公开(公告)号：US20160271252A1

公开(公告)日：2016-09-22

申请号：US15166476

申请日：2016-05-27

Applicant: Insys Development Company, Inc.

Inventor： Kiran Kumar Vangara ,  Huaguang Li ,  Ningxin Yan ,  Hung Q. Nguyen ,  Venkat R. Goskonda

IPC: A61K47/14 ,  A61K9/00 ,  A61K47/44 ,  A61K47/10 ,  A61K47/26 ,  A61K31/047 ,  A61K47/22

CPC classification number: A61K47/14 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/08 ,  A61K31/047 ,  A61K31/05 ,  A61K31/352 ,  A61K47/10 ,  A61K47/22 ,  A61K47/26 ,  A61K47/44

Abstract: The present invention is generally directed to substantially pure cannabidiol, stable cannabinoid pharmaceutical formulations, and methods of their use.

公开(公告)号：US10722510B2

公开(公告)日：2020-07-28

申请号：US15238909

申请日：2016-08-17

Applicant: Insys Development Company, Inc.

Inventor： Kiran Amancha ,  Shivani Chilampalli ,  Thrimoorthy Potta ,  Ningxin Yan ,  Venkat R. Goskonda

IPC: A61K31/485 ,  A61K47/10 ,  A61K9/08 ,  A61K9/00 ,  A61K47/18 ,  A61K47/02

Abstract: The invention provides stable liquid formulations containing naloxone, a pharmaceutically acceptable salt or a derivative thereof. The invention further provides methods for treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering the liquid formulations of the present invention both intranasally and sublingually to a patient in need thereof. Further, the invention provides a method of treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering intranasally and sublingually the naloxone formulations of the present invention.

公开(公告)号：US20180289639A1

公开(公告)日：2018-10-11

申请号：US16007998

申请日：2018-06-13

Applicant: Insys Development Company, Inc.

Inventor： Thrimoorthy Potta ,  Craig Bastian ,  Ningxin Yan ,  Venkat Goskonda ,  Chandeshwari Chilampalli ,  Rachana Inavolu ,  Eshwaran Narayanan

IPC: A61K31/137 ,  A61K47/02 ,  A61K47/12 ,  A61P37/08 ,  A61K9/00 ,  A61K9/12

Abstract: The present invention is directed to epinephrine spray formulations. The present invention is further directed to methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatments.

公开(公告)号：US10016403B2

公开(公告)日：2018-07-10

申请号：US15478430

申请日：2017-04-04

Applicant: Insys Development Company, Inc.

Inventor： S. George Kottayil ,  Venkat R. Goskonda ,  Zhongyuan Zhu ,  Linet Kattookaran ,  Neha Parikh

IPC: A61K31/4468 ,  A61K9/00 ,  A61K31/445 ,  A61K31/435 ,  A61M11/00 ,  A61K47/10

CPC classification number: A61K31/4468 ,  A61K9/0056 ,  A61K9/006 ,  A61K31/435 ,  A61K31/445 ,  A61K47/10 ,  A61M11/00

Abstract: The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable salt thereof, or derivative thereof, suitable for administration to a patient, and methods for treatment with the formulations.

公开(公告)号：US09867818B2

公开(公告)日：2018-01-16

申请号：US15246343

申请日：2016-08-24

Applicant: Insys Development Company, Inc.

Inventor： Kiran P. Amancha ,  Chandeshwari S. Chilampalli ,  Venkat R. Goskonda

IPC: A61K31/485 ,  A61K9/00 ,  A61K47/10 ,  A61K31/4748 ,  A61K47/20

CPC classification number: A61K31/485 ,  A61K9/006 ,  A61K31/085 ,  A61K31/198 ,  A61K31/375 ,  A61K31/4748 ,  A61K47/10 ,  A61K47/20 ,  A61K2300/00

Abstract: The invention provides sublingual formulations containing buprenorphine, a pharmaceutically acceptable salt thereof, or a derivative thereof. The invention further provides sublingual formulations containing buprenorphine and naloxone, pharmaceutically acceptable salts thereof or derivatives thereof. The invention further provides a method of treating pain or opioid dependence by administering sublingual formulations containing buprenorphine, a pharmaceutically acceptable salt thereof, or a derivative thereof to a patient in need thereof.

