公开(公告)号：US20170030874A1

公开(公告)日：2017-02-02

申请号：US15294877

申请日：2016-10-17

Applicant: VUV Analytics, Inc.

Inventor： Dale A. Harrison ,  Anthony T. Hayes ,  Phillip Walsh

IPC: G01N30/78 ,  G01N21/33

CPC classification number: G01N30/78 ,  G01J3/02 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/15 ,  G01N21/33 ,  G01N30/02 ,  G01N30/74 ,  G01N33/0004 ,  G01N33/0027 ,  G01N2021/0325 ,  G01N2021/151 ,  G01N2021/158 ,  G01N2021/335 ,  G01N2030/025 ,  G01N2030/027 ,  G01N2201/024 ,  G01N2201/0633 ,  G01N2201/12 ,  G01N30/7266

Abstract: An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples. Vacuum ultra-violet wavelengths may be utilized. Some of the disclosed techniques can be used for detecting the presence of trace concentrations of gaseous species. A preferable gas flow cell is disclosed. Some of the disclosed techniques may be used with a gas chromatography system so as to detect and identify species eluted from the column. Some of the disclosed techniques may be used in conjunction with an electrospray interface and a liquid chromatography system so as to detect and identify gas phase ions of macromolecules produced from solution. Some of the disclosed techniques may be used to characterize chemical reactions. Some of the disclosed techniques may be used in conjunction with an ultra short-path length sample cell to measure liquids.

公开(公告)号：US09534951B2

公开(公告)日：2017-01-03

申请号：US14426590

申请日：2013-09-05

Applicant: JENOPTIK Polymer Systems GmbH ,  Roche Diagnostics Operations, Inc.

Inventor： Jan Buchwald ,  Susanne Gaumitz ,  Stefan Kalveram ,  Sebastian Trick

IPC: H01L25/16 ,  G01J1/04 ,  G01N21/47 ,  G02B5/20 ,  H01L31/167 ,  C23C14/22 ,  G01J1/42

CPC classification number: G01J1/0411 ,  C23C14/22 ,  C23C14/221 ,  G01J1/42 ,  G01N21/474 ,  G01N2201/0633 ,  G02B5/20 ,  H01L25/167 ,  H01L31/167 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A measuring module for remission photometric analysis of one or a plurality of specimens is provided with the following features: a transmitter with a transmission channel for transmitting a measuring radiation to location of the specimen; a first focusing device for focusing the measuring radiation on the specimen; a receiver with a receiving channel to receive the radiation reflected by the specimen; a second focusing device made of plastic for focusing the measuring radiation reflected by the specimen onto the receiver, whereby the second focusing device further comprises a filter which is designed to filter a fluorescence radiation from the specimen excited by the measuring radiation.

Abstract translation: 一个或多个样本的光度测量分析测量模块具有以下特征：具有传输通道的发射器，用于将测量辐射传输到试样的位置; 用于将测量辐射聚焦在样本上的第一聚焦装置; 接收器，具有用于接收由样本反射的辐射的接收通道; 由塑料制成的第二聚焦装置，用于将由样品反射的测量辐射聚焦到接收器上，由此第二聚焦装置还包括被设计成过滤来自由测量辐射激发的样品的荧光辐射的滤光器。

公开(公告)号：US20160356720A1

公开(公告)日：2016-12-08

申请号：US15119055

申请日：2015-02-28

Applicant: Imec VZW

Inventor： Pol VAN DORPE ,  Peter PEUMANS

IPC: G01N21/65 ,  A61B5/00 ,  A61B5/1455 ,  G01N33/49 ,  A61B5/145

CPC classification number: G01N21/65 ,  A61B5/0066 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/443 ,  A61B2562/0233 ,  A61B2562/0238 ,  G01J1/0204 ,  G01J1/0425 ,  G01J1/0477 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0227 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0291 ,  G01J3/1895 ,  G01J3/26 ,  G01J3/36 ,  G01J3/44 ,  G01J2003/1213 ,  G01N33/49 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/0636 ,  G02B6/0026 ,  G02B6/0031 ,  G02B6/0038 ,  G02B6/0048

Abstract: The present disclosure relates to systems, methods, and sensors configured to characterize a radiation beam. At least one embodiment relates to an optical system. The optical system includes an optical radiation guiding system. The optical radiation guiding system includes a collimator configured to collimate the radiation beam into a collimated radiation beam. The optical radiation guiding system also includes a beam shaper configured to distribute power of the collimated radiation beam over a discrete number of line shaped fields. A spectrum of the collimated radiation beam entering the beam shaper is delivered to each of the discrete number of line shaped fields. The optical system further includes a spectrometer chip. The spectrometer chip is configured to process the spectrum of the collimated radiation beam in each of the discrete number of line shaped fields coming from the beam shaper.

