公开(公告)号：US10168313B2

公开(公告)日：2019-01-01

申请号：US13835672

申请日：2013-03-15

Applicant: AgaMatrix, Inc.

Inventor： Sridhar Iyengar ,  Ian Harding ,  Richard Williams ,  Kevin Cai

IPC: G01N33/487 ,  G01N27/327

Abstract: A method for obtaining information encoded on an electrochemical test strip is provided. The test strip has two electrodes disposed within a sample space and the information is encoded on the test strip prior to introduction of liquid sample. The method includes the step of introducing sample to the sample space so that the sample is in contact with the two electrodes within the sample space. In another step a value is determined that is representative of the double layer capacitance of the test strip and/or the equivalent capacitance of the test strip. The determined value is then translated into information reflecting a characteristic of the test strip prior to introduction of sample.

公开(公告)号：US20180231552A1

公开(公告)日：2018-08-16

申请号：US15944148

申请日：2018-04-03

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Sridhar Iyengar ,  Richard Williams

IPC: G01N33/573 ,  C12Q1/00 ,  G01N33/543 ,  G01N27/416

CPC classification number: G01N33/573 ,  C12Q1/001 ,  G01N27/4166 ,  G01N33/5438 ,  G01N2333/90 ,  G01N2333/902

Abstract: A method and apparatus for electrochemical detection of analyte in a sample makes use of a binding interaction and relies on the discovery that asymmetric distribution of a redox enzyme between two electrodes that occurs when a redox enzyme-containing reagent is immobilized at the surface of one electrode can be detected as a chemical potential gradient arising from an asymmetry in the distribution of oxidized or reduced redox substrate. This chemical potential gradient can be detected potentiometrically by observing the potential difference between the electrodes in an open circuit, or amperometrically by observing the current flow between the electrodes when the circuit is closed. In both cases, the observation of asymmetry can be done without the application of an external potential or current to the electrodes.

公开(公告)号：US20160091449A1

公开(公告)日：2016-03-31

申请号：US14964756

申请日：2015-12-10

Applicant: AgaMatrix, Inc.

Inventor： Sridhar Iyengar ,  Ian Harding ,  Charles Boiteau ,  Colin Butters

IPC: G01N27/327 ,  G01N33/487 ,  G01J1/42

CPC classification number: G01N27/3272 ,  G01J1/42 ,  G01N21/255 ,  G01N21/7703 ,  G01N21/8483 ,  G01N27/327 ,  G01N27/3273 ,  G01N33/48707 ,  G01N33/48771 ,  G01N2201/08

Abstract: A test strip with an incorporated optical waveguide and deflectors punched through the optical waveguide allows light to exit through a layer of the test strip and be detected by a photo detector. Using light and a photodetector, these uniquely coded strips are identified. The waveguide can be constructed by sandwiching two layers of the test strip around a light transmissible layer. This configuration allows light to be transmitted through the test strip and out the other end, as well as allowing some light to escape the deflector. This light is detected by a photodetector mounted in the analyte test meter. The deflectors may be placed in patterns such that detection of this light indicates certain characteristics of the strip, such as non-counterfeit, regional identification, type of analyte tested, and coding information.

公开(公告)号：US20140262828A1

公开(公告)日：2014-09-18

申请号：US13835672

申请日：2013-03-15

Applicant: AgaMatrix, Inc.

Inventor： Sridhar Iyengar ,  Ian Harding ,  Richard Williams ,  Kevin Cai

IPC: G01N27/327

CPC classification number: G01N33/48771 ,  G01N27/3274

Abstract: A method for obtaining information encoded on an electrochemical test strip is provided. The test strip has two electrodes disposed within a sample space and the information is encoded on the test strip prior to introduction of liquid sample. The method includes the step of introducing sample to the sample space so that the sample is in contact with the two electrodes within the sample space. In another step a value is determined that is representative of the double layer capacitance of the test strip and/or the equivalent capacitance of the test strip. The determined value is then translated into information reflecting a characteristic of the test strip prior to introduction of sample.

Abstract translation: 提供了一种用于获得编码在电化学测试条上的信息的方法。 测试条具有设置在样品空间内的两个电极，并且在引入液体样品之前将该信息编码在测试条上。 该方法包括将样品引入样品空间以使样品与样品空间内的两个电极接触的步骤。 在另一步骤中，确定代表测试条的双层电容和/或测试条的等效电容的值。 然后将确定的值转换为在引入样品之前反映测试条的特性的信息。

公开(公告)号：US11408849B2

公开(公告)日：2022-08-09

申请号：US16840990

申请日：2020-04-06

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Richard Williams ,  Sridhar Iyengar

IPC: G01N27/327 ,  C12Q1/00 ,  G01N27/30

Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.

公开(公告)号：US10520458B2

公开(公告)日：2019-12-31

申请号：US14987872

申请日：2016-01-05

Applicant: AgaMatrix, Inc.