公开(公告)号：US20170239230A1

公开(公告)日：2017-08-24

申请号：US15478499

申请日：2017-04-04

Applicant: Insys Development Company, Inc.

Inventor： S. George Kottayil ,  Venkat R. Goskonda ,  Zhongyuan Zhu ,  Linet Kattookaran ,  Neha Parikh

IPC: A61K31/4468 ,  A61K9/00

CPC classification number: A61K31/4468 ,  A61K9/0053 ,  A61K9/0056 ,  A61K9/006 ,  A61K31/435 ,  A61K31/445 ,  A61K47/10 ,  A61M11/00

Abstract: The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable sale thereof, or derivative thereof, suitable for administration to a patient, and methods for treatment with the formulations.

公开(公告)号：US20170224634A1

公开(公告)日：2017-08-10

申请号：US15499178

申请日：2017-04-27

Applicant: Insys Development Company, Inc.

Inventor： Kiran Kumar Vangara ,  Huaguang Li ,  Ningxin Yan ,  Hung Q. Nguyen ,  Venkat R. Goskonda

IPC: A61K31/05 ,  A61K47/44 ,  A61K47/22 ,  A61K9/00 ,  A61K47/14

CPC classification number: A61K31/05 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/08 ,  A61K31/355 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/44 ,  A61K2300/00

Abstract: The present invention is generally directed to substantially pure cannabidiol, stable cannabinoid pharmaceutical formulations, and methods of their use.

公开(公告)号：US20160361667A1

公开(公告)日：2016-12-15

申请号：US15174286

申请日：2016-06-06

Applicant: Insys Development Company, Inc.

Inventor： Ashok Jagannath Chavan ,  Rakeshkumar Joshi ,  Scott Newton Crisman ,  Patrick Karchung Kwan

IPC: B01D15/00 ,  B65B7/28 ,  B65D43/00

CPC classification number: B01D15/00 ,  B09B3/0075 ,  B65B7/28

Abstract: The present invention is directed to a disposal system for unused pharmaceuticals comprised of a container and bentonite clay affixed to one or more substrates. Further the present invention is directed to a disposal system for unused portions of a liquid fentanyl spray comprising a container and bentonite clay affixed to one or more substrates.

Abstract translation: 本发明涉及一种用于未使用药物的处理系统，该处理系统由固定在一个或多个基底上的容器和膨润土组成。 此外，本发明涉及一种用于液体芬太尼喷雾器的未使用部分的处置系统，其包括固定到一个或多个基底上的容器和膨润土。

公开(公告)号：US10441538B2

公开(公告)日：2019-10-15

申请号：US15876553

申请日：2018-01-22

Applicant: Insys Development Company, Inc.

Inventor： Kiran Amancha ,  Chandeshwari Chilampalli ,  Thrimoorthy Potta ,  Ningxin Yan ,  Venkat R. Goskonda ,  Eshwaran Narayanan

IPC: A61K31/485 ,  A61K47/10 ,  A61K47/12 ,  A61K9/08 ,  A61P25/36 ,  A61K9/00

Abstract: The invention provides stable liquid formulations containing naloxone, a pharmaceutically acceptable salt or a derivative thereof. The invention further provides methods for treating opioid overdose, opioid dependence, and congenital insensitivity to pain with anhidrosis by administering the liquid formulations of the present invention intranasally to a patient in need thereof. Further, the invention provides a method of treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering intranasally the naloxone formulations of the present invention.

公开(公告)号：US20190216750A1

公开(公告)日：2019-07-18

申请号：US16290853

申请日：2019-03-01

Applicant: Insys Development Company, Inc.

Inventor： Thrimoorthy Potta ,  Craig Bastian ,  Ningxin Yan ,  Venkat Goskonda ,  Chandeshwari Chilampalli ,  Rachana Inavolu ,  Eshwaran Narayanan

IPC: A61K31/137 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61P37/08

CPC classification number: A61K31/137 ,  A61K9/0043 ,  A61K47/02 ,  A61K47/10 ,  A61K47/183 ,  A61K47/186 ,  A61P37/08

Abstract: The present invention is directed to epinephrine spray formulations. The present invention is further directed to methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatments.