公开(公告)号：US20100087845A1

公开(公告)日：2010-04-08

申请号：US12449085

申请日：2008-01-22

Applicant: Clifford Spiro ,  James Hicks

Inventor： Clifford Spiro ,  James Hicks

IPC: A61B17/3211

CPC classification number: A61B17/3211

Abstract: Methods for ameliorating tissue trauma from a surgical incision comprise making the surgical incision with a cutting instrument comprising a cutting instrument body defining two opposed sides and a direction of elongation, and having at least one cutting edge extending along the direction of elongation. The cutting edge defines an ultimate edge and two beveled faces adjacent the ultimate edge. The cutting edge of the cutting instrument has at least one characteristic selected from the group consisting of (a) a uniform ultimate edge having a maximum height deviation of 4 m or less along any 680 m segment of thereof; (b) each beveled face having a maximum height deviation of 4 m or less along any 680 m segment of thereof; and (c) each beveled face adjacent the ultimate edge having a root mean square surface roughness (Rq) of not more than about 200 nm. Improved cutting instruments are also provided.

Abstract translation: 用于从外科切口改善组织创伤的方法包括使用包括限定两个相对侧和延伸方向的切割仪器主体的切割仪器进行外科切口，并且具有沿着伸长方向延伸的至少一个切割边缘。 切割边缘限定了最终边缘和与最终边缘相邻的两个斜面。 切割工具的切割边缘具有选自以下的至少一种特征：（a）沿其任何680m的段具有最大高度偏差为4m或更小的均匀极限边缘; （b）每个斜面的任何680米段的最大高度偏差为4米或更小; 和（c）与最终边缘相邻的每个倾斜面具有不大于约200nm的均方根粗糙度（Rq）。 还提供了改进的切割工具。

公开(公告)号：US20070195195A1

公开(公告)日：2007-08-23

申请号：US11359881

申请日：2006-02-21

Applicant: James Hicks

Inventor： James Hicks

IPC: H04N7/00 ,  H04N5/44

CPC classification number: H04N5/4403 ,  G08C17/02 ,  G08C23/04 ,  G08C2201/40 ,  G08C2201/41 ,  G08C2201/50 ,  H04N5/775 ,  H04N5/85 ,  H04N21/42207 ,  H04N21/42221 ,  H04N21/43632 ,  H04N2005/4407

Abstract: A remote control unit for an entertainment system comprising a television or other display device, and a plurality of peripheral devices connected to the televisions. The remote control unit is adapted to send and receive information signals to and from the television and to the peripheral devices to control the devices. The television and remote control unit both preferably includes a receiver and transmitter and appropriate memory and logic coupled to the transmitter and receiver. Alternatively, the remote control unit preferably includes a receiver and transmitter and a repeater coupled to the receiver and the transmitter. In operation, the remote control unit sends commands to the television, which responds by sending information or a specific command back to the remote control unit. The remote control unit then retrieves and sends a specific command or repeats and sends the command received from the television to the appropriate peripheral device.

Abstract translation: 一种用于娱乐系统的遥控单元，包括电视机或其他显示设备，以及连接到电视机的多个外围设备。 遥控单元适于向电视机和外围设备发送和接收信息信号以控制设备。 电视和遥控单元优选地包括接收器和发射器以及耦合到发射器和接收器的适当的存储器和逻辑。 或者，遥控单元优选地包括接收器和发射器以及耦合到接收器和发射器的中继器。 在操作中，遥控单元向电视机发送命令，该电视机通过发送信息或特定命令来响应遥控单元。 然后，遥控单元检索并发送特定命令或重复发送从电视机接收的命令到相应的外围设备。

公开(公告)号：US20060275769A1

公开(公告)日：2006-12-07

申请号：US10541598

申请日：2004-01-06

Applicant: Ashlee Moses ,  Klaus Fruh ,  Jeffrey King ,  James Hicks ,  Camilo Raggo ,  Jay Nelson

Inventor： Ashlee Moses ,  Klaus Fruh ,  Jeffrey King ,  James Hicks ,  Camilo Raggo ,  Jay Nelson

IPC: C12Q1/70 ,  C12Q1/68

CPC classification number: A01K67/0271 ,  A01K2227/105 ,  A01K2267/0331 ,  A01K2267/0337 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/12 ,  C12Q1/6886 ,  C12Q1/705 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: The present invention uses gene expression profiling, and gene silencing methods to identify and provide a plurality of ‘validated’ KSHV-induced cellular gene sequences and pathways useful as targets for modulation of KSHV-mediated effects on cellular proliferation and phenotype (e.g., cancer) associated with latent and lytic phases of the Kaposi's sarcoma-associated herpesvirus (KSHV; Human herpesvirus 8; HHV8) life cycle. Particular embodiments provide therapeutic compositions, and methods for modulation of KSHV infection or KSHV-mediated effects on cellular proliferation and phenotype, comprising inhibition of KSHV-induced gene sequences. Additional embodiments provide screening assays for compounds useful to modulate KSHV infection or KSHV-mediated effects on cellular proliferation and phenotype. Further embodiments provide diagnostic and/or prognostic assays for KSHV infection.

Abstract translation: 本发明使用基因表达谱和基因沉默方法来鉴定并提供多个“验证的”KSHV诱导的细胞基因序列和途径，其可用作调节KSHV介导的对细胞增殖和表型（例如癌症）的作用的靶标， 与卡波西肉瘤相关疱疹病毒（KSHV;人类疱疹病毒8; HHV8）生命周期的潜伏和溶解期相关。 具体实施方案提供用于调节KSHV感染或KSHV介导的对细胞增殖和表型的影响的治疗组合物和方法，包括KSHV诱导的基因序列的抑制。 另外的实施方案提供了用于调节KSHV感染或KSHV介导的细胞增殖和表型效应的化合物的筛选测定。 其他实施方案提供用于KSHV感染的诊断和/或预后测定。

公开(公告)号：US20060040957A1

公开(公告)日：2006-02-23

申请号：US10071032

申请日：2002-02-08

Applicant: Richard Dyer ,  William Harter ,  James Hicks ,  Adam Johnson ,  Jie Li ,  William Roark ,  Kevon Shuler

Inventor： Richard Dyer ,  William Harter ,  James Hicks ,  Adam Johnson ,  Jie Li ,  William Roark ,  Kevon Shuler

IPC: A61K31/519 ,  C07D498/04

CPC classification number: C07D487/04 ,  C07D513/04

Abstract: Selective MMP-13 inhibitors are bicyclic pyrimidines of the Formula I or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or alkyl; R2, R3, and R4 include hydrogen, halo, alkyl, C≡C(CH2)m aryl, CO2 alkyl, CO2(CH2)m aryl, COHN alkyl, and CONH(CH2)m aryl; and X is O, S, SO, SO2, CH2, C═O, CHOH, NH, or NR5. A compound of Formula I, or a pharmaceutically acceptable salt thereof, is useful for treating cancer or arthritis.

Abstract translation: 选择性MMP-13抑制剂是式I的二环嘧啶或其药学上可接受的盐，其中R 1是氢或烷基; R 2，R 3和R 4包括氢，卤素，烷基，C≡C（CH 2）2， ）芳基，CO 2烷基，CO 2（CH 2 CH 2）m， 芳基，COHN烷基和CONH（CH 2 CH 2）m芳基; X是O，S，SO，SO 2，CH 2，C-O，CHOH，NH或NR 5。 式I化合物或其药学上可接受的盐可用于治疗癌症或关节炎。

公开(公告)号：US20050241537A1

公开(公告)日：2005-11-03

申请号：US11057329

申请日：2005-02-11

Applicant: James Hicks ,  Ryan Scott

Inventor： James Hicks ,  Ryan Scott

IPC: C04B14/00 ,  C04B18/08 ,  C04B28/02

CPC classification number: C04B18/08 ,  C04B28/02 ,  Y02W30/92 ,  Y10S106/01 ,  C04B14/06 ,  C04B14/102 ,  C04B14/106 ,  C04B20/0076 ,  C04B2103/10 ,  C04B14/303 ,  C04B22/064 ,  C04B22/10 ,  C04B24/06

Abstract: A rapid hardening hydraulic cement is provided that is made substantially exclusively from a subbituminous fly ash with no portland cement or other strengthening aid.

