公开(公告)号：US20170027492A1

公开(公告)日：2017-02-02

申请号：US15144441

申请日：2016-05-02

Applicant: OptiScan Biomedical Corporation

Inventor： Michael Butler ,  Eugene Lim ,  Craig Johnson

IPC: A61B5/15 ,  A61M39/10 ,  A61B5/145 ,  A61B5/155 ,  A61B5/1455

CPC classification number: A61B5/157 ,  A61B5/0059 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/14557 ,  A61B5/1459 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/412 ,  A61B5/6866 ,  A61B2560/0228 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61M5/1415 ,  A61M5/142 ,  A61M5/16827 ,  A61M5/1723 ,  A61M39/10 ,  A61M39/1011 ,  A61M2005/14208 ,  A61M2039/1033 ,  A61M2205/12 ,  A61M2205/128 ,  G01N21/03 ,  G01N21/07 ,  G01N21/35 ,  G01N33/491 ,  G01N2021/0346 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17

Abstract: Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can be connected to the source of bodily fluid via a connector that is configured to maintain uniform velocity across the connector and reduce the dead space volume.

Abstract translation: 描述了用于测定来自样品如血液或血浆的一种或多种分析物的浓度的方法和系统。 本文描述的系统可以被配置为从体液源抽出一定体积的样品，将抽出的样品的第一部分引导到分析物监测系统，并将样品的第二部分返回给患者。 分析物监测系统可以经由连接器连接到体液源，该连接器被配置为保持穿过连接器的均匀速度并减少死空间体积。

公开(公告)号：US09554742B2

公开(公告)日：2017-01-31

申请号：US14589867

申请日：2015-01-05

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: G01N33/48 ,  A61B5/157 ,  A61B5/1455 ,  A61B5/15 ,  G01N33/49 ,  A61B5/00 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/153 ,  G01N21/03 ,  G01N21/07 ,  A61M5/172 ,  G06F19/00 ,  A61M5/142 ,  G01N21/35 ,  A61M5/14 ,  A61M5/168

CPC classification number: A61B5/157 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/14557 ,  A61B5/1459 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/6866 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61M5/1415 ,  A61M5/142 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/12 ,  A61M2205/128 ,  G01N21/03 ,  G01N21/07 ,  G01N21/35 ,  G01N33/491 ,  G01N2021/0346 ,  G06F19/00 ,  G06F19/3468

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

Abstract translation: 公开了用于确定流体（例如血液）中分析物浓度的系统和方法。 该系统可以从患者抽取血液并将血液输送到样品池。 流体（例如，等离子体）的特定组分可以被分离和/或定位，使得在流体的特定组分（例如，等离子体）中测量分析物的浓度。 样品池可以包括具有两个窗件的样品容器。 该系统可以具有流体通道，其具有构造成与多腔导管配合而不泄漏的顶端。 多腔导管可以具有近端和远端端口。 流体压力系统可以被配置成周期性地从脉管系统中抽取流体通过近端血管内开口和近端口，同时保持低压和/或流速，从而降低反转容器中的流体流动的风险，并将输注物上游到另一个 血管内开放。

公开(公告)号：US20150198501A1

公开(公告)日：2015-07-16

申请号：US14573868

申请日：2014-12-17

Applicant: OptiScan Biomedical Corporation

Inventor： Peter Rule ,  James D. Causey, III

IPC: G01M3/28

CPC classification number: G01M3/2846 ,  A61B5/14532 ,  A61B5/15 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150854 ,  A61B5/150862 ,  A61B5/15087 ,  A61B5/157 ,  A61M5/1413 ,  A61M5/16831 ,  A61M5/16854 ,  A61M2205/15

Abstract: Various embodiments disclosed herein relate to detecting leaks in a patient monitoring system. The system can include a fluid handling network configured to receive a fluid sample drawn from a patient and to deliver at least a portion of the fluid sample to an analyte measurement system. The system can isolate at least a portion of the fluid handling network, can apply pressure to the at least a portion of the fluid handling network, can measure the pressure in the at least a portion of the fluid handling network, and can determine whether a leak is present in the at least a portion of the fluid handling network based at least in part on the measured pressure.

