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公开(公告)号：US20200026056A1
公开(公告)日：2020-01-23
申请号：US16557623
申请日：2019-08-30
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Yunlu ZOU , Nicholas NEWBERG , Gregory CRANDALL
Abstract: A digital pathology imaging apparatus includes a single line scan camera sensor optically coupled with first and second optical paths. In a first embodiment, transmission mode illumination and oblique mode illumination are simultaneously used during a single stage movement that captures a low resolution macro image of the entire sample area and the entire label area of the slide via the first optical path. In a second embodiment, transmission mode illumination is used during a first stage movement that captures a low resolution macro image of at least the entire sample area via the first optical path and oblique mode illumination is used during a second stage movement that captures a low resolution macro image of at least the entire label area via the first optical path.
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公开(公告)号：US20190162741A1
公开(公告)日：2019-05-30
申请号：US16206504
申请日：2018-11-30
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Nicholas NEWBERG
Abstract: A digital slide scanning apparatus includes a safety light curtain that operates to disable the motor that rotates the carousel when the presence of an object (e.g., the fingers of an operator) is detected within a predetermined area of the carousel. The light curtain also operates to disable the motor that rotates the carousel when an improperly positioned glass slide or slide rack is detected. The digital slide scanning apparatus also includes a multi-color status indicator for each rack slot that indicates the rack slot location of an improperly positioned glass slide or slide rack.
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公开(公告)号：US20220334369A1
公开(公告)日：2022-10-20
申请号：US17631394
申请日：2020-08-06
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Nicholas NEWBERG
Abstract: A digital pathology apparatus includes a housing with a rail system that allows the housing to slide off of the apparatus to expose the internal elements of the apparatus for easy maintenance. The housing includes a latch and sensor system that securely latches the housing in the closed position and senses when the housing is opened so that the moving parts of the apparatus can be safely stopped to avoid potential injury. The housing also includes electromagnetic shielding on a minimal portion of its interior surface to reduce electromagnetic radiation emanating from the apparatus. The digital pathology apparatus also includes a speakerless audio system that engages with a portion of the interior surface of the housing that is not covered with electromagnetic shielding. The speakerless audio system provides an audio user interface while maintaining a contiguous surface on the housing to cover the digital pathology apparatus.
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公开(公告)号：US20220326494A1
公开(公告)日：2022-10-13
申请号：US17631385
申请日：2020-08-05
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Peyman NAJMABADI , Nicholas NEWBERG , Prentash DJELOSEVIC , Aaron STEARRETT
Abstract: Control processes for a slide-scanning system comprising a carousel with a plurality of rack slots configured to receive slide racks via an exposed portion of the scanning system. In an embodiment, initializing the scanning system comprises automatically homing back-end and front-end components, wherein the front-end components comprise the carousel. An inventory of all slide racks in the carousel is automatically generated. If any slide rack was being processed by any back-end components, the slide rack is automatically unloaded into a corresponding rack slot. In addition, the carousel is automatically positioned to expose a starting subset of the rack slots within the exposed portion. This starting subset may comprise a maximum segment of adjacent empty rack slots.
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公开(公告)号：US20200351414A1
公开(公告)日：2020-11-05
申请号：US16933844
申请日：2020-07-20
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Nicholas NEWBERG , Prentash DJELOSEVIC
Abstract: A slide rack determination system for a digital slide scanning apparatus. In an embodiment, a motor drives a slide rack at a known rate toward an engagement surface. The elapsed time until engagement may be used to detect the presence or absence of the slide rack and/or the height of the slide rack. In addition, one or more sensors may detect one or more features of the slide rack, and these feature(s) may be used to determine the presence or absence of a slide rack, whether usage of the slide rack is supported or unsupported by the digital slide scanning apparatus, the orientation of the slide rack, and/or the manufacturer and/or model of the slide rack.
