公开(公告)号：US11931368B2

公开(公告)日：2024-03-19

申请号：US16650961

申请日：2018-09-28

Applicant: CRITITECH, INC.

Inventor： Michael Baltezor ,  Matthew McClorey ,  Joseph S. Farthing ,  Mark Williams ,  Jacob Sittenauer

IPC: A61K31/569 ,  A61K9/00 ,  A61K9/16 ,  A61K31/496 ,  A61P9/00

CPC classification number: A61K31/569 ,  A61K9/0075 ,  A61K9/1688 ,  A61K31/496 ,  A61P9/00

Abstract: Disclosed herein are particles of at least 95% by weight of a glucocorticoid that have a specific surface area of at least 10 m2/g, methods for making, such particles, and methods for their use as therapeutics. Also disclosed herein are particles of at least 95% by weight of an indolinone that have a specific surface area of at least 10 m2/g, methods for making such particles, and methods for-their use as therapeutics.

公开(公告)号：US11737972B2

公开(公告)日：2023-08-29

申请号：US18046002

申请日：2022-10-12

Applicant: CRITITECH, INC.

Inventor： Gere S. diZerega ,  Michael Baltezor ,  Charles J. Decedue ,  Sam Campbell ,  Matthew McClorey ,  Marc Iacobucci ,  Holly Maulhardt

IPC: A61K9/10 ,  A61K9/00 ,  A61P35/00 ,  A61B8/08 ,  A61B8/12 ,  A61K9/107 ,  A61K9/14 ,  A61K31/337 ,  A61K47/26 ,  A61P1/18 ,  A61K9/16

CPC classification number: A61K9/0019 ,  A61B8/0841 ,  A61B8/12 ,  A61K9/10 ,  A61K9/107 ,  A61K9/14 ,  A61K31/337 ,  A61K47/26 ,  A61P1/18 ,  A61P35/00 ,  A61K9/1688

Abstract: Disclosed herein are methods for treating epithelial cysts, including pancreatic cysts, in a subject by intracystic injection of compositions comprising antineoplastic particles, including taxane particles such as paclitaxel particles and docetaxel particles.

公开(公告)号：US20230111288A1

公开(公告)日：2023-04-13

申请号：US18046002

申请日：2022-10-12

Applicant: CRITITECH, INC.

Inventor： Gere S. diZerega ,  Michael Baltezor ,  Charles J. Decedue ,  Sam Campbell ,  Matthew McClorey ,  Marc Iacobucci ,  Holly Maulhardt

IPC: A61K9/00 ,  A61P35/00 ,  A61B8/08 ,  A61B8/12 ,  A61K9/107 ,  A61K9/14 ,  A61K31/337 ,  A61K47/26 ,  A61P1/18 ,  A61K9/10

Abstract: Disclosed herein are methods for treating epithelial cysts, including pancreatic cysts, in a subject by intracystic injection of compositions comprising antineoplastic particles, including taxane particles such as paclitaxel particles and docetaxel particles.

公开(公告)号：US11123322B2

公开(公告)日：2021-09-21

申请号：US16669310

申请日：2019-10-30

Applicant: CRITITECH, INC.

Inventor： Michael Baltezor ,  Joseph Farthing ,  Jake Sittenauer ,  Jahna Espinosa ,  Samuel Campbell ,  Matthew McClorey ,  Julia K. Fischer ,  Mark D. Williams ,  Gary E. Clapp

IPC: A61K31/337 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/51 ,  B01J19/10 ,  B01J19/26 ,  B01J2/04 ,  B01J3/00 ,  B01J4/00 ,  A61J3/02 ,  B01D46/24 ,  B01J3/02 ,  B05B1/34 ,  B05B13/02

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US09918957B2

公开(公告)日：2018-03-20

申请号：US15499397

申请日：2017-04-27

Applicant: CRITITECH, INC.

Inventor： Michael Baltezor ,  Joseph Farthing ,  Jake Sittenauer ,  Jahna Espinosa ,  Samuel Campbell ,  Matthew McClorey ,  Julia K. Fischer ,  Mark D. Williams

IPC: A61K31/337 ,  A61K9/16 ,  B01J3/02 ,  B01J3/00

CPC classification number: A61K31/337 ,  A61J3/02 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1605 ,  A61K9/1682 ,  A61K9/1688 ,  A61K9/5192 ,  B01D46/24 ,  B01D2271/02 ,  B01J2/04 ,  B01J3/008 ,  B01J3/02 ,  B01J4/002 ,  B01J19/10 ,  B01J19/26 ,  B05B1/3489 ,  B05B13/0278 ,  B05D2401/90

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US11918691B2

公开(公告)日：2024-03-05

申请号：US18154419

申请日：2023-01-13

Applicant: CRITITECH, INC.

