公开(公告)号：US20080108120A1

公开(公告)日：2008-05-08

申请号：US11848748

申请日：2007-08-31

Applicant: Yoon-kyoung CHO ,  Jeong-gun LEE ,  Beom-seok LEE ,  Jong-myeon PARK

Inventor： Yoon-kyoung CHO ,  Jeong-gun LEE ,  Beom-seok LEE ,  Jong-myeon PARK

IPC: C12N13/00 ,  B04B5/10 ,  C12M1/10

CPC classification number: B01L3/502738 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0076 ,  F16K2099/0084

Abstract: A centrifugal force-based microfluidic device for nucleic acid extraction and a microfluidic system are provided. The microfluidic device includes a body of revolution; a microfluidic structure disposed in the body of revolution, the microfluidic structure including a plurality of chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structure transmitting the fluid using centrifugal force due to rotation of the body of revolution; and magnetic beads contained in one of the chambers which collect a target material from a biomaterial sample flowing into the chamber, wherein the microfluidic structure washes the magnetic beads which collect the target material, and separates nucleic acid by electromagnetic wave irradiation from an external energy source to the magnetic beads. The microfluidic system includes the microfluidic device; a rotation operating unit which rotates the body of revolution; and an external energy source which irradiates electromagnetic waves.

Abstract translation: 提供了用于核酸提取的离心力微流体装置和微流体系统。 微流体装置包括一个革命体; 设置在旋转体内的微流体结构，所述微流体结构包括多个室，连接所述室的通道和设置在通道中的阀以控制流体流动，所述微流体结构由于所述体的旋转而使用离心力传递流体 的革命 以及包含在其中一个室中的磁珠，其从流入腔室的生物材料样品收集目标材料，其中微流体结构洗涤收集目标材料的磁珠，并通过来自外部能量源的电磁波照射分离核酸 到磁珠。 微流体系统包括微流体装置; 使旋转体旋转的旋转操作单元; 以及照射电磁波的外部能量源。

公开(公告)号：US06353587B1

公开(公告)日：2002-03-05

申请号：US09219991

申请日：1998-12-23

Applicant: Young Chi Hong ,  Young Joo Kim ,  Beom Seok Lee

Inventor： Young Chi Hong ,  Young Joo Kim ,  Beom Seok Lee

IPC: G11B700

CPC classification number: G11B7/1353 ,  G11B7/1275 ,  G11B7/1356 ,  G11B7/1365 ,  G11B2007/0006

Abstract: A first light source of an optical pickup emits a first laser beam having a first predetermined wavelength. A second light source emits a second laser beam that substantially perpendicularly crosses the first laser beam and has a second predetermined wavelength different from the first predetermined wavelength. A holographic beam splitter is slopingly disposed where the laser beams cross. The holographic beam splitter has a hologram diffractive surface on one surface and a coating layer on another surface for being penetrated by and reflecting the laser beams at a first predetermined ratio. A flat beam splitter is arranged on a first path of the laser beams from the holographic beam splitter to be penetrated by and reflect the laser beams at a second predetermined ratio. A collimator lens is arranged on a second path of the laser beams from the flat beam splitter to shape the laser beams. An objective lens focuses the shaped laser beams at least upon an optical disc. A photodiode reads out recorded and error information from the laser beams when reflected from the optical disc.

Abstract translation: 光学拾取器的第一光源发射具有第一预定波长的第一激光束。 第二光源发射基本上垂直于第一激光束并且具有与第一预定波长不同的第二预定波长的第二激光束。 全息分束器被倾斜地设置在激光束交叉的地方。 全息分束器在一个表面上具有全息衍射表面，在另一个表面上具有用于以第一预定比例穿透和反射激光束的另一表面上的涂层。 平面分束器布置在来自全息分束器的激光束的第一路径上，以第二预定比率穿透和反射激光束。 准直透镜布置在来自平坦分束器的激光束的第二路径上以形成激光束。 物镜将成形的激光束至少聚焦在光盘上。 当从光盘反射时，光电二极管从激光束读出记录和误差信息。

公开(公告)号：US08499793B2

公开(公告)日：2013-08-06

申请号：US12979049

申请日：2010-12-27

Applicant: Jong-myeon Park ,  Yoon-kyuong Cho ,  Jeong-gun Lee ,  Beom-seok Lee ,  Sung-woo Hong

Inventor： Jong-myeon Park ,  Yoon-kyuong Cho ,  Jeong-gun Lee ,  Beom-seok Lee ,  Sung-woo Hong

IPC: F15C1/04

CPC classification number: F16K99/0019 ,  B01L3/502738 ,  B01L2300/0803 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0032 ,  F16K99/0034 ,  F16K99/004 ,  F16K2099/0084 ,  Y10T137/1827 ,  Y10T137/2196 ,  Y10T137/6606 ,  Y10T137/7755

Abstract: Provided are a valve unit and a reaction apparatus having the valve unit. The valve unit includes a phase transition material, which melts and expands upon an application of the electromagnetic waves to the valve filler, and the valve filler is directed into the channel through the connection passage and closes the channel. The valve unit also includes heat generation particles, which are dispersed in the phase transition material and generate heat upon an application of electromagnetic wave energy.

