公开(公告)号：US5273406A

公开(公告)日：1993-12-28

申请号：US758749

申请日：1991-09-12

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: F04B43/10

CPC classification number: F04B43/10

Abstract: A pneumatically actuated pumping device contains three or more tubular bladders enclosed in rigid jackets and interconnected through openings at both ends forming a common internal pumping channel. Every tubular bladder is enclosed in a separate coaxial jacket, equipped with a special pressure port to assure an access to the internal volume between the jacket and the bladder. Each combination of the bladder and the jacket represents one actuating segment of the pumping device. An independent pneumatic controller distributes a predetermined pattern of a pressure and vacuum pulses through the pressure port and into the enclosed volume between the jacket and the bladder of each individual segment, providing for a selective collapse of the bladders. Every actuating segment, while collapsing, produces either a bidirectional propelling or valving action. The properly selected sequence of distribution of the pressure and vacuum pulses assures a corresponding closing and opening of actuating segments, providing a desired pumping action in a chosen direction with a preselected speed and pressure. Restoration of the collapsed bladders is assured by the resilience of the bladder material, and can be additionally assisted by providing a pulse of negative pressure into the volume between the bladder and the jacket.

Abstract translation: 气动泵送装置包含封闭在刚性夹套中的三个或更多个管状囊，并且通过两端的开口互连，形成共同的内部泵送通道。 每个管状囊封闭在一个单独的同轴套管中，配备一个特殊的压力端口，以确保进入护套和膀胱之间的内部体积。 气囊和护套的每个组合表示泵送装置的一个致动段。 独立的气动控制器通过压力端口将压力和真空脉冲的预定模式分配到每个单独部分的护套和囊之间的封闭体积中，从而提供气囊的选择性塌陷。 每个启动段在塌缩时产生双向推进或阀门作用。 正确选择的压力和真空脉冲的分布顺序确保相应的致动段的关闭和打开，以预选的速度和压力在选定的方向上提供期望的泵送作用。 通过膀胱材料的弹性来确保塌缩的囊的恢复，并且可以通过在膀胱和护套之间的体积中提供负压脉冲来辅助。

公开(公告)号：US20070183936A1

公开(公告)日：2007-08-09

申请号：US10566648

申请日：2004-07-30

Applicant: John Newsam ,  Ilya Feygin ,  Samir Mitragotri ,  Robert King-Smith

Inventor： John Newsam ,  Ilya Feygin ,  Samir Mitragotri ,  Robert King-Smith

IPC: B01L3/00

CPC classification number: G01N21/253 ,  B01L3/5025 ,  B01L3/50853 ,  B01L2300/045 ,  B01L2300/0609 ,  B01L2300/0618 ,  B01L2300/0829 ,  B01L2400/0611 ,  B01L2400/0633 ,  B01L2400/065 ,  G01N13/00 ,  G01N21/03 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/78 ,  G01N33/5082 ,  Y10T436/255

Abstract: The present invention teaches apparatus (511) and methods for screening the effect of test formulations on the barrier properties of a membrane (212), that are especially beneficial when skin is used as the test membrane (212). The apparatus (511) and methods enable more efficient measurements of skin permeabilization, of the permeation of molecular or particulate entities through skin, and of the absorption and adsorption by skin of ingredients in fluid formulations, together with screening of exfoliation of material from the exterior of the stratum corneum. The apparatus (511) provide for fluid contact to the skin from both donor and receptor sides, for measurements of skin electrical response in the presence of test formulations, of permeation and permeation enhancement, for the depth profiling of test formulation constituents through the skin, of stratum corneum component disruption, and of loss of material from the stratum corneum.

Abstract translation: 本发明教导了用于筛选试验制剂对膜（212）的阻隔性能的影响的装置（511），当皮肤用作测试膜时（212）是特别有利的。 装置（511）和方法能够更有效地测量皮肤透化，分子或颗粒物质通过皮肤的渗透，以及流体配方中成分的皮肤吸收和吸附以及从外部筛选材料的剥离 的角质层。 设备（511）提供从供体和受体侧的流体接触皮肤，用于在测试制剂存在下测量皮肤电响应，渗透和渗透增强，用于通过皮肤测试制剂成分的深度分布， 的角质层组分破坏，以及角质层材料的损失。

