公开(公告)号：US20100200728A1

公开(公告)日：2010-08-12

申请号：US12697618

申请日：2010-02-01

Applicant: Gal Ingber

Inventor： Gal Ingber

IPC: G01J1/32

CPC classification number: G01J1/32 ,  G01J3/42 ,  G01J2003/2866 ,  G01N21/031 ,  G01N21/253 ,  G01N2201/0415 ,  G01N2201/0469 ,  G01N2201/0692

Abstract: A method and device for enhancing the power correction of optical measurements in an optical measurement arrangement, the steps including: providing a light source for producing a light beam; splitting the light beam into two beams; directing a first split light beam through an interrogation area and into an optics separation device; directing the light beams from the optics separation device and a second split light beam representing the intensity of the illumination of the main light beam of the light source into cells of a detector array; measuring and assessing the information obtained in the cells; and using this information to calculate the corrected value for the cells receiving the light beams from the optics separation device in order to adjust the power for the intensity of the light beam of the light source and/or to correct the intensity of the light beams from the interrogation area.

Abstract translation: 一种用于增强光学测量装置中的光学测量的功率校正的方法和装置，所述步骤包括：提供用于产生光束的光源; 将光束分成两束; 将第一分裂光束引导通过询问区并进入光学分离装置; 引导来自光学分离装置的光束和将光源的主光束的照明强度表示为检测器阵列的单元的第二分裂光束; 测量和评估细胞中获得的信息; 并且使用该信息来计算接收来自光学分离装置的光束的单元的校正值，以便调整光源的光束强度的功率和/或校正来自光源的光束的强度 询问区。

公开(公告)号：US10288632B2

公开(公告)日：2019-05-14

申请号：US12885993

申请日：2010-09-20

Applicant: Gal Ingber ,  William G. Atterbury ,  Dave Holley ,  Thomas A. Klausing ,  John S. Laudo ,  Jason A. Schaefer ,  Sherwood Talbert ,  John Tallarico

Inventor： Gal Ingber ,  William G. Atterbury ,  Dave Holley ,  Thomas A. Klausing ,  John S. Laudo ,  Jason A. Schaefer ,  Sherwood Talbert ,  John Tallarico

IPC: G01N35/02 ,  B04B9/14 ,  G01N35/00 ,  G01N35/04

Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.

公开(公告)号：US20120196271A1

公开(公告)日：2012-08-02

申请号：US13356672

申请日：2012-01-24

Applicant: Gal Ingber

Inventor： Gal Ingber

IPC: C12Q3/00 ,  C12M1/36

CPC classification number: G01N21/07 ,  G01N21/31 ,  G01N2201/063

Abstract: A system and a method for optimizing an iris setting, used in combination with a lamp, for each excitation wavelength for each carousel run in an apparatus for identifying and measuring bacteria in biological samples. The system includes a feedback control loop positioned between a filter wheel and an optical cup for measuring the intensity level of the excitation wavelength, and feeding this information to an iris having an iris setting control device such that the iris setting may be adjusted based upon the measured intensity level to control and optimize the level of light fed to the filter wheel from the lamp. The iris setting can be adjusted so that the level of light fed to the filter wheel remains constant during the lifetime of the lamp and to ensure that the level of light fed to the sample remains below the level at which photo-bleaching occurs.

Abstract translation: 用于在用于识别和测量生物样品中的细菌的装置中运行的每个转盘的每个激发波长优化与灯组合使用的虹膜设置的系统和方法。 该系统包括位于滤光轮和光学杯之间的反馈控制回路，用于测量激发波长的强度水平，并将该信息馈送到具有光圈设置控制装置的光圈，使得可以基于 测量强度水平以控制和优化从灯进入滤光轮的光的水平。 可以调节光圈设置，使得在灯的寿命期间馈送到滤光轮的光的水平保持恒定，并且确保馈送到样品的光的水平保持低于发生光漂白的水平。

