公开(公告)号：US20100216208A1

公开(公告)日：2010-08-26

申请号：US12659277

申请日：2010-03-02

Applicant: Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Harris Rosenbaum

Inventor： Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Harris Rosenbaum

IPC: C12N13/00 ,  C12M1/00

CPC classification number: G03H1/0005 ,  A61L2/08 ,  B01D21/0009 ,  B01D21/01 ,  B01D21/262 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0864 ,  B01L2400/0454 ,  B03C1/00 ,  B03C1/002 ,  B03C1/288 ,  B03C5/005 ,  B04B13/00 ,  G01N15/0205 ,  G01N21/6486 ,  G01N27/447 ,  G01N27/44756 ,  G01N33/487 ,  G01N33/5091 ,  G01N2015/0053 ,  G01N2201/061 ,  G01N2458/00 ,  G02B21/32 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/085 ,  G03H2225/32 ,  G21K5/08 ,  H05H3/04

Abstract: The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

Abstract translation: 本发明提供了一种用于分离血液和其他类型的细胞组分的方法，装置和系统，并且可以与全息光学捕获操作或其他形式的光学镊子组合。 示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。 然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。 全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。

公开(公告)号：US20100201978A1

公开(公告)日：2010-08-12

申请号：US12450402

申请日：2008-03-24

Applicant: Masaru Hori ,  Hiroyuki Kano ,  Shoji Den

Inventor： Masaru Hori ,  Hiroyuki Kano ,  Shoji Den

IPC: G01N21/31

CPC classification number: H05H1/0025 ,  G01N21/15 ,  G01N21/3103 ,  G01N2021/158 ,  G01N2201/023 ,  G01N2201/0233 ,  G01N2201/061

Abstract: To provide a light source which realizes accurate determination of the particle density of a plasma atmosphere without disturbing the state of the plasma atmosphere.The light source of the invention includes a tubular casing 12; a cooling medium passage 30 for causing a cooling medium to flow therethrough, the passage being provided along the inner wall of the casing; a lens 50 provided at a tip end of the casing; a first electrode 44 and a second electrode 45 which are provided in the casing and before the lens so as to be vertical to the axis of the casing and parallel to each other; and an insulating spacer 46 provided between the first electrode and the second electrode. The light source further includes a hole 47 axially penetrating the center portions of the first electrode, the insulating spacer, and the second electrode; and an electric discharge gas passage for introducing an electric discharge gas, along the inner wall of the cooling medium passage, to the back surface of the lens so that the electric discharge gas is reflected by the lens and flows through the hole.

Abstract translation: 提供一种实现等离子体气氛的粒子密度的精确测定而不干扰等离子体气氛的状态的光源。 本发明的光源包括管状壳体12; 用于使冷却介质流过其中的冷却介质通道30，所述通道沿着所述壳体的内壁设置; 设置在所述壳体的前端的透镜50; 第一电极44和第二电极45，其设置在壳体内并且在透镜之前垂直于壳体的轴线并且彼此平行; 以及设置在第一电极和第二电极之间的绝缘间隔件46。 光源还包括轴向穿过第一电极，绝缘间隔物和第二电极的中心部分的孔47; 以及放电气体通道，用于沿着冷却介质通道的内壁将放电气体引导到透镜的背面，使得放电气体被透镜反射并流过孔。

公开(公告)号：US20090294703A1

公开(公告)日：2009-12-03

申请号：US12538641

申请日：2009-08-10

Applicant: Marc A. Unger ,  Geoffrey Richard Facer ,  Barry Clerkson ,  Christopher G. Cesar ,  Neil Switz

Inventor： Marc A. Unger ,  Geoffrey Richard Facer ,  Barry Clerkson ,  Christopher G. Cesar ,  Neil Switz

IPC: G01N21/64

CPC classification number: C12Q1/686 ,  B01J2219/00576 ,  B01J2219/00704 ,  B01L3/5027 ,  B01L7/52 ,  G01N21/64 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6486 ,  G01N21/75 ,  G01N21/8483 ,  G01N27/44721 ,  G01N2021/6421 ,  G01N2201/061 ,  G02B21/16 ,  G02B21/36

Abstract: An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluorescent emission signals derived from one or more samples in the at least one chamber of the at least one microfluidic device. The chamber has a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path. The apparatus also includes an optical lens system coupled to the imaging path. The optical lens system is adapted to transmit the one or more fluorescent signals associated with the chamber.

Abstract translation: 一种用于从微流体装置成像一个或多个选定的荧光指示的装置。 该装置包括耦合到至少一个微流体装置中的至少一个室的成像路径。 成像路径提供从至少一个微流体装置的至少一个室中的一个或多个样品衍生的一个或多个荧光发射信号的传输。 腔室具有腔室尺寸，腔室尺寸的特征在于与成像路径垂直的实际空间尺寸。 该装置还包括耦合到成像路径的光学透镜系统。 光学透镜系统适于透射与腔室相关联的一个或多个荧光信号。

公开(公告)号：US20090290781A1

公开(公告)日：2009-11-26

申请号：US12280524

申请日：2007-02-22

Applicant: Caulier Yannick ,  Spinnler Klaus ,  Couronne Robert

Inventor： Caulier Yannick ,  Spinnler Klaus ,  Couronne Robert

IPC: G01N21/88 ,  G03B15/02 ,  G06K9/00

CPC classification number: G01N21/952 ,  G01N21/8806 ,  G01N2201/061

Abstract: An illuminating device is provided that includes, but is not limited to a cylindrical lighting unit with a cylindrical slit diaphragm arranged in the interior thereof. The lighting unit includes, but is not limited to a cylindrical light source with a cylindrical diffusor arranged therein, and the slit diaphragm has a cylinder with axially extending slits that are arranged in such a way that incident beams coupled in perpendicular to the slit diaphragm axis (O) converge in a point (M) that is spaced apart from the cylinder axis in the interior of the slit diaphragm through the slits.

Abstract translation: 提供一种照明装置，其包括但不限于在其内部布置有圆柱形狭缝光阑的圆柱形照明单元。 照明单元包括但不限于其中布置有圆柱形扩散器的圆柱形光源，并且狭缝光阑具有带轴向延伸狭缝的圆柱体，其以这样的方式布置，使得入射光束垂直于狭缝光阑轴线 （O）会聚在通过狭缝在狭缝隔膜的内部与气缸轴线间隔开的点（M）中。

公开(公告)号：US20090032449A1

公开(公告)日：2009-02-05

申请号：US12213109

申请日：2008-06-13

Applicant: Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Harris Rosenbaum

Inventor： Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Harris Rosenbaum

IPC: B01D35/30

CPC classification number: G03H1/0005 ,  A61L2/08 ,  B01D21/0009 ,  B01D21/01 ,  B01D21/262 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0864 ,  B01L2400/0454 ,  B03C1/00 ,  B03C1/002 ,  B03C1/288 ,  B03C5/005 ,  B04B13/00 ,  G01N15/0205 ,  G01N21/6486 ,  G01N27/447 ,  G01N27/44756 ,  G01N33/487 ,  G01N33/5091 ,  G01N2015/0053 ,  G01N2201/061 ,  G01N2458/00 ,  G02B21/32 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/085 ,  G03H2225/32 ,  G21K5/08 ,  H05H3/04

Abstract: The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

Abstract translation: 本发明提供了一种用于分离血液和其他类型的细胞组分的方法，装置和系统，并且可以与全息光学捕获操作或其他形式的光学镊子组合。 示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。 然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。 全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。

公开(公告)号：US20080088952A1

公开(公告)日：2008-04-17

申请号：US11953538

申请日：2007-12-10

Applicant: Marc Unger ,  Geoffrey Facer ,  Barry Clerkson ,  Christopher Cesar ,  Neil Switz

Inventor： Marc Unger ,  Geoffrey Facer ,  Barry Clerkson ,  Christopher Cesar ,  Neil Switz

IPC: G02B27/02 ,  G01N21/76 ,  G02B7/02

CPC classification number: C12Q1/686 ,  B01J2219/00576 ,  B01J2219/00704 ,  B01L3/5027 ,  B01L7/52 ,  G01N21/64 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6486 ,  G01N21/75 ,  G01N21/8483 ,  G01N27/44721 ,  G01N2021/6421 ,  G01N2201/061 ,  G02B21/16 ,  G02B21/36

Abstract: An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluorescent emission signals derived from one or more samples in the at least one chamber of the at least one microfluidic device. The chamber has a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path. The apparatus also includes an optical lens system coupled to the imaging path. The optical lens system is adapted to transmit the one or more fluorescent signals associated with the chamber.

Abstract translation: 一种用于从微流体装置成像一个或多个选定的荧光指示的装置。 该装置包括耦合到至少一个微流体装置中的至少一个室的成像路径。 成像路径提供从至少一个微流体装置的至少一个室中的一个或多个样品衍生的一个或多个荧光发射信号的传输。 腔室具有腔室尺寸，腔室尺寸的特征在于与成像路径垂直的实际空间尺寸。 该装置还包括耦合到成像路径的光学透镜系统。 光学透镜系统适于透射与腔室相关联的一个或多个荧光信号。

公开(公告)号：US07301631B1

公开(公告)日：2007-11-27

申请号：US11084827

申请日：2005-03-21

Applicant: Blaine D. Johs ,  Ping He ,  Galen L. Pfeiffer ,  Steven E. Green ,  Christopher A. Goeden ,  Martin M. Liphardt

Inventor： Blaine D. Johs ,  Ping He ,  Galen L. Pfeiffer ,  Steven E. Green ,  Christopher A. Goeden ,  Martin M. Liphardt

IPC: G01J4/00

CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/10 ,  G01N21/211 ,  G01N2201/061 ,  G01N2201/0636

Abstract: A system for stabilizing the angle of incidence a beam of electromagnetic radiation from a vertically oriented Arc lamp onto a horizontally oriented sample surface.

Abstract translation: 一种用于将来自垂直取向的弧光灯的电磁辐射束入射到水平取向的样品表面上的入射角的系统。

公开(公告)号：US07214346B2

公开(公告)日：2007-05-08

申请号：US10467242

申请日：2002-02-06

Applicant: James Douglas Harper ,  Richard Hart Mathews ,  Bernadette Johnson ,  Martha Susan Petrovick ,  Ann Rundell ,  Frances Ellen Nargi ,  Timothy Stephens ,  Linda Marie Mendenhall ,  Mark Alexander Hollis ,  Albert M. Young ,  Todd H. Rider ,  Eric David Schwoebel ,  Trina Rae Vian

Inventor： James Douglas Harper ,  Richard Hart Mathews ,  Bernadette Johnson ,  Martha Susan Petrovick ,  Ann Rundell ,  Frances Ellen Nargi ,  Timothy Stephens ,  Linda Marie Mendenhall ,  Mark Alexander Hollis ,  Albert M. Young ,  Todd H. Rider ,  Eric David Schwoebel ,  Trina Rae Vian

IPC: G01N21/00 ,  G01N21/01 ,  G01N21/62 ,  G01N21/63 ,  G01N21/64 ,  G01N33/52

CPC classification number: G01N33/554 ,  G01N15/0205 ,  G01N21/07 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/75 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/54393 ,  G01N33/56983 ,  G01N33/582 ,  G01N2021/6439 ,  G01N2201/025 ,  G01N2201/061 ,  Y10S435/808 ,  Y10S436/805

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

Abstract translation: 本发明涉及用于检测一个或多个目标颗粒的光电子系统。 该系统包括反应室，样品收集器，光学检测器和含有细胞的储存器，每个细胞具有存在于每个细胞表面上并且对待检测的靶颗粒是特异性的受体，其中结合 受体的目标颗粒直接或间接激活报告分子，从而产生可测量的光信号。

公开(公告)号：US20060195045A1

公开(公告)日：2006-08-31

申请号：US11314963

申请日：2005-12-21

Applicant: Jennifer Gable ,  James Braig ,  Kenneth Li ,  Kenneth Witte ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Jennifer Gable ,  James Braig ,  Kenneth Li ,  Kenneth Witte ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/155

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: A fluid handling module is configured for removable engagement with a reusable main fluid handling instrument. The module comprises a housing, an infusion fluid passageway, a sample fluid passageway, and a fluid component separator. The infusion fluid passageway has a first port and a second port spaced from the first port, and a lumen extending from the first port to the second port. The sample fluid passageway is connected to the infusion fluid passageway. The fluid component separator is connected to the sample fluid passageway.

Abstract translation: 流体处理模块被配置为可移除地与可重复使用的主流体处理仪器接合。 模块包括壳体，输液流体通道，样品流体通道和流体组分分离器。 输液流体通道具有与第一端口间隔开的第一端口和第二端口，以及从第一端口延伸到第二端口的内腔。 样品流体通道连接到输液流体通道。 流体组分分离器连接到样品流体通道。

公开(公告)号：US4906093A

公开(公告)日：1990-03-06

申请号：US222403

申请日：1988-07-21

Applicant: Carlo Trossarelli

Inventor： Carlo Trossarelli

IPC: G01J3/02 ,  G01J3/10 ,  G01N21/87

CPC classification number: G01J3/10 ,  G01N21/87 ,  G01J3/0221 ,  G01N2201/061 ,  G01N2201/0636

Abstract: An illuminator for the spectroscopic illumination of minerals, gems, etc., in which a substance under examination is illuminated by means of a source of white light, comprises at least one optical fiber (22) for transmitting the illumination light, passed through the substance under examination, to an observation spectroscope (30).

Abstract translation: 用于通过白光源照射待检物质的矿物，宝石等的分光照明的照明器包括：至少一个光纤（22），用于透射照射光，通过物质 在检查中，观察分光镜（30）。