公开(公告)号：US10654907B2

公开(公告)日：2020-05-19

申请号：US15111639

申请日：2015-01-28

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Naoto Hirano ,  Munehide Nakatsugawa ,  Toshiki Ochi

IPC: C07K14/725 ,  C12N15/10 ,  C12N5/078

Abstract: Provided is a method for determining a TCR polypeptide chain that can form a TCR specific for a peptide of interest. Also provided are methods and compositions for producing a cell expressing a T cell receptor (TCR) specific for a peptide of interest, methods and compositions for producing a TCR chain nucleic acid and/or pair of TCR chain polypeptides and/or nucleic acids encoding a TCR, a cell population comprising the cell harboring the nucleic acids encoding a TCR obtained by said method, and a method for treating a disorder comprising administering to the subject said cell population.

公开(公告)号：US10570143B2

公开(公告)日：2020-02-25

申请号：US16155846

申请日：2018-10-09

Applicant: University Health Network

Inventor： Yong Liu ,  Heinz W. Pauls ,  Radoslaw Laufer ,  Sze-Wan Li ,  Peter Brent Sampson ,  Miklos Feher ,  Grace Ng ,  Narendra Kumar B. Patel ,  Yunhui Lang

IPC: C07D487/04 ,  C07D519/00

Abstract: The present teachings provide a compound represented by structural formula (1-0), or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20200038457A1

公开(公告)日：2020-02-06

申请号：US16357529

申请日：2019-03-19

Applicant: University Health Network

Inventor： Jeffrey A. MEDIN ,  Christopher J. PAIGE

IPC: A61K35/545 ,  A61K38/20 ,  C12N15/86 ,  A61K48/00 ,  A61K39/00 ,  C07K14/54 ,  C12N7/00

Abstract: Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as leukemia.

公开(公告)号：US10517937B2

公开(公告)日：2019-12-31

申请号：US15503916

申请日：2015-08-17

Applicant: University Health Network

Inventor： Li Zhang ,  Jong Bok Lee ,  Branson Chen

IPC: A61K35/17 ,  A61K39/00 ,  A61K31/7068

Abstract: Methods for the treatment of cancer using double negative (DN) T cells are described. The DNTs may be used for the treatment of chemotherapy-resistant cancers such as recurring or relapsing acute myeloid leukemia (AML). The use of allogenic DNTs, such as those derived from healthy donors, that do not exhibit toxicity towards normal host tissues and the complications associated with graft-versus-host-disease, is also described.

公开(公告)号：US10506969B2

公开(公告)日：2019-12-17

申请号：US15169524

申请日：2016-05-31

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Azadeh Yadollahi ,  Frank Rudzicz ,  Shumit Saha

IPC: A61B5/00 ,  A61B5/08 ,  A61B5/11 ,  A61B7/00

Abstract: Described are various embodiments of an acoustic upper airway assessment system and method, and sleep apnea assessment system and method relying thereon. In one embodiment, a non-invasive method is described for assessing upper airway anatomy in a subject while breathing. This method comprises receiving as input at a hardware processor a digital signal representative of respiratory sounds generated by the subject while breathing; isolating digital respiratory sound segments from said digital signal; computationally extracting a designated spectral feature from each of said segments to characterize said respiratory sounds within each of said segments; automatically evaluating each said extracted spectral feature against a preset upper airway anatomy metric associated with said designated spectral feature to characterize a given upper airway anatomy measure in the subject while breathing; and outputting a sleep apnea severity indication based on said characterized upper airway anatomy measure.

公开(公告)号：US20190350968A1

公开(公告)日：2019-11-21

申请号：US16525428

申请日：2019-07-29

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： William Mark Erwin

IPC: A61K31/737 ,  C08L5/08 ,  C07K14/475 ,  A61K47/38 ,  A61K47/36 ,  A61K47/26 ,  A61K47/20 ,  A61K9/00 ,  A61P19/02 ,  C07K14/495 ,  C07H5/06 ,  A61K31/7008 ,  A61K9/08 ,  C07H3/02 ,  A61K38/18

Abstract: There is disclosed herein compositions, methods, uses and systems for reducing pain in a patient that emanates from a body area, preferably spine or joint. Methods of treatment or prevention are described for a disease or condition selected from degenerative disc disease, disc injury, pain, arthritis, or suspected arthritis.

公开(公告)号：US10464999B2

公开(公告)日：2019-11-05

申请号：US15201423

申请日：2016-07-02

Applicant: PROTHENA BIOSCIENCES LIMITED ,  UNIVERSITY HEALTH NETWORK

Inventor： Yue Liu ,  Tarlochan S. Nijjar ,  Avijit Chakrabartty ,  Jeffrey N. Higaki

IPC: G01N33/38 ,  A61K39/00 ,  C07K16/46 ,  C07K16/18 ,  A61K51/10

Abstract: The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.

公开(公告)号：US20190292193A1

公开(公告)日：2019-09-26

申请号：US16318426

申请日：2017-07-13

Applicant: University Health Network

Inventor： Sze-Wan Li ,  Heinz W. Pauls ,  Peter Brent Sampson

IPC: C07D487/04

Abstract: The present invention relates to a novel co-crystal of the compound of formula (I): (Formula (I)) wherein the co-former molecule is bisphosphate hemihydrate, to processes for the preparation of the co-crystal, to pharmaceutical compositions containing the co-crystal, to the use of such a co-crystal in the manufacture of a medicament for use in the treatment of cancer and to methods of treating such diseases in the human or animal body by administering a therapeutically effective amount of such a co-crystal.

公开(公告)号：US10407915B2

公开(公告)日：2019-09-10

申请号：US15452646

申请日：2017-03-07

Applicant: University Health Network

Inventor： Andrew John Hart ,  Geoffrey Roy Fernie ,  T. Daniel Smyth ,  Victoria P. Komisar ,  Emily Catherine King ,  Peter George Murray

IPC: E04F11/18 ,  F16B7/04 ,  E04H17/14 ,  E05B65/00 ,  E04F10/00 ,  E06B11/02 ,  E04G7/02

Abstract: A locking member for a gate apparatus comprises a body mountable to a gripping array of a support, said body having a mating form mutually engageable with the gripping array, whereby axial motion of said body relative to said gripping array is inhibited. A member extends away from said body, said member defining a cross-tie mount for receiving a mating end of a cross-tie. The cross-tie mount has a cross-tie end retainer which is movable between a first position securing said cross-tie in said cross-tie mount, and a second position permitting release of said cross-tie from said cross-tie mount, whereby the cross-tie may be moved to function as a gate.

公开(公告)号：US10362956B2

公开(公告)日：2019-07-30

申请号：US15677711

申请日：2017-08-15

Applicant: University Health Network

Inventor： Vijay Singh Chauhan ,  Rupin Haily Dalvi

IPC: A61B5/04 ,  A61B5/046 ,  A61B18/14 ,  A61B5/00 ,  A61B18/00 ,  A61B5/042

Abstract: Various embodiments are described herein for detecting a rotor at a location of a heart that experiences cardiac fibrillation. This generally involves obtaining a plurality of bipolar EGMs for a recording duration using a circular bipolar electrode array positioned at the location of the heart; detecting a dominant periodicity Cycle Length (CL) and identifying periodic activations for each bipolar EGM associated with the dominant periodicity CL; tracking the identified periodic activations across each bipolar EGM to define rotational activations and determining when a path taken by the tracked rotational activations corresponds to a rotational activation pattern of a rotor; and detecting the rotor when a number and completeness of the tracked rotational activations meet predefined rotor criteria.