Abstract translation: 提供了一种快速硬化水硬水泥，其基本上仅由没有波特兰水泥或其它增强助剂的次烟灰飞灰制成。

公开(公告)号：US20050131281A1

公开(公告)日：2005-06-16

申请号：US10737229

申请日：2003-12-15

Applicant: Steven Ayer ,  Donald Denning ,  Frank Bomba ,  Andrew Christian ,  James Hicks

Inventor： Steven Ayer ,  Donald Denning ,  Frank Bomba ,  Andrew Christian ,  James Hicks

IPC: A61B5/06 ,  A61B5/07 ,  A61B19/00

CPC classification number: A61B5/42 ,  A61B5/062 ,  A61B5/073 ,  A61B5/4833 ,  A61B90/90 ,  A61B90/98

Abstract: A method and apparatus keeps track of ingestible objects (such as pills or food items) ingested by humans or animals. The objects are supplied with radio frequency identification (RFID) tags encoding data describing the objects. The humans or animals ingesting the objects are equipped with RFID sensors for detecting, decoding, and archiving the data encoded in the tags. A user may scan the body of the human or animal subject with a sensor to determine if a tagged object has been ingested. The tags may be covered with substances or contain elements that dissolve upon entering a digestive system. This allows detection of ingestion and also allows the RFID tag encoding to change in the course of digestion.

Abstract translation: 一种方法和装置跟踪人或动物摄入的可摄取物体（如药丸或食物）。 这些对象被提供有编码描述对象的数据的射频识别（RFID）标签。 摄入物体的人体或动物装备有用于检测，解码和归档标签中编码的数据的RFID传感器。 用户可以用传感器扫描人或动物受试者的身体，以确定是否已经被标记的物体被摄取。 标签可能被物质覆盖或含有在进入消化系统时溶解的元素。 这允许检测摄取，并且还允许RFID标签编码在消化过程中改变。

公开(公告)号：US20160340735A9

公开(公告)日：2016-11-24

申请号：US13491359

申请日：2012-06-07

Applicant: James Hicks ,  Alexander Krasnitz

Inventor： James Hicks ,  Alexander Krasnitz

IPC: C40B30/04 ,  A61K39/395 ,  A61P35/00 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  A61K31/337 ,  A61K39/39558 ,  A61K2039/545 ,  C12Q2600/106 ,  C12Q2600/156 ,  A61K2300/00

Abstract: The invention relates to the fields of therapeutics and identifying candidates for therapy, in particular to a method of identifying candidates for trastuzumab (Herceptin®) therapy in a patient presenting with breast cancer based on the presence or absence of specific genetic markers in a tumor sample from said patient.

Abstract translation: 本发明涉及治疗领域和鉴定治疗候选物，特别是基于肿瘤样品中特异性遗传标记物的存在或不存在，确定呈现乳腺癌患者的曲妥珠单抗（Herceptin？）治疗候选者的方法 来自所述患者。

公开(公告)号：US09404156B2

公开(公告)日：2016-08-02

申请号：US13278333

申请日：2011-10-21

Applicant: James Hicks ,  Nicholas Navin ,  Jennifer Troge ,  Zihua Wang ,  Michael Wigler

Inventor： James Hicks ,  Nicholas Navin ,  Jennifer Troge ,  Zihua Wang ,  Michael Wigler

IPC: C12P19/34 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C07H21/00

CPC classification number: C12Q1/6874 ,  C12Q1/683 ,  C12Q1/6881 ,  C12Q1/6886 ,  C12Q2600/156 ,  G06F19/20 ,  C12Q2525/155 ,  C12Q2525/191 ,  C12Q2535/122 ,  C12Q2537/159 ,  C12Q2537/16

Abstract: A method for obtaining from genomic material genomic copy number information unaffected by amplification distortion, comprising obtaining segments of the genomic material, tagging the segments with substantially unique tags to generate tagged nucleic acid molecules, such that each tagged nucleic acid molecule comprises one segment of the genomic material and a tag, subjecting the tagged nucleic acid molecules to polymerase chain reaction (PCR) amplification, generating tag associated sequence reads by sequencing the product of the PCR reaction, assigning each tagged nucleic acid molecule to a location on a genome associated with the genomic material by mapping the subsequence of each tag associated sequence read corresponding to a segment of the genomic material to a location on the genome, and counting the number of tagged nucleic acid molecules assigned to the same location on the genome having a different tag, thereby obtaining genomic copy number information unaffected by amplification distortion.

