公开(公告)号：US20100275219A1

公开(公告)日：2010-10-28

申请号：US12428831

申请日：2009-04-23

Applicant: William G. Carlson ,  Ian MacQuarrie ,  Eric Wieder ,  Bin Ye

Inventor： William G. Carlson ,  Ian MacQuarrie ,  Eric Wieder ,  Bin Ye

IPC: G06F9/44 ,  G06F15/173

CPC classification number: H04L41/069 ,  G06F3/0605 ,  G06F3/0653 ,  G06F3/067

Abstract: A network storage monitor system includes a device driver running on each of at least one first computer and a monitor application running on a second computer in communication with the each first computer. Each first computer also is in communication with a network storage switch and the network storage switch is in communication with at least one storage device. Each device driver sends to the second computer data regarding a storage event when the storage event is initiated by the respective first computer.

Abstract translation: 网络存储监视器系统包括在至少一个第一计算机中的每一个上运行的设备驱动器和在与每个第一计算机通信的第二计算机上运行的监视应用程序。 每个第一计算机还与网络存储交换机通信，网络存储交换机与至少一个存储设备通信。 当存储事件由相应的第一计算机启动时，每个设备驱动程序向第二计算机发送关于存储事件的数据。

公开(公告)号：US20100210630A1

公开(公告)日：2010-08-19

申请号：US12771659

申请日：2010-04-30

Applicant: Damian Arnaiz ,  Greg Brown ,  Emmanuel Claret ,  Arwed Cleve ,  David Davey ,  William Guilford ,  Seock-Kyu Khim ,  Thomas Kirkland ,  Monica J. Kochanny ,  Amy Liang ,  David Light ,  John Parkinson ,  David Vogel ,  Guo Ping Wei ,  Bin Ye

Inventor： Damian Arnaiz ,  Greg Brown ,  Emmanuel Claret ,  Arwed Cleve ,  David Davey ,  William Guilford ,  Seock-Kyu Khim ,  Thomas Kirkland ,  Monica J. Kochanny ,  Amy Liang ,  David Light ,  John Parkinson ,  David Vogel ,  Guo Ping Wei ,  Bin Ye

IPC: A61K31/551 ,  C07D487/08 ,  A61K31/504 ,  C07D243/08 ,  C07D263/32 ,  A61K31/421 ,  C07D211/58 ,  A61K31/4468 ,  C07D207/09 ,  A61K31/40 ,  C07D413/00 ,  A61K31/5377 ,  A61P29/00

CPC classification number: C07D487/08 ,  C07B2200/07 ,  C07C217/58 ,  C07C229/08 ,  C07C229/38 ,  C07C233/78 ,  C07C255/57 ,  C07C271/20 ,  C07C2601/14 ,  C07D207/04 ,  C07D207/09 ,  C07D207/16 ,  C07D211/26 ,  C07D211/34 ,  C07D211/58 ,  C07D243/08 ,  C07D263/14 ,  C07D263/32 ,  C07D277/22 ,  C07D277/68 ,  C07D295/04 ,  C07D295/096 ,  C07D295/16 ,  C07D401/10 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D451/02 ,  C07D451/04

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract translation: 本发明涉及式（I）化合物：其中r，q，R，R2，R3，R4，R5a，R5b，R5c，R6a，R6b，R6c，R7，R8和R9在本文中描述为单立体异构体 或作为立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药的混合物; 其是白三烯A4水解酶抑制剂，因此可用于治疗炎症性疾病。 还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。

公开(公告)号：US20090086930A1

公开(公告)日：2009-04-02

申请号：US12238176

申请日：2008-09-25

Applicant: Jiake Xu ,  Bin Ye

Inventor： Jiake Xu ,  Bin Ye

IPC: A61B6/04

CPC classification number: A61B6/04 ,  A61B6/102 ,  Y10S5/943

Abstract: A medical table in which a top plate for a patient to lie on is supported by a pedestal base in a manner to be able to move parallel to a plate surface, includes a detecting device for detecting that fingers holding the top plate are about to collide against the pedestal base when moving the top plate, and a stopping device for stopping movement of the top plate according to a detection signal from the detecting device.