Abstract translation: 提供具有阀单元的阀单元和反应装置。 阀单元包括相变材料，其在将电磁波施加到阀填充器时熔化和膨胀，并且阀填料通过连接通道引导到通道中并关闭通道。 阀单元还包括发散颗粒，其分散在相变材料中并且在施加电磁波能量时产生热量。

公开(公告)号：US08333935B2

公开(公告)日：2012-12-18

申请号：US13168298

申请日：2011-06-24

Applicant: Beom-seok Lee ,  Jeong-gun Lee ,  Jong-myeon Park ,  Yoon-kyoung Cho

Inventor： Beom-seok Lee ,  Jeong-gun Lee ,  Jong-myeon Park ,  Yoon-kyoung Cho

IPC: C40B40/00

CPC classification number: B01L3/502738 ,  B01L3/502707 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/0621 ,  B01L2200/16 ,  B01L2300/04 ,  B01L2300/0636 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677 ,  Y10T436/15

Abstract: Disclosed is a microfluidic device including a microfluidic structure formed in a platform in which various examinations, such as an immune serum examination, can be automatically performed using the biomolecule microarray chip. The biomolecule microarray chip-type microfluidic device using a biomolecule microarray chip comprises: a platform which is rotatable; a microfluidic structure disposed in the platform, comprising: a plurality of chambers; a plurality of channels connecting the chambers each other; and a plurality of valves controlling flow of fluids through the channels, wherein the microfluidic structure controls flow of a fluid sample using rotation of the platform and the valves; and a biomolecule microarray chip mounted in the platform such that biomolecule capture probes bound to the biomolecule microarray chip contact the fluid sample in the microfluidic structure.

Abstract translation: 公开了一种微流体装置，其包括在平台中形成的微流体结构，其中可以使用生物分子微阵列芯片自动执行各种检查，例如免疫血清检查。 使用生物分子微阵列芯片的生物分子微阵列芯片型微流器件包括：可旋转的平台; 设置在平台中的微流体结构，包括：多个室; 连接所述室的多个通道; 以及多个阀，其控制通过所述通道的流体流动，其中所述微流体结构通过所述平台和所述阀的旋转来控制流体样品的流动; 以及安装在平台中的生物分子微阵列芯片，使得与生物分子微阵列芯片结合的生物分子捕获探针与微流体结构中的流体样品接触。

公开(公告)号：US08119079B2

公开(公告)日：2012-02-21

申请号：US12053656

申请日：2008-03-24

Applicant: Yoon-kyoung Cho ,  Beom-seok Lee ,  Jeong-gun Lee

Inventor： Yoon-kyoung Cho ,  Beom-seok Lee ,  Jeong-gun Lee

IPC: B01J19/00

CPC classification number: B01L3/502738 ,  B01L3/50273 ,  B01L2200/028 ,  B01L2300/0803 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/0683 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/255 ,  Y10T436/2575

Abstract: A microfluidic apparatus having a substrate including a channel through which a fluid is conveyed, a fluid container in which at least one kind of fluid is accommodated and which is disposed on the substrate so as to allow the fluid to flow toward the channel, and a fluid flow controller which controls a flow of the fluid toward the channel from the fluid container.

Abstract translation: 一种微流体装置，其具有包括流体被输送的通道的基板，容纳有至少一种流体的流体容器，并且设置在所述基板上以允许流体朝向所述流路流动， 流体流量控制器，其控制流体朝向来自流体容器的通道的流动。

公开(公告)号：US07910379B2

公开(公告)日：2011-03-22

申请号：US12888927

申请日：2010-09-23

Applicant: Beom-seok Lee ,  Jeong-gun Lee ,  Hye-jung Cho ,  In-seok Kang ,  Jae-suk Moon ,  Jin-seok Hong

Inventor： Beom-seok Lee ,  Jeong-gun Lee ,  Hye-jung Cho ,  In-seok Kang ,  Jae-suk Moon ,  Jin-seok Hong

IPC: B01L3/02 ,  B01L99/00

CPC classification number: B01L3/0262 ,  B01J19/0046 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00689 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01J2219/00743 ,  B01L2300/0819 ,  B01L2300/0838 ,  B01L2400/027 ,  Y10T436/11 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/25 ,  Y10T436/2575

