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公开(公告)号：US20200295527A1
公开(公告)日：2020-09-17
申请号：US16765740
申请日：2018-11-20
Inventor： Fabien ZOMER , Pierre FAVIER , Antoine COURJAUD
Abstract: Disclosed is a system for generating a spatially localized, high-intensity laser beam, including: a laser source designed to generate a burst of N laser pulses with a duration of less than or equal to one picosecond, the N laser pulses having a first repetition frequency greater than or equal to 0.5 gigahertz; a resonant optical cavity designed to receive and store the burst of N laser pulses, the resonant optical cavity being designed to focus the burst of N laser pulses in an interaction region of the resonant optical cavity; and a servo control system designed to control the first repetition frequency relative to the roundtrip distance in the resonant optical cavity, such that the N pulses of the burst are superimposed temporally and spatially by constructive interferences in the interaction region so as to form one giant ultra-short and high-energy pulse.
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公开(公告)号：US20200292802A1
公开(公告)日：2020-09-17
申请号：US16782716
申请日：2020-02-05
Applicant: JASCO Corporation
Inventor： Kento AIZAWA , Yoshiko KUBO , Norihito FUJIWARA , Katsunori MORII
Abstract: The present invention relates to improvement in accuracy of an automatic sample detection technique in spectrometry of a microspectroscope.A microspectroscope 10 comprises: a light source 12 that emits an excitation light to a sample 20; a condensing lens 16 that emits the excitation light to a predetermined position of the sample 20 and condenses a reflected light or a transmitted light from the sample 20; a spectrometer 24 that detects a condensed light; and an analysis control unit 30 for analyzing a signal from the spectrometer 24; the microspectroscope 10 that uses an observation image of the sample 20 to perform spectrometry, wherein the analysis control unit 30 comprises: an image storage part 32 that converts the observation image to an all-in-focus image to store the all-in-focus image; and a control part 34 that makes the microspectroscope 10 to perform measurement, and the control part 34 uses the all-in-focus image and performs a template matching as a matching action of the image to perform position correction to a position deviation of a sample point that is a target of spectrometry in the sample.
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公开(公告)号：US20200292457A1
公开(公告)日：2020-09-17
申请号：US16840773
申请日：2020-04-06
Applicant: InSilixa, Inc.
Inventor： Arjang Hassibi , Arun Manickam , Rituraj Singh , Robert G. Kuimelis
IPC: G01N21/64 , H04N5/3745 , G01J3/44
Abstract: The present disclosure provides methods, apparatus and systems for time-gated fluorescent-based detection. Time-based fluorescence analysis can be used in certain biochemical assays by measuring the emitted photon flux from fluorophores after an individual excitation pulse.
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公开(公告)号：US20200292453A1
公开(公告)日：2020-09-17
申请号：US16813538
申请日：2020-03-09
Applicant: HITACHI HIGH-TECH SCIENCE CORPORATION
Inventor： Jun HORIGOME , Kai MARUYAMA , Koji KURITA , Hideyuki SAKAMOTO , Rino NAKAJIMA , Naoki SUZUKI
Abstract: A fluorescence photometer includes a photometer unit and an optical fiber unit. The photometer unit includes a light source, an excitation-side spectroscope for separating light emitted from the light source to generate excitation light, and a fluorescence-side spectroscope for separating fluorescent light emitted from a sample irradiated with the excitation light to generate monochromatic light. The optical fiber unit guides the excitation light to the sample placed outside the photometer unit and guides the fluorescent light emitted from the sample to the photometer unit and includes an image fiber for capturing an image of the sample, an excitation-side fiber arranged around the image fiber and for guiding the excitation light to the sample, and a fluorescence-side fiber arranged around the image fiber and to guide the fluorescent light emitted from the sample to the photometer unit. The excitation-side fiber and the fluorescence-side fiber are arranged to surround the image fiber.
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公开(公告)号：US20200284657A1
公开(公告)日：2020-09-10
申请号：US16647867
申请日：2018-09-14
Applicant: Polyvalor, Limited Partnership
Inventor： Frederic Leblond , Karl St-Arnaud , Francois Daoust
Abstract: A system and method for imaging a sample using Raman spectrometry. Optical fibers having opposite first ends and second ends are arranged with the first ends and second ends in respective two-dimensional arrays. The two-dimensional arrays maintain relative positions of the optical fibers to one another from the first ends to the second ends in a way that the first end of each optical fibers of the bundle can simultaneously collect a corresponding Raman signal portion scattered from specific spatial coordinates of the area of the sample. The so-collected Raman signal portions are propagated towards the corresponding second end, from which are outputted and detected simultaneously using an array of detectors.
