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    MEASURING APPARATUS AND SPECIMEN INFORMATION OBTAINING SYSTEM
    171.
    发明申请
    MEASURING APPARATUS AND SPECIMEN INFORMATION OBTAINING SYSTEM 审中-公开
    测量装置和样本信息获取系统

    公开(公告)号：US20140367579A1

    公开(公告)日：2014-12-18

    申请号：US14301479

    申请日：2014-06-11

    Applicant: CANON KABUSHIKI KAISHA

    Inventor： Yoichi Otsuka

    IPC: G01N21/17 ,  G01J1/42

    CPC classification number: G01N21/17 ,  G01J3/18 ,  G01N21/65 ,  G01N2021/1734 ,  G01N2201/10

    Abstract: A measurement apparatus includes a first light source unit configured to emit a first light having a first wavelength, and a scanning unit configured to move an irradiation position of the first light with respect to a specimen, so as to scan the specimen with the first light. The first light source unit includes a wavelength changing unit configured to change the first wavelength. Movement of the irradiation position is performed by the scanning unit while the wavelength changing unit is changing the first wavelength. A changing cycle of the first wavelength by the wavelength changing unit is shorter than a position moving cycle by the scanning unit.

    Abstract translation: 测量装置包括：第一光源单元，被配置为发射具有第一波长的第一光;以及扫描单元，被配置为移动相对于样本的第一光的照射位置，以便用第一光扫描样本 。 第一光源单元包括被配置为改变第一波长的波长改变单元。 当波长改变单元改变第一波长时，由扫描单元执行照射位置的移动。 波长改变单元的第一波长的变化周期比扫描单元的位置移动周期短。

    NON-SURGICAL METHOD OF TREATMENT FOR CATARACT
    173.
    发明申请
    NON-SURGICAL METHOD OF TREATMENT FOR CATARACT 有权
    非手术治疗方法

    公开(公告)号：US20140031327A1

    公开(公告)日：2014-01-30

    申请号：US13944477

    申请日：2013-07-17

    Applicant: REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Jason E. Gestwicki

    IPC: C07J9/00 ,  C12Q1/34 ,  G01N33/68

    CPC classification number: A61K31/575 ,  A61K9/0048 ,  A61K31/045 ,  A61K47/6951 ,  B82Y5/00 ,  C07J9/00 ,  C12Q1/34 ,  G01N21/6428 ,  G01N33/68 ,  G01N2201/10 ,  G01N2333/4709 ,  G01N2500/20

    Abstract: The invention provides inhibitors of α-crystallin aggregation and methods of using α-crystallin aggregation inhibitors to, e.g., treat or prevent cataracts in a subject having or at risk of developing cataracts. The invention further provides high throughput methods of screening compounds for modulation of protein thermal stability, the method comprising contacting a protein with each of a plurality of test compounds; and (b) measuring the melting transition (Tm) of the protein in the presence of each of the plurality of test compounds, wherein a compound that decreases or increases the apparent Tm by at least 2 standard deviations is identified as a pharmacological protein chaperone.

    Abstract translation: 本发明提供α-晶状体蛋白聚集的抑制剂和使用α-晶状蛋白聚集抑制剂的方法，例如治疗或预防具有或有发生白内障危险的受试者的白内障。 本发明进一步提供筛选化合物用于调节蛋白质热稳定性的高通量方法，所述方法包括使蛋白质与多种测试化合物中的每一种接触; 在（b）测定在多种测试化合物中存在的蛋白质的熔融转变（Tm），其中将表观Tm降低或增加至少2个标准偏差的化合物被鉴定为药理学蛋白质分子伴侣。

    Laser confocal microarray scanner
    175.
    发明授权
    Laser confocal microarray scanner 有权
    激光共焦微阵列扫描仪

    公开(公告)号：US07615758B2

    公开(公告)日：2009-11-10

    申请号：US11795660

    申请日：2005-06-02

    Applicant: Xianhua Wang ,  Hui Xu ,  Jianxin Ye ,  Yelei Sun ,  Guoliang Huang ,  Jing Cheng

    Inventor： Xianhua Wang ,  Hui Xu ,  Jianxin Ye ,  Yelei Sun ,  Guoliang Huang ,  Jing Cheng

    IPC: F21V9/16

    CPC classification number: G01N21/6458 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6421 ,  G01N2201/10 ,  G01N2201/103

    Abstract: The invention provides a laser microarray scanner for microarray scanning, comprising an optical system, a scanning platform, and a data processing system. During scanning, the optical system remains fixed, and the microarray placed on the scanning platform moves relative to the optical system. The microarray scanner disclosed herein has high scanning speed, high sensitivity, high resolution, and high signal-to-noise ratio, thus is ideal for use in microarray scanning

    Abstract translation: 本发明提供一种用于微阵列扫描的激光微阵列扫描器，包括光学系统，扫描平台和数据处理系统。 在扫描期间，光学系统保持固定，并且放置在扫描平台上的微阵列相对于光学系统移动。 本文公开的微阵列扫描器具有高扫描速度，高灵敏度，高分辨率和高信噪比，因此是理想的用于微阵列扫描

    High speed laser scanning inspection system
    176.
    发明授权
    High speed laser scanning inspection system 有权
    高速激光扫描检测系统

    公开(公告)号：US07589835B2

    公开(公告)日：2009-09-15

    申请号：US12099705

    申请日：2008-04-08

    Applicant: Daniel Some

    Inventor： Daniel Some

    IPC: G01N21/00

    CPC classification number: G01N21/9501 ,  G01N2021/479 ,  G01N2021/8825 ,  G01N2021/95676 ,  G01N2201/10 ,  G01N2201/104

    Abstract: An optical inspection system rapidly evaluates a substrate by illumination of an area of a substrate larger than a diffraction-limited spot using a coherent laser beam by breaking temporal or spatial coherence. Picosecond or femtosecond pulses from a modelocked laser source are split into a plurality of spatially separated beamlets that are temporally and/or frequency dispersed, and then focused onto a plurality of spots on the substrate. Adjacent spots, which can overlap by up to about 60-70 percent, are illuminated at different times, or at different frequencies, and do not produce mutually interfering coherence effects. Bright-field and dark-field detection schemes are used in various combinations in different embodiments of the system.