Inventor： Gere S. Dizerega ,  Michael Baltezor ,  Sam Campbell ,  Charles J. Decedue ,  Matthew McClorey ,  Holly Maulhardt

IPC: A61K9/16 ,  A61K31/337 ,  C07K16/28 ,  A61K9/00 ,  A61K39/00

CPC classification number: A61K9/1652 ,  A61K31/337 ,  C07K16/2818 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K2039/54

Abstract: Disclosed are combination therapy methods useful for the therapeutic treatment of cancer by combining local administration of compositions containing antineoplastic particles, such as taxane particles, with systemic administration of compositions containing immunotherapeutic agents. Local administration methods include topical application, pulmonary administration, intratumoral injection, intraperitoneal injection, arid intracystic injection.

公开(公告)号：US20230372234A1

公开(公告)日：2023-11-23

申请号：US18351711

申请日：2023-07-13

Applicant: CRITITECH, INC.

Inventor： Gere S. diZerega ,  Michael Baltezor ,  Charles J. Decedue ,  Sam Campbell ,  Matthew McClorey ,  Marc Iacobucci ,  Holly Maulhardt

IPC: A61K9/00 ,  A61P35/00 ,  A61B8/08 ,  A61B8/12 ,  A61K9/107 ,  A61K9/14 ,  A61K31/337 ,  A61K47/26 ,  A61P1/18 ,  A61K9/10

CPC classification number: A61K9/0019 ,  A61P35/00 ,  A61B8/0841 ,  A61B8/12 ,  A61K9/107 ,  A61K9/14 ,  A61K31/337 ,  A61K47/26 ,  A61P1/18 ,  A61K9/10 ,  A61K9/1688

Abstract: Disclosed herein are methods for treating epithelial cysts, including pancreatic cysts, in a subject by intracystic injection of compositions comprising antineoplastic particles, including taxane particles such as paclitaxel particles and docetaxel particles.

公开(公告)号：US11738029B2

公开(公告)日：2023-08-29

申请号：US18053557

申请日：2022-11-08

Applicant: CRITITECH, INC.

Inventor： Jacob Sittenauer ,  Aranza Barreda Abarca ,  Shelby Clark ,  Joseph Farthing ,  Mark Williams ,  Gere Dizerega ,  Michael Baltezor

IPC: A61K31/55 ,  A61K9/16

CPC classification number: A61K31/55 ,  A61K9/16 ,  A61K9/1688

Abstract: Compositions of particles having at least 95% by weight of rucaparib and a specific surface area (SSA) of at least 12 m2/g, methods for their use, and methods for their production are provided.

公开(公告)号：US11738014B2

公开(公告)日：2023-08-29

申请号：US18053491

申请日：2022-11-08

Applicant: CRITITECH, INC.

Inventor： Jacob Sittenauer ,  Aranza Barreda Abarca ,  Shelby Clark ,  Joseph Farthing ,  Mark Williams ,  Gere Dizerega ,  Michael Baltezor

IPC: A61K31/454 ,  A61K9/16 ,  A61K9/00

CPC classification number: A61K31/454 ,  A61K9/008 ,  A61K9/1688

Abstract: Compositions of particles having at least 95% by weight of niraparib and a specific surface area (SSA) of at least 5 m2/g, methods for their use, and methods for their production are provided.

公开(公告)号：US10993927B2

公开(公告)日：2021-05-04

申请号：US17023635

申请日：2020-09-17

Applicant: CRITITECH, INC.

Inventor： Michael Baltezor ,  Joseph Farthing ,  Jake Sittenauer ,  Jahna Espinosa ,  Samuel Campbell ,  Matthew McClorey ,  Julia K. Fischer ,  Mark D. Williams ,  Gary E. Clapp

IPC: A61K31/337 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/51 ,  A61J3/02 ,  B01J19/10 ,  B01J19/26 ,  B01J2/04 ,  B01J3/00 ,  B01J4/00 ,  B01D46/24 ,  B01J3/02 ,  B05B1/34 ,  B05B13/02

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.