公开(公告)号：US20110042582A1

公开(公告)日：2011-02-24

申请号：US12865186

申请日：2009-02-05

Applicant: Gal Ingber ,  William G. Atterbury ,  Dave Holley ,  John S. Laudo ,  Jason A. Schaefer ,  Sherwood Talbert ,  John Tallarico ,  Thomas A. Klausing

Inventor： Gal Ingber ,  William G. Atterbury ,  Dave Holley ,  John S. Laudo ,  Jason A. Schaefer ,  Sherwood Talbert ,  John Tallarico ,  Thomas A. Klausing

IPC: G01J1/58 ,  G01N1/10

CPC classification number: G01N21/6486 ,  B01L3/5085 ,  B01L3/50851 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2300/0609 ,  B01L2300/0809 ,  B01L2300/0851 ,  B01L2300/12 ,  B01L2300/168 ,  B01L2300/1844 ,  C12M41/36 ,  G01N21/0303 ,  G01N21/0332 ,  G01N35/026 ,  G01N2021/0382 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6482 ,  G01N2035/00346 ,  G01N2035/0429 ,  G01N2035/0449 ,  G01N2201/0633

Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.

Abstract translation: 本发明涉及用于进行微生物（例如生物样品中的细菌）的鉴定和定量的系统。 更具体地，本发明涉及一种包括一次性盒和具有锥形表面的光学杯或比色杯的系统; 包括光学读取器和热控制器的光学系统; 光学分析仪; 冷却系统; 和改进的光谱仪。 该系统可以利用样品处理器中的一次性盒，以及光学分析仪中的光学杯或反应杯。

公开(公告)号：US20070037135A1

公开(公告)日：2007-02-15

申请号：US11500163

申请日：2006-08-07

Applicant: Russell Barnes ,  Gal Ingber ,  Jonathan Gurfinkel

Inventor： Russell Barnes ,  Gal Ingber ,  Jonathan Gurfinkel

IPC: C12Q1/00 ,  G06F19/00 ,  C12M1/34 ,  G01J3/42

CPC classification number: G01N21/6486 ,  G01N21/21 ,  G01N21/31 ,  G01N21/51 ,  G01N21/645 ,  G01N2021/6417 ,  G01N2021/6419 ,  G01N2021/6482 ,  G01N2021/6491 ,  G01N2201/0612 ,  G01N2201/129 ,  G01N2201/1293

Abstract: A system for the identification and quantification of a biological sample suspended in a liquid includes a fluorescence excitation module with at least one excitation light source; a sample interface module optically coupled to the fluorescence excitation module for positioning a biological sample to receive excitation light from the at least one excitation light source; a fluorescence emission module optically coupled to the sample interface module and comprising at least one detection device for detecting fluorescence excitation-emission matrices of the biological sample; and a computer module operatively coupled to the fluorescence emission module. The computer module performs multivariate analysis on the fluorescence excitation-emission matrices of the biological sample to identify and quantify the biological sample. The multivariate analysis may comprise extended partial least squared analysis for identification and quantification of the biological sample. A method for the identification and quantification of a biological sample suspended in a liquid is also provided.

Abstract translation: 用于鉴定和定量悬浮在液体中的生物样品的系统包括具有至少一个激发光源的荧光激发模块; 光学耦合到所述荧光激发模块的样品接口模块，用于定位生物样品以接收来自所述至少一个激发光源的激发光; 荧光发射模块，其光学耦合到所述样品接口模块，并且包括用于检测所述生物样品的荧光激发发射基质的至少一个检测装置; 以及可操作地耦合到所述荧光发射模块的计算机模块。 计算机模块对生物样品的荧光激发发射基质进行多变量分析，以鉴定和定量生物样品。 多变量分析可以包括用于生物样品的鉴定和定量的扩展的部分最小二乘分析。 还提供了用于鉴定和定量悬浮在液体中的生物样品的方法。