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Patent Agency Ranking
公开(公告)号：US20200209600A1
公开(公告)日：2020-07-02
申请号：US16812010
申请日：2020-03-06
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Leng-Chun CHEN , Yunlu ZOU , Allen OLSON , Peyman NAJMABADI , Greg CRANDALL , Nicholas NEWBERG , Aaron STEARRETT
Abstract: Two-pass capture of a macro image. In an embodiment, a scanning apparatus comprises a stage, a high-resolution camera, and a lens that provides a field of view, substantially equal in width to a slide width, to the high-resolution camera. The apparatus also comprises a first illumination system for transmission-mode illumination, and a second illumination system for reflection-mode illumination. Processor(s) move the stage in a first direction to capture a first macro image of a specimen during a single pass while the field of view is illuminated by the first illumination system, and move the stage in a second direction to capture a second macro image of the specimen during a single pass while the field of view is illuminated by the second illumination system. The processor(s) identify artifacts in the second macro image, and, based on those artifacts, correct the first macro image to generate a modified first macro image.
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公开(公告)号：US20190166293A1
公开(公告)日：2019-05-30
申请号：US16206631
申请日：2018-11-30
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Nicholas NEWBERG , Prentash DJELOSEVIC
Abstract: A digital pathology scanning apparatus is configured to initiate a rescan of a portion of a sample responsive to detecting a mechanical vibration during image acquisition that exceeds a predetermined threshold. The digital pathology scanning apparatus includes a plurality of sensors and a processor that analyzes sensor data received during movement of a scanning stage supporting a sample during image acquisition. The processor is configured to identify a mechanical vibration imparted on the scanning stage during image acquisition and determine if the mechanical vibration exceeds a predetermined threshold. If the predetermined threshold is exceeded, the processor is configured to initiate a rescan of the portion of the sample being scanned at the time of the mechanical vibration.
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公开(公告)号：US20190166272A1
公开(公告)日：2019-05-30
申请号：US16201989
申请日：2018-11-27
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Nicholas NEWBERG , Prentash DJELOSEVIC
Abstract: A slide rack determination system for a digital slide scanning apparatus. In an embodiment, a motor drives a slide rack at a known rate toward an engagement surface. The elapsed time until engagement may be used to detect the presence or absence of the slide rack and/or the height of the slide rack. In addition, one or more sensors may detect one or more features of the slide rack, and these feature(s) may be used to determine the presence or absence of a slide rack, whether usage of the slide rack is supported or unsupported by the digital slide scanning apparatus, the orientation of the slide rack, and/or the manufacturer and/or model of the slide rack.
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公开(公告)号：US20190101555A1
公开(公告)日：2019-04-04
申请号：US16152212
申请日：2018-10-04
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Nicholas NEWBERG
Abstract: A scanning stage with opposing edges to secure a slide during scanning and guide the slide during unloading. In an embodiment, the system includes a reference edge with a surface facing a first edge of the slide and an opposing edge with a surface facing a second edge of the slide. The opposing edge is controlled by a processor to engage the second edge of the slide and press the first edge of the slide against the reference edge surface. The opposing edge surface is parallel to a side of a slide rack slot into which the slide will be inserted during unloading. The system also includes an assembly having a pull bar configured to pull the glass slide from the scanning stage into the slide rack slot while the first edge of the slide is simultaneously being pressed against the reference edge surface by the opposing edge surface.
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公开(公告)号：US20240205546A1
公开(公告)日：2024-06-20
申请号：US18587240
申请日：2024-02-26
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Nicholas NEWBERG , Prentash DJELOSEVIC
CPC classification number: H04N23/685 , G02B21/0036 , G02B21/008 , H04N3/02 , H04N25/711 , G01P13/00 , G06T2207/10056 , G06T2207/20201 , G06T2207/30024 , H04N23/67
Abstract: A digital pathology scanning apparatus is configured to initiate a rescan of a portion of a sample responsive to detecting a mechanical vibration during image acquisition that exceeds a predetermined threshold. The digital pathology scanning apparatus includes a plurality of sensors and a processor that analyzes sensor data received during movement of a scanning stage supporting a sample during image acquisition. The processor is configured to identify a mechanical vibration imparted on the scanning stage during image acquisition and determine if the mechanical vibration exceeds a predetermined threshold. If the predetermined threshold is exceeded, the processor is configured to initiate a rescan of the portion of the sample being scanned at the time of the mechanical vibration.
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