Abstract:
A system and method for splitting a fluid into fluid products with a component count within a designated component count range and volume within a designated volume range. The method includes measuring an initial component concentration of a source container, weighing a source container to determine the volume of fluid, calculating the final component count and final volume for each of the source and at least one satellite container, calculating the amount of component additive solution to add the source container and flowing the amount of component additive solution from a component additive solution container into the source container, and splitting the fluid so that each divided fluid amount has a final component count within a designated component count range and a final volume within a designated volume range.
Abstract:
A system for splitting a fluid includes a source support configured to support a source container and a satellite support configured to support a satellite container fluidly connected to the source container. A weight scale is associated with each of the supports. The system also includes a clamp system and a controller. The controller determines a plurality of possible distributions of the fluid between the source container and the satellite container based at least in part on the concentration or amount of said constituent and the combined weight measured by each weight scale, then controls the clamp system to selectively allow and prevent fluid flow from the source container to the satellite container so as to distribute the fluid between the source container and the satellite container according to one of the distributions, with at least one of the possible distributions being an uneven distribution of the fluid.
Abstract:
Fluid flow conduits and apparatus and methods for joining the conduits, preferably in a sterile manner, are disclosed. Each conduit has a polymeric open end that is sealed by a sealing member that may include a heating element. The polymeric end material is melted, the sealing members are moved to expose the melted open ends of the conduits and the ends are brought together to form a fused or welded connection between the conduits.
Abstract:
A system for splitting a fluid includes a source support configured to support a source container of a fluid flow circuit and at least one satellite support, with each satellite support configured to support a different satellite container fluidly connected to the source container. A weight scale is associated with each of the supports. The system also includes a clamp system and a controller. The controller is configured to control each weight scale to measure a combined weight of the container and the contents of the container supported by the support associated with the weight scale. The controller is configured to control the clamp system to selectively allow and prevent fluid flow from the source container to each satellite container based at least in part upon the weights measured by each weight scale. Fluid flow continues until the contents of each container have reached a target volume.
Abstract:
A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the reservoir for the concentrated red blood cells (RCC) has a first chamber for receiving anticoagulant used for priming the separator and purging the system of air prior to the initial draw cycle and a second chamber for receiving separated red blood cells. Because the entire volume of second chamber of the RCC reservoir may now receive separated red blood cells and no AC prime volume, a greater amount of whole blood may be processed in the first draw cycle, thus resulting in a greater total volume of Immunoglobulin G (IgG) being collected during the plasmapheresis procedure.
Abstract:
A system for splitting a fluid includes a source support configured to support a source container of a fluid flow circuit and at least one satellite support, with each satellite support configured to support a different satellite container fluidly connected to the source container. A weight scale is associated with each of the supports. The system also includes a clamp system and a controller. The controller is configured to control each weight scale to measure a combined weight of the container and the contents of the container supported by the support associated with the weight scale. The controller is configured to control the clamp system to selectively allow and prevent fluid flow from the source container to each satellite container based at least in part upon the weights measured by each weight scale. Fluid flow continues until the contents of each container have reached a target volume.
Abstract:
A sterile connection device includes first and second carriages. The first carriage defines a first portion of a proximal slot and a first portion of a distal slot, while the second carriage defines second portions of the proximal and distal slots. A controller executes a sterile connection procedure in which a solid cutting blade is heated, followed by the heated blade being moved to a cutting position to cut sealed proximal and distal tubes received by the slots. The second carriage moves proximally or distally with respect to the first carriage so as to align the cut ends of the tubes. The heated blade then moves out of the cutting position, followed by the first carriage moving toward the second carriage so as to press the cut ends of the tubes into contact with each other so as to sterilely connect the cut ends and define a joined tube.
Abstract:
An irradiation device includes a fluid treatment chamber having first and second opposing sides configured to receive a biological fluid container therebetween, and at least one light source disposed adjacent at least one of the first and second sides of the fluid treatment chamber. The at least one light source includes a light guide having a front planar surface that defines in part the at least one of the first and second sides of the fluid treatment chamber, and at least one light emitting diode (LED) disposed at an edge of the light guide outside the fluid treatment chamber and configured to direct light into the light guide. The light guide has a back surface opposite the front planar surface, the back surface with one or more reflectors that depend into the light guide in the direction of the front surface.
Abstract:
Fluid flow conduits and apparatus and methods for joining the conduits, preferably in a sterile manner, are disclosed. Each conduit has a polymeric open end that is sealed by a sealing member that may include a heating element. The polymeric end material is melted, the sealing members are moved to expose the melted open ends of the conduits and the ends are brought together to form a fused or welded connection between the conduits.
Abstract:
An optical detection assembly for monitoring a biological fluid in a vessel includes two fluid-adjustment structures, which are spaced apart and configured to receive at least a portion of a biological fluid-containing vessel therebetween. A light source (which may be associated with one of the fluid-adjustment structures) is configured to emit light through a thickness of the biological fluid in the vessel, while a light detector (which may be associated with the other one of the fluid-adjustment structures) is configured to receive at least a portion of the light from the light source after it has passed through the biological fluid in the vessel. At least a portion of at least one of the fluid-adjustment structures is configured to move with respect to at least a portion of the other one so as to change the thickness of the biological fluid in the monitored portion of the vessel.