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公开(公告)号：US09677139B2
公开(公告)日：2017-06-13
申请号：US13491359
申请日：2012-06-07
Applicant: James Hicks , Alexander Krasnitz
Inventor： James Hicks , Alexander Krasnitz
IPC: C12Q1/68 , A61K39/395 , A61K31/337 , A61K39/00
CPC classification number: C12Q1/6886 , A61K31/337 , A61K39/39558 , A61K2039/545 , C12Q2600/106 , C12Q2600/156 , A61K2300/00
Abstract: The invention relates to the fields of therapeutics and identifying candidates for therapy, in particular to a method of identifying candidates for trastuzumab (Herceptin®) therapy in a patient presenting with breast cancer based on the presence or absence of specific genetic markers in a tumor sample from said patient.
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公开(公告)号：US09370941B2
公开(公告)日：2016-06-21
申请号：US14237140
申请日：2012-08-06
Applicant: Malcolm Rae , James Hicks
Inventor： Malcolm Rae , James Hicks
CPC classification number: B41J11/0015 , B41F23/04 , B41F23/0409 , B41F23/0483
Abstract: A double-walled housing (3) for an ultra-violet ink curing apparatus (1), comprising an inner skin (5) and an outer wall (7) secured together by at least one locking means (9), wherein the locking means (9) is adapted to secure the inner skin (5) and the outer wall (7) together while permitting relative movement of the inner skin (5) along the length of the outer wall (7).
Abstract translation: 一种用于紫外线油墨固化装置（1）的双壁壳体（3），包括通过至少一个锁定装置（9）固定在一起的内表皮（5）和外壁（7），其中锁定装置 （9）适于将内皮（5）和外壁（7）固定在一起，同时允许内皮（5）沿着外壁（7）的长度相对运动。
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公开(公告)号：USD651568S1
公开(公告)日：2012-01-03
申请号：US29360924
申请日：2010-05-03
Applicant: James Hicks
Designer： James Hicks
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4.发明申请Methods of treatment and diagnosis of Kaposi's sarcoma (KS) and KS related diseases 审中-公开治疗和诊断卡波西肉瘤（KS）和KS相关疾病的方法公开(公告)号：US20070072209A1
公开(公告)日：2007-03-29
申请号：US11455281
申请日：2006-06-15
Applicant: Ashlee Moses , Klaus Frueh , Jeffrey King , James Hicks , Camilo Raggo , Jay Nelson
Inventor： Ashlee Moses , Klaus Frueh , Jeffrey King , James Hicks , Camilo Raggo , Jay Nelson
CPC classification number: G01N33/5011 , G01N33/57407
Abstract: Aspects of the present invention use gene expression profiling, and gene silencing methods to identify and provide a plurality of ‘validated’ KSHV-induced cellular gene sequences and pathways useful as targets for modulation of KSHV-mediated effects on cellular proliferation and phenotype (e.g., cancer) associated with latent and lytic phases of the Kaposi's sarcoma-associated herpesvirus (KSHV; Human herpesvirus 8; HHV8) life cycle. Particular embodiments provide therapeutic compositions, and methods for modulation and treatment of KSHV infection or KSHV-mediated effects on cellular proliferation and phenotype, comprising inhibition of KSHV-induced gene sequences or products thereof. Additional embodiments provide screening assays for compounds useful to modulate KSHV infection or KSHV-mediated effects on cellular proliferation and phenotype. Further embodiments provide diagnostic and/or prognostic assays for KSHV infection or related conditions. Additional embodiments provide novel in vivo models for KSHV infection or related conditions. Yet further aspects provide novel methods for transforming a mammalian cell, comprising expressing, by recombinant means, a transforming amount of RDCI, Neuritin, or both, and further provide cells transformed thereby.
Abstract translation: 本发明的方面使用基因表达谱和基因沉默方法来鉴定并提供多个“验证的”KSHV诱导的细胞基因序列和可用作调节KSHV介导的细胞增殖和表型效应的靶标的途径（例如， 癌症）与卡波西肉瘤相关疱疹病毒（KSHV;人类疱疹病毒8; HHV8）生命周期的潜伏和溶解期相关。 具体实施方案提供用于调节和治疗KSHV感染或KSHV介导的对细胞增殖和表型的影响的治疗组合物和方法，包括KSHV诱导的基因序列或其产物的抑制。 另外的实施方案提供了用于调节KSHV感染或KSHV介导的细胞增殖和表型效应的化合物的筛选测定。 另外的实施方案提供用于KSHV感染或相关病症的诊断和/或预后测定。 另外的实施方案提供用于KSHV感染或相关条件的新的体内模型。 另外的方面提供了用于转化哺乳动物细胞的新方法，包括通过重组方式表达转化量的RDCI，神经细胞或二者，并进一步提供由其转化的细胞。
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5.发明申请公开(公告)号：US20210103642A9
公开(公告)日：2021-04-08
申请号：US15960445
申请日：2018-04-23
Applicant: Michael H. Wigler , James Hicks , Alexander Krasnitz , Anders Zetterberg
Inventor： Michael H. Wigler , James Hicks , Alexander Krasnitz , Anders Zetterberg
Abstract: The present invention provides methods and compositions related to genomic profiling, and in particular, to assigning probabilistic measure of clinical outcome for a patient having a disease or a tumor using segmented genomic profiles such as those produced by representational oligonucleotide microarray analysis (ROMA).
