公开(公告)号：US20120330115A1

公开(公告)日：2012-12-27

申请号：US13423029

申请日：2012-03-16

Applicant: James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: A61B5/157

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

公开(公告)号：US20120184451A1

公开(公告)日：2012-07-19

申请号：US13309852

申请日：2011-12-02

Applicant: Srikanth Singamaneni ,  Evan Kharasch ,  Jeremiah Morrissey ,  Chang Hee Lee

Inventor： Srikanth Singamaneni ,  Evan Kharasch ,  Jeremiah Morrissey ,  Chang Hee Lee

IPC: G01N21/55 ,  C40B30/04 ,  C40B40/00 ,  C40B40/18 ,  B82Y15/00

CPC classification number: G01N33/54346 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y20/00 ,  B82Y40/00 ,  G01N21/554 ,  G01N21/658 ,  G01N33/54373 ,  G01N33/57438 ,  G01N2201/02

Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.

Abstract translation: 用于特定蛋白质的天然和/或合成抗体粘附到纳米颗粒上。 将纳米颗粒粘附到底物上，将底物暴露于可含有特定蛋白质的样品。 然后用表面增强拉曼散射技术和/或局部表面等离子体共振技术测试底物以量化样品中特定蛋白质的量。

公开(公告)号：US08197770B2

公开(公告)日：2012-06-12

申请号：US12359874

申请日：2009-01-26

Applicant: Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: B01L3/00

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  G06F19/00 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: A fluid handling module is configured for removable engagement with a reusable main fluid handling instrument. The module includes a module housing and a first fluid passageway extending from the module housing. The first fluid passageway has a patient end remote from the housing. The first fluid passageway is configured to provide fluid communication with a bodily fluid in a patient. A fluid component separator is in fluid communication with the first fluid passageway. The fluid component separator is configured to separate at least one component from a portion of the bodily fluid drawn from the patient. A spectroscopic sample cell is configured to hold at least a portion of the first component.

Abstract translation: 流体处理模块被配置为可移除地与可重复使用的主流体处理装置接合。 模块包括模块壳体和从模块壳体延伸的第一流体通道。 第一流体通道具有远离壳体的患者端。 第一流体通道被配置为提供与患者体内的体液的流体连通。 流体组分分离器与第一流体通道流体连通。 流体组分分离器构造成将至少一种组分与从患者抽出的体液的一部分分离。 光谱样品池被配置为保持第一组分的至少一部分。

公开(公告)号：US08139207B2

公开(公告)日：2012-03-20

申请号：US13210347

申请日：2011-08-15

Applicant: James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: G01N33/48

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

公开(公告)号：US20110300619A1

公开(公告)日：2011-12-08

申请号：US13210347

申请日：2011-08-15

Applicant: James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: C12M1/34

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

公开(公告)号：US20110256551A1

公开(公告)日：2011-10-20

申请号：US13088102

申请日：2011-04-15

Applicant: Vincent Linder ,  David Steinmiller ,  Jason Taylor

Inventor： Vincent Linder ,  David Steinmiller ,  Jason Taylor

IPC: G01N33/53 ,  C12M1/34

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.

Abstract translation: 描述了用于分析样品的系统和方法，并且在某些实施方案中，被配置为接收包含样品的盒以执行样品分析的微流体样品分析器。 微流体样品分析仪可用于控制各种微流体系统（如微流体点护理诊断平台）中的流体流动，混合和样品分析。 有利地，在一些实施例中，与常规台式系统相比，微流体样品分析仪可能是便宜的，尺寸减小并且使用简单。 还描述了可以与样品分析仪一起操作的盒。

公开(公告)号：US20110253224A1

公开(公告)日：2011-10-20

申请号：US13088112

申请日：2011-04-15

Applicant: Vincent Linder ,  David Steinmiller

Inventor： Vincent Linder ,  David Steinmiller

IPC: F17D3/00

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.