Abstract translation: 本公开涉及被配置为表征辐射束的系统，方法和传感器。 至少一个实施例涉及光学系统。 光学系统包括光学辐射引导系统。 光辐射引导系统包括准直器，其被配置成将辐射束准直成准直的辐射束。 光学辐射引导系统还包括光束整形器，其被配置为分布在离散数量的线状场上的准直辐射束的功率。 进入光束整形器的准直辐射束的光谱被传送到离散数量的线状场中的每一个。 光学系统还包括光谱仪芯片。 光谱仪芯片被配置为处理来自光束整形器的离散数量的线状场中的每一个中的准直辐射束的光谱。

公开(公告)号：US09506866B2

公开(公告)日：2016-11-29

申请号：US13960387

申请日：2013-08-06

Applicant: POCARED DIAGNOSTICS LTD.

Inventor： Gal Ingber ,  William G. Atterbury ,  Dave Holley ,  John S. Laudo ,  Jason A. Schaefer ,  Sherwood Talbert ,  John Tallarico ,  Thomas A. Klausing

IPC: G01N21/64 ,  G01N21/03 ,  G01N35/02 ,  B01L3/00 ,  C12M1/34 ,  G01N35/00 ,  G01N35/04

CPC classification number: G01N21/6486 ,  B01L3/5085 ,  B01L3/50851 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2300/0609 ,  B01L2300/0809 ,  B01L2300/0851 ,  B01L2300/12 ,  B01L2300/168 ,  B01L2300/1844 ,  C12M41/36 ,  G01N21/0303 ,  G01N21/0332 ,  G01N35/026 ,  G01N2021/0382 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6482 ,  G01N2035/00346 ,  G01N2035/0429 ,  G01N2035/0449 ,  G01N2201/0633

Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.

公开(公告)号：US20160327479A1

公开(公告)日：2016-11-10

申请号：US14703616

申请日：2015-05-04

Applicant: SpectraSensors, Inc.

Inventor： Alfred Feitisch ,  Peter Dorn ,  James Tedesco ,  Xiang Liu

IPC: G01N21/39 ,  G01J3/02

CPC classification number: G01N21/39 ,  G01J3/0208 ,  G01N21/031 ,  G01N21/3504 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/0633

Abstract: A spectrometer includes a light source configured to emit a beam along a beam path through a sample volume comprising an analyte. Also included is at least one detector positioned to detect at least a portion of the beam emitted by the light source, and at least one reflector positioned along the beam path intermediate the light source and the at least one detector having a surface roughness greater than a predefined level such as 20 Å RMS.

Abstract translation: 光谱仪包括被配置为沿着光束路径发射通过包含分析物的样品体积的光束的光源。 还包括至少一个检测器，其被定位成检测由光源发射的光束的至少一部分，以及沿光束路径定位的至少一个反射器，其位于光源之间，并且至少一个检测器具有大于 预定义的水平，例如20？RMS。

公开(公告)号：US20160305926A1

公开(公告)日：2016-10-20

申请号：US15087601

申请日：2016-03-31

Applicant: SamanTree Medical SA

Inventor： Bastien Rachet ,  Davor Kosanic ,  Etienne Shaffer

IPC: G01N33/483 ,  G01N21/64 ,  G02B21/16

CPC classification number: G01N21/77 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/4833 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2021/7786 ,  G01N2201/0633 ,  G01N2201/068 ,  G02B21/0012 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/0044 ,  G02B21/0076 ,  G02B21/0088 ,  G02B21/16 ,  G02B21/24 ,  G02B21/26 ,  G02B21/34 ,  G02B21/361

Abstract: The disclosed technology brings histopathology into the operating theatre, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theatre, “optical slices” of fresh tissue—without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin “optical section” of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.

公开(公告)号：US20160238827A1

公开(公告)日：2016-08-18

申请号：US14380392

申请日：2013-02-22

Applicant: The U.S.A. of America, as represented by The Secretary, Dept. of Health and Human Services

Inventor： Hari Shroff ,  Andrew York

IPC: G02B21/00 ,  G01N21/64

CPC classification number: G02B21/0072 ,  G01N21/6458 ,  G01N2021/6478 ,  G01N2201/0633 ,  G02B21/0032 ,  G02B21/0036 ,  G02B21/004 ,  G02B21/0076

Abstract: A multi-focal selective illumination microscopy (SIM) system for generating multi-focal patterns of a sample is disclosed. The multi-focal SIM system performs a focusing, scaling and summing operation on each multi-focal pattern in a sequence of multi-focal patterns that completely scan the sample to produce a high resolution composite image.

Abstract translation: 公开了一种用于产生样品的多焦点图案的多焦点选择性照明显微镜（SIM）系统。 多焦点SIM卡系统以完全扫描样本以产生高分辨率合成图像的多焦点图案序列对每个多焦点图案进行聚焦，缩放和求和操作。

公开(公告)号：US09410882B2

公开(公告)日：2016-08-09

申请号：US14890428

申请日：2013-05-13

Applicant: HACH LANGE GMBH

Inventor： Barbara Haase ,  Manfred Battefeld ,  Andreas Mitreiter ,  Michael Kussmann ,  Bas De Heij ,  Clemens Hanschke ,  Wayne Perdue

IPC: G01N21/00 ,  G01N21/51

CPC classification number: G01N21/51 ,  G01N21/53 ,  G01N2021/513 ,  G01N2201/0633 ,  G01N2201/0636

Abstract: A turbidimeter for measuring a turbidity of a liquid sample in a sample cuvette includes a cuvette receiving device configured to position the sample cuvette in a defined cuvette position, a light source configured to generate a parallel light beam in the sample cuvette, an annular 45° collecting mirror configured to surround the sample cuvette, a scattering body arranged concentric to the annular 45° collecting mirror, a scattering light detector arranged to receive light scattered by the scattering body, and an annular 45° concentration mirror arranged coaxially to the annular 45° collecting mirror and optically opposite to the annular 45° collecting mirror. The annular 45° collecting mirror is arranged concentric to the light beam. The annular 45° concentration mirror is configured to surround the scattering body.