Abstract translation: 一种用于从基因组材料获得未受扩增变形影响的基因组拷贝数信息的方法，包括获得所述基因组材料的片段，用基本上唯一的标签标记片段以产生标记的核酸分子，使得每个标记的核酸分子包含 基因组材料和标签，对标记的核酸分子进行聚合酶链反应（PCR）扩增，通过对PCR反应的产物进行测序产生标签相关序列读数，将每个标记的核酸分子分配到与 基因组材料通过将对应于基因组材料的片段的每个标签相关序列的亚序列映射到基因组上的位置，并计数分配给具有不同标签的基因组上相同位置的标记核酸分子的数目，从而 获得不受扩增影响的基因组拷贝数信息 扭曲变形。

公开(公告)号：US20140292970A1

公开(公告)日：2014-10-02

申请号：US14237140

申请日：2012-08-06

Applicant: Malcolm Rae ,  James Hicks

Inventor： Malcolm Rae ,  James Hicks

IPC: B41J11/00

CPC classification number: B41J11/0015 ,  B41F23/04 ,  B41F23/0409 ,  B41F23/0483

Abstract: A double-walled housing (3) for an ultra-violet ink curing apparatus (1), comprising an inner skin (5) and an outer wall (7) secured together by at least one locking means (9), wherein the or each locking means (9) is adapted to secure the inner skin (5) and the outer wall (7) together whilst permitting relative movement of the inner skin (5) along the length of the outer wall (7).

Abstract translation: 一种用于紫外线油墨固化设备（1）的双壁壳体（3），包括通过至少一个锁定装置（9）固定在一起的内表皮（5）和外壁（7），其中所述或每个 锁定装置（9）适于将内部皮肤（5）和外壁（7）固定在一起，同时允许内部皮肤（5）沿着外壁（7）的长度相对运动。

公开(公告)号：US20050179825A1

公开(公告)日：2005-08-18

申请号：US10686747

申请日：2003-10-15

Applicant: James Hicks

Inventor： James Hicks

IPC: H04N3/22 ,  H04N3/26 ,  H04N9/28 ,  H04N9/31

CPC classification number: H04N9/31 ,  H04N9/28

Abstract: Systems and methods that facilitate automatic convergence and geometry alignment in projection systems such as a PTV. The automatic convergence system (ACS) preferably includes a CCD camera mounted inside the PTV and focused on the entire inside of a projection screen Fresnel lens. Alternatively, the ACS may include a deployable reflective sheet, preferably in the form of a roll up screen. In operation, signals from the CCD camera corresponding to test patterns projected onto the Fresnel lens or reflective sheet are analyzed and used to align, center or steer raster patterns to compensate for convergence error at a particular location. In a convergence mode, the video is blanked and then successive monochrome video test patterns are projected on the screen. The images captured by the CCD camera are used to memorize the location of landing points of one color test pattern from one of the projection units and then to align the other color patterns from the other projection units to the same landing points as the first color pattern. In a geometry alignment mode, the difference in brightness between an image striking the Fresnel screen and the over scanned area of the PTV cabinet is used to determine the border of the screen. This information is then used to provide reference marks for all geometrical adjustments done automatically using a similar process of successive test patterns and analysis.

Abstract translation: 便于投影系统（如PTV）中自动收敛和几何对准的系统和方法。 自动会聚系统（ACS）优选地包括安装在PTV内部并聚焦在投影屏幕菲涅耳透镜的整个内部的CCD照相机。 或者，ACS可以包括可展开的反射片，优选地以卷起屏幕的形式。 在操作中，分析来自对应于投影到菲涅尔透镜或反射片上的测试图案的CCD照相机的信号，以用于对准，中心或转向光栅图案以补偿特定位置的收敛误差。 在收敛模式下，视频被消隐，然后在屏幕上投影连续的单色视频测试图案。 由CCD照相机拍摄的图像用于从其中一个投影单元存储一个颜色测试图案的着陆点的位置，然后将其他投影单元的其他颜色图案与第一颜色图案相同的着陆点 。 在几何对准模式中，使用菲涅耳屏幕上的图像与PTV机柜的扫描区域之间的亮度差来确定屏幕的边界。 然后使用该信息为使用相似的连续测试模式和分析过程自动完成的所有几何调整提供参考标记。