公开(公告)号：US20090153130A1

公开(公告)日：2009-06-18

申请号：US11556783

申请日：2006-11-06

Applicant: Jeo-young SHIM ,  Kyu-sang LEE ,  Chang-eun YOO ,  Kyu-youn HWANG ,  Young-a KIM ,  Kyu-tae YOO ,  Yeon-ja CHO

Inventor： Jeo-young SHIM ,  Kyu-sang LEE ,  Chang-eun YOO ,  Kyu-youn HWANG ,  Young-a KIM ,  Kyu-tae YOO ,  Yeon-ja CHO

IPC: G01N27/00 ,  H01L29/772 ,  H01L21/335

CPC classification number: G01N33/54373 ,  B01J2219/00529 ,  B01J2219/00596 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00722 ,  G01N27/4145

Abstract: Provided is a Field-Effect Transistor (FET)-based biosensor including: a substrate; a source and a drain, disposed on the substrate, having opposite polarity to the substrate; a gate, disposed on the substrate, contacting the source and the drain; and an inorganic film capable of binding with a biomolecule, disposed on a surface of the gate. A method of manufacturing the FET-based biosensor and a method of detecting a biomolecule using the FET-based biosensor is also provided. The FET-based biosensor can be manufactured using a semiconductor fabrication process without performing an additional process. Therefore, the inorganic film can be selectively deposited on a surface of a specific gate of a single FET, or on the surfaces of some gates of a plurality of FETs using patterning. Furthermore, the FET-based biosensor can be used to effectively detect trace amounts of a target biomolecule in a sample.

Abstract translation: 提供了一种基于场效应晶体管（FET）的生物传感器，包括：基板; 源极和漏极，设置在衬底上，具有与衬底相反的极性; 栅极，设置在基板上，与源极和漏极接触; 以及能够与生物分子结合的无机膜，其设置在栅极的表面上。 还提供了制造基于FET的生物传感器的方法和使用基于FET的生物传感器检测生物分子的方法。 基于FET的生物传感器可以使用半导体制造工艺制造而不执行额外的工艺。 因此，无机膜可以选择性地沉积在单个FET的特定栅极的表面上，或者使用图案化沉积在多个FET的一些栅极的表面上。 此外，基于FET的生物传感器可以用于有效地检测样品中痕量的目标生物分子。

公开(公告)号：US20060205013A1

公开(公告)日：2006-09-14

申请号：US11336110

申请日：2006-01-20

Applicant: Jeo-young Shim ,  Su-hyeon Kim ,  Kyu-tae Yoo ,  Sung-ouk Jung ,  Joon-shik Park

Inventor： Jeo-young Shim ,  Su-hyeon Kim ,  Kyu-tae Yoo ,  Sung-ouk Jung ,  Joon-shik Park

IPC: G01N33/53

CPC classification number: B82Y30/00 ,  B82Y15/00 ,  G01N27/4145

Abstract: Provided is a field effect transistor (FET) type biosensor including a source electrode, a gate, and a drain electrode. A ligand that can bind to a side of a nucleic acid is added to the surface of the gate. In a conventional FET type biosensor, it is difficult to detect a signal within the debye length because a target nucleic acid is directly fixed to the surface of a gate of the conventional FET. However, in the present invention, this problem can be overcome and the debye length can be increased by treating the surface of a gate of an FET sensor with a ligand that can bind to a side of a nucleic acid. The ligand can be adsorbed onto the surface of the gate. In this case, the nucleic acid is adsorbed parallel to the surface of the gate, not perpendicular to the surface of the gate, thus generating an effective depletion region. In addition, hybridization efficiency can be increased because a hybridized sample can be injected into an FET sensor at high ionic strength.

Abstract translation: 提供了包括源电极，栅极和漏电极的场效应晶体管（FET）型生物传感器。 可以结合核酸一侧的配体加入到门的表面。 在传统的FET型生物传感器中，由于目标核酸直接固定在常规FET的栅极表面，难以检测德拜长度内的信号。 然而，在本发明中，可以克服这个问题，并且可以通过用可以结合核酸一侧的配体处理FET传感器的栅极的表面来增加德拜长度。 配体可以吸附在栅极的表面上。 在这种情况下，核酸被平行于栅极的表面吸附，而不垂直于栅极的表面，从而产生有效的耗尽区域。 此外，杂交效率可以提高，因为杂化样品可以以高离子强度注入FET传感器。

公开(公告)号：US20060189725A1

公开(公告)日：2006-08-24

申请号：US11338994

申请日：2006-01-25

Applicant: Jeo-young Shim ,  Sung-ouk Jung ,  Ji-na Namgoong ,  Kyu-tae Yoo ,  Jang-seok Ma

Inventor： Jeo-young Shim ,  Sung-ouk Jung ,  Ji-na Namgoong ,  Kyu-tae Yoo ,  Jang-seok Ma

IPC: G01N21/47

CPC classification number: C03C17/28 ,  C03C2218/111 ,  C03C2218/365 ,  G01N21/278 ,  G01N21/6452

Abstract: Provided is a calibration apparatus for an optical scanner, including a substrate on which a molecule capable of forming an excimer is immobilized. A method of manufacturing the calibration apparatus and a method of calibrating an optical scanner using the calibration apparatus are also provided.