Abstract translation: 本文公开的各种实施例涉及检测患者监测系统中的泄漏。 该系统可以包括流体处理网络，该流体处理网络被配置为接收从患者抽取的流体样品并将至少一部分流体样品输送到分析物测量系统。 该系统可以隔离流体处理网络的至少一部分，可以向流体处理网络的至少一部分施加压力，可以测量流体处理网络的至少一部分中的压力，并且可以确定是否 至少部分地基于所测量的压力，在流体处理网络的至少一部分中存在泄漏。

公开(公告)号：US20150168294A1

公开(公告)日：2015-06-18

申请号：US14335491

申请日：2014-07-18

Applicant: OptiScan Biomedical Corporation

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: G01N21/35 ,  A61B10/00 ,  A61B5/15 ,  A61B5/151 ,  A61B5/157

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

公开(公告)号：US20150045641A1

公开(公告)日：2015-02-12

申请号：US14208672

申请日：2014-03-13

Applicant: OptiScan Biomedical Corporation

Inventor： Peter Rule

IPC: A61M5/142 ,  A61B5/1468 ,  A61M5/172 ,  A61B5/157 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/145

CPC classification number: A61M5/142 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1468 ,  A61B5/15003 ,  A61B5/150229 ,  A61B5/150992 ,  A61B5/157 ,  A61B5/7275 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/7435 ,  A61B5/7475 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2205/505 ,  A61M2230/201

Abstract: Systems for rapid and accurate analyte measurement are described. For example, periodic glucose measurements can be achieved with high accuracy in a critical care environment by drawing blood into a device more than once per hour, analyzing blood (for example using infrared radiation through plasma). Safety and accuracy can be achieved by improved fluid control and avoidance of clotting. Data can be conveyed (e.g., displayed) to a user. A user can be allowed to annotate the data. For example, a touchscreen or other interface can allow addition of notes on a running graph of data, indicating events or other items of interest that may correspond to data readings or to particular times.

Abstract translation: 描述了用于快速和准确分析物测量的系统。 例如，通过每小时将血液吸入装置多于一次，分析血液（例如使用通过血浆的红外线辐射），可以在重要的护理环境中以高精度实现周期性葡萄糖测量。 通过改善流体控制和避免凝结可以实现安全性和准确性。 可以将数据传送（例如，显示）给用户。 可以允许用户对数据进行注释。 例如，触摸屏或其他界面可以允许在正在运行的数据图上添加笔记，指示可能对应于数据读数或特定时间的事件或感兴趣的其他项目。

公开(公告)号：US20140236047A1

公开(公告)日：2014-08-21

申请号：US14259940

申请日：2014-04-23

Applicant: OptiScan Biomedical Corporation

Inventor： Michael Butler ,  Eugene Lim ,  Craig Johnson

IPC: A61B5/15 ,  A61M39/10 ,  A61B5/155

CPC classification number: A61B5/150992 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/15003 ,  A61B5/150229 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/412 ,  A61B2560/0437 ,  A61M39/10 ,  A61M39/1011 ,  A61M39/26 ,  A61M2039/1027 ,  A61M2039/1033 ,  A61M2039/263 ,  A61M2205/0222 ,  A61M2205/0238

Abstract: Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a sample from a source of fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample. The analyte monitoring system can be connected to the fluid source via a connector that is configured to improve fluid flow and reduce blood clotting risk. These goals can be accomplished, for example, by employing coatings in or on a connector, positioning a resilient substance at or near the junction, by reducing dead space volume, by using resiliency to improve fit, by extending a portion of one connector to better mate with a portion of another connector, etc.