公开(公告)号：US07028726B2

公开(公告)日：2006-04-18

申请号：US10761681

申请日：2004-01-21

Applicant: Ilya Feygin ,  John M. Newsam

Inventor： Ilya Feygin ,  John M. Newsam

IPC: B65B1/04

CPC classification number: G01N35/1083 ,  B01F13/1058 ,  B01F13/1072 ,  B01F2215/0032 ,  B01F2215/005 ,  B05B7/066 ,  B05B12/18 ,  G01N35/1002 ,  G01N35/1065 ,  G01N2035/1088

Abstract: A liquid dispenser that uses rotary motion to create a relative movement between one or more dispensing elements and one or more receivers is disclosed. The dispensing elements are fluidically coupled to one or more reservoirs, which contain ingredients that are to be dispensed by the dispensing elements into one or more receivers. The receivers are disposed on a receiver support structure that is located beneath the dispensing elements. In some embodiments, the dispenser operates according to a quasi-continuous dispensing protocol or quasi-simultaneous dispensing protocol, or both quasi-continuous and quasi-simultaneous dispensing protocol.

Abstract translation: 公开了一种使用旋转运动以在一个或多个分配元件和一个或多个接收器之间产生相对运动的液体分配器。 分配元件流体地联接到一个或多个储存器，其包含将由分配元件分配到一个或多个接收器中的成分。 接收器设置在位于分配元件下方的接收器支撑结构上。 在一些实施方案中，分配器根据准连续分配方案或准同时分配方案或准连续和准同步分配方案进行操作。

公开(公告)号：US06742549B1

公开(公告)日：2004-06-01

申请号：US10348769

申请日：2003-01-21

Applicant: Ilya Feygin ,  John M. Newsam

Inventor： Ilya Feygin ,  John M. Newsam

IPC: B65B300

CPC classification number: B01F15/0404 ,  B01F13/1055 ,  B01F13/1072 ,  B01F15/0441 ,  B01F2215/0037 ,  B01J2219/00306 ,  B01J2219/0036 ,  B01L3/0293 ,  B01L2200/14 ,  C40B60/14

Abstract: A system and for creating multiple mixtures is disclosed. The illustrative system described herein includes dispensing elements that are moved into alignment with various receivers (or vice versa) to deliver ingredients. In some embodiments, the system requires only one dispensing element (e.g., valve, nozzle, orifice, etc.) per ingredient dispensed, irrespective of the number of receivers in the system. In accordance with the principles of this invention, the system is operated such that a plurality of ingredients are incrementally added to the receivers. Incremental addition is performed in such a way that, from the “perspective” of the mixture being formed, the ingredients are added quasi-continuously (i.e., a near-continuous flow of an ingredient) or quasi-simultaneously (i.e., all ingredients are added at nearly the same time), or both.

Abstract translation: 公开了一种用于产生多种混合物的系统。 本文描述的说明性系统包括分配元件，其移动成与各种接收器对准（或反之亦然）以输送成分。 在一些实施例中，不管系统中的接收器的数量如何，系统仅需要分配每种成分的一个分配元件（例如，阀，喷嘴，孔口等）。 根据本发明的原理，操作系统使得多个成分被递增地添加到接收器。 以这样的方式进行增量添加：从形成的混合物的“角度”中，准备连续（即，成分的近连续流）或准同时添加成分（即，所有成分为 几乎同时添加）或两者兼而有之。

公开(公告)号：US06733252B2

公开(公告)日：2004-05-11

申请号：US10143403

申请日：2002-05-10

Applicant: Ilya Feygin ,  John M. Newsam

Inventor： Ilya Feygin ,  John M. Newsam

IPC: F04B4310

CPC classification number: B67D7/00 ,  B67D7/62 ,  B67D7/741 ,  F04B43/10

Abstract: A fluid-handling system capable, in various embodiments, of storing, mixing, and dispensing fluids, and also regulating the flow of fluids. The system includes a cartridge having a non-expandable housing, and a bladder within the housing. In some variations, a drive-liquid is introduced into a region between the housing and the bladder, which causes fluid contained within the bladder to dispense. In some other variations, the drive-liquid is introduced into the bladder, which causes the bladder to expand and expel fluid that is contained with the housing.