Abstract translation: 提供了一种用于光学扫描仪的校准装置，包括其上固定有能够形成准分子的分子的基底。 还提供了一种制造校准装置的方法和使用校准装置校准光学扫描器的方法。

公开(公告)号：US08035175B2

公开(公告)日：2011-10-11

申请号：US11613258

申请日：2006-12-20

Applicant: Jeo-young Shim ,  Kyu-sang Lee ,  Kyu-tae Yoo ,  Won-seok Chung

Inventor： Jeo-young Shim ,  Kyu-sang Lee ,  Kyu-tae Yoo ,  Won-seok Chung

IPC: H01L27/14

CPC classification number: G01N27/4145

Abstract: A field effect transistor for detecting ionic material and a method of detecting ionic material using the field effect transistor. The field effect transistor for detecting ionic material includes a substrate formed of a semiconductor material, a source region and a drain region spaced apart from each other in the substrate and doped with an opposite conductivity type to that of the substrate, a channel region interposed between the source region and the drain region, an insulating layer disposed on the channel region and formed of an electrically insulating material, a first reference electrode disposed at an edge of the upper portion of the insulating layer and a second reference electrode disposed to be spaced apart from the insulating layer.

Abstract translation: 用于检测离子材料的场效应晶体管和使用场效应晶体管检测离子材料的方法。 用于检测离子材料的场效应晶体管包括由衬底形成的衬底，源极区和漏极区，在衬底中彼此间隔开并且掺杂有与衬底相反的导电类型，沟道区介于 源极区域和漏极区域，设置在沟道区域上并由电绝缘材料形成的绝缘层，设置在绝缘层的上部的边缘处的第一参考电极和设置成间隔开的第二参考电极 从绝缘层。

公开(公告)号：US07928740B2

公开(公告)日：2011-04-19

申请号：US11939969

申请日：2007-11-14

Applicant: Won Seok Chung ,  Kyu Tae Yoo ,  Jeo Young Shim ,  Junghoon Lee ,  Misun Cha ,  JungIm Han ,  Seungwon Jung

Inventor： Won Seok Chung ,  Kyu Tae Yoo ,  Jeo Young Shim ,  Junghoon Lee ,  Misun Cha ,  JungIm Han ,  Seungwon Jung

IPC: G01R27/08

CPC classification number: G01N33/551 ,  G01N27/127 ,  G01N33/5438 ,  Y10S977/852

Abstract: A device and method are disclosed for detecting biomolecules. More specifically, by measuring the change in the electrical properties of a complex between a probe and carbon nanotubes, a non-label detection is achieved, capable of a rapid, sensitive and electrical detection of the presence and concentration of biomolecules in a sample solution.

Abstract translation: 公开了用于检测生物分子的装置和方法。 更具体地，通过测量探针和碳纳米管之间的络合物的电学性质的变化，实现了非标记检测，能够快速，灵敏和电检测样品溶液中生物分子的存在和浓度。

公开(公告)号：US20100183812A1

公开(公告)日：2010-07-22

申请号：US12709741

申请日：2010-02-22

Applicant: Jeo-young Shim ,  Sung-ouk Jung ,  Jin-na Namgoong ,  Kyu-tae Yoo ,  Jang-seok Ma

Inventor： Jeo-young Shim ,  Sung-ouk Jung ,  Jin-na Namgoong ,  Kyu-tae Yoo ,  Jang-seok Ma

IPC: B05D3/10

CPC classification number: C03C17/28 ,  C03C2218/111 ,  C03C2218/365 ,  G01N21/278 ,  G01N21/6452

Abstract: Provided is a calibration apparatus for an optical scanner, including a substrate on which a molecule capable of forming an excimer is immobilized. A method of manufacturing the calibration apparatus and a method of calibrating an optical scanner using the calibration apparatus are also provided.

Abstract translation: 提供了一种用于光学扫描仪的校准装置，包括其上固定有能够形成准分子的分子的基底。 还提供了一种制造校准装置的方法和使用校准装置校准光学扫描器的方法。

公开(公告)号：US07659149B2

公开(公告)日：2010-02-09

申请号：US11345790

申请日：2006-02-02

Applicant: Kyu-tae Yoo ,  Sung-ouk Jung ,  Jun-hong Min ,  Ji-na Namgoong ,  Soo-hyung Choi ,  Jeo-young Shim

Inventor： Kyu-tae Yoo ,  Sung-ouk Jung ,  Jun-hong Min ,  Ji-na Namgoong ,  Soo-hyung Choi ,  Jeo-young Shim

IPC: C12Q1/68 ,  H01L21/66 ,  H01L21/00 ,  H01L21/336 ,  H01L29/80

CPC classification number: G01N33/54306

Abstract: Provided is a method of sensing biomolecules using a bioFET, the method including: forming a layer including Au on a gate of the bioFET; forming a probe immobilized on a substrate separated from the gate by a predetermined distance, and a biomolecule having a thiol group (—SH) which is incompletely bonded to the probe; reacting the probe with a sample including a target molecule; and measuring a current flowing in a channel region between a source and a drain of the bioFET.