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Patent Agency Ranking
6.发明申请VARIETAL COUNTING OF NUCLEIC ACIDS FOR OBTAINING GENOMIC COPY NUMBER INFORMATION 有权用于获取基因组复制号码信息的核酸的数量计数公开(公告)号：US20140065609A1
公开(公告)日：2014-03-06
申请号：US13278333
申请日：2011-10-21
Applicant: James Hicks , Nicholas Navin , Jennifer Troge , Zihua Wang , Michael Wigler
Inventor： James Hicks , Nicholas Navin , Jennifer Troge , Zihua Wang , Michael Wigler
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C12Q1/683 , C12Q1/6881 , C12Q1/6886 , C12Q2600/156 , G06F19/20 , C12Q2525/155 , C12Q2525/191 , C12Q2535/122 , C12Q2537/159 , C12Q2537/16
Abstract: A method for obtaining from genomic material genomic copy number information unaffected by amplification distortion, comprising obtaining segments of the genomic material, tagging the segments with substantially unique tags to generate tagged nucleic acid molecules, such that each tagged nucleic acid molecule comprises one segment of the genomic material and a tag, subjecting the tagged nucleic acid molecules to polymerase chain reaction (PCR) amplification, generating tag associated sequence reads by sequencing the product of the PCR reaction, assigning each tagged nucleic acid molecule to a location on a genome associated with the genomic material by mapping the subsequence of each tag associated sequence read corresponding to a segment of the genomic material to a location on the genome, and counting the number of tagged nucleic acid molecules assigned to the same location on the genome having a different tag, thereby obtaining genomic copy number information unaffected by amplification distortion.
Abstract translation: 一种用于从基因组材料获得未受扩增变形影响的基因组拷贝数信息的方法，包括获得所述基因组材料的片段，用基本上唯一的标签标记片段以产生标记的核酸分子，使得每个标记的核酸分子包含 基因组材料和标签，对标记的核酸分子进行聚合酶链反应（PCR）扩增，通过对PCR反应的产物进行测序产生标签相关序列读数，将每个标记的核酸分子分配到与 基因组材料通过将对应于基因组材料的片段的每个标签相关序列的亚序列映射到基因组上的位置，并计数分配给具有不同标签的基因组上相同位置的标记核酸分子的数目，从而 获得不受扩增影响的基因组拷贝数信息 扭曲变形。
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7.发明申请GENETIC MARKERS INDICATIVE OF A CANCER PATIENT RESPONSE TO TRASTUZUMAB (HERCEPTIN) 有权遗传标记表示患者对TRASTUZUMAB（HERCEPTIN）的反应公开(公告)号：US20120328607A1
公开(公告)日：2012-12-27
申请号：US13491359
申请日：2012-06-07
Applicant: James Hicks , Alexander Krasnitz
Inventor： James Hicks , Alexander Krasnitz
IPC: C40B30/04 , A61K39/395 , A61P35/00 , C12Q1/68
CPC classification number: C12Q1/6886 , A61K31/337 , A61K39/39558 , A61K2039/545 , C12Q2600/106 , C12Q2600/156 , A61K2300/00
Abstract: The invention relates to the fields of therapeutics and identifying candidates for therapy, in particular to a method of identifying candidates for trastuzumab (Herceptin®) therapy in a patient presenting with breast cancer based on the presence or absence of specific genetic markers in a tumor sample from said patient.