Abstract translation: 描述了用于测定来自样品如血液或血浆的一种或多种分析物的浓度的方法和系统。 本文描述的系统可以被配置为从流体源抽出样品，将抽出的样品的第一部分引导到分析物监测系统并返回样品的第二部分。 分析物监测系统可以通过连接器连接到流体源，连接器被配置成改善流体流动并降低凝血风险。 这些目标可以通过例如通过在连接器中或连接器上使用涂层来实现，通过使弹性来改善配合，通过减少死空间体积来将弹性物质定位在接合点处或附近，通过将一个连接器的一部分延伸到更好的方式 与另一个连接器的一部分配合等

公开(公告)号：US20200227144A1

公开(公告)日：2020-07-16

申请号：US16680468

申请日：2019-11-11

Applicant: OptiScan Biomedical Corporation

Inventor： David N. Callicoat ,  Monnett H. Soldo

IPC: G16C99/00 ,  G01N33/66 ,  G16B99/00

Abstract: Examples of methods and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. In one example, the method can reduce the error in the estimation of analyte concentration in the presence of interferents. The method can include the use of one or more calibration set to determine analyte concentration. From a sample measurement, each calibration set can be tested to determine if it is eligible to estimate the analyte concentration in the sample. An estimate of analyte concentration can then be produced, based at least in part on the eligible calibration sets and on the sample measurement. In some implementations, if no calibration sets are eligible, an action is taken such as not outputting an estimate, displaying an alarm or alert, or providing a notification.

公开(公告)号：US20200178869A1

公开(公告)日：2020-06-11

申请号：US16539872

申请日：2019-08-13

Applicant: OptiScan Biomedical Corporation

Inventor： Richard Keenan ,  Jeffrey Chiou ,  Jennifer Gable ,  Kenneth I-Shen Li ,  Roger Tong ,  Mike Recknor ,  James R. Braig

IPC: A61B5/157 ,  G01N33/50

Abstract: A fluid handling system for use in bodily fluid analysis. The system comprises a first fluid handling module configured to interface with a main instrument. The first fluid handling module has a first fluid handling network and the first fluid handling network includes an infusate passage and an infusion fluid pressure member suitable for moving fluid within the infusate passage. The fluid handling system also has a second fluid handling module separate from the first module which is configured to interface with the main instrument. The second fluid handling module has a second fluid handling network and at least one sample analysis cell which is accessible via the second fluid handling network. The first and second modules are configured to interconnect and provide fluid communication between the first and second fluid handling network and the sample cells.

公开(公告)号：US20180263555A1

公开(公告)日：2018-09-20

申请号：US15853249

申请日：2017-12-22

Applicant: OptiScan Biomedical Corporation

Inventor： Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/00

CPC classification number: A61B5/4839 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/157 ,  A61B5/6866 ,  A61M5/1415 ,  A61M5/1452 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/201

Abstract: Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can include an automated blood withdrawal system that is configured to withdraw blood from the patient's vasculature at low pressure and/or withdrawal rates so as to reduce or prevent contamination of the withdrawn fluid from the infusion fluids.

公开(公告)号：US20180259420A1

公开(公告)日：2018-09-13

申请号：US15863630

申请日：2018-01-05

Applicant: OptiScan Biomedical Corporation

Inventor： Peter Rule ,  James D. Causey

IPC: G01M3/28 ,  A61M5/14 ,  A61B5/15 ,  A61B5/145 ,  A61M5/168 ,  A61B5/157

CPC classification number: G01M3/2846 ,  A61B5/14532 ,  A61B5/15 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150854 ,  A61B5/150862 ,  A61B5/15087 ,  A61B5/157 ,  A61M5/1413 ,  A61M5/16831 ,  A61M5/16854 ,  A61M2205/15

Abstract: Various embodiments disclosed herein relate to detecting leaks in a patient monitoring system. The system can include a fluid handling network configured to receive a fluid sample drawn from a patient and to deliver at least a portion of the fluid sample to an analyte measurement system. The system can isolate at least a portion of the fluid handling network, can apply pressure to the at least a portion of the fluid handling network, can measure the pressure in the at least a portion of the fluid handling network, and can determine whether a leak is present in the at least a portion of the fluid handling network based at least in part on the measured pressure.