Abstract translation: 用于测量样品比色皿中的液体样品的浊度的浊度计包括配置成将样品比色皿定位在规定的比色杯位置的比色皿接收装置，被配置为在样品比色皿中产生平行光束的光源，环形45° 收集镜，被配置为围绕样品比色皿，与环形45°收集镜同心设置的散射体，布置成接收由散射体散射的光的散射光检测器和与环状45°同轴设置的环形45°浓度反射镜 收集反射镜并与环形45°收集镜光学相对。 环形45°收集镜与光束同心设置。 环形45°浓度反射镜被配置为围绕散射体。

公开(公告)号：US20160108471A1

公开(公告)日：2016-04-21

申请号：US14894634

申请日：2014-04-17

Applicant: OPTOELETTRONICA ITALIA S.R.L.

Inventor： Alfredo MAGLIONE ,  Cristina RESS

IPC: C12Q1/68 ,  G01N21/63 ,  G01N21/77

CPC classification number: C12Q1/6876 ,  C12Q1/6825 ,  C12Q2600/178 ,  G01N21/63 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/77 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/0633

Abstract: A kit for detecting a micro-RNA of interest in at least one sample (C) extracted from a body fluid, including: at least one device (2) including a housing casing (2a) in which at least one housing seat (2b) is obtained for said at least one sample (C), and at least one opening (2c) through which said housing seat (2b) is accessible from the outside; at least one container means (3) for said at least one sample (C), said at least one container means (3) being insertable/disconnectable in/from said housing seat (2b) through said at least one opening (2c); at least one optical excitation group (5), housed in said housing casing (2a), designed to emit at least one excitation light radiation (λ,λ1) towards said at least one housing seat (2b); at least one detection group (6), designed to detect at least one emission light radiation (λ2), that can be generated, in use, by said at least one sample (C), said at least one sample (C) being optically excitable by said at least one excitation light radiation (λ, λ1) emitted by said at least one optical excitation group (5), said at least one detection group (6) being designed to supply at least one electric output signal (SO-signal output) correlated with the quantity, in said at least one sample (C), of said micro-RNA of interest; at least one processing unit (7) designed to receive and process said at least one electric signal (SO) and to output an index correlated with the quantity of said micro-RNA of interest in said at least one sample (C); said at least one container means (3) being made of a material permeable to said at least one excitation light radiation (λ, λ1) and to said at least one emission light radiation (λ2); said at least one group (6) for detecting said emission light radiation (λ2) comprises at least one sensor means (6a) of silicon photomultiplier type.

公开(公告)号：US20160070947A1

公开(公告)日：2016-03-10

申请号：US14787048

申请日：2013-04-30

Applicant: GLORY LTD.

Inventor： Akira BOGAKI ,  Takahiro YANAGIUCHI ,  Takaaki MORIMOTO ,  Satoru OSHIMA

IPC: G06K9/00 ,  G01N21/59 ,  G01N21/55 ,  G07D7/12

CPC classification number: G06K9/00013 ,  G01N21/55 ,  G01N21/59 ,  G01N2201/061 ,  G01N2201/0633 ,  G07D7/12 ,  G07D7/121

Abstract: Light is emitted on one side of a paper sheet 100, which is being transported on a transport path, from a first light source 11, and light is emitted on other side of the paper sheet 100 from a second light source 21 and a fourth light source 22. A first light receiving sensor 14 receives a first reflected light, which is the light emitted by the first light source 11 and reflected from the one side of the paper sheet 100. A second light receiving sensor 24 receives a second reflected light, which is the light emitted by the second light source 21 and the fourth light source 22 and reflected from the other side of the paper sheet 100, and receives a transmitted light that is the light emitted by the first light source 11 and that has passed through the paper sheet 100. With this, satisfactory reflection image and transmission image of the paper sheet can be acquired while realizing the downsizing of the device.

Abstract translation: 光从第一光源11在传送路径上被传送的纸张100的一侧发射，并且光从第二光源21和第四光发射到纸张100的另一侧 第一光接收传感器14接收第一反射光，第一反射光是由第一光源11发射并从纸张100的一侧反射的光。第二光接收传感器24接收第二反射光， 其是由第二光源21和第四光源22发射并从纸张100的另一侧反射的光，并且接收作为由第一光源11发射并已经通过的光的透射光 由此，可以在实现装置的小型化的同时获得良好的反射图像和纸张的透射图像。