Abstract translation: 一种医疗台，其中用于患者躺着的顶板以能够平行于板表面的方式由基座支撑，包括检测装置，用于检测保持顶板的手指即将碰撞 在移动顶板时抵靠基座;以及停止装置，用于根据来自检测装置的检测信号停止顶板的移动。

公开(公告)号：US07485455B2

公开(公告)日：2009-02-03

申请号：US10632342

申请日：2003-08-01

Applicant: Jonathan C. Makielski ,  Bin Ye ,  Michael J. Ackerman

Inventor： Jonathan C. Makielski ,  Bin Ye ,  Michael J. Ackerman

IPC: C12N15/12 ,  C12N5/10 ,  C12N15/63

CPC classification number: C12Q1/6883 ,  C07K14/705 ,  C12Q2600/156

Abstract: The present invention discloses four groups of SCN5A variants that represent the most common SCN5A variants in humans. A specific mutation in one of the variants has been shown to display a different phenotype in relation to a human heart disease than other variants and known human sodium channel α subunits with corresponding mutations. The present invention provides new tools to study mutations and to design or identify new diagnostic and treatment strategies or agents for sodium channel related diseases or conditions.

Abstract translation: 本发明公开了四组代表人类中最常见的SCN5A变体的SCN5A变体。 与其他变体和具有相应突变的已知人钠通道α亚基相比，其中一个变体中的特异性突变显示出与人类心脏病相关的不同表型。 本发明提供用于研究突变并设计或鉴定用于钠通道相关疾病或病症的新诊断和治疗策略或药剂的新工具。

公开(公告)号：US20080293087A1

公开(公告)日：2008-11-27

申请号：US11931916

申请日：2007-10-31

Applicant: Jonathan C. Makielski ,  Nian-Qing Shi ,  Bin Ye

Inventor： Jonathan C. Makielski ,  Nian-Qing Shi ,  Bin Ye

IPC: C12Q1/02 ,  C07H21/00 ,  C07K14/00 ,  C12N15/63 ,  C12N5/00

CPC classification number: C07K14/705

Abstract: The present invention relates to isolated sulfonylurea receptor polynucleotides and polypeptides, as well as vectors and cells lines containing the polynucleotides and polypeptides. The present invention also relates to methods of using cell lines containing the polynucleotides and polypeptides to identify agents that are useful in ischemic preconditioning.

Abstract translation: 本发明涉及分离的磺酰脲受体多核苷酸和多肽，以及含有多核苷酸和多肽的载体和细胞系。 本发明还涉及使用含有多核苷酸和多肽的细胞系来鉴定可用于缺血预处理的试剂的方法。

公开(公告)号：US20050020605A1

公开(公告)日：2005-01-27

申请号：US10865976

申请日：2004-06-10

Applicant: Shou-Fu Lu ,  Gary Phillips ,  Bin Ye

Inventor： Shou-Fu Lu ,  Gary Phillips ,  Bin Ye

IPC: C07D401/14 ,  C07D409/14 ,  C07D471/04 ,  C07 ,  A61K31/4545 ,  A61K31/496

CPC classification number: C07D401/14 ,  C07D409/14 ,  C07D471/04

Abstract: The present invention relates to a series of compounds which are CCR-5 receptor antagonists of the general formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein.

Abstract translation: 本发明涉及一系列化合物，其是通式I的CCR-5受体拮抗剂或其药学上可接受的盐，其中变量在本文中定义。

公开(公告)号：US20050009120A1

公开(公告)日：2005-01-13

申请号：US10869027

申请日：2004-06-17

Applicant: Samuel Mok ,  Bin Ye ,  Daniel Cramer

Inventor： Samuel Mok ,  Bin Ye ,  Daniel Cramer

IPC: G01N33/574 ,  C07H21/04

CPC classification number: G01N33/574 ,  C12Q1/6886 ,  C12Q2600/112 ,  G01N33/57449

Abstract: The present invention is directed to diagnostic methods based upon the expression of the protein osteopontin. In particular, it is concerned with assays of urine samples collected from women for the purpose of determining whether they are at increased risk for having ovarian cancer.