Abstract: Disclosed is an apparatus and method for ejecting droplets using charge concentration and liquid bridge breakup. The droplet ejection apparatus includes a reservoir storing a liquid; a capillary nozzle having a lower end submerged in the liquid stored in the reservoir and an upper end exposed outside the surface of the liquid, the capillary nozzle transferring the liquid to the upper end using capillary force; a potentiostat for applying a voltage to the liquid; a substrate mount on which a substrate is disposed to face the upper end of the capillary nozzle; and a distance adjusting unit for reciprocatingly moving the substrate between first and second positions with respect to the capillary nozzle, wherein the first position denotes a position where a distance between the upper end of the capillary nozzle and the surface of the substrate is less than a effective distance.

Abstract translation: 公开了一种使用电荷浓度和液桥分解喷射液滴的装置和方法。 液滴喷射装置包括储存液体的储存器; 毛细喷嘴，其下端浸没在存储在储存器中的液体中，上端暴露在液体表面之外，毛细喷嘴使用毛细管力将液体传送到上端; 用于向液体施加电压的恒电位仪; 基板安装件，基板设置在其上面对毛细管喷嘴的上端; 以及距离调节单元，用于使所述基板相对于所述毛细管喷嘴在第一位置和所述第二位置之间往复移动，其中所述第一位置表示所述毛细管喷嘴的上端与所述基板的表面之间的距离小于 有效距离。

公开(公告)号：US07909427B2

公开(公告)日：2011-03-22

申请号：US12552567

申请日：2009-09-02

Applicant: Su-hyeon Kim ,  Jeong-gun Lee ,  Jong-suk Chung ,  Hye-jung Cho ,  Nam Huh ,  In-seok Kang ,  Beom-seok Lee

Inventor： Su-hyeon Kim ,  Jeong-gun Lee ,  Jong-suk Chung ,  Hye-jung Cho ,  Nam Huh ,  In-seok Kang ,  Beom-seok Lee

IPC: B41J29/393

CPC classification number: B41J2/06 ,  B01J19/0046 ,  B01J2219/00364 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00693 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00743 ,  B41J2/04535 ,  B41J2/0456 ,  B41J2/04576

Abstract: A device for printing a droplet onto a substrate includes: a droplet generating member which is needle-shaped and comprises a receiving portion disposed vertically to receive a solution, and a discharge hole connected to the receiving portion and formed on a bottom of the receiving portion so that the solution can be discharged from the receiving portion; a substrate disposed below the droplet generating member, the substrate includes a target portion to which the droplet discharged from the discharge hole of the droplet generating member is dropped and attached; a voltage applier applying a voltage to the droplet so that the droplet can be dropped onto the target portion of the substrate; a volume measuring unit measuring the volume of the droplet; and a droplet control unit maintaining the volume of the droplet at a predetermined level based on the measured volume of the droplet.

Abstract translation: 用于将液滴印刷到基板上的装置包括：液滴产生构件，其为针状并且包括垂直设置以接收溶液的接收部分，以及连接到接收部分并形成在接收部分的底部上的排出孔 使得溶液可以从接收部分排出; 设置在所述液滴产生部件下方的基板，所述基板包括从所述液滴产生部件的排出孔排出的液滴滴落并附着到的目标部分; 电压施加器，向所述液滴施加电压，使得所述液滴能够落到所述基板的所述目标部分上; 体积测量单元，测量液滴的体积; 以及液滴控制单元，其基于所测量的液滴体积将液滴的体积保持在预定水平。

公开(公告)号：US20090322828A1

公开(公告)日：2009-12-31

申请号：US12552567

申请日：2009-09-02

Applicant: Su-hyeon KIM ,  Jeong-gun LEE ,  Jong-suk CHUNG ,  Hye-jung CHO ,  Nam HUH ,  In-seok KANG ,  Beom-seok LEE

Inventor： Su-hyeon KIM ,  Jeong-gun LEE ,  Jong-suk CHUNG ,  Hye-jung CHO ,  Nam HUH ,  In-seok KANG ,  Beom-seok LEE

IPC: B41J2/06

CPC classification number: B41J2/06 ,  B01J19/0046 ,  B01J2219/00364 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00693 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00743 ,  B41J2/04535 ,  B41J2/0456 ,  B41J2/04576

Abstract: A device for printing a droplet onto a substrate includes: a droplet generating member which is needle-shaped and comprises a receiving portion disposed vertically to receive a solution, and a discharge hole connected to the receiving portion and formed on a bottom of the receiving portion so that the solution can be discharged from the receiving portion; a substrate disposed below the droplet generating member, the substrate includes a target portion to which the droplet discharged from the discharge hole of the droplet generating member is dropped and attached; a voltage applier applying a voltage to the droplet so that the droplet can be dropped onto the target portion of the substrate; a volume measuring unit measuring the volume of the droplet; and a droplet control unit maintaining the volume of the droplet at a predetermined level based on the measured volume of the droplet.