Abstract translation: 通常描述用于控制微流体系统中的流体的系统和方法。 在一些实施例中，流体的控制涉及使用来自在微流体系统中发生的一个或多个过程或事件的反馈。 例如，检测器可以在微流体系统的测量区域处检测一种或多种流体，并且可以对应于流体产生一个或多个信号或信号模式。 在某些情况下，信号的信号或图案可以对应于强度，持续时间，在时间上或相对于另一进程相对于第二位置的时间位置和/或事件之间的平均时间段。 使用该数据，控制系统可以确定是否调制微流体系统中随后的流体流动。 在一些实施方案中，这些和其它方法可用于进行质量控制以确定微流体系统的操作异常。

公开(公告)号：US08011133B2

公开(公告)日：2011-09-06

申请号：US11823140

申请日：2007-06-27

Applicant: Adda Sayers ,  Dean M. Tranel ,  Travis A. Hanselman ,  Stephen D. Strachan

Inventor： Adda Sayers ,  Dean M. Tranel ,  Travis A. Hanselman ,  Stephen D. Strachan

IPC: A01B79/00 ,  A01B79/02 ,  A01C1/00 ,  A01G1/00 ,  A01H3/00

CPC classification number: G01N21/17 ,  A01G7/00 ,  G01N1/4077 ,  G01N15/06 ,  G01N15/10 ,  G01N15/1463 ,  G01N33/0098 ,  G01N2021/1765 ,  G01N2201/02 ,  G01N2201/125 ,  G06K9/00134 ,  G06Q99/00

Abstract: An apparatus and method of quantitatively obtaining a measurement of pollen of a plant. One method of counting comprises imaging the sample with the pollen well-distributed in the focal plane of the imager. Image evaluation software can identify and count objects in the image that are consistent with pollen. Total pollen count for the plant can be derived from the count of pollen of the sample, proportionality of the sample volume to the starting volume, and proportionality of area of sample imaged to total area of sample. Pollen quantification can be used for research or commercial production decisions relative to the plant or its seed.

Abstract translation: 一种定量获得植物花粉测量的装置和方法。 一种计数方法包括用分布在成像器的焦平面中的花粉成像样品。 图像评估软件可以识别和计数与花粉一致的图像中的对象。 植物的总花粉计数可以从样品的花粉计数，样品体积与起始体积的比例以及样品的面积与样品总面积的比例来得出。 花粉量化可用于相对于植物或其种子的研究或商业生产决策。

公开(公告)号：US07907985B2

公开(公告)日：2011-03-15

申请号：US11316676

申请日：2005-12-21

Applicant: Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/00 ,  A61M1/00 ,  G01N35/00 ,  G01N9/30

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  G06F19/00 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.

Abstract translation: 提供了可移除地与体液分析器接合的流体处理模块。 模块可以包括流体处理元件和流体部件分离器，其可经由流体处理元件接近并且被配置为分离输送到流体组分分离器的体液的至少一个组分。 流体处理元件可以具有至少一个控制元件接口。

公开(公告)号：US20110057117A1

公开(公告)日：2011-03-10

申请号：US12841725

申请日：2010-07-22

Applicant: Adrian Fawcett ,  David Tracy ,  Kevin Daley Simmons

Inventor： Adrian Fawcett ,  David Tracy ,  Kevin Daley Simmons

IPC: G01J1/58 ,  F21S4/00 ,  F21V5/00 ,  F21V9/16

CPC classification number: G01N21/6486 ,  B01L7/52 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2300/1805 ,  G01N21/0332 ,  G01N21/6452 ,  G01N2021/0367 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/02 ,  G01N2201/062 ,  G01N2201/0626 ,  G01N2201/0627 ,  G01N2201/0636

Abstract: Optical systems, and corresponding methods, for multiple reactions are provided. The optical systems are in a fixed position relative to a thermal assembly and include at least one array of excitation sources (e.g., light emitting diodes (LEDs)) configured to output excitation energy along an excitation optical path. In addition, a detector configured to receive emission energy along a detection optical path in the same plane as the excitation optical path is also provided.

Abstract translation: 提供了多种反应的光学系统和相应的方法。 光学系统相对于热组件处于固定位置，并且包括被配置为沿着激发光路输出激发能量的至少一组激励源（例如，发光二极管（LED））。 此外，还提供了被配置为沿着与激励光路相同的平面中的检测光路接收发射能量的检测器。