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公开(公告)号:US20250012974A1
公开(公告)日:2025-01-09
申请号:US18765612
申请日:2024-07-08
Applicant: University of Utah Research Foundation
Inventor: Rajesh MENON
IPC: G02B6/26
Abstract: A segmented image-relay fiber can include concatenating image-relay fiber segments. Each segment can include, or consist of, an optical fiber and an imaging lens. Each segment can accurately reproduce (e.g., with little to no losses or distortion of the image) a light intensity distribution in its input plane at its output plane, while reducing the distortion of the image that occurs in many typical fiber optic image transfers. This approach can be used for a variety of applications, such as micro-endoscopy and communication transmissions that can benefit from spatially preserved information. The recorded images can also be analyzed or processed using various computational methods, including machine learning (e.g., a trained algorithm), to enhance performance.
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12.
公开(公告)号:US20240409690A1
公开(公告)日:2024-12-12
申请号:US18737657
申请日:2024-06-07
Applicant: University of Utah Research Foundation
Inventor: Caleb Reese , Chen Wang
IPC: C08G75/045 , C08G73/12 , H01L21/48 , H01L21/56 , H01L23/538
Abstract: Disclosed herein is a degradable polyimide substrate that may be reliably used as an electronic substrate in flexible electronics. The degradable polyimide substrate is formed via thiol-ene click chemistry reactions between diallyl imide or other alkene monomers and thiol monomers, that can be activated by photoirradiation at relatively low temperatures (e.g., about 80° C.). As a result, the degradable polyimide substrates disclosed herein may be cured using a simple, energy efficient curing process that allows for streamlined manufacturing of circuits including multilayered circuits. In some instances, epoxy monomers may be added to the monomer resin used to form the polyimide substrate, wherein selective curing may yield polymer substrates with varying degrees of flexibility and rigidity.
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公开(公告)号:US12163198B2
公开(公告)日:2024-12-10
申请号:US18069601
申请日:2022-12-21
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor: Hong Yong R. Sohn , Syamantak Roy
IPC: C21B13/00
Abstract: An alternative approach to producing iron from iron concentrates produced from low grade iron ore without going through pelletization and induration. Such a method may include providing iron ore concentrate in a small particle form, passing the iron ore concentrate through a moving bed conveyor reduction furnace with at least one of hydrogen or natural gas, wherein the concentrate is present in a layer that is no more than about 5 cm thick, the hydrogen gas or natural gas reducing the concentrate so as to remove oxygen therefrom, converting the iron ore concentrate to iron that has a composition similar to direct reduced iron (DRI) or sponge iron product, having about 90-95% iron, up to about 10% oxygen, with other trace impurities. Energy consumption is reduced by 30-50% and CO2 emissions are reduced by 60-95%, depending on whether natural gas or hydrogen is used.
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公开(公告)号:US12162923B2
公开(公告)日:2024-12-10
申请号:US17549367
申请日:2021-12-13
Applicant: University of Utah Research Foundation
Inventor: Mingnan Chen , Peng Zhao
IPC: A61K38/39 , A61K9/00 , A61K9/107 , A61K9/51 , A61K38/16 , A61K39/00 , A61K39/39 , A61K39/395 , A61K47/34 , A61P35/00 , C07K14/36 , C07K14/78 , C07K16/28
Abstract: Disclosed herein, are nanoparticles comprising one or more immune-tolerant elastin-like polypeptide tetramers and one or more immune-tolerant elastin-like fusion molecules. Also, disclosed herein are pharmaceutical compositions including the nanoparticles; methods of administering the nanoparticles to patients for the treatment of cancer; and methods of making the nanoparticles.
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公开(公告)号:US20240398590A1
公开(公告)日:2024-12-05
申请号:US18797168
申请日:2024-08-07
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor: Tommaso LENZI , Lukas R. GABERT , Connelly Ray BUCHANAN , Samuel WESTGARD , Minh TRAN
Abstract: A semi-powered foot and ankle prosthesis (100) has a foot member (128) coupled to the ankle frame (112) and movable with respect to the ankle frame (112). A linear actuator (144) is coupled to and between the ankle frame (112) and the foot member (128) to move the foot member (128) with respect to the ankle frame (112). The linear actuator (144) has a drive motor (150). A locking mechanism (104) selectively engages the drive motor (150) to selectively lock movement of the drive motor (150) to resist a force on the foot member (128) from backdriving the linear actuator (144).
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公开(公告)号:US20240392248A1
公开(公告)日:2024-11-28
申请号:US18697153
申请日:2022-09-30
Inventor: Teruo OKANO , David W. GRAINGER , Masatoshi OKA , Kyungsook KIM , Sumako KAMEISHI , Sun UK SONG , Celia M. DUNN
IPC: C12N5/0775 , A61L27/38
Abstract: The disclosure provides a human bone marrow-derived mesenchymal stem cell (hBMSC) sheet comprising one or more layers of human hBMSCs, wherein the cell sheet is prepared from a human clonal bone marrow-derived mesenchymal stem cell line generated from a single cell. The disclosure also provides methods for producing human bone marrow-derived mesenchymal stem cell sheets comprising culturing hBMSCs in culture solution on a temperature-responsive polymer which has been coated onto a substrate surface of a cell culture support, wherein the temperature-responsive polymer has a lower critical solution temperature in water of 0-80° C.; adjusting the temperature of the culture solution to below the lower critical solution temperature, whereby the substrate surface is made hydrophilic and adhesion of the cell sheet to the surface is weakened; and detaching the cell sheet from the culture support. The cell sheet may be treated with interferon gamma (IFN-γ) or basic fibroblast growth factor (bFGF).
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17.
公开(公告)号:US20240390516A1
公开(公告)日:2024-11-28
申请号:US18688724
申请日:2022-09-01
Inventor: Michael Hughes , Kevin Foust , Sandeep Dhall , Judith L. Fridovich-Keil , Shauna A. Rasmussen , Jennifer M.I. Daenzer , Kent Lai
Abstract: Provided are recombinant adeno-associated virus (r.AAV) vectors comprising a transgene to express galactose-1-phosphate uridylyl transferase (GALT); virions comprising said vectors (r.AAV virions); methods of their production; methods of their use, including methods for treating galactosemia, GALT-deficiency, symptoms therefrom: and kits. These recombinant adeno-associated virus (rAAV) vectors comprise a method of treating galactosemia in a subject in need.
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公开(公告)号:US12150973B2
公开(公告)日:2024-11-26
申请号:US17051341
申请日:2019-04-17
Applicant: University of Utah Research Foundation
Inventor: Dean Tantin
Abstract: Disclosed herein, are compounds comprising a peptide, wherein the peptide is OCA-B or an OCA-B fragment thereof; a linker; and a cell penetrating peptide. Also described herein, are methods of administering compounds to subjects for the treatment of Type I diabetes and blocking the interaction between OCA-B and Jmjd1a.
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公开(公告)号:US20240376621A1
公开(公告)日:2024-11-14
申请号:US18315999
申请日:2023-05-11
Applicant: University of Utah Research Foundation
Abstract: A method of producing iron metal by electrolysis of iron ore can include introducing iron ore into an anode chamber. The anode chamber can include a first electrolyte and an anode. The anode can oxidize water to form O2 gas and H+ ions in the anode chamber. The iron ore can be dissolved to form Fe3+ and/or Fe2+ ions in the anode chamber. The Fe3+ and/or Fe2+ ions can be transferred from the anode chamber to a cathode chamber through a cation exchange membrane that separates the anode chamber from the cathode chamber. The cathode chamber can include a second electrolyte and a cathode. The Fe3+ and/or Fe2+ ions can be reduced to form iron metal at the cathode.
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公开(公告)号:US12139724B2
公开(公告)日:2024-11-12
申请号:US17721690
申请日:2022-04-15
Applicant: University of Utah Research Foundation
Inventor: Tara L. Deans
IPC: C12N5/078 , C12N5/074 , C12N5/0789 , C12N15/85
Abstract: Disclosed herein are methods of producing platelets and red blood cells using synthetic biology and uses thereof. The methods disclosed herein can also be used to produce platelets and red blood cells comprising a therapeutic agent. The cells produced by the methods disclosed herein can be used to treat, manage, prevent and diagnosis various diseases and disorders and be used as a research tool.
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