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    In vitro diagnostic device with integrated plasma separator
    11.
    发明授权
    In vitro diagnostic device with integrated plasma separator 有权

    公开(公告)号：US12285758B2

    公开(公告)日：2025-04-29

    申请号：US17500251

    申请日：2021-10-13

    Applicant: Fenwal, Inc.

    Inventor： James Madsen

    IPC: B01L3/00 ,  G01N1/40

    Abstract: A lab-on-a-chip cartridge includes a housing defining four separate chambers. A fluid (such as whole blood) flows through one of the chambers and into another one of the chambers, which includes a filter membrane. The filter membrane is rotated to separate a first fluid component (such as plasma) from a second fluid component (such as red blood cells), with the first fluid component passing through the filter membrane and the second fluid component not passing through the filter membrane. The separated first and second fluid components each flow into a different one of the remaining chambers, with the first fluid component contacting a lab-on-a-chip device for analyzing the first fluid component.

    Automated splitting of a fluid
    12.
    发明授权
    Automated splitting of a fluid 有权

    公开(公告)号：US12222235B2

    公开(公告)日：2025-02-11

    申请号：US17627245

    申请日：2020-07-16

    Applicant: Fenwal, Inc.

    Inventor： James Madsen ,  Kyungyoon Min

    IPC: G01G13/26 ,  G01G13/00

    Abstract: A system for splitting a fluid includes a source support configured to support a source container of a fluid flow circuit and at least one satellite support, with each satellite support configured to support a different satellite container fluidly connected to the source container. A weight scale is associated with each of the supports. The system also includes a clamp system and a controller. The controller is configured to control each weight scale to measure a combined weight of the container and the contents of the container supported by the support associated with the weight scale. The controller is configured to control the clamp system to selectively allow and prevent fluid flow from the source container to each satellite container based at least in part upon the weights measured by each weight scale. Fluid flow continues until the contents of each container have reached a target volume.

    Reversible Sterile Connection System
    14.
    发明申请
    Reversible Sterile Connection System 有权

    公开(公告)号：US20210308443A1

    公开(公告)日：2021-10-07

    申请号：US17220566

    申请日：2021-04-01

    Applicant: Fenwal, Inc.

    Inventor： James Madsen

    IPC: A61M39/16 ,  A61M39/04 ,  A61L2/10

    Abstract: Sterile connection systems and methods are disclosed. The systems and methods allow for connection of the facing ends of plastic tubing defining flow paths without welding or tube cutting. The two ends may be disconnected, re-sterilized and subsequently reused to make a new sterile connection.

    Adjustment of the thickness of a biological fluid being monitored by an optical detection assembly
    16.
    发明授权
    Adjustment of the thickness of a biological fluid being monitored by an optical detection assembly 有权

    公开(公告)号：US12235208B2

    公开(公告)日：2025-02-25

    申请号：US17719539

    申请日：2022-04-13

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters ,  Daniel R. Boggs ,  James Madsen ,  Jeannette Wu ,  Matthew Fang

    IPC: G01N21/05 ,  B01L3/00 ,  G01N21/03

    Abstract: An optical detection assembly for monitoring a biological fluid in a vessel includes two fluid-adjustment structures, which are spaced apart and configured to receive at least a portion of a biological fluid-containing vessel therebetween. A light source (which may be associated with one of the fluid-adjustment structures) is configured to emit light through a thickness of the biological fluid in the vessel, while a light detector (which may be associated with the other one of the fluid-adjustment structures) is configured to receive at least a portion of the light from the light source after it has passed through the biological fluid in the vessel. At least a portion of at least one of the fluid-adjustment structures is configured to move with respect to at least a portion of the other one so as to change the thickness of the biological fluid in the monitored portion of the vessel.

    Blood Pack Donation System for Biomarker Collection During Whole Blood Donation
    18.
    发明申请
    Blood Pack Donation System for Biomarker Collection During Whole Blood Donation 有权

    公开(公告)号：US20230084959A1

    公开(公告)日：2023-03-16

    申请号：US17897475

    申请日：2022-08-29

    Applicant: Fenwal, Inc.

    Inventor： James Madsen

    IPC: B01L3/00 ,  A61B5/15 ,  A61J1/14 ,  A61J1/10

    Abstract: A blood pack donation system configured for use with a lab-on-a-chip device for biomarker collection during whole blood donation including a blood collection container, a biomarker collection container, a first flow path connected to an opening in the blood collection container and to a first outlet opening of a lab-on-a-chip device, a second flow path connected to an opening in the biomarker collection container and to a second outlet opening of the lab-on-a-chip device, and a third flow path connected to a needle and to an inlet opening of the lab-on-a-chip device. The system may be used in a single pass collection procedure. A second version includes a fourth flow path connected to the first flow path and to the third flow path, with a plurality of flow control components that selectively control flow to provide a single pass collection procedure or a multiple pass collection procedure.

    System and method for irradiating biological fluids
    19.
    发明授权
    System and method for irradiating biological fluids 有权

    公开(公告)号：US11577016B2

    公开(公告)日：2023-02-14

    申请号：US16945378

    申请日：2020-07-31

    Applicant: Fenwal, Inc.

    Inventor： James Madsen

    IPC: A61M1/36 ,  A61L2/00 ,  A61L2/10

    Abstract: An irradiation device includes a fluid treatment chamber having first and second opposing sides configured to receive a biological fluid container therebetween, and at least one light source disposed adjacent at least one of the first and second sides of the fluid treatment chamber. The at least one light source includes a light guide having a front planar surface that defines in part the at least one of the first and second sides of the fluid treatment chamber, and at least one light emitting diode (LED) disposed at an edge of the light guide outside the fluid treatment chamber and configured to direct light into the light guide. The light guide has a back surface opposite the front planar surface, the back surface with one or more reflectors that depend into the light guide in the direction of the front surface.

    In Vitro Diagnostic Device with Integrated Plasma Separator
    20.
    发明申请
    In Vitro Diagnostic Device with Integrated Plasma Separator 有权

    公开(公告)号：US20220111383A1

    公开(公告)日：2022-04-14

    申请号：US17500251

    申请日：2021-10-13

    Applicant: Fenwal, Inc.

    Inventor： James Madsen

    IPC: B01L3/00 ,  G01N1/40

    Abstract: A lab-on-a-chip cartridge includes a housing defining four separate chambers. A fluid (such as whole blood) flows through one of the chambers and into another one of the chambers, which includes a filter membrane. The filter membrane is rotated to separate a first fluid component (such as plasma) from a second fluid component (such as red blood cells), with the first fluid component passing through the filter membrane and the second fluid component not passing through the filter membrane. The separated first and second fluid components each flow into a different one of the remaining chambers, with the first fluid component contacting a lab-on-a-chip device for analyzing the first fluid component.

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