Abstract translation: 本发明涉及基于蛋白质骨桥蛋白表达的诊断方法。 特别地，它涉及从妇女收集的尿液样品的测定，以确定它们是否具有增加患有卵巢癌的风险。

公开(公告)号：US06747031B2

公开(公告)日：2004-06-08

申请号：US10121379

申请日：2002-04-12

Applicant: Damian O. Arnaiz ,  John J. Baldwin ,  David D. Davey ,  James J. Devlin ,  Roland Ellwood Dolle, III ,  Shawn David Erickson ,  Kirk McMillan ,  Michael M. Morrissey ,  Michael H. J. Ohlmeyer ,  Gonghua Pan ,  Vidyadhar Madhav Paradkar ,  John Parkinson ,  Gary B. Phillips ,  Bin Ye ,  Zuchun Zhao

Inventor： Damian O. Arnaiz ,  John J. Baldwin ,  David D. Davey ,  James J. Devlin ,  Roland Ellwood Dolle, III ,  Shawn David Erickson ,  Kirk McMillan ,  Michael M. Morrissey ,  Michael H. J. Ohlmeyer ,  Gonghua Pan ,  Vidyadhar Madhav Paradkar ,  John Parkinson ,  Gary B. Phillips ,  Bin Ye ,  Zuchun Zhao

IPC: A61K31506

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

Abstract translation: 式（I）的N-杂环衍生物：本文描述以及其它N-杂环作为一氧化氮合酶的抑制剂。 含有这些化合物的药物组合物，使用这些化合物作为一氧化氮合酶抑制剂的方法以及合成这些化合物的方法也在本文中描述。

公开(公告)号：US06432947B1

公开(公告)日：2002-08-13

申请号：US09383813

申请日：1999-08-26

Applicant: Damian O. Arnaiz ,  John J. Baldwin ,  David D. Davey ,  James J. Devlin ,  Roland Ellwood Dolle, III ,  Shawn David Erickson ,  Kirk McMillan ,  Michael M. Morrissey ,  Michael H. J. Ohlmeyer ,  Gonghua Pan ,  Vidyadhar Madhav Paradkar ,  John Parkinson ,  Gary B. Phillips ,  Bin Ye ,  Zuchun Zhao

Inventor： Damian O. Arnaiz ,  John J. Baldwin ,  David D. Davey ,  James J. Devlin ,  Roland Ellwood Dolle, III ,  Shawn David Erickson ,  Kirk McMillan ,  Michael M. Morrissey ,  Michael H. J. Ohlmeyer ,  Gonghua Pan ,  Vidyadhar Madhav Paradkar ,  John Parkinson ,  Gary B. Phillips ,  Bin Ye ,  Zuchun Zhao

IPC: A61K31506

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

Abstract translation: 式（I）的N-杂环衍生物：本文描述以及其它N-杂环作为一氧化氮合酶的抑制剂。 含有这些化合物的药物组合物，使用这些化合物作为一氧化氮合酶抑制剂的方法以及合成这些化合物的方法也在本文中描述。

公开(公告)号：US06380221B1

公开(公告)日：2002-04-30

申请号：US09631450

申请日：2000-08-03

Applicant: Damian O. Arnaiz ,  Yuo-Ling Chou ,  Brian D. Griedel ,  Rushad E. Karanjawala ,  Monica J. Kochanny ,  Wheeseong Lee ,  Amy Mei Liang ,  Michael M. Morrissey ,  Gary B. Phillips ,  Karna Lyn Sacchi ,  Steven T. Sakata ,  Kenneth J. Shaw ,  R. Michael Snider ,  Shung C. Wu ,  Bin Ye ,  Zuchun Zhao

Inventor： Damian O. Arnaiz ,  Yuo-Ling Chou ,  Brian D. Griedel ,  Rushad E. Karanjawala ,  Monica J. Kochanny ,  Wheeseong Lee ,  Amy Mei Liang ,  Michael M. Morrissey ,  Gary B. Phillips ,  Karna Lyn Sacchi ,  Steven T. Sakata ,  Kenneth J. Shaw ,  R. Michael Snider ,  Shung C. Wu ,  Bin Ye ,  Zuchun Zhao

IPC: A61K3144

CPC classification number: C07D401/04 ,  C07D333/38 ,  C07D333/70 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D473/06 ,  C07D473/34

Abstract: This invention is directed to compounds of formula (III): wherein B, C, D, E, R1, R2 and R3 are disclosed herein. These components are disclosed as being useful as anti-coagulants.

Abstract translation: 本发明涉及式（III）化合物：其中B，C，D，E，R 1，R 2和R 3在本文中公开。 这些组分被公开用作抗凝剂。