Abstract translation: 在各种实施例中，能够存储，混合和分配流体以及还调节流体流动的流体处理系统。 该系统包括具有不可扩张壳体的盒，以及壳体内的囊。 在一些变型中，驱动液体被引入到壳体和囊之间的区域中，这导致包含在囊内的流体分配。 在一些其他变型中，驱动液体被引入到囊中，这使得膀胱膨胀并排出与壳体一起容纳的流体。

公开(公告)号：US06524531B1

公开(公告)日：2003-02-25

申请号：US09395399

申请日：1999-09-14

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: B01L300

CPC classification number: B01L3/0265 ,  B01L3/021 ,  B01L2400/0487 ,  G01N2035/00237 ,  G01N2035/00247 ,  Y10T436/2575

Abstract: A hand-held, single-channel dispenser/aspirator is disclosed. The present dispenser/aspirator comprises a body portion for gripping the dispenser and a head portion. In some embodiments, the head portion includes a valve, a liquid conduit and a removable liquid reservoir. The liquid conduit places the liquid reservoir and the dispensing valve in fluid communication. A gas conduit received by the body portion of the dispenser is operable to pressurize the fluid reservoir, or draw a partial vacuum therein. Controls located on the body portion operate the dispenser. The liquid reservoir is advantageously disposed near the valve, so that a relatively short length of liquid conduit is required to operatively connect the reservoir and the dispensing valve, thereby improving the accuracy of the dispensing operation.

Abstract translation: 公开了一种手持式单通道分配器/抽吸器。 本发明的分配器/抽吸器包括用于夹持分配器的主体部分和头部。 在一些实施例中，头部包括阀，液体导管和可移除液体储存器。 液体导管将液体储存器和分配阀置于流体连通状态。 由分配器的主体部分容纳的气体管道可操作以对流体储存器加压或在其中抽取部分真空。 位于身体部位的控制操作分配器。 液体储存器有利地设置在阀附近，使得需要相对较短长度的液体导管来可操作地连接储存器和分配阀，从而提高分配操作的精度。

公开(公告)号：US06315957B1

公开(公告)日：2001-11-13

申请号：US09232774

申请日：1999-01-15

Applicant: Ilya Feygin ,  Edward Theodore Heebner, Jr.

Inventor： Ilya Feygin ,  Edward Theodore Heebner, Jr.

IPC: B01L1100

CPC classification number: G01N1/4077 ,  B01L3/50255 ,  Y10T436/255

Abstract: In some embodiments, the present invention provides a method and an article for segregating solid support media or other solids, from liquid, while at the same time maintaining such solids and liquid in intimate contact as may be required for various processing or chemical operations. In an illustrative embodiment, the present article comprises a filter pocket plate consisting of a plate with a plurality holes. A foraminous material projects through each hole in the plate such that a “pocket” is formed within each hole. In use, the aforedescribed filter pocket plate engages a vessel having one or more wells suitable for retaining liquid and for receiving the filter pockets. The filter pockets contain a solid material that is to be exposed to the liquid in the well. After exposure is complete, the solid material is readily removed from the liquid by simply disengaging the filter pocket plate, which retains the solid support media, from the vessel, which retains the liquid. In some embodiments, the present invention includes disengagement means for automatically removing the filter pocket plate from a cooperating vessel.

Abstract translation: 在一些实施方案中，本发明提供了用于将固体支持介质或其它固体与液体隔离的方法和制品，同时保持与各种加工或化学操作所需的这种固体和液体紧密接触。 在一个说明性的实施例中，本文包括由具有多个孔的板组成的过滤器袋板。 多孔材料通过板中的每个孔突出，使得在每个孔内形成“口袋”。 在使用中，上述过滤器袋板与具有一个或多个适用于保持液体并用于接收过滤袋的孔的容器接合。 过滤袋包含待暴露于井中的液体的固体材料。 曝光完成后，通过简单地将保留固体支持介质的过滤器袋板从保持液体的容器中分离出来，容易地从液体中除去固体材料。 在一些实施例中，本发明包括用于从合作容器自动移除过滤器袋板的分离装置。

公开(公告)号：US06202539B1

公开(公告)日：2001-03-20

申请号：US09273145

申请日：1999-03-19

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: F01B2900

CPC classification number: F15B15/10

Abstract: An article comprising a Z-axis positioning stage is disclosed. The Z-axis positioning stage includes at least one collapsible/expandable cell or cavity that is defined within a region bounded by a lower and a movable upper surface and a side wall depending therefrom. Means for collapsing/expanding the cavity is operatively connected to the cavity. During collapse of the cavity, the upper surface drops towards the lower surface. During expansion of the cavity, the upper surface rises away from lower surface. The upper surface thus functions as a movable stage, which is capable of moving an object placed thereon in a vertical direction (i.e., along the z-axis).

Abstract translation: 公开了一种包括Z轴定位台的物品。 Z轴定位台包括至少一个可折叠/可扩张的电池或空腔，其限定在由下部和可移动的上表面以及与之相对的侧壁所限定的区域内。 用于塌陷/膨胀空腔的装置可操作地连接到空腔。 在空腔塌陷期间，上表面向下表面下降。 在空腔膨胀期间，上表面远离下表面。 因此，上表面起到可移动台的作用，所述可移动台能够沿垂直方向（即沿着z轴）移动放置在其上的物体。

公开(公告)号：US5348526A

公开(公告)日：1994-09-20

申请号：US111549

申请日：1993-08-25

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: B43M3/02 ,  B65H45/12 ,  B65H45/20

CPC classification number: B43M3/02 ,  B65H45/12 ,  B65H2407/21

Abstract: A hand held, manually operated paper folding device, made out of thin, high density material, divided into four sections by specially introduced flexible joints. Three of the sections are similar and together equal the size of a standard paper sheet which is placed on top of these sections prior to the folding process. The fourth section is about 1/8" narrower, which allows it to be folded on top of the adjacent third section, providing means to accommodate, align and hold paper sheets between the third and the forth sections, while also permitting the following folding of all three equal sections in a zig zag fashion, generating within one motion, buckling, formation of two sharp creases and the uniform triple folding of all inserted paper sheets. The inherent springiness of the folded paper sheets and the paper sheet folding device itself assures the release of all paper sheets after the completion of the folding process and release of the paper sheet folding device.

Abstract translation: 手动，手动折纸装置，由薄，高密度材料制成，通过专门引入的柔性接头分为四个部分。 三个部分是类似的，并且一起等于在折叠过程之前放置在这些部分之上的标准纸张的尺寸。 第四部分约1/8英寸，允许折叠在相邻的第三部分的顶部，提供在第三和第四部分之间容纳，对准和保持纸张的装置，同时还允许以下折叠 所有三个相等的部分以锯齿形方式产生，在一个运动内产生弯曲，形成两个尖锐的折痕以及所有插入的纸张的均匀三重折叠。 折叠纸张和纸张折叠装置本身的固有弹性确保折页处理完成之后所有纸张的释放和纸张折页装置的释放。

公开(公告)号：US4724835A

公开(公告)日：1988-02-16

申请号：US889596

申请日：1986-07-25

Applicant: Saul Liss ,  Bernard S. Liss ,  Sam Krakower ,  Ilya Feygin

Inventor： Saul Liss ,  Bernard S. Liss ,  Sam Krakower ,  Ilya Feygin

IPC: A61N5/06 ,  A61N5/067 ,  G01J1/42 ,  H01S5/00 ,  A61B17/36

CPC classification number: G01J1/4257 ,  A61N5/0616 ,  H01S5/0014 ,  A61N2005/065 ,  A61N2005/0665 ,  A61N2005/067 ,  G01J2001/4238

Abstract: Laser therapeutic apparatus irradiates an area of cutaneous and/or subcutaneous physical injury, with a pulsed laser wave, producing healing and pain reduction. A pulsed laser beam of desired frequency is produced by reducing the output of an oscillator via a frequency multiplier which is varied in accordance with the off-nominal frequency deviation desired, if any. The rate multiplier output wave is divided down to a selected frequency and, after amplification, generates pulsed lasing energy.In accordance with varying aspects of the instant invention, a plurality of output lasing units, and optical diffusing lenses, are provided for controlled irradiation of an entire injured area. Circuitry is also provided for detecting pulsed infrared light.

Abstract translation: 激光治疗仪器用脉冲激光波照射皮肤和/或皮下的身体伤害区域，产生愈合和疼痛减轻。 所需频率的脉冲激光束通过经由倍频器减小振荡器的输出而产生，该倍频器根据所需的非标称频率偏差（如果有的话）而变化。 速率倍增器输出波被分为选定频率，放大后产生脉冲激光能量。 根据本发明的不同方面，提供了多个输出激光单元和光学漫射透镜，用于受控照射整个受伤区域。 电路还用于检测脉冲红外光。