儿以降低生命后期的肥胖风险。

公开(公告)号：US08857645B2

公开(公告)日：2014-10-14

申请号：US13892052

申请日：2013-05-10

Applicant: Abbott Laboratories

Inventor： James P. Perry ,  Craig A. McCardell ,  Jeremy McBroom ,  David Compeau ,  Ashley A. Gohlke ,  William J. Hook ,  Katherine J. Jordan ,  Frank S. Walczak ,  Peter B. Clarke ,  J. Kevin Clay ,  Richard C. Darr ,  Jack E. Elder ,  Marc A. Pedmo ,  Charles R. Schotthoefer

IPC: B65D51/18 ,  B65D51/24 ,  B65B7/28 ,  B65D53/00 ,  B65D21/02 ,  B65B3/04

CPC classification number: B65D51/24 ,  B65B3/04 ,  B65B7/28 ,  B65D17/501 ,  B65D17/502 ,  B65D21/02 ,  B65D21/0209 ,  B65D43/0235 ,  B65D43/163 ,  B65D51/20 ,  B65D53/00 ,  B65D55/02 ,  B65D2251/0021 ,  B65D2251/0028 ,  B65D2251/009 ,  B65D2251/0093

Abstract: A container (210) for holding granular or powdered material and formed by a top wall (212), a bottom wall (214), a front wall (216), a rear wall (218), a first side wall (220), and a second side wall (222). A rotatably removable lid (D) is interiorly mounted with a scoop (32) and is pivotally hinged to a collar (300) that includes a sealing gasket (330). The collar (300) mounts to the walls of the container (210). A sealing wall 240 of the lid (D) cooperates with the gasket 300 to prevent the contents from spilling. The container (210) incorporates powder control features, a container wall junction (50) preferred geometry and congruent scoop (32) enabling convenient access to the contents, a tolerance variation accommodating and strength improving, J-shaped collar (300) and interlocking indentations (290) and flex clips (310), and a pressure controlling portion (350) that prevents unwanted deformation due to pressure differentials.

Abstract translation: 用于保持颗粒或粉末材料并由顶壁（212），底壁（214），前壁（216），后壁（218），第一侧壁（220）形成的容器（210） 和第二侧壁（222）。 可旋转地拆卸的盖（D）内部安装有勺（32），并且枢转地铰接到包括密封垫圈（330）的套环（300）。 套环（300）安装到容器（210）的壁上。 盖（D）的密封壁240与垫圈300配合以防止内容物溢出。 容器（210）包含粉末控制特征，容器壁结（50）优选的几何形状和一致的勺子（32），能够方便地接近内容物，容差变化容纳和强度改善，J形领（300）和互锁凹痕 （290）和挠性夹子（310）以及防止由于压差引起的不必要变形的压力控制部分（350）。

公开(公告)号：US20140287532A1

公开(公告)日：2014-09-25

申请号：US14295116

申请日：2014-06-03

Applicant: Abbott Laboratories

Inventor： Toru Yoshimura ,  Kenju Fujita ,  Barry L. Dowell

IPC: G01N33/53

CPC classification number: G01N33/5306 ,  G01N33/57423 ,  G01N33/86 ,  G01N2333/5758

Abstract: To provide a more convenient and more accurate method of assaying ProGRP by improving the stability of ProGRP which is known to be unstable in a biological sample.By using a blood sample in a condition in which a blood coagulation factor is not activated is used as a sample, the degradation of ProGRP is suppressed, whereby it is possible to store a sample for a long period of time and to improve the accuracy of an assay.

Abstract translation: 通过提高已知在生物样品中不稳定的ProGRP的稳定性来提供更方便和更准确的测定ProGRP的方法。 通过使用血液凝固因子未活化的状态下的血液样品作为样品，可以抑制ProGRP的降解，能够长时间存储样品，提高准确度 一个测定。