Abstract translation: 用于将液滴印刷到基板上的装置包括：液滴产生构件，其为针状并且包括垂直设置以接收溶液的接收部分，以及连接到接收部分并形成在接收部分的底部上的排出孔 使得溶液可以从接收部分排出; 设置在所述液滴产生部件下方的基板，所述基板包括从所述液滴产生部件的排出孔排出的液滴滴落并附着到的目标部分; 电压施加器，向所述液滴施加电压，使得所述液滴能够落到所述基板的所述目标部分上; 体积测量单元，测量液滴的体积; 以及液滴控制单元，其基于所测量的液滴体积将液滴的体积保持在预定水平。

公开(公告)号：US20090143250A1

公开(公告)日：2009-06-04

申请号：US12115572

申请日：2008-05-06

Applicant: Beom-seok LEE ,  Jeong-gun LEE ,  Jong-myeon PARK ,  Yoon-kyoung CHO

Inventor： Beom-seok LEE ,  Jeong-gun LEE ,  Jong-myeon PARK ,  Yoon-kyoung CHO

IPC: C40B60/12

CPC classification number: B01L3/502738 ,  B01L3/502707 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/0621 ,  B01L2200/16 ,  B01L2300/04 ,  B01L2300/0636 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677 ,  Y10T436/15

Abstract: Disclosed is a microfluidic device including a microfluidic structure formed in a platform in which various examinations, such as an immune serum examination, can be automatically performed using the biomolecule microarray chip. The biomolecule microarray chip-type microfluidic device using a biomolecule microarray chip comprises: a platform which is rotatable; a microfluidic structure disposed in the platform, comprising: a plurality of chambers; a plurality of channels connecting the chambers each other; and a plurality of valves controlling flow of fluids through the channels, wherein the microfluidic structure controls flow of a fluid sample using rotation of the platform and the valves; and a biomolecule microarray chip mounted in the platform such that biomolecule capture probes bound to the biomolecule microarray chip contact the fluid sample in the microfluidic structure.

Abstract translation: 公开了一种微流体装置，其包括在平台中形成的微流体结构，其中可以使用生物分子微阵列芯片自动执行各种检查，例如免疫血清检查。 使用生物分子微阵列芯片的生物分子微阵列芯片型微流器件包括：可旋转的平台; 设置在平台中的微流体结构，包括：多个室; 连接所述室的多个通道; 以及多个阀，其控制通过所述通道的流体流动，其中所述微流体结构通过所述平台和所述阀的旋转来控制流体样品的流动; 以及安装在平台中的生物分子微阵列芯片，使得与生物分子微阵列芯片结合的生物分子捕获探针与微流体结构中的流体样品接触。

公开(公告)号：US20090139578A1

公开(公告)日：2009-06-04

申请号：US12182545

申请日：2008-07-30

Applicant: Suhyeon Kim ,  Jeonggun Lee ,  Beom-seok Lee

Inventor： Suhyeon Kim ,  Jeonggun Lee ,  Beom-seok Lee

IPC: F16K17/36

CPC classification number: B01L3/502715 ,  B01L3/502753 ,  B01L2200/025 ,  B01L2300/02 ,  B01L2300/0627 ,  B01L2300/0806 ,  B01L2300/168 ,  B01L2400/0409 ,  Y10T137/0391 ,  Y10T137/0753

Abstract: Provided are a centrifugal force based platform formed to be rotatable and including a home mark having a retro-reflective property of light, and a centrifugal force based microfluidic system including the platform. The method of determining a home position of the centrifugal force based platform includes: rotating the platform formed and including a home mark having a retro-reflective property of light; emitting light from a light-emitting unit to the platform; and detecting the emitted light, which is retro-reflected by the home mark, in a light-receiving unit, and then determining the home position of the platform based on the detected light.

Abstract translation: 提供了一种基于离心力的平台，其形成为可旋转的，并且包括具有光的反射性能的归位标记，以及包括该平台的基于离心力的微流体系统。 确定基于离心力的平台的起始位置的方法包括：旋转所形成的平台并且包括具有光的回射性能的原点标记; 将发光单元发射到平台; 并且在光接收单元中检测由归属标记反射的发射光，然后基于检测到的光来确定平台的原始位置。