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171.发明申请公开(公告)号：US20220054710A1
公开(公告)日：2022-02-24
申请号：US17465102
申请日：2021-09-02
Applicant: Worcester Polytechnic Institute
Inventor： Jeannine Coburn , Glenn Gaudette , Nhi Phan
Abstract: Provided herein are enzymatically decellularized cells, and methods of producing said cells, that can be used in a scaffold. The scaffolds featured herein are biocompatible and can comprise decellularized cells that have been modified to express a bioactive agent or molecule.
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公开(公告)号：US11249100B2
公开(公告)日：2022-02-15
申请号：US16240720
申请日：2019-01-05
Applicant: Worcester Polytechnic Institute
Inventor： Dirk Albrecht , Ross Lagoy
Abstract: Systems and methods for delivering fluid to a microfluidic device is provided. The system includes a multi-well plate having a plurality of wells and an inlet tube having a first end being in communication with the one or more wells of the multi-well plate and a second end being in communication with a microfluidic device. The first end of the inlet tube is moveable between the plurality of wells of the multi-well plate to deliver fluid to the microfluidic device from the plurality of wells of the multi-well plate.
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公开(公告)号：US11248995B2
公开(公告)日：2022-02-15
申请号：US16129581
申请日：2018-09-12
Applicant: Worcester Polytechnic Institute
Inventor： Dirk Albrecht , Ross Lagoy , Kyra Burnett
IPC: G01N1/30 , G01N1/44 , G01N1/36 , G01N21/64 , G01N33/483
Abstract: Devices and methods for capturing and imaging a specimen, such as a living organism, are disclosed. In some embodiments, a method for imaging a living organism in vivo includes placing at least one specimen into a hydrogel polymer on a substrate, and curing the hydrogel to embed the at least one specimen within the cured hydrogel such that the at least one specimen is kept alive and the movement of the at least one specimen within the cured hydrogel is restricted. The at least one embedded specimen can be imaged.
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公开(公告)号：US20210372001A1
公开(公告)日：2021-12-02
申请号：US17330922
申请日：2021-05-26
Applicant: Worcester Polytechnic Institute
Inventor： Yan Wang , Xiaotu MA , Eric Gratz , Jinzhao Fu , Panawan Vanaphuti
Abstract: A recycling and synthesis of charge material for secondary batteries generates single-crystal charge materials for producing batteries with greater charge cycle longevity. Charge material particles undergo a heating for fusing or enhancing grain boundaries between polycrystalline particles. The resulting, more well-defined grain boundaries are easily etched by a relatively weak mineral acid solution. The acid solution removes material at the grain boundaries to separate secondary particles into primary particles along the grain boundaries. The resulting single crystal (monocrystalline) charge material particles are washed and filtered, and typically re-sintered to accommodate any needed lithium (lithium carbonate), and result in a charge material with larger surface area, higher lithium diffusivity and lower cation ordering.
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公开(公告)号：US20210171931A1
公开(公告)日：2021-06-10
申请号：US16931967
申请日：2020-07-17
Applicant: Worcester Polytechnic Institute
Inventor： Amy Peterson , Marsha Rolle , Ivan Ding
Abstract: Device, and methods of using or making the device, for engineering cells in vitro are disclosed. In some aspects, a cell culture device comprises at least one glass or polymer surface configured for incubating cells in a culture medium; a charged molecule electrostatically bound to the surface; and a polyelectrolyte multilayer (PEM) electrostatically bound to the charged molecule, the PEM comprising one or more bi-layers of oppositely charged polyelectrolytes, and the PEM having a sufficient thickness to permit release of the charged molecule into the culture medium in a controlled released manner.
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Patent Agency Ranking
公开(公告)号：US20210127783A1
公开(公告)日：2021-05-06
申请号：US17094978
申请日：2020-11-11
Applicant: Worcester Polytechnic Institute
Inventor： Christopher A. Brown , Tristin J. Carlton , Eric Motler , Douglas Rives , Austin Lindner , Joshua M. Herlands , Jessica K.Y. Chen , Lorenzo M. Dube , James J. Muller , Pedro D. Oporto , Olivia G. Steen , Andrew R. Vickery
Abstract: A protective headgear device, or helmet, protects against head injuries such as concussions and CTE by imposing a network of constant force members (CFMs) between an outer impact shell and an inner fitted capsule engaging the skull/head surface. CFMs exhibit a force absorbing behavior that differs from conventional linear spring behavior that impose a counterforce proportional to the displaced distance. CFMs occupy a compact void between the outer impact shell and the inner fitted capsule by component miniaturization and tethers that redirect forces within the void. An absence of conventional foam and straps increases accommodation for the CFMs and connection tethers/attachments. The CFMs exhibit a substantially constant force that avoids a sharp impactful response associated with head injuries.
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公开(公告)号：US10953432B2
公开(公告)日：2021-03-23
申请号：US16000154
申请日：2018-06-05
Applicant: Worcester Polytechnic Institute
Inventor： Pratap Rao
Abstract: A superhydrophobic surface is formed by growing a plurality of etchable, sacrificial structures, and depositing a discontinuous hydrophobic material onto the sacrificial structures. The discontinuity facilitates etching of the sacrificial structures to remove the grown structures while leaving the deposited material intact to result in surface features for achieving superior hydrophobic properties.
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公开(公告)号：US10952888B2
公开(公告)日：2021-03-23
申请号：US16014386
申请日：2018-06-21
Applicant: Worcester Polytechnic Institute
Inventor： Marko Popovic , Saivimal Sridar , Corey Majeika , Nicholas Deisadze , Erika Giancarlo
Abstract: Variable stiffness devices and methods of their use are provided. In some embodiments, a variable stiffness device comprises an inner member defining a compartment for receiving an actuating fluid; an outer member disposed around the inner member; and a granular medium disposed between the inner member and the outer member; wherein the inner member is being moveable in a radial direction from a relaxed state to an expanded state by introducing the actuating fluid into the compartment of the inner member to compress the granular medium against the outer member to increase the stiffness of the device.
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公开(公告)号：US10949965B2
公开(公告)日：2021-03-16
申请号：US16004547
申请日：2018-06-11
Applicant: WORCESTER POLYTECHNIC INSTITUTE
Inventor： Peder C. Pedersen , Diane M. Strong , Emmanuel Agu , Bengisu Tulu , Lei Wang , Qian He , Raymond M Dunn
Abstract: The wound assessing method and system provide a convenient, quantitative mechanism for diabetic foot ulcer assessment.
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公开(公告)号：US10888138B2
公开(公告)日：2021-01-12
申请号：US15675989
申请日：2017-08-14
Applicant: Worcester Polytechnic Institute
Inventor： Christopher A. Brown , Nicholas Workman , Michael Doyle , Jessica Shelsky , Jessica K. Y. Cheu , Lorenzo M. Dube , James J. Muller , Pedro D. Oporto , Olivia G. Steen , Andrew R. Vickery
Abstract: An impact absorbing footwear device employs opposed planar sole portions engaged by a selective resistance coupling that biases the opposed planar sole portions in a non-linear manner in response to forces exerted by the wearer against the sole portion in frictional contact with a floor surface. The planar sole portions are disposed in a footwear appliance that takes the form of an athletic shoe sole. The selective resistance coupling includes a plurality of resilient deformation members that engage the planar sole portions in an opposed circumferentially aligned manner, selectively deform in response to pressure exerted by the wearer for preventing ACL and other impact related injuries, and recover to an undeformed rest position without breakaway to allow the wearer uninterrupted usage while dampening forces that surpass an injury threshold from the resilient deformation that allows the planar sole portions to temporarily misalign.
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