Abstract translation: 提供了一种使用bioFET感测生物分子的方法，该方法包括：在bioFET的栅极上形成包含Au的层; 形成固定在与栅极分离预定距离的基板上的探针，以及具有与探针不完全结合的硫醇基（-SH）的生物分子; 使探针与包含靶分子的样品反应; 以及测量在bioFET的源极和漏极之间的沟道区域中流动的电流。

公开(公告)号：US20090170056A1

公开(公告)日：2009-07-02

申请号：US12116244

申请日：2008-05-07

Applicant: Yun-sun NAM ,  Jay-woo Kim ,  Soo-hyun Bae ,  Byung-soo Gim ,  Kyu-tae Yoo

Inventor： Yun-sun NAM ,  Jay-woo Kim ,  Soo-hyun Bae ,  Byung-soo Gim ,  Kyu-tae Yoo

IPC: G09B19/00 ,  A61B5/00

CPC classification number: G09B23/28 ,  G09B19/0092 ,  G16H20/60

Abstract: Provided are a method and an apparatus for providing educational material. The method includes: receiving information about a health state and lifestyle of a patient from a remote terminal at every predetermined period of time; selecting educational material appropriate for the patient from a plurality of pieces of educational material based on the information; and providing the selected educational material to the remote terminal. As a result, educational material appropriate for private characters of a patient can be selected and provided.

Abstract translation: 提供了用于提供教育材料的方法和装置。 该方法包括：在每个预定时间段从远程终端接收关于患者的健康状况和生活方式的信息; 基于该信息从多张教材中选择适合于患者的教材; 并将所选教育材料提供给远程终端。 因此，可以选择和提供适合于患者的私人角色的教材。

公开(公告)号：US20070231211A1

公开(公告)日：2007-10-04

申请号：US11695886

申请日：2007-04-03

Applicant: Kyu-tae Yoo ,  Kyu-sang Lee ,  Jeo-young Shim ,  Won-seok Chung ,  Yeon-ja Cho

Inventor： Kyu-tae Yoo ,  Kyu-sang Lee ,  Jeo-young Shim ,  Won-seok Chung ,  Yeon-ja Cho

IPC: G01N30/96

CPC classification number: G01N33/54373 ,  G01N27/4145

Abstract: Provided is a method of detecting the presence of a target bio-molecule or a concentration of the bio-molecule using a field effect transistor. The method includes: contacting a first sample having a first target bio-molecule with a reference electrode of a field effect transistor; measuring a first electric signal change of the field effect transistor; contacting a second sample with a sensing surface of the same field effect transistor; measuring a second electric signal change of the field effect transistor; and comparing the first electric signal with the second electric signal.

Abstract translation: 提供了使用场效应晶体管检测目标生物分子的存在或生物分子的浓度的方法。 该方法包括：将具有第一目标生物分子的第一样品与场效应晶体管的参比电极接触; 测量场效应晶体管的第一电信号变化; 使第二样品与相同场效应晶体管的感测表面接触; 测量场效应晶体管的第二电信号变化; 以及将所述第一电信号与所述第二电信号进行比较。

公开(公告)号：US07151301B2

公开(公告)日：2006-12-19

申请号：US11057642

申请日：2005-02-14

Applicant: Kyu-tae Yoo ,  Geun-bae Lim ,  Joon-ho Kim ,  Kak Namkoong

Inventor： Kyu-tae Yoo ,  Geun-bae Lim ,  Joon-ho Kim ,  Kak Namkoong

IPC: H01L29/76

CPC classification number: G01N27/4145

Abstract: There is provided a biomolecule FET enhancing a sensitivity. The biomolecule FET includes a substrate, first and second impurity regions formed on both sides of the substrate, and doped with impurities of a polarity opposite to that of the substrate, a gate formed on the substrate and being in contact with the first and second impurity regions, and a probe biomolecule attached to the gate. A region of the gate adjacent to the first impurity region is wider than a region thereof adjacent to the second impurity region. A density of the probe biomolecule attached to the surface of the gate is increased, and when detecting a level of hybridization of the probe biomolecule and the target biomolecule, its sensitivity is improved.

Abstract translation: 提供了提高灵敏度的生物分子FET。 生物分子FET包括基板，形成在基板两侧的第一和第二杂质区，并且掺杂极性与基板极性相反的杂质;形成在基板上并与第一和第二杂质接触的栅极 区域，以及连接到门的探针生物分子。 与第一杂质区相邻的栅极的区域比与第二杂质区相邻的区域宽。 附着在栅极表面的探针生物分子的密度增加，并且当检测到探针生物分子和靶生物分子的杂交水平时，其灵敏度得到改善。