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Patent Agency Ranking
公开(公告)号：US20200278255A1
公开(公告)日：2020-09-03
申请号：US16289596
申请日：2019-02-28
Applicant: BioSpex, Inc.
Inventor： Zhenyou Wang , Wei Yang
Abstract: Systems and methods for reducing fluorescence and systematic noise in time-gated spectroscopy are disclosed. Exemplary methods include: a method for reducing fluorescence and systematic noise in time-gated spectroscopy may comprise: providing first light using an excitation light source; receiving, by a detector, first scattered light from a material responsive to the first light during a first time window; detecting a peak intensity of the first scattered light; receiving, by the detector, second scattered light from the material responsive to the first light during a second time window; detecting a peak intensity of the second scattered light; recovering a spectrum of the material by taking a ratio of the peak intensity of the first scattered light and the peak intensity of the second scattered light; and identifying at least one molecule of the material using the recovered spectrum and a database of identified spectra.
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公开(公告)号：US20200271517A1
公开(公告)日：2020-08-27
申请号：US16488165
申请日：2018-02-23
Applicant: Tailorlux GmbH
Inventor： Alex Deitermann
Abstract: A method is claimed for identifying and quantifying a material or mixture of materials, where the material or the mixture of materials comprises one or more components X identifiable by means of spectroscopic methods and/or with a hyperspectral camera. The method comprises the steps ofA. generating one or more signals by excitation with a radiation source in the range of 280-1100 nm and recording thereof by a suitable spectrometer system, a hyperspectral camera or a photodiode, B. evaluating the signal(s) and/or hyperspectral image(s) obtained and assigning the signal(s) and/or hyperspectral image(s) to a component X, and subsequently assigning the identified component X to a material or a mixture of materials, C. quantitatively determining the material or mixture of materials.
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188.发明申请公开(公告)号：US20200268252A1
公开(公告)日：2020-08-27
申请号：US16798001
申请日：2020-02-21
Applicant: Deep Smart Light Limited
Inventor： Karina Litvinova
IPC: A61B5/00 , G01J3/44 , G01J3/10 , G01J3/18 , G01J3/02 , A61B5/1455 , A61B1/04 , A61B1/307 , A61B1/267 , A61B1/24 , A61B1/00 , G06N20/00
Abstract: Provided is a obtaining an excitation-emission matrix, wherein the excitation-emission matrix is measured with a spectrometer by: illuminating a biological tissue with stimulant light at a first wavelength to cause a first fluorescent emission of light by the biological tissue, measuring a first set of intensities of the first fluorescent emission of light at a plurality of different respective emission wavelengths, illuminating the biological tissue with stimulant light at a second wavelength to cause a second fluorescent emission of light by the biological tissue, and measuring a second set of intensities of the second fluorescent emission of light at a plurality of different respective emission wavelengths; and inferring a classification of the biological tissue or a concentration of a substance in the biological tissue with a multi-layer neural network or other machine learning model.
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公开(公告)号：US10753805B2
公开(公告)日：2020-08-25
申请号：US15479681
申请日：2017-04-05
Applicant: Kaiser Optical Systems Inc.
Inventor： Joseph B. Slater , James M. Tedesco , Alfred Feitisch
Abstract: A radiation shield for near-infrared detectors of the type used in Raman spectroscopic systems comprises a chamber enclosing the detector and a cooling device in thermal contact with the chamber and the detector to reduce the level of unwanted radiation to which the detector would otherwise be exposed. The chamber may include a window in optical alignment with the detector, and the window may include one or more coatings to pass wavelengths in a range of interest or block radiation at wavelengths outside of this range. The shield may be enclosed in an evacuated dewar having a window which may also include one or more coatings to favor the wavelength range.
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190.发明申请公开(公告)号：US20200264050A1
公开(公告)日：2020-08-20
申请号：US16451901
申请日：2019-06-25
Applicant: Wayne State University
Inventor： Gregory William Auner , Michelle Ann Brusatori , Changhe Huang
Abstract: Apparatuses, systems, and methods for Raman spectroscopy are described. In certain implementations, a spectrometer is provided. The spectrometer may include a plurality of optical elements, comprising an entrance aperture, a collimating element, a volume phase holographic grating, a focusing element, and a detector array. The plurality of optical elements are configured to transfer the light beam from the entrance aperture to the detector array with a high transfer efficiency over a preselected spectral band.
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