    Abstract translation: 光学检查系统通过打破时间或空间相干性，通过使用相干激光束照射大于衍射受限点的基板的面积来快速评估基板。 来自锁模激光源的皮秒或飞秒脉冲被分割成时间上和/或频率分散的多个空间上分离的子束，然后聚焦到衬底上的多个点上。 可以重叠高达约60-70％的相邻斑点在不同的时间或不同的频率被照亮，并且不产生相互干扰的相干效应。 在系统的不同实施例中，明场和暗场检测方案以各种组合使用。

    HIGH SPEED LASER SCANNING INSPECTION SYSTEM
    177.
    发明申请
    HIGH SPEED LASER SCANNING INSPECTION SYSTEM 有权
    高速激光扫描检测系统

    公开(公告)号：US20080212081A1

    公开(公告)日：2008-09-04

    申请号：US12099705

    申请日：2008-04-08

    Applicant: Daniel Some

    Inventor： Daniel Some

    IPC: G01N21/00 ,  G02B27/10 ,  G01N21/55 ,  G01J3/00 ,  G01N21/47 ,  G02B5/122

    CPC classification number: G01N21/9501 ,  G01N2021/479 ,  G01N2021/8825 ,  G01N2021/95676 ,  G01N2201/10 ,  G01N2201/104

    Abstract: An optical inspection system rapidly evaluates a substrate by illumination of an area of a substrate larger than a diffraction-limited spot using a coherent laser beam by breaking temporal or spatial coherence. Picosecond or femtosecond pulses from a modelocked laser source are split into a plurality of spatially separated beamlets that are temporally and/or frequency dispersed, and then focused onto a plurality of spots on the substrate. Adjacent spots, which can overlap by up to about 60-70 percent, are illuminated at different times, or at different frequencies, and do not produce mutually interfering coherence effects. Bright-field and dark-field detection schemes are used in various combinations in different embodiments of the system.

    Abstract translation: 光学检查系统通过打破时间或空间相干性，通过使用相干激光束照射大于衍射受限点的基板的面积来快速评估基板。 来自锁模激光源的皮秒或飞秒脉冲被分割成时间上和/或频率分散的多个空间上分离的子束，然后聚焦到衬底上的多个点上。 可以重叠高达约60-70％的相邻斑点在不同的时间或不同的频率被照亮，并且不产生相互干扰的相干效应。 在系统的不同实施例中，明场和暗场检测方案以各种组合使用。

    Heating element for a rotating multiplex fluorescence detection device
    179.
    发明申请
    Heating element for a rotating multiplex fluorescence detection device 审中-公开
    用于旋转多重荧光检测装置的加热元件

    公开(公告)号：US20070009382A1

    公开(公告)日：2007-01-11

    申请号：US11174691

    申请日：2005-07-05

    Applicant: William Bedingham ,  Peter Ludowise ,  Barry Robole

    Inventor： William Bedingham ,  Peter Ludowise ,  Barry Robole

    IPC: G01N35/00

    CPC classification number: G01N21/645 ,  B01L3/5027 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0806 ,  B01L2300/1805 ,  B01L2300/1844 ,  B01L2300/1872 ,  G01N21/07 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/0407 ,  G01N2201/08 ,  G01N2201/10 ,  G01N2201/101

    Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. The device further includes a heating element for heating one or more process chambers on the disk. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.

    Abstract translation: 描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。 例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。 检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。 该装置还包括多个可移除的光学模块，其被光学配置为激发物种并捕获由不同波长的物质发射的荧光。 耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。 该装置还包括用于加热盘上的一个或多个处理室的加热元件。 此外，该装置可以通过利用激光加热阀来定位和选择性地打开阀分离腔来控制盘中的流体流动。

    High speed laser scanning inspection system
    180.
    发明申请
    High speed laser scanning inspection system 有权

    公开(公告)号：US20060132758A1

    公开(公告)日：2006-06-22

    申请号：US11317156

    申请日：2005-12-22

    Applicant: Daniel Some

    Inventor： Daniel Some

    IPC: G01N21/88

    CPC classification number: G01N21/9501 ,  G01N2021/479 ,  G01N2021/8825 ,  G01N2021/95676 ,  G01N2201/10 ,  G01N2201/104

    Abstract: An optical inspection system rapidly evaluates a substrate by illumination of an area of a substrate larger than a diffraction-limited spot using a coherent laser beam by breaking temporal or spatial coherence. Picosecond or femtosecond pulses from a modelocked laser source are split into a plurality of spatially separated beamlets that are temporally and/or frequency dispersed, and then focused onto a plurality of spots on the substrate. Adjacent spots, which can overlap by up to about 60-70 percent, are illuminated at different times, or at different frequencies, and do not produce mutually interfering coherence effects. Bright-field and dark-field detection schemes are used in various combinations in different embodiments of the system.

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