Inventor： Charles Boiteau ,  Martin Forest ,  Sridhar Iyengar ,  Baoguo Wei

IPC: G01N27/30 ,  G01N33/487 ,  G01N27/327

Abstract: The present invention provides a method and apparatus for creating test strips that may be identified based on differences in electrical conduction or resistance between contact point on the test strip. This is achieved by creating a base test strip with contact points that may be connected to other contact points by an electrical connection. These base test strips may be modified to create a difference in electrical conductivity between contact points, or a contact point may be eliminated. This modification can be used to distinguish different types of test strips based on electrical signature. Additionally, the base test strip may be created such that multiple modifications are possible to distinguish numerous characteristics of test strips.

公开(公告)号：US09939440B2

公开(公告)日：2018-04-10

申请号：US15017787

申请日：2016-02-08

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Sridhar Iyengar ,  Richard Williams

IPC: G01N27/416 ,  G01N33/573 ,  C12Q1/00 ,  G01N33/543

CPC classification number: G01N33/573 ,  C12Q1/001 ,  G01N27/4166 ,  G01N33/5438 ,  G01N2333/90 ,  G01N2333/902

Abstract: A method and apparatus for electrochemical detection of analyte in a sample makes use of a binding interaction and relies on the discovery that asymmetric distribution of a redox enzyme between two electrodes that occurs when a redox enzyme-containing reagent is immobilized at the surface of one electrode can be detected as a chemical potential gradient arising from an asymmetry in the distribution of oxidized or reduced redox substrate. This chemical potential gradient can be detected potentiometrically by observing the potential difference between the electrodes in an open circuit, or amperometrically by observing the current flow between the electrodes when the circuit is closed. In both cases, the observation of asymmetry can be done without the application of an external potential or current to the electrodes.

公开(公告)号：US20160209349A1

公开(公告)日：2016-07-21

申请号：US14987872

申请日：2016-01-05

Applicant: AgaMatrix, Inc.

Inventor： Charles Boiteau ,  Martin Forest ,  Sridhar Iyengar ,  Baoguo Wei

IPC: G01N27/30

Abstract: The present invention provides a method and apparatus for creating test strips that may be identified based on differences in electrical conduction or resistance between contact point on the test strip. This is achieved by creating a base test strip with contact points that may be connected to other contact points by an electrical connection. These base test strips may be modified to create a difference in electrical conductivity between contact points, or a contact point may be eliminated. This modification can be used to distinguish different types of test strips based on electrical signature. Additionally, the base test strip may be created such that multiple modifications are possible to distinguish numerous characteristics of test strips.

公开(公告)号：US20160061763A1

公开(公告)日：2016-03-03

申请号：US14871650

申请日：2015-09-30

Applicant: AGAMATRIX, INC.

Inventor： Sridhar Iyengar ,  Charles Boiteau ,  Martin Forest ,  Colin Butters

IPC: G01N27/327

CPC classification number: G01N27/3272 ,  A61B5/05 ,  A61B5/14 ,  A61B5/150022 ,  C12Q1/00 ,  G01N27/327 ,  G01N27/3273 ,  G01N33/48771

Abstract: A test meter for receiving a test strip comprises: (a) a housing; (b) electronic circuitry disposed within the housing and (c) a strip port connector connected to the electronic circuitry and extending to an opening in the housing, said strip port connector connecting the electronic circuitry with a received test strip. The strip port connector contains a pair of top and bottom contacts, said top and bottom contacts having a proximal end and a distal end and a central contact portion, the top and bottom contacts of the pair are transversely aligned with one another; and the distal ends of the top and bottom contacts are separated or separable from one another by insertion of a test strip between the opposed contacts. The contacts and the meter are adapted to permit detection of faulty contacts and/or coding associated with an inserted test strip.

Abstract translation: 用于接收测试条的测试仪包括：（a）壳体; （b）设置在壳体内的电子电路和（c）连接到电子电路并延伸到壳体中的开口的条形端口连接器，所述条形端口连接器将电子电路与接收的测试条连接。 带状端口连接器包括一对顶部和底部触点，所述顶部和底部触点具有近端和远端以及中心接触部分，该对的顶部和底部触点彼此横向对准; 并且通过在相对的触点之间插入测试条，顶部和底部触点的远端彼此分离或分离。 触点和仪表适于允许检测与插入的测试条相关联的故障触点和/或编码。

公开(公告)号：US20140326616A1

公开(公告)日：2014-11-06

申请号：US14278299

申请日：2014-05-15

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Richard Williams ,  Sridhar Iyengar

IPC: G01N27/30

CPC classification number: G01N27/3274 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/327 ,  G01N27/3272 ,  G01N27/3273

Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.

Abstract translation: 在施加到使用还原介体的电化学测试条的样品中的氧或红细胞的存在通过作为样品的温度的函数确定的添加剂校正因子来校正，并且反映 样品的氧气承载能力。 测量的氧气承载能力也可用于确定血细胞比容并区分血液样本和应用于测试条的对照溶液。