Abstract translation: 本发明涉及治疗领域和鉴定治疗候选物，特别是基于肿瘤样品中特异性遗传标记物的存在或不存在，确定呈现乳腺癌患者的曲妥珠单抗（Herceptin？）治疗候选者的方法 来自所述患者。
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公开(公告)号：US20050219426A1
公开(公告)日：2005-10-06
申请号：US10837465
申请日：2004-04-29
Applicant: Brian Maxson , James Hicks
Inventor： Brian Maxson , James Hicks
CPC classification number: H04N9/28
Abstract: Systems and methods are provided that facilitate automatic convergence and geometry alignment in projection systems. Preferably, an optical element such as a lens array is coupled to all areas of the projection system's screen and to a detector element such as a photocell array. In operation, each lens of the lens array is adapted to map an individual portion or region of the screen onto the photocell array. A microprocessor, controller or the like uses the data output from the photocells to instruct an alignment controller to center or steer the beams to compensate for convergence error at a particular location. In a center alignment mode, four (4) or more beacon dots located about the periphery of the screen are detected to determine screen size and position, which is used to center the video image and the centers of the mapped regions on the screen.
Abstract translation: 提供了有助于投影系统中的自动会聚和几何对准的系统和方法。 优选地，诸如透镜阵列的光学元件耦合到投影系统的屏幕的所有区域以及诸如光电池阵列的检测器元件。 在操作中，透镜阵列的每个透镜适于将屏幕的单独部分或区域映射到光电晶体阵列上。 微处理器，控制器等使用从光电管输出的数据来指示对准控制器使波束中心或转向以补偿特定位置处的收敛误差。 在中心对准模式中，检测位于屏幕周边周围的四（4）个或更多个信标点，以确定用于将视频图像和映射区域的中心对准在屏幕上的屏幕尺寸和位置。
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公开(公告)号：US20050134006A1
公开(公告)日：2005-06-23
申请号：US10996963
申请日：2004-11-24
Applicant: Jeffrey Adams , Mark Whitlow , James Hicks , George Whittier
Inventor： Jeffrey Adams , Mark Whitlow , James Hicks , George Whittier
IPC: F02F11/00 , F16J20060101 , F16J15/08
CPC classification number: F16J15/0825 , F16J2015/0856 , F16J2015/0862 , F16J2015/0875
Abstract: A head gasket assembly comprising a gasket body comprising a plurality of layers of gasket material a combustion aperture extending through said gasket body, the aperture defined by an inner periphery of the gasket, said periphery adapted to be fitted with a resilient seal element, and a resilient seal element disposed about the inner periphery of the aperture in the gasket body, said seal element being formed of a helically-wound metal wire or metal tube seal at least partially surrounded by a jacket having a flange protruding therefrom and engaging the gasket body.
Abstract translation: 一种头垫片组件，包括垫圈主体，其包括多个衬垫材料层，延伸穿过所述垫圈主体的燃烧孔，所述孔由所述垫圈的内周限定，所述周边适于装配弹性密封元件， 弹性密封元件围绕垫圈主体中的孔的内周设置，所述密封元件由螺旋缠绕的金属线或金属管密封件形成，金属线或金属管密封件至少部分地由护套所包围，该护套具有从其突出的凸缘并与垫圈本体接合。
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10.发明申请公开(公告)号：US20050045142A1
公开(公告)日：2005-03-03
申请号：US10802196
申请日：2004-03-17
Applicant: Frederick Rozario , William Albertson , James Hicks
Inventor： Frederick Rozario , William Albertson , James Hicks
CPC classification number: F01L1/146 , F01L13/0005 , F01L2001/0476 , F01L2001/054 , F01L2001/2427 , F01L2105/00 , F01L2810/02
Abstract: An oil lubrication and control system, for an engine having cylinder deactivation switching lifters operated at the pressure of the full oil system, is provided with an auxiliary pressure relief valve which opens to control maximum oil pressure in the system whenever the engine speed and temperature conditions lie beyond the ability of the oil pump pressure control unit to maintain the maximum pressure limit. Addition of the auxiliary pressure relief valve allows extended operation of the switching lifters, which are limited by their construction to operation below a prescribed pressure limit. In a preferred embodiment, the auxiliary pressure relief valve is mounted in the engine crankcase in a bore connected directly with the main oil gallery to provide mounting and actuation of the auxiliary pressure relief valve with a minimum of modifications to the engine oil system design.
Abstract translation: 一种油润滑和控制系统，用于具有在全油系统的压力下操作的气缸停用切换升降器的发动机，设置有辅助压力释放阀，其在发动机速度和温度条件下打开以控制系统中的最大油压 超出了油泵压力控制单元维持最大压力极限的能力。 辅助减压阀的添加允许开关升降器的延长操作，其由其结构限制在低于规定压力极限的操作。 在优选实施例中，辅助减压阀安装在发动机曲轴箱中的直接与主油道相连接的孔中，以提供对发动机机油系统设计的最小修改的辅助减压阀的安装和致动。
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