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    Method for Determination of Analyte Concentrations and Related Apparatus
    14.
    发明申请
    Method for Determination of Analyte Concentrations and Related Apparatus 有权
    测定分析物浓度的方法及相关仪器

    公开(公告)号：US20150276669A1

    公开(公告)日：2015-10-01

    申请号：US14642982

    申请日：2015-03-10

    Applicant: AgaMatrix, Inc.

    Inventor： Steven Diamond ,  Ian Harding ,  Sridhar G. Iyengar ,  Baoguo Wei

    IPC: G01N27/416

    CPC classification number: G01N27/4166 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/3272 ,  G01N27/3273 ,  G01N27/4161 ,  G01N33/48707

    Abstract: A method is provided for determining analyte concentrations, for example glucose concentrations, that utilizes a dynamic determination of the appropriate time for making a glucose measurement, for example when a current versus time curve substantially conforms to a Cottrell decay, or when the current is established in a plateau region. Dynamic determination of the time to take the measurement allows each strip to operate in the shortest appropriate time frame, thereby avoiding using an average measurement time that may be longer than necessary for some strips and too short for others.

    Abstract translation: 提供了一种用于确定分析物浓度（例如葡萄糖浓度）的方法，其利用动态确定用于进行葡萄糖测量的适当时间，例如当电流对时间曲线基本上符合Cottrell衰变时，或当电流建立时 在高原地区。 动态确定进行测量的时间允许每个条带在最短的适当时间范围内运行，从而避免使用平均测量时间长于某些条带所需的时间，而对于其他条带来说太短。

    Reagents for electrochemical test strips
    18.
    发明授权
    Reagents for electrochemical test strips 有权

    公开(公告)号：US11905547B2

    公开(公告)日：2024-02-20

    申请号：US17004655

    申请日：2020-08-27

    Applicant: AgaMatrix, Inc.

    Inventor： Ian Harding ,  Mary Y. Lee ,  Sandie Tan

    IPC: G01N33/52 ,  C12Q1/26

    CPC classification number: C12Q1/26 ,  G01N33/521

    Abstract: A dry reagent composition that includes an active redox enzyme that oxidizes an analyte as a specific substrate to produce an inactive reduced form of the enzyme; and a salt of ferricyanide provides improved performance in electrochemical test strips such as those used for detection of glucose. The salt of ferricyanide consists of ferricyanide and positively-charged counter ions, and the positively charged counter ions are selected such that the salt of ferricyanide is soluble in water, and such that the salt of ferricyanide or the crystalline phase of the salt of ferricyanide has a solubility in water and/or a lower E0eff at a concentration of 100 mM than potassium ferricyanide. For example, the salt of ferricyanide may be tetramethylammonium ferricyanide.

    Analyte determination method and analyte meter
    19.
    发明授权
    Analyte determination method and analyte meter 有权

    公开(公告)号：US11408849B2

    公开(公告)日：2022-08-09

    申请号：US16840990

    申请日：2020-04-06

    Applicant: AgaMatrix, Inc.

    Inventor： Ian Harding ,  Richard Williams ,  Sridhar Iyengar

    IPC: G01N27/327 ,  C12Q1/00 ,  G01N27/30

    Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.

    Electrochemical analyte detection apparatus and method
    20.
    发明授权
    Electrochemical analyte detection apparatus and method 有权

    公开(公告)号：US09939440B2

    公开(公告)日：2018-04-10

    申请号：US15017787

    申请日：2016-02-08

    Applicant: AgaMatrix, Inc.

    Inventor： Ian Harding ,  Sridhar Iyengar ,  Richard Williams

    IPC: G01N27/416 ,  G01N33/573 ,  C12Q1/00 ,  G01N33/543

    CPC classification number: G01N33/573 ,  C12Q1/001 ,  G01N27/4166 ,  G01N33/5438 ,  G01N2333/90 ,  G01N2333/902

    Abstract: A method and apparatus for electrochemical detection of analyte in a sample makes use of a binding interaction and relies on the discovery that asymmetric distribution of a redox enzyme between two electrodes that occurs when a redox enzyme-containing reagent is immobilized at the surface of one electrode can be detected as a chemical potential gradient arising from an asymmetry in the distribution of oxidized or reduced redox substrate. This chemical potential gradient can be detected potentiometrically by observing the potential difference between the electrodes in an open circuit, or amperometrically by observing the current flow between the electrodes when the circuit is closed. In both cases, the observation of asymmetry can be done without the application of an external potential or current to the electrodes.

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