公开(公告)号：US10091984B2

公开(公告)日：2018-10-09

申请号：US14907167

申请日：2014-07-22

Applicant: Streck, Inc.

Inventor： Rohan M. Fernando ,  Wayne L. Ryan ,  Brad Hunsley

IPC: A01N1/02 ,  G01N33/574

Abstract: Methods and compositions for stabilizing a biological sample for analysis, comprising the steps of obtaining in a sample collection device a biological sample from a subject, the biological sample including at least one circulating tumor cell from the subject. The methods may include a step of contacting the biological sample with a protective agent composition that includes a preservative agent, an optional anticoagulant, and a quenching agent to form a mixture that includes the protective agent composition and the sample.

公开(公告)号：US20180243406A1

公开(公告)日：2018-08-30

申请号：US15967058

申请日：2018-04-30

Applicant: Streck, Inc.

Inventor： Wayne L. Ryan ,  James A. Grunkemeyer

IPC: A61K39/275 ,  C12N7/00 ,  A61K39/12 ,  A61K39/00

CPC classification number: A61K39/275 ,  A61K39/12 ,  A61K2039/5252 ,  C12N7/00 ,  C12N2760/16134 ,  C12N2760/16163

Abstract: The present invention is directed at a composition comprising a live swine flu virus having an infectious component and a plurality of surface antigens in contact with a formaldehyde donor agent having a molecular weight that is less than about 400 g/mol. Preferably, the formaldehyde donor agent is selected from a non-crosslinking chemical fixative that contains urea.

公开(公告)号：US20180223335A1

公开(公告)日：2018-08-09

申请号：US15941383

申请日：2018-03-30

Applicant: Streck, Inc.

Inventor： Matthew R. Kreifels ,  Scott E. Whitney ,  Joel R. TerMaat

IPC: C12Q1/686 ,  G01N21/64

CPC classification number: C12Q1/686 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0627 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate reduced sample read time and rapid reading of multiple light wavelengths.

公开(公告)号：US20180216165A1

公开(公告)日：2018-08-02

申请号：US15937446

申请日：2018-03-27

Applicant: Streck, Inc.

Inventor： M. Rohan Fernando

IPC: C12Q1/6806

CPC classification number: C12Q1/6806 ,  C09K15/20 ,  C12Q2527/125 ,  C12Q2527/127

Abstract: A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

公开(公告)号：US10006861B2

公开(公告)日：2018-06-26

申请号：US14911671

申请日：2014-06-30

Applicant: Streck, Inc.

Inventor： Matthew R. Kreifels ,  Scott E. Whitney ,  Gregg Wilder ,  John Flanagan ,  James Dowling ,  Philip Hills ,  Michael Tilleman ,  Jeremie Jackson

IPC: G01N21/64 ,  C12Q1/686 ,  B01L7/00

CPC classification number: G01N21/6428 ,  B01L7/52 ,  C12Q1/686 ,  C12Q2561/113 ,  C12Q2563/107 ,  G01N21/645 ,  G01N2201/062 ,  G01N2201/068

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.

公开(公告)号：US09932632B2

公开(公告)日：2018-04-03

申请号：US13833349

申请日：2013-03-15

Applicant: Streck, Inc.

Inventor： Matthew R. Kreifels ,  Scott E. Whitney ,  Joel R. TerMaat

IPC: G01N21/00 ,  C12Q1/68 ,  G01N21/64

CPC classification number: C12Q1/686 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0627 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate reduced sample read time and rapid reading of multiple light wavelengths.

公开(公告)号：US20220326157A1

公开(公告)日：2022-10-13

申请号：US17843132

申请日：2022-06-17

Applicant: STRECK, INC.

Inventor： Matthew R. Kreifels ,  Scott E. Whitney ,  Gregg Wilder ,  John Flanagan ,  James Dowling ,  Philip Hills ,  Michael Tilleman ,  Jeremie Jackson

IPC: G01N21/64 ,  C12Q1/686

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.

公开(公告)号：US10674721B2

公开(公告)日：2020-06-09

申请号：US16153273

申请日：2018-10-05

Applicant: Streck, Inc.

Inventor： Rohan M. Fernando ,  Wayne L. Ryan ,  Brad Hunsley

IPC: A01N1/02 ,  G01N33/574

Abstract: Compositions and Methods for Stabilizing Circulating Tumor Cells Methods and compositions for stabilizing a biological sample for analysis, comprising the steps of obtaining in a sample collection device a biological sample from a subject, especially blood, the biological sample including at least one circulating tumor cell from the subject. The methods may include a step of contacting the biological sample with a protective agent composition that includes a preservative agent, an optional anticoagulant, and a quenching agent to form a mixture that includes the protective agent composition and the sample.

公开(公告)号：US20190330685A1

公开(公告)日：2019-10-31

申请号：US16310074

申请日：2017-06-15

Applicant: STRECK, INC.

Inventor： Maria Torres ,  Nancy Hanson ,  Joel Lechner ,  Stephanie Cossette ,  Cathy Scheer ,  Matthew R. Kreifels ,  Stacey Morrow ,  Christopher Connelly ,  Laura R. Porter ,  Randy Fowler

IPC: C12Q1/689 ,  C12Q1/686 ,  C12Q1/6809 ,  C12Q1/6837 ,  C12Q1/6851

Abstract: Assays and methods for detecting resistance to beta-lactam antibiotics including detection of multiple β-lactamase family specific gene targets by polymerase chain reaction or microarray. One or more kits including primers and/or probes for identification of β-lactamase genes selected from the group consisting of one or more of the following: MOX-like, FOX-like, ACC-like, ACT/MIR-like, CMY-2-like, DHA-like, CTX-M-14-like, CTX-M-15-like, VIM-like, NDM-like, IMP-like, KPC-like, and OXA-48-like, OXA-51-like, OXA-143-like, OXA-58-like, OXA-23-like, OXA-24/40-like, TEM-like, and SHV-like. A kit may also include one or more primers and/or probes for the identification a non-beta lactamase gene family which confers antibiotic resistance, such as the MCR-1 gene.

公开(公告)号：US20170145475A1

公开(公告)日：2017-05-25

申请号：US15355444

申请日：2016-11-18

Applicant: Streck, Inc.

Inventor： Bradford A. Hunsley ,  Jianbing Qin

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  C12N15/1003 ,  C12Q1/686 ,  C12Q2523/32 ,  C12Q2527/125

Abstract: A screening method for the identification of a characteristic of a target nucleic acid in a whole blood sample, including positioning a composition comprising whole blood and at least one preservative agent within a centrifuge, centrifugating the composition to isolate a plasma that includes at least one target nucleic acid for further analysis and analyzing the at least one target nucleic acid to identify a characteristic about the at least one target nucleic acid, and a composition including the plasma, the preservative agent, and any other